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RNA snippet suppresses spread of aggressive breast cancer

CAMBRIDGE, Mass. (June 11, 2009) A low cellular level of a tiny fragment of RNA appears to increase the spread of breast cancer in mouse models of the disease, according to researchers at Whitehead Institute for Biomedical Research. Measuring levels of this so-called microRNA, which is also a...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

AUGUSTA, Ga. A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say. Levels of the protein, βarrestin2, are lower in some prostate cancer cells t...

Turmeric extract suppresses fat tissue growth in rodent models

BOSTON (May 18, 2009) Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed...

Protein 'switch' suppresses skin cancer development

HOUSTON - The protein IKKalpha (IKKα) regulates the cell cycle of keratinocytes and plays a key role in keeping these specialized skin cells from becoming malignant, researchers at The University of Texas M. D. Anderson Cancer Center report in the Sept. 9 issue of Cancer Cell. "We have sh...

Protein suppresses allergic response in mice

A protein in mice known as RGS13 suppresses allergic reactions, including the severe, life-threatening allergic reaction known as anaphylaxis, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Because RGS1...

Dual Gene Therapy Suppresses Lung Cancer in Preclinical Test

Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M. D. Anderson Cancer Center //and the University of Texas Southwestern Medical Center report in the Jan...

Measles Suppresses AIDS Virus

HIV-positive children ill with measles may get a temporary respite from the virus that causes AIDS. Levels of HIV are suppressed while measles infection rages, the team found. "We were surprised by these findings, because we expected to see HIV replication increase, not decrease with measles//," Dr...

New Anesthesia May Be Safer for Critically Ill

...e with other agents to help keep the person under, a method that requires intense monitoring of blood pressure to avoid critical drops. Etomidate also suppresses the adrenal glands, an effect that can last for up to several days. According to the August issue of Anesthesiology , the research team added a mo...

Watson Pharmaceuticals Receives a Complete Response Letter for Its 24-Week Formulation of TRELSTAR(R) (triptorelin pamoate) NDA from US FDA

...developed by Debiopharm Group and marketed by Watson, administers a synthetic luteinizing hormone releasing hormone (LHRH) agonist, triptorelin, which suppresses the production of testosterone in the testicles. Prostatic cancer proliferation is regulated in part by the level and activity of testosterone. TRELS...

'Easter Island' Drug Adds Years to Mice

...or, Maine. The mice appeared to do well while taking the drug, but it is unclear if rapamycin would have a similar effect in humans. Also, the drug suppresses the immune system in people, leaving them open to the risk of infection. "We don't know that the benefits in people at this point will be greater...
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Paper in International Journal of Oncology Reports Alfacell's ONCONASE(R) Suppresses Intracellular Oxidative Stress

SOMERSET, N.J., Aug. 22 /PRNewswire-FirstCall/ - Alfacell Corporation (Nasdaq: ACEL ) today announced that a paper published in the International Journal of Oncology (2007; Vol. 31, Issue 3: 663-669) reports that ONCONASE(R) substantially decreases reactive oxygen intermediates (ROI) in norma...

Scientists Discover Why Teeth Form in a Single Row

... in the number of tooth rows across species may be due to evolutionary changes in the control of the BMP4/Msx1 pathway," Jiang said. "In mammals, Osr2 suppresses this pathway to restrict teeth within a single row." One of the nation's top academic medical centers, the University of Rochester Medical Cen...

ISTA Pharmaceuticals' New Drug Application for Bepreve(TM) Accepted for Review by U.S. Food and Drug Administration

...ales in 2007. Bepreve is a non-sedating, highly selective antagonist of the histamine (H1) receptor. It has a stabilizing effect on mast cells and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an effective treatment agai...

Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference

...O, Peter Parker. "We have shown previously in cell-culture assays and in a mouse model for human colon cancer that our tk RNAi technology effectively suppresses beta-catenin, a key oncogene in FAP. These new results are very encouraging, and represent another significant milestone in our work to turn the promi...

Medarex Announces Initiation of Phase 1b Clinical Development Program with MDX-1106 for the Treatment of Cancer

...face of activated lymphocytes (T-cells). The binding of PD-1 with one of two ligands (PD-L1 or PD-L2) is an important negative regulation pathway that suppresses or inhibits activated lymphocytes. Recent research has noted increased PD-1 expression levels on antigen specific T-cells in both the oncology and chr...

Novexel to Present Five Posters at the Joint Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Disease Society of America (ICAAC/IDSA) Meeting

...of the most important factors affecting the pharmacodynamics of the combination is maintaining a critical concentration of the inhibitor (NXL104) that suppresses beta-lactamase activity. (Poster A-023). A second poster describes the use of a ceftazidime/NXL104 disk diffusion assay for the detection and identifi...

Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy

... models alone or in combination with chemotherapy. The results show that RNAi-mediated reduction of Nrf2 expression generates reactive oxygen species, suppresses tumor growth, and increases sensitivity to chemotherapeutic drug-induced cell death. Elena Feinstein, M.D., Ph.D., Chief Scientific Officer of Quark...

Data from In Vivo Disease Models on Taligen Therapeutics' Pipeline Candidates to be Presented at the XXII International Complement Workshop

...r 196 Oral Presentation: mAb171 Treatment with a highly inhibitory monoclonal antibody directed to the C3d ligand binding site on human CR2/CD21 suppresses antigen-specific immune responses in vivo Liudmila Kulik*, Jonathan P. Hannan, Brigitte T. Huber, V. Michael Holers Oct. 1, 2008, Animal models (R...

Quark Pharmaceuticals Announces First Patient Dosing by Pfizer in Phase II Trial of RNAi Therapy in Diabetic Macular Edema

...arget VEGF and its receptors, PF-4523655 inhibits abnormal blood vessel growth and leakage independently of the VEGF pathway, reduces inflammation and suppresses apoptosis. Therefore, PF-4523655 is a siRNA therapeutic candidate with the potential to be efficacious when used as a monotherapy and in combination...

Watson Announces Positive Data for Its New Investigational Products for Benign Prostatic Hyperplasia and Overactive Bladder

... Debiopharm Group, a Swiss biopharmaceutical specialist, is a synthetic hormone known as a luteinizing hormone releasing hormone (LHRH) agonist, which suppresses the production of testosterone in the testicles. The growth of the prostate is regulated in part by the level and activity of testosterone. TRELSTAR(R...
suppresses in Medical Dictionary

Melatonin

...the pineal gland that stimulates color change in the epidermis of amphibians and Darkness stimulates the production of melatonin while light suppresses its activity. ... Many researchers also believe that melatonin levels are related to the ... Information about melatonin from the American Aca...

Erythropoietin

...e hormone erythropoietin . ... erythropoietin receptor activity. • guanyl-nucleotide exchange factor activity. • protein binding ... SOCS-3 suppresses erythropoietin (EPO) signaling by ... The kidneys produce a hormone, erythropoietin , that instructs the bone marrow to ... Erythropoietin ....

Cortisol level

...mmediately feel. ... Something special from one of our experts. ... Cortisol increases blood sugar levels , increases blood pressure, and suppresses ... cortisol level natural treatment side effects with the use of this hormone are common, information on high level ... Cortisol lev...
suppresses in Biological News

Molecule that suppresses immune response under study in type 1 diabetes

AUGUSTA, Ga. - The idea is to teach the immune system of children at high risk for type 1 diabetes not to attack the insulin-producing cells of the pancreas. "We want to create a no-go zone," said Dr. Andrew Mellor, immunologist who directs the Medical College of Georgia Immunotherapy Center. T...

Mustard seed meal suppresses weeds in container-grown ornamentals

PROSSER, WA Mustard is one of the most widely used condiments on the planet. Prized for its oils, mustard plants grow wild in North Africa, the Middle East, and the Mediterranean, and is grown commercially in the United Kingdom, Canada, and the United States. During processing, the useful oils...

Dual gene therapy suppresses lung cancer in preclinical test

Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center report in the Jan. ...

Nanodiamonds deliver insulin for wound healing

...Insulin accelerates wound healing by acting as a growth hormone. It encourages skin cells to proliferate and divide, restores blood flow to the wound, suppresses inflammation and fights infection. Earlier investigations have confirmed an increase in alkalinity of wound tissue, due to bacterial colonization, to ...

Short stressful events may improve working memory

...t link acute stress to the enhancement of glutamate receptors and working memory. "In addition," noted Yan, "we have discovered that chronic stress suppresses the transmission of glutamate in the prefrontal cortex of male rodents, which is opposite to the facilitating effect of acute stress, and that estroge...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...d vessels in tumors. He discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor of the VEGFR2 kinase function wa...

Neural stem cell differentiation factor discovered

... neural stem cells into neurons. It has been well defined that Notch signaling drives the formation of astrocytes from neural stem cells while it suppresses the formation of neurons and the maturation of oligodendrocytes" explains Mirko Schmidt at the Institute of Neurology. Inhibition of Notch signaling r...

MicroRNAs help control HIV life cycle

... the journal Molecular Cell . Tariq Rana, Ph.D., director of the Program for RNA Biology at Burnham, and colleagues, found that the microRNA miR29 suppresses translation of the HIV-1 genome by transporting the HIV mRNA to processing-bodies (P-bodies), where they are stored or destroyed. This results in a re...

Environmental cues control reproductive timing and longevity, University of Minnesota study shows

...interact to guide reproduction, explains R. Ford Denison, adjunct professor in the College of Biological Sciences and Ratcliff's adviser. Testosterone suppresses the immune system. So when environmental conditions trigger high levels, reproduction is high but longevity drops. Environmental factors also contr...

Tumor suppressor gene in flies may provide insights for human brain tumors

...n mammals, that can apparently prevent brain tumors from forming. "Our data explicitly show that the fruitfly protein PP2A (protein phosphatase 2A) suppresses brain tumor formation and controls the balance of self-renewal and differentiation of neural stem cells," said Hongyan Wang, Ph.D, assistant professor...
suppresses in Biological Technology

NIST discovers how strain at grain boundaries suppresses high-temperature superconductivity

Researchers at the National Institute of Standards and Technology (NIST) have discovered that a reduction in mechanical strain at the boundaries of crystal grains can significantly improve the performance of high-temperature superconductors (HTS). Their results* could lead to lower cost and signif...

Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...od vessels in tumors. He discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor of the VEGFR2 kinase function was...

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

...ge of 15 in the U.S. were infected with HIV in 2005, the most recent year for which data is available. HIV antiretroviral therapy (ART) is designed to suppresses or stop HIV disease progression. About Quest Diagnostics Quest Diagnostics is the world's leading provider of diagnostic testing, informatio...

Anti-cancer gene discovered: Perspective for therapy

..., and then moving into mouse and human patients, researchers at VIB connected to the Center for Human Genetics (K.U. Leuven) showed that the same gene suppresses cancer in all three. Reciprocally, switching off the gene leads to cancer. The scientists think there is a good chance that the gene can be switched o...

GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research

...re taking a closer look at the phosphoinositide 3-kinase (PI3-kinase) pathway as studies continue to demonstrate that inhibiting this biological route suppresses tumor growth, reports Genetic Engineering & Biotechnology News (GEN) . The pathway is involved in angiogenesis, cell growth, differentiation, and...

ISTA Pharmaceuticals Files New Drug Application with U.S. FDA for Bepreve(TM)

...hanisms of action: it is a non-sedating, highly selective antagonist of the histamine (H1) receptor, it has a stabilizing effect on mast cells, and it suppresses the migration into and activation of eosinophils in inflamed tissues. The compound's primary mechanisms of action are believed to make it an effective...

Antiangiogenic Role of 2ME2 Demonstrated in Rheumatoid Arthritis Models

...E, Banquerigo ML, Lee JK, Park EJ, Fogler WE, and Plum SM. An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses synovial VEGF and bFGF gene expression. J Rheumatol 2008;35:2119- 28). (Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ) Results fr...

FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes

...ecretion --- and it has also been confirmed that they improve the functioning of the beta cells themselves. Furthermore it is known that because GLP-1 suppresses glucagon secretion from the pancreas, the production of sugar in liver cells is also suppressed and appetite is suppressed as well. About Takeda Pha...

New Innovation Set to Revolutionise Spray Technology - Used to Protect Against the Scottish Biting Midge & Help Fight MRSA in the NHS

... of choice for all quality liquids. Our air purifier Cleanaer™ is proving highly successful. It not only removes particles from the air but also suppresses them to prevent them re-circulating. We have started initial tests on killing bacteria and hope to move to trials against MRSA in the coming months.&q...

Revealing the regulating mechanism behind signal transduction in the brain

... So, it is no surprise that FMRP plays an important role in the development and functioning of the brain. The researchers have already shown that FMRP suppresses protein production, but how has remained a mystery. A shared job with CYFIP1 Ilaria Napoli and her colleagues from Claudia Bagni's group are now...
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MasterAmp 10X PCR Enhancer from EPICENTRE Biotechnologies

Description:...lates. Using MasterAmp™ PCR Enhancer in PCR eliminates the base-pair composition dependence of DNA melting, increases enzyme?s thermal stability, suppresses pauses of DNA polymerase, and reduces secondary DNA structure. As a result, long DNA templates, difficult DNA templates (e.g., those with a high GC co...
Company:EPICENTRE Biotechnologies

MasterAmp 10X PCR Enhancer from EPICENTRE Biotechnologies

Description:...A templates. Using MasterAmp PCR Enhancer in PCR eliminates the base-pair composition dependence of DNA melting, increases enzyme?s thermal stability, suppresses pauses of DNA polymerase, and reduces secondary DNA structure. As a result, long DNA templates, difficult DNA templates (e.g., those with a high GC co...
Company:EPICENTRE Biotechnologies

SDSaway from Protea Biosciences, Inc.

Description:...nce of SDS in biological samples imparts a negative charge to the tightly bound SDS-protein complex, inhibits enzymatic activity during digestion, and suppresses ion signals and presents as a contaminant in mass spectrometry analyses. We recommend that SDSaway be used with Proteas PILFer (In-line protein filtr...
Company:Protea Biosciences, Inc.

FluoroGuard Antifade Reagent from Bio-Rad

Description:... FluoroGuard antifade reagent is used to inhibit photobleaching in confocal and standard fluorescence microscopy. The unique formulation effectively suppresses photobleaching in a wide variety of fixed specimens stained or labeled with fluorescein, rhodamine, sulforhodamine 101, coumarin, DAPI, propidium iodi...
Company:Bio-Rad
suppresses in Biological Definition

Gene therapy

...mpany) conducted experiments injecting retroviruses into lung cancer patients. After the injections of vectors containing p53 — a gene that suppresses tumours — directly in to the cancerous tissue, the tumours stopped growing and were broken down by the body. Adenoviruses are larger, DNA-bas...
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Untranslated RNA

...tunt virus ... of the 5' untranslated region (UTR) in the (+)-strand RNA genome of tomato bushy ... 3'UTR RNA from Alpha-Tropomyosin Gene suppresses Tumor Activity. ... Expression of prohibitin 3' untranslated region suppressor RNA alters ... Untranslated Regions of mRNAs Play a Role in ...

Untranslated region

...ranslated region (3' UTR) is a particular ... article "Three prime untranslated region ". Read more ... 3'UTR RNA from Alpha-Tropomyosin Gene suppresses Tumor Activity. ... Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces ... Untranslated , region ,biological ,biology...

Transformed phenotype

... phenotype at ... cm2 were determined for the transformed 6m2 and 54-5A4 cells, respectively. ... ... predominant mechanisms by which the drug suppresses the transformed phenotype . ... of TM-1 induces a transformed phenotype in immortalized cells (20) , suggesting ... ... Control of Transf...

Skeletal muscle

...embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They are... Myostatin suppresses skeletal muscle development. ... Activation of Skeletal Muscle . The contraction of skeletal muscle is controlled by the nervous system. .....

Epistasis

...phenotype is expressed is... epistasis n. , pl. -ses ( ). An interaction between nonallelic genes, especially an interaction in which one gene suppresses the expression of Epistasis - the interaction between two or more genes to control a single phenotype ... Remember that epistasis is the in...

Cone cells

... and green cone cells are simultaneously stimulated with monochromatic ... The loss of the tumor suppressor RB in cone cells of the eye suppresses cell death and promotes cell survival, leading to the development of retinoblastoma. ... segments are physically isolated from the cell bodie...

Anti-sense strand

...ogy,biology terms,biology abbreviations ... of this mRNA uses the antisense strand as a template. ... Antisense means a molecule which does suppresses transcription with a ... Antisense is likely to synthesize a strand of nucleic acid like DNA, RNA that ... ... gene encoding PG by introd...

Antisense strand

...' since functional open ... refer to the three corresponding frames in a coding antisense strand . ... Antisense means a molecule which does suppresses transcription with a ... Antisense is likely to synthesize a strand of nucleic acid like DNA, RNA that ... Encyclopedia article about Anti...

Antisense

...disease, it is possible to synthesize a strand of nucleic acid that will bind to the messenger RNA... Antisense means a molecule which does suppresses transcription with a ... Antisense having a series complementary to a segment of genetic objects and ... antisense adj. Of or relating to a...
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