RNA snippet suppresses spread of aggressive breast cancer
CAMBRIDGE, Mass. (June 11, 2009) A low cellular level of a tiny fragment of RNA appears to increase the spread of breast cancer in mouse models of the disease, according to researchers at Whitehead Institute for Biomedical Research. Measuring levels of this so-called microRNA, which is also a...Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment
AUGUSTA, Ga. A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say. Levels of the protein, βarrestin2, are lower in some prostate cancer cells t...Turmeric extract suppresses fat tissue growth in rodent models
BOSTON (May 18, 2009) Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed...Protein 'switch' suppresses skin cancer development
HOUSTON - The protein IKKalpha (IKKα) regulates the cell cycle of keratinocytes and plays a key role in keeping these specialized skin cells from becoming malignant, researchers at The University of Texas M. D. Anderson Cancer Center report in the Sept. 9 issue of Cancer Cell. "We have sh...Protein suppresses allergic response in mice
A protein in mice known as RGS13 suppresses allergic reactions, including the severe, life-threatening allergic reaction known as anaphylaxis, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Because RGS1...Dual Gene Therapy Suppresses Lung Cancer in Preclinical Test
Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M. D. Anderson Cancer Center //and the University of Texas Southwestern Medical Center report in the Jan...New Anesthesia May Be Safer for Critically Ill
...e with other agents to help keep the person under, a method that requires intense monitoring of blood pressure to avoid critical drops. Etomidate also suppresses the adrenal glands, an effect that can last for up to several days. According to the August issue of Anesthesiology , the research team added a mo...'Easter Island' Drug Adds Years to Mice
...or, Maine. The mice appeared to do well while taking the drug, but it is unclear if rapamycin would have a similar effect in humans. Also, the drug suppresses the immune system in people, leaving them open to the risk of infection. "We don't know that the benefits in people at this point will be greater...Scientists Discover Why Teeth Form in a Single Row
... in the number of tooth rows across species may be due to evolutionary changes in the control of the BMP4/Msx1 pathway," Jiang said. "In mammals, Osr2 suppresses this pathway to restrict teeth within a single row." One of the nation's top academic medical centers, the University of Rochester Medical Cen...Molecule that suppresses immune response under study in type 1 diabetes
AUGUSTA, Ga. - The idea is to teach the immune system of children at high risk for type 1 diabetes not to attack the insulin-producing cells of the pancreas. "We want to create a no-go zone," said Dr. Andrew Mellor, immunologist who directs the Medical College of Georgia Immunotherapy Center. T...Mustard seed meal suppresses weeds in container-grown ornamentals
PROSSER, WA Mustard is one of the most widely used condiments on the planet. Prized for its oils, mustard plants grow wild in North Africa, the Middle East, and the Mediterranean, and is grown commercially in the United Kingdom, Canada, and the United States. During processing, the useful oils...Dual gene therapy suppresses lung cancer in preclinical test
Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center report in the Jan. ...Nanodiamonds deliver insulin for wound healing
...Insulin accelerates wound healing by acting as a growth hormone. It encourages skin cells to proliferate and divide, restores blood flow to the wound, suppresses inflammation and fights infection. Earlier investigations have confirmed an increase in alkalinity of wound tissue, due to bacterial colonization, to ...Short stressful events may improve working memory
...t link acute stress to the enhancement of glutamate receptors and working memory. "In addition," noted Yan, "we have discovered that chronic stress suppresses the transmission of glutamate in the prefrontal cortex of male rodents, which is opposite to the facilitating effect of acute stress, and that estroge...Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...d vessels in tumors. He discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor of the VEGFR2 kinase function wa...Neural stem cell differentiation factor discovered
... neural stem cells into neurons. It has been well defined that Notch signaling drives the formation of astrocytes from neural stem cells while it suppresses the formation of neurons and the maturation of oligodendrocytes" explains Mirko Schmidt at the Institute of Neurology. Inhibition of Notch signaling r...MicroRNAs help control HIV life cycle
... the journal Molecular Cell . Tariq Rana, Ph.D., director of the Program for RNA Biology at Burnham, and colleagues, found that the microRNA miR29 suppresses translation of the HIV-1 genome by transporting the HIV mRNA to processing-bodies (P-bodies), where they are stored or destroyed. This results in a re...Environmental cues control reproductive timing and longevity, University of Minnesota study shows
...interact to guide reproduction, explains R. Ford Denison, adjunct professor in the College of Biological Sciences and Ratcliff's adviser. Testosterone suppresses the immune system. So when environmental conditions trigger high levels, reproduction is high but longevity drops. Environmental factors also contr...Tumor suppressor gene in flies may provide insights for human brain tumors
...n mammals, that can apparently prevent brain tumors from forming. "Our data explicitly show that the fruitfly protein PP2A (protein phosphatase 2A) suppresses brain tumor formation and controls the balance of self-renewal and differentiation of neural stem cells," said Hongyan Wang, Ph.D, assistant professor...NIST discovers how strain at grain boundaries suppresses high-temperature superconductivity
Researchers at the National Institute of Standards and Technology (NIST) have discovered that a reduction in mechanical strain at the boundaries of crystal grains can significantly improve the performance of high-temperature superconductors (HTS). Their results* could lead to lower cost and signif...Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...od vessels in tumors. He discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor of the VEGFR2 kinase function was...Anti-cancer gene discovered: Perspective for therapy
..., and then moving into mouse and human patients, researchers at VIB connected to the Center for Human Genetics (K.U. Leuven) showed that the same gene suppresses cancer in all three. Reciprocally, switching off the gene leads to cancer. The scientists think there is a good chance that the gene can be switched o...GEN Reports Growing Focus on PI3-Kinase Pathway in Cancer Research
...re taking a closer look at the phosphoinositide 3-kinase (PI3-kinase) pathway as studies continue to demonstrate that inhibiting this biological route suppresses tumor growth, reports Genetic Engineering & Biotechnology News (GEN) . The pathway is involved in angiogenesis, cell growth, differentiation, and...ISTA Pharmaceuticals Files New Drug Application with U.S. FDA for Bepreve(TM)
...hanisms of action: it is a non-sedating, highly selective antagonist of the histamine (H1) receptor, it has a stabilizing effect on mast cells, and it suppresses the migration into and activation of eosinophils in inflamed tissues. The compound's primary mechanisms of action are believed to make it an effective...Antiangiogenic Role of 2ME2 Demonstrated in Rheumatoid Arthritis Models
...E, Banquerigo ML, Lee JK, Park EJ, Fogler WE, and Plum SM. An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses synovial VEGF and bFGF gene expression. J Rheumatol 2008;35:2119- 28). (Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ) Results fr...Revealing the regulating mechanism behind signal transduction in the brain
... So, it is no surprise that FMRP plays an important role in the development and functioning of the brain. The researchers have already shown that FMRP suppresses protein production, but how has remained a mystery. A shared job with CYFIP1 Ilaria Napoli and her colleagues from Claudia Bagni's group are now...MasterAmp 10X PCR Enhancer from EPICENTRE Biotechnologies
Description:...lates. Using MasterAmp PCR Enhancer in PCR eliminates the base-pair composition dependence of DNA melting, increases enzyme?s thermal stability, suppresses pauses of DNA polymerase, and reduces secondary DNA structure. As a result, long DNA templates, difficult DNA templates (e.g., those with a high GC co...MasterAmp 10X PCR Enhancer from EPICENTRE Biotechnologies
Description:...A templates. Using MasterAmp PCR Enhancer in PCR eliminates the base-pair composition dependence of DNA melting, increases enzyme?s thermal stability, suppresses pauses of DNA polymerase, and reduces secondary DNA structure. As a result, long DNA templates, difficult DNA templates (e.g., those with a high GC co...SDSaway from Protea Biosciences, Inc.
Description:...nce of SDS in biological samples imparts a negative charge to the tightly bound SDS-protein complex, inhibits enzymatic activity during digestion, and suppresses ion signals and presents as a contaminant in mass spectrometry analyses. We recommend that SDSaway be used with Proteas PILFer (In-line protein filtr...FluoroGuard Antifade Reagent from Bio-Rad
Description:... FluoroGuard antifade reagent is used to inhibit photobleaching in confocal and standard fluorescence microscopy. The unique formulation effectively suppresses photobleaching in a wide variety of fixed specimens stained or labeled with fluorescein, rhodamine, sulforhodamine 101, coumarin, DAPI, propidium iodi...