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Sulfonylurea in Medical News

Avandia Raises Risk of Heart Failure, Fractures

...g were the final results of the RECORD trial, which involved 4,447 patients with type 2 diabetes, randomly selected to take Avandia plus metformin and sulfonylurea or just metformin and sulfonylurea. "There was better persistence of glucose control over a course of five years, an approximate doubling in heart ...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Glitazones have not yet been sufficiently investigated

...ls are insufficiently controlled by metformin or a sulfonylurea alone. A 3-drug therapy in combination with sulfonylurea and metformin is also possible: however, glitazone... this therapy regimen if a previous combination of sulfonylurea and metformin failed to achieve the desired succes...

Amylin, Lilly Update on FDA Review of BYETTA(R) (exenatide) Injection Monotherapy Submission

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...d over that of placebo. Therefore, a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia...headache. In clinical trials in combination with a sulfonylurea (glimepiride), with or without metformin, JANUVIA ....1) When used with a sulfonylurea, a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia...

Sanofi-aventis Q3 2008 Adjusted EPS Excluding Selected Items(1):

...008 New ADA/EASD Treatment Recommendations: Experts Recommend considering a basal insulin or sulfonylurea when treatment goals not achieved with metformin alone Financial Timetable February 11, 2009 2008 results April ...

Weekly Drug Helps Type 2 Diabetics

... Subjects using exenatide once weekly experienced minor side effects, such as mild nausea. Minor incidents of hypoglycemia occurred in patients using sulfonylurea therapy. Amylin Pharmaceuticals Inc., the maker of Byetta, is working with Eli Lilly and Co. and Alkermes Inc. to develop exenatide once weekly. ...

Phase 3 results for alogliptin

...age of patients achieved HbA1c levels of less than or equal to 7 percent. Similar results were seen in the add-on to metformin, thiazolidinedione and sulfonylurea studies. Across all studies, patients achieved significant reductions in HbA1c, up to 0.80 percent, depending on the alogliptin dose and their treatm...

Study shows pine bark naturally reduces cardiovascular risk factors in diabetics

...rial consisted of 48 men and women, 40 to 75 years of age, with noninsulin-dependent type II diabetes, taking anti-diabetic medication with metformin, sulfonylurea and glitazones. Furthermore, they took antihypertensive medications with ACE inhibitors such as Lisinopril. Despite their medication their fasting blo...

Study Shows Pine Bark Naturally Reduces Cardiovascular Risk Factors in Diabetics

...rial consisted of 48 men and women, 40 to 75 years of age, with noninsulin-dependent type II diabetes, taking anti-diabetic medication with metformin, sulfonylurea and glitazones. Furthermore, they took antihypertensive medications with ACE inhibitors such as Lisinopril. Despite their medication their fasting blo...
Sulfonylurea in Medical Technology

Exenatide Once Weekly Provided Superior Glucose Control Compared to Lantus(R) in Head-to-Head DURATION-3 Study

... for patients on metformin background therapy, and 20 percent with exenatide once weekly versus 44 percent with Lantus for patients on metformin and a sulfonylurea background therapy, differences that are statistically significant in both treatment groups. Study Design The 26-week open-label, supe...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Large, Long-Term Study Shows Avandia Has No Increased Overall Cardiovascular Risk Compared to Other Commonly Used Diabetes Medicines

...ompare cardiovascular outcomes of patients on Avandia added to metformin or sulfonylurea to those on metformin and sulfonylurea. The study confirmed its primary hyp... nearly five years) previously demonstrated by Avandia versus metformin and sulfonylurea in the ADOPT study. Although RECORD was not designed to study microvas...

Spherix Elects New Independent Director, and Elects Chairman of the Board

...e sales and marketing functions, and was actively involved in the promotion of Avandia and the subsequent combinations of Avandia with metformin and a sulfonylurea from the time of their respective market introductions. With the election of Mr. Peter to Spherix's Board, the Company has notified NASDAQ that i...

Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Plans for Exenatide Once Weekly NDA Submission by End of First Half of 2009 Reaffirmed Following FDA Feedback

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Type 2 Diabetes Patients Taking Exenatide Once Weekly, a Phase 3 Investigational Diabetes Therapy, Showed Improvements in Glycemic Control, Weight

...e once weekly and with BYETTA use were limited to patients using background sulfonylurea therapy. In both groups, nausea was predominantly mild and transient and oc...d sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effec...

Phase 3 Results for Alogliptin Demonstrated Significant Blood Sugar Reductions in Monotherapy and Four Add-on Therapy Studies

...percent -- insulin add-on: -0.63 percent, -0.71 percent, -0.13 percent -- sulfonylurea add-on: -0.38 percent, -0.52 percent, +0.01 percent A greater percentage ...44 percent (P=.008), 23 percent -- metformin add-on: 52 percent (P -- sulfonylurea add-on: 30 percent (P=.057), 35 percent (P=.002), 18 percent In all f...
Sulfonylurea in Biological News

Moderate use averts failure of type 2 diabetes drugs in animal model

...beta cells also survive and can continue to produce insulin after long-term sulfonylurea exposure, it may be possible to rethink treatment strategies, Nichols sugge...lls also make less insulin. Physicians typically treat the condition with a sulfonylurea and metformin, a drug that increases insulin sensitivity. Sulfonylureas ...
Sulfonylurea in Biological Technology

New Drug Application for Exenatide Once Weekly Accepted for Review by FDA

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

DuPont and Bayer CropScience Expand Collaboration With Broad License Agreements

...des provide growers with improved crop safety. DuPont also receives rights to offer blends of isoxadifen with certain defined HPPD herbicides and its sulfonylurea herbicides as well as licenses that will enable DuPont to introduce a broad class of future crop protection product offerings. A number of other ...

Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Exenatide Clinical Data Analysis Shows No Increased Risk of Cardiovascular Events

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008

...s used with a medicine that contains a sulfonylurea, hypoglycemia (low blood sugar) is a possible side effect. To reduce this possibility, the dose of sulfonylurea medicine may need to be reduced while using BYETTA. Other common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, fee...

GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes

...ifference between rosiglitazone in combination with either metformin or sulfonylurea vs. the active comparators of metformin plus sulfonylurea. In addition...tients who fail treatment on metformin and sulfonylurea, or for whom sulfonylurea or metformin are contraindicated. The rosiglitazone patients are ...

In-Vitro Metabolism Studies Using Data-Dependent LC/MSn

.... This approach will be illustrated with the example of the analysis of metabolites derived from glyburide (glibenclamide), a potent sulfonylurea drug. 1,2 Goal In this report, the application of benchtop ion trap API mass spectrometry to charact...
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