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Statement from IDF on studies suggesting possible link between insulin glargine and cancer

The International Diabetes Federation (IDF) today called for urgent assessment and responses from regulatory authorities into a possible link between the use of insulin glargine (an insulin analogue) and increased risk of cancer based on findings published on 26 June, 2009 in Diabetelogia , the j...

Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons

PHILADELPHIA - Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease. Now, the same group has shown th...

Delays in UK child brain tumor diagnosis

...y delays in diagnosis, which are leading to poor outcomes compared with the rest of Europe and the USA. This is true for teenagers too, with evidence suggesting that many visit their GP numerous times before being referred." David Kershaw, who lost his two year old son, Jake, to a brain tumour, is angry ab...

New Research Suggests Most Are Willing to Make Tradeoffs and Would Embrace Comprehensive Health Care Reform

...n's health reform plan enjoyed a 71 percent approval rating early on, but legislation quickly stalled and that rating slipped to less than 40 percent, suggesting that opposition easily swayed a public that had not yet worked through the issues and reached a firm judgment. The Voices for Health Care pr...

Consumer Reports Launches Online Hospital Ratings for More Than 3,400 U.S. Hospitals

...Lebanon Hospital Center (Bronx, NY). As noted above, several hospitals in the list containing the lowest Patient Ratings are in New York City, suggesting that teaching hospitals that practice an aggressive approach to chronic care are not leaving a positive impression on New Yorkers. "It's especially i...

Hard to Treat Diseases, Inc. (HTDS) Experiments with Hyperbaric Oxygenation (HBO) Traumatic Brain Injury

...vealed that repetitive HBO treatments, which started 1 hour after traumatic brain injury significantly, reduced axonal loss and neuronal degeneration, suggesting that HBO was able to attenuate the effects of brain damage by reducing the progression of neuronal injury. These data indicate that HBO-induced prev...
Suggesting in Medical Technology

R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023

... As described above, percutaneous absorption of the drug was not high even after continuous application in the morning and at night for 5 days, suggesting hardly any safety problem. Yukihiko Mashima, Representative Director and President of R-Tech Ueno, commented as follows. "We are pleased to a...

Results From Drug Trials and New Risk Factors Announced at International Alzheimer's Conference

...are not FDA-approved for MCI. They also found that clinicians vary greatly in the education and support they provide or recommend for people with MCI, suggesting that there is a need for practice guidelines. There are now more than 26 million people living with dementia around the world. The cost of c...

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

...jor Histocompatibility Complex, a region on chromosome 6 densely packed with genes regulating immune response. This lends support to previous research suggesting a possible environmental link between schizophrenia immune response. It has long been known, for example, that a disproportionately large number of sc...

Lilly Announces Positive Phase II Data on Investigational Medicine for Patients with Type 2 Diabetes

...ng fasting serum glucose and hemoglobin A1C (HbA1C). In this study, LY2189265 showed an insulinotropic (stimulating the secretion of insulin) effect, suggesting it produced the desired outcome in participants. In Study GBCJ, LY2189265 was generally well-tolerated. "We are excited about these data and t...

Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW

...anges in biomarker serum concentrations ranged between 2.2 EU/mL and 4.3 EU/mL. These results are consistent with reports in the scientific literature suggesting biomarker stability over similar time periods. Further studies are required to evaluate the impact of therapy on biomarker stability over longer perio...

New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer

...onal orally administered irreversible inhibitor of the HER-2 and EGFR kinases. "The data gathered from these studies provide additional evidence suggesting that neratinib, when combined with these therapies, is an active agent in HER-2 positive breast cancer," says Ramona Swaby, M.D., Department of Medica...
Suggesting in Medical Products

PYY, Total ELISA Test

Description:...ed that, unlike leptin, there was no evidence of resistance to PYY3-36 in obese subjects. Endogenous levels of PYY3-36 were low in the obese subjects, suggesting that PYY3-36 deficiency may contribute to the pathogenesis of obesity and infusion of PYY3-36 caused a significant decrease in the cumulative 24-hour ...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-2 RIA Test

Description:...d and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I [1], suggesting a role in regulation of IGF-II action. Studies in the fetal sheep indicate that IGFBP-2 is produced in many tissues, apparently coincident with IGF-II...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-2 ELISA Test

Description:...d and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I [1], suggesting a role in regulation of IGF-II action. Studies in the fetal sheep indicate that IGFBP-2 is produced in many tissues, apparently coincident with IGF-II...
Company:Diagnostic Systems Laboratories, Inc.

Leptin IRMA Test

Description:...orced feeding where changes within 24 to 48 hours are readily observed in serum leptin concentrations. Similarly, there are rapid declines postpartum suggesting that something other than the amount of adipose tissue may regulate circulating levels of leptin. Many areas of leptin physiology remain to be invest...
Company:Diagnostic Systems Laboratories, Inc.

Leptin ELISA Test

Description:...orced feeding where changes within 24 to 48 hours are readily observed in serum leptin concentrations. Similarly, there are rapid declines postpartum suggesting that something other than the amount of adipose tissue may regulate circulating levels of leptin. Many areas of leptin physiology remain to be invest...
Company:Diagnostic Systems Laboratories, Inc.

Erythropoietin RIA Test

Description:...the EPO receptor bears some homology to several other growth factor receptors, including those for interleukins 2 and 6, prolactin and growth hormone, suggesting possible functional similarities for these growth factor systems [1]. In the fetus, the liver is the major site of EPO production [1, 2, 3]. Postnat...
Company:Diagnostic Systems Laboratories, Inc.
Suggesting in Medical Definition

Depolarization-induced suppression of inhibition

...ee demonstrated heavy involvement of the CB1 cannabinoid receptor in DSI, suggesting that the endocannabinoids were the brain's mediators of DSI. They showed ...se knock-out mice are not known to exhibit DSI in any regions of the brain, suggesting that the CB1 receptor is the crucial mediator for DSI (Kreitzer & Regeh...

Sexual orientation and medicine

...categorization of homosexuality as a mental illness with the diagnosis of ego-dystonic homosexuality. 1993 Dr. Dean Hamer publishes a paper suggesting a genetic component to sexual orientation. [3] 1995 Saquinavir , the first protease inhibitor is approved for public use by the FDA . ...
Suggesting in Medical Dictionary

Photophobia

...obia (Handbook of Signs ... Brief and Straightforward Guide: What is Photophobia ? ... Although " photophobia " literally means "fear of light," suggesting that this is ... Learn about the causes of Photophobia and treatments for Photophobia in the Symptoms Dictionary at HowStuffWorks. ... Severe ...

Mutation

...ations per generation in an ... Mutation rates can be determined fairly precisely in ... ... of an ExoI- mutation augmented this sensitivity, suggesting ... Media for mutation assays contained either rifampicin (Rif) or ... Mutation rates in ... Mutations are permanent, transmissible changes ...

Melanin

...ile investigating a fungus known to cause an infection in people with AIDS, two ... antibody, that binds to melanin based on scientific evidence suggesting ... ...

Masculinization

...rtant in the ... Masculinization was induced in rainbow trout, Oncorhynchus mykiss genetic all ... be crucial for effective masculinization , suggesting that these genes act ... Noun: masculinization . The abnormal development of male sexual characteristics in a female (usually as ... masculini...

Hand

...part of the human arm located below the forearm, Information about Hand in the free online English dictionary and encyclopedia. ... 3. Something suggesting the shape or function of the human hand , especially: ... A community about hand cart. Tag and discover new products. ... hand cart. Home Pro...

Exacerbate

...ng and make a clash of forces inevitable. Stafford Cripps ... On this page: What is Irritable Bowel Syndrome(IBS)? What causes IBS? ... periods, suggesting that reproductive hormones can exacerbate IBS problems. ... As leaders of the former Khmer Rouge regime testify in a human rights tribunal, in h...
Suggesting in Biological News

The hepatitis healing power of blueberry leaves

...gues noted its effective concentration against HCV was 100 times less than the toxic threshold, and similar chemicals are found in many edible plants, suggesting it should be safe as a dietary supplement. In the meantime, the researchers now hope to explore the detailed mechanisms of how this chemical stops HCV...

AGU journal highlights -- Aug. 6, 2009

...C. Their nitrous oxide emission rates are about 3 times less. The authors' estimate for methane is similar to basin-wide studies of the Pacific Ocean, suggesting that IPCC overestimates were likely generated by an overly coarse sampling method. Title: Methane and nitrous oxide emissions from the ocean: A r...

August 2009 Geology and GSA Today media highlights

...habitants in the Silurian seas. The stepwise changes observed among the fish faunas resemble those of conodonts, another extinct group of vertebrates, suggesting a similar mode of life and response to the Lau Event. Super-heavy pyrite (34Spyr > 34SCAS) in the terminal Proterozoic Nama G...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...ver-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those cancers," Wellstein says. Researchers at Lombardi/Georgetown University Medical Center ...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

... The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children's Research Hospital. The research appears in the J...

121 breeding tigers estimated to be found in Nepal

...n was estimated just one decade ago. The estimated number of tigers in important range countries is frighteningly low, with a recent government census suggesting there may be as few as 1,300 tigers left in India, the species' stronghold. And tigers are facing an epidemic of poaching and habitat loss across thei...
Suggesting in Biological Technology

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

Technology also has potential to fight cancer, rheumatoid arthritis, as well as enhance the effectiveness of vaccines VIENNA, Va., April 27 /PRNewswire-FirstCall/ -- CEL-SCI Corporation (NYSE Amex: CVM ) announced today the presentation of data at the 11th annual National Foundation of Infe...

CorMatrix Announces Pre-Clinical Data Suggesting Next Generation ECM Technology(TM) Can Improve Cardiac Function

- Data presented at American Heart Association Annual Scientific Sessions - NEW ORLEANS, Nov. 10 /PRNewswire/ -- CorMatrix Cardiovascular, Inc., an Atlanta-based company dedicated to developing and delivering unique extracellular matrix (ECM(TM)) biomaterial devices that harness the body's innat...

New clues about a hydrogen fuel catalyst

...eacting with ammonia borane. Then they compared the simulated data with real data gathered about the catalyst. The two sets of data matched very well, suggesting the structure they had come up with was very close to reality. The chemical nature of the structure, along with additional experimental data, allo...

Video shows nanotube spins as it grows

...on that accompanies nanotube growth. It brings to mind Galileo's famous quote, 'And yet, it does turn.'" In February, Yakobson offered a new theory suggesting that nanotubes grow like tiny, woven tapestries, with new atoms attaching to twisting atomic threads. The new video appears to support the theory, ind...

FDA Grants First Authorization of a Commercial 2009 H1N1 Flu Test for use During Pandemic Flu Emergency to Quest Diagnostics' Focus Diagnostics Business

...ent, while those 61 to 80 years of age have experienced positivity rates of approximately 14 percent. "Our data are consistent with CDC data suggesting that this pandemic flu virus is disproportionately affecting children and young adults, as compared to older adults," Jay M. Lieberman, M.D., medical ...

Oprah, Luke Skywalker and Maradona -- new study investigates how our brains respond to them

...chical structure within the areas they recorded from. Moreover, Professor Quian Quiroga found neurons responding to his own pictures and name, thus suggesting that such neuronal representations can be generated relatively fast, because he was unknown to the patient a day or two before the recording took plac...
Suggesting in Biological Products

Porcine Leptin ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:...orced feeding where changes within 24 to 48 hours are readily observed in serum leptin concentrations. Similarly, there are rapid declines postpartum suggesting that something other than the amount of adipose tissue may regulate circulating levels of leptin. Many areas of leptin physiology remain to be invest...
Company:Diagnostic Systems Laboratories, Inc.
Suggesting in Biological Definition

Cloning

...be younger than they should be. Analysis of the cow's telomeres showed they had not only been 'reset' to birth-length, but they were actually longer - suggesting these clones would live longer life spans than normal cows (but many have died young after excessive growth). Researchers think that this could eventu...

Common descent

...39, "Generation") In 1859 , Charles Darwin's The Origin of Species was published. The views about common descent expressed therein vary between suggesting that there was a single "first creature" to allowing that there may have been more than one. Here are the relevant quotations from the Conclusion : ...

DNA

...y . However, it was only in the early 20th century that researchers began suggesting that it might storeb genetic information. This was only accepted after the ...i V. Timofeeff-Ressovsky , and Karl G. Zimmer published results in 1935 suggesting that chromosomes are very large molecules the structure of which can be cha...

Glycolysis

...e is converted to lactate, as in many microorganisms. Evolution Glycolysis is the only metabolic pathway common to nearly all living organisms, suggesting great antiquity; it may have originated with the first prokaryotes , 3.5 billion years ago or more. Pathway The first step in glycolysis is p...

Long-term potentiation

...knamed "Doogie mice" after the precocious doctor Doogie Howser , had larger long-term potentiation and excelled at spatial learning tasks, once again suggesting LTP's involvement in the formation of hippocampal-dependent memories. Related topics learning long-term depression memory ...

Nutrition

...ers, the director of the Nutrition, Food & Health Research Centre at King’s College London, who says:“In trials, there is no evidence suggesting that reducing fat intake has an effect on obesity. As long as your expenditure equals what you eat, you won't put on weight, regardless of how high th...
Suggesting in Biological Dictionary

Transformed phenotype

... mechanisms by which the drug suppresses the transformed phenotype . ... of TM-1 induces a transformed phenotype in immortalized cells (20) , suggesting ... ... Control of Transformed Phenotype in Hybrids between SV40- Transformed and Normal Human Cells ... Genetics of Cell Transformation by ...

Replication bubble

...therefore said to be bi-directional. ... ... (ssDNA) in structures that resemble replication bubbles 4. While wild type (WT) ... post release, suggesting that replication bubbles do not expand in HU ... Replication bubbles were observed in most fragments derived from a 40-kb single ... Repli...

Pseudogene

... The discovery of a functional nitric oxide synthase (NOS) pseudogene compels us to understand pseudogenes in a new light. It confirms earlier clues suggesting that ... Pseudogene nonfunctionality tacitly assumes that any functional peptide ... It is now known that a snail's pseudogene can direct the...

Myotome

... enhanced and restricted to myotome . ... proceeded, qBrn-2 positive cells in myotome migrated dorsally and ventrally, ... ... differentiates, suggesting that myotome development requires additional signals. ... Xtwi is expressed in the notochord and lateral plate, but not in the myotome ; ... ...

Homozygosity

...s who have inherited a susceptibility gene ... for TG in the Hutterites, using two homozygosity -by-descent ... associations with low TG levels, suggesting that homozygosity ... However, homozygosity rather than compound heterozygosity, is frequently ... Homozygosity Mapping ... Homozygosity ...

Endoreduplication

...ation of the genome of specialized cells. Moreover, the increase in the ploidy level correlates with an increase in nuclear volume and cell size, suggesting that... endoreduplication ( ¦endōrē′düplə′kāshən ) ( cell and molecular biology ) Appearance in mitotic cells of certain chromosomes or ...
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(Date:7/11/2014)... 11, 2014 The increased risk of kidney injury ... resuscitation fluids reflects the mass of HES molecules, according ... official journal of the International Anesthesia Research Society (IARS). ... harmful effect of HES on cultured human renal proximal ... Christian Wunder and colleagues of University Hospital Wrzburg, Austria. ...
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