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Succinate in Medical News

Bedford Laboratories(TM) to Begin Shipping Sumatriptan Succinate Injection

BEDFORD, Ohio, Feb. 25 /PRNewswire/ -- Bedford Laboratories(TM), a division of Ben Venue Laboratories, Inc., today announced the launch of Sumatriptan Succinate Injection. This product is AP rated and is equivalent to Imitrex(R) by GlaxoSmithKline. Sumatriptan is a vascular headache suppressant ...

Metoprolol Succinate Recalled: Brand Name Drug Scarce But Still Available at Low Cost from Other Countries, PharmacyChecker.com Announces

Due to recent recalls, many U.S. pharmacies are now out-of-stock of the popular beta-blocker metoprolol succinate. The original, brand name version, Toprol XL, is in very low supply. PharmacyChecker.com finds that consumers can obtain Toprol XL from licensed pharmacies in other countries -- and...

Par Pharmaceutical Reports EPS of $0.71 for Second Quarter 2009

...arter ended June 27, 2009, net sales of metoprolol succinate reached $306 million, an increase of 173% from the... Par remained the exclusive supplier of metoprolol succinate through the second quarter. Par is the authorized...ly driven by the lack of competition in metoprolol succinate and meclizine, as well as the launches of sumatrip...

Watson Pharmaceuticals Receives FDA Approval for Generic Toprol XL(R) 25 MG and 50 MG

...iated New Drug Applications (ANDAs) for metoprolol succinate extended-release tablets USP in the 25 mg and 50 mg strengths. Metoprolol succinate extended-release tablets are the generic equivalen...to AstraZeneca's Toprol XL(R) tablets. Metoprolol succinate extended-release is a beta-blocker used to treat a...

AstraZeneca Announces TOPROL-XL(R) (Metoprolol Succinate) is Now Available

...of TOPROL-XL and the authorized generic metoprolol succinate following published reports that two generic compa... had recalled or suspended shipments of metoprolol succinate in late 2008 and early 2009. "After the two g...enough TOPROL-XL and authorized generic metoprolol succinate to meet historical demand levels. The authorized ...

Par Pharmaceutical Reports Adjusted EPS of $0.49 for First Quarter 2009

... Metoprolol: For the quarter ended March 28, 2009, net sales of metoprolol succinate reached $112.2 million, an increase of 127% from the fourth quarter 2008. ... the first quarter of 2009, Par became the exclusive supplier of metoprolol succinate resulting in increased volume and price. Par is the authorized generic for...

Watson Pharmaceuticals Reports First Quarter 2009 Results; Raises 2009 Outlook

...ate sodium tablets. Generic other revenue decreased $17.8 million to $6.5 million due to a decline in royalties from Sandoz's sales of metoprolol succinate extended-release tablets 50mg and a decline in royalties from GlaxoSmithKline's sales of Wellbutrin XL(R). Generic gross profit was $163.2 milli...

Par Pharmaceutical Reports Fourth Quarter and Full Year 2008 Results

...in 2007 due primarily to the launch of sumatriptan succinate injection, increased sales of metoprolol and Megac... dronabinol in July, and the launch of sumatriptan succinate in November, and increased sales of metoprolol succinate to new customers. Gross Margin Par's 200...

KV Pharmaceutical Company Reports Fiscal 2009 First Quarter Results

...an-expected approval and launch of the 50 mg strength of generic metoprolol succinate extended-release tablets in May 2008; and -- A net sales gain of 52.6% ov...the initial launch and supply of the 25 mg and 50 mg strength of metoprolol succinate extended-release tablets; -- $1.5 million increase in expense associated ...

Beyond PTEN: Alternate genes linked to breast, thyroid and kidney cancer predisposition

...otypes must exist," says lead study author Dr. Charis Eng, the Hardis Chair and Director of the Genomic Medicine Institute at the Cleveland Clinic. succinate dehydrogenase (SDH) is a mitochondrial enzyme that is responsible for energy production and is therefore vital to all organs and organisms. Mutations ...
Succinate in Medical Technology

Pooled Studies Showed Desvenlafaxine Succinate Significantly Improved Painful Symptoms and Anxious Symptoms Associated with Major Depressive Disorder in Adults, Compared With Placebo

Pooled Findings Presented at 2007 APA Meeting Also Showed No Significant Impact on Weight for Desvenlafaxine Succinate COLLEGEVILLE, Pa., May 21, 2007 /PRNewswire-FirstCall/ -- Findings from two separate pooled analyses - one examining the effect of desvenlafaxine succinate on anxious symptoms and...

New Study Results Provide Additional Data about Short- and Long-Term Use of Desvenlafaxine Succinate in the Treatment of Adults with Major Depressive Disorder

- Data Presented at 2007 APA Meeting - COLLEGEVILLE, Pa., May 21, 2007 /PRNewswire-FirstCall/ -- Data from four new studies examining safety and efficacy of desvenlafaxine succinate, a serotonin-norepinephrine reuptake inhibitor (SNRI) being studied as a potential treatment for adults with major d...

Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)

...) today announced it had begun shipping metoprolol succinate extended release 50 mg tablets. As previously anno...MS Health. Important information about metoprolol succinate extended release tablets Metoprolol succinate extended release is indicated for the treatment of...

Trexima (Sumatriptan/Naproxen Sodium) Superior Efficacy Data Published in JAMA

...cy compared to placebo and its individual components." Trexima is the proposed brand name for a single tablet containing sumatriptan 85 mg as the succinate salt, formulated with RT Technology(TM), and naproxen sodium 500 mg, for the acute treatment of migraine. These studies were the pivotal efficacy stud...

Wyeth Presents Phase 3 Data for Pristiq, an Investigational Non-Hormonal Therapy for Menopausal Hot Flashes and Night Sweats

...hree days. Efficacy and Safety of Desvenlafaxine succinate for Treatment of Menopausal Vasomotor Symptoms T... of starting therapy. Efficacy of Desvenlafaxine succinate in the Treatment of Menopausal Vasomotor Symptoms ...od. A Placebo-Controlled Trial of Desvenlafaxine succinate and Tibolone for Menopausal Vasomotor Symptoms T...
Succinate in Biological News

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

...rcent of paragangliomas are hereditary. Of the four familial PGL syndromes, three forms have previously been associated with mutations in genes of the succinate dehydrogenase (SDH) complex, an enzyme complex involved in the ability of cells to extract energy from nutrients. Studies in Yeast "Defects in...

Research yields pricey chemicals from biodiesel waste

...byproduct of biodiesel production -- into formate, succinate and other valuable organic acids. "Biodiesel pr...echnologies that produce high-value chemicals like succinate and formate hold even more promise for biodiesel r... the bacterium that produces up to 100 times more. succinate is a high-demand chemical feedstock that's used to...

Bacteria are key to 'green' plastics, drugs

...n" methods to make key chemical intermediates like succinate is a high priority for the chemical industry. Gree...-scale fermentation." The centerpiece of Rice's succinate technology is a mutant form of E. coli that makes succinate as it's only metabolic byproduct. The bug contains...
Succinate in Biological Technology

ETHEX Corporation Issues Nationwide Voluntary Recall of Products

...one HCl Tablets, 8mg (58177-449-04) Metoprolol succinate ER Tablets, 50mg (58177-369-04, 369-09 & 369-11) Metoprolol succinate ER Tablets, 100mg (58177-368-04, 368-09 & 368-11) Metoprolol succinate ER Tablets, 25mg (58177-293-04, 293-09 & 293-1...

Bioamber announces world's first bio-based succinic acid plant: helping to reduce dependence on fossil fuels

...of bio-based succinic acid can use various renewable feedstocks such as wheat, corn, sugar cane, rice, lingo-cellulose and glycerin. Succinic acid and succinate esters can be used as building blocks in a multitude of markets including biopolymers, plastics, polyesters, resins, runway deicers, non-toxic solvent...

KV Pharmaceutical Company Announces Approval for the 50 mg Strength of Generic Version of Toprol-XL(R)

...of All Four Dosage Strengths of Generic Metoprolol succinate Extended-Release Tablets Following Approval of ... (ANDA) to market its 50 mg strength of metoprolol succinate extended-release tablets. The Company expects to b...te line of all four dosage strengths of metoprolol succinate extended-release tablets -- 200 mg, 100 mg, 50 mg ...

Watson Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results; Provides 2008 Outlook

... Generic other revenue increased $77.3 million to $93.0 million for 2007, due primarily to the addition of royalties from Sandoz's sales of metoprolol succinate extended-release tablets and GlaxoSmithKline's sales of Wellbutrin XLP(R) 150mg. Generic segment gross margin increased from 30 percent in 2006 to 3...

New Phase 3 Data Showed PRISTIQ Significantly Reduced Symptoms of Major Depressive Disorder Versus Placebo

...ization of PRISTIQ. More About the Studies Poster 145: Liebowitz M., et al. Evaluation of the Efficacy and Safety of Fixed Doses of Desvenlafaxine succinate at 50 mg and 100 mg in Outpatients with Major Depressive Disorder in 2 Placebo-Controlled Trials Data presented are from two identically designed mu...

KV Pharmaceutical Company Reports Record Revenues for Fiscal 2008 Second Quarter and Six Months on a Preliminary Basis

...trengths of AstraZeneca's Toprol-XL(R), Metoprolol succinate Extended Release Tablets and to continued growth o...ct lines. Net revenue contribution from Metoprolol succinate Extended Release Tablets during the second quarter...Corporation, with the contribution from Metoprolol succinate Extended Release Tablets launched in July 2007, re...

Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo

...on, also presented was a secondary analysis of a previously presented 52-week study with desvenlafaxine. Poster 412: Archer D., et al. Desvenlafaxine succinate Efficacy for the Relief of Vasomotor Symptoms Associated With Menopause: A Double-Blind, Placebo-Controlled Trial The analysis of the 12-week trial s...
Succinate in Biological Definition

Citric acid cycle

...ynthetase Hydrolysis GDP + P i GTP + CoA-SH VII. succinate 7. succinate dehydrogenase Oxidation FAD FADH 2 VIII. Fumarate ...

Electron transfer chain

... membrane and accepts electrons from electron donors such as NADH or succinate , shuttles these electrons from within the mitochondrial matrix across th...ADH dehydrogenase , also called NADH coenzyme Q reductase. Complex II - succinate - coenzyme Q reductase . Complex III - Coenzyme Q - cytochrome c reduct...

Citric acid cycle

...ynthetase Hydrolysis GDP + P i GTP + CoA-SH VII. succinate 7. succinate dehydrogenase Oxidation FAD FADH 2 VIII. Fumarate ...

Mitochondrion

...ss creates 3 molecules of NADH and 1 molecule of FADH 2 , which go on to participate in the electron transport chain . With the exception of succinate dehydrogenase , which is bound to the inner mitochondrial membrane, all of the enzymes of the Krebs cycle are dissolved in the mitochondrial matrix. ...

Mitochondrion

...ss creates 3 molecules of NADH and 1 molecule of FADH 2 , which go on to participate in the electron transport chain . With the exception of succinate dehydrogenase , which is bound to the inner mitochondrial membrane, all of the enzymes of the Krebs cycle are dissolved in the mitochondrial matrix. ...
Succinate in Biological Dictionary

FADH2

...across ... In the form of FADH2 , it is one of the cofactors that can transfer electrons to ... FADH2 is produced as a prosthetic group in succinate dehydrogenase, an enzyme ... FADH2 Reduced form of flavin adenine dinucleotide. ... What is the role of molecules such as nadph nadh and f...
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