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Subunits in Medical News

Brain Imaging (MRI/PET) and Measurements of Proteins in Spinal Fluid May Improve Alzheimer's Prediction and Diagnosis

...al progression to Alzheimer's, so that they can be targeted for Alzheimer's-specific treatments." The researchers found that results of three subunits of the memory tests could be combined to reach a classification accuracy of 89.9% for distinguishing people who progressed from MCI to Alzheimer's ver...

Caltech chemists say antibody surrogates are just a 'click' away

...ique makes use of the "in situ click chemistry" method, introduced by Sharpless in 2001, in which chemicals are created by joiningor "clicking"smaller subunits together. To create a capture agent for a particular protein, the scientists devised a stepwise approach in which the first subunit of the captur...

Variants of 'umami' taste receptor contribute to our individualized flavor worlds

...inable.' The researchers next examined DNA from these 87 individuals to look for variations in the genes that code for T1R1 and T1R3, two protein subunits that combine to form the G-protein coupled receptor T1R1-T1R3. Comparing DNA structure to the glutamate taste responses of each individual, they foun...

Dad's Genes May Play Greater Role Than Thought

...istones to protamine." Cairns said that the gene packaging issue is related to another biological aspect of DNA expression -- DNA methylation. Some subunits of the DNA molecules ordinarily have molecules called methyl groups attached to them. Lack of methylation can also contribute to infertility, he said....

Motor proteins may be vehicles for drug delivery

...said William Hancock, associate professor of bioengineering, Penn State. "And it runs on cylindrical tracks -- or microtubules -- made of many protein subunits meshed together into a long polymer that is one ten thousandth the diameter of hair." Hancock and his colleagues are studying a particular motor pr...

Protein helps immune cells to divide and conquer

...of this protein is required, but the amino acid transport function is dispensable for B cell proliferation. "CD98hc interacts with certain integrin subunits to prompt signaling events that control cell migration, survival and proliferation. Our study shows that the rapid proliferation of B cells, necessar...
Subunits in Medical Technology

DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC

...ccine consists of a combination of three non-toxic subunits of botulinum toxin that induced protection against...shed in Infection and Immunity show that non-toxic subunits (protein components of the natural toxin) of three...sible for blocking neurotransmitter functions. The subunits can bind avidly to receptors on the surface of muc...

DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC

... the toxin that is responsible for blocking neurotransmitter functions. The subunits can bind avidly to receptors on the surface of mucosal cells and traverse l...ed for widespread immunization. New multivalent vaccines based on non-toxic subunits are being developed, including BT-VACC™. About DOR BioPharma, Inc. ...
Subunits in Medical Products

Free Activin AB ELISA Test

Description:...synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to eit...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:...synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to eit...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:...synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to eit...
Company:Diagnostic Systems Laboratories, Inc.

Inhibin B ELISA Test

Description:...terodimeric proteins that suppress the secretion of FSH (follicle stimulating hormone) from the pituitary. Inhibin consists of two distinct chains, or subunits (alpha and beta), linked together. Inhibin A consists of the alpha-subunit and betaA-subunit. Inhibin B consists of the alpha-subunit and betaB-subuni...
Company:Diagnostic Systems Laboratories, Inc.

Inhibin A ELISA Test

Description:...terodimeric proteins that suppress the secretion of FSH (follicle stimulating hormone) from the pituitary. Inhibin consists of two distinct chains, or subunits (alpha and beta), linked together. Inhibin A consists of the alpha-subunit and betaA-subunit. Inhibin B consists of the alpha-subunit and betaB-subuni...
Company:Diagnostic Systems Laboratories, Inc.

CRP, Ultra-Sensitive ELISA Test

Description:...This acute inflammation-dependent response can lead to a 1000-fold or greater increase in serum CRP levels. CRP comprises five non-covalently bound subunits forming a discord of 105 kDa molecular weight. CRP, a pentraxin family protein, is noteworthy because of the speed and degree to which its concentrati...
Company:Diagnostic Systems Laboratories, Inc.
Subunits in Medical Dictionary

Ferritin

... Ferritin is a globular protein complex consisting of 24 protein subunits and is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. Ferriti...
Subunits in Biological News

Carnegie donates landmark clones to biology

...east and immature eggs of the frog Xenopus in the presence of ammonium. The researchers were totally surprised that the mechanism in which three subunits regulate each other was found in the primitive archaebacteria. It means that it evolved billions of years ago. The fact that the C-terminus is found i...

Structural biology scores with protein snapshot

...D., professor of Biochemistry, and colleagues report the NMR structure of the large bacterial protein diacylglycerol kinase (DAGK), a complex of three subunits that each cross the membrane three times (for a total of nine membrane spans). The group's ability to determine the NMR structure of DAGK suggests t...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

...College of Virginia Commonwealth University. Since then, she has studied the structure and activities of the meprins and has located the genes for the subunits in both the mouse and human chromosomes. After coming to Penn State Hershey in 1992, her studies have focused on the biomedical significance of the me...

Two new studies on circadian rhythms

...nsation. Pursuing two uncharacterized circadian protein mutants shown to affect compensation in an unusual way, the investigators identified different subunits of the same enzyme, CK2. They developed new ways to manipulate the genome and showed, by controlling expression, that the level of CK2 dictates th...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

...e of protein complexes to be visualized. When combined with sodium dodecyl sulfate PAGE (SDS-PAGE), the procedure can resolve the complexes and their subunits by their molecular weight. In conjunction with differential in-gel electrophoresis (DIGE), BN-PAGE can be used to quantify changes in protein complex...

Uncooperative voltage sensors

...her recent complementary techniques, "promises to unmask some of the previously inscrutable features of the allosteric communication among entwined Kv subunits and between the homologous domains of sodium channels." ...
Subunits in Biological Technology

Gene-Specific Primers for NMDA Receptor Subunits

Additional tools for neuroscience researchers Robert Buchner Peter L. Pingerelli Michael D. Browning Mary Ellen Simcox Stratagene Cloning Systems, Inc. Stratagene is now offering gene-specific primer sets for the rat and human NMDA receptor. In this article, we descr...

Wisconsin giant continues to dominate the health care IT market

...lt added, Weve invested to make it bigger, better and more substantial. This has seen GE Healthcare in the past decade expand its revenue from all its subunits from $4 billion to $15 billion and their employee numbers grow to 40,000, including 6,500 in Wisconsin with an estimated 2,000 more to come. With t...

The Bio-Rad Silver Stain, Rev E

...lectrophoresis 3, 206210 (1982) 10. Conti-Tronconi BM et al., Molecular weight and structural nonequivalence of the mature α subunits of Torpedo californica acetylcholine receptor, Proc Natl Acad Sci USA 81, 26312634 (1984) 11. Conti-Tronconi B et al., Brain and ...

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

...protein which exists at the normal pH of bovine milk as a dimer with a molecular weight of 36,000, and consists of two monomeric subunits with molecular weight of 18,000 (162 residues). Several genetic variants of βLG have been detected, 9 of which the bovine ...

Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B

...Prunkard et al. 1986). Biochemical, immunochemical, and physical characterization of purified GDH homohexamers revealed that the subunits (α, 55.5 kD; , 53 kD) composing these holoenzymes are nearly identical; however, kinetic characterization of the enzymes sh...

Apoptosis detection by annexin V and active caspase-3 with the Agilent 2100 bioanalyzer

...is and/or cleavage by another protease8. Active caspase-3, a marker for cells undergoing apoptosis, consists of a heterodimer of 17 and 12 kDa subunits which is derived from the 32 kDa proenzyme9. A convenient and broadly accepted method to study the activity of caspase-3 during apoptosis in...
Subunits in Biological Products

Mouse Anti-20S proteasome subunits alpha 1 Monoclonal Antibody, Unconjugated, Clone MCP231 from Upstate

Description: Anti-20S proteasome subunits alpha 1, 2, 3, 5, 6 & 7, clone MCP231 Immunogen: Dinitrophenylated proteasomes Molecular Weight: 29 and 32 kDa....
Company:Upstate

Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Human BRF2. Reactivity / Specificity Cross-reacts with Human. Not yet tested in other species. Background Information BRF2 is one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. BRF...
Company:GeneTex

Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC

Description:...oxidase assembly is incomplete because of mutations in genes for structural subunits of the enzyme SURF1 is significantly over-expressed. This is evident in Rho0 fibroblasts which are missing mtDNA and hence cannot synthesize subunits I, II and III of cytochrome c oxidase....
Company:MitoScience LLC

Mouse Anti-Bovine Complex V (F1F0 ATP Synthase) Heart Mitochondria Monoclonal Antibody, Unconjugated, Clone 12F4AD8AF8 from MitoScience LLC

Description:...detection of these modifications. Potential uses for the Complex V immunocapture kit include but are not limited to examining alterations of Complex V subunits in inherited mitochondrial diseases, Alzheimers disease, angiogenesis, hypertension and aging....
Company:MitoScience LLC

Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

Description:...the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protei...
Company:GeneTex

Rabbit Anti-GluR4 Antibody, Unconjugated from Lab Vision

Description:...ses of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2) which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when a...
Company:Lab Vision
Subunits in Biological Definition

Coenzyme A

...s referred to as the Pyruvate Dehydrogenase Reaction. It is catalyzed by an enzyme-complex called pyruvate dehydrogenase . The enzyme consists of 60 subunits : 24 pyruvate dehydrogenase, 24 dihydrolipoyl transacetylase , and 12 dihydrolipoyl dehydrogenase (commonly denoted E1, E2, and E3). 24 pyruvate dehy...

Actin

... 2.2 Networks Microfilaments assembly The globular Actin is known as G-actin, while the filamentous polymer composed of G-actin subunits (a microfilament), is called F-actin. The microfilaments are the thickest of the cytoskeleton, with only 7 nm in diameter . Much like the microtubu...

Allostery

...d, Nemethy, and Filmer. Both postulate that enzyme subunits exist in one of two conformations, tensed (T) or relaxed (R), and that relaxed subunits bind substrate more readily than those in the tens...oncerted model of allostery postulates that enzyme subunits are connected in such a way that a conformational ...

Allostery

...d, Nemethy, and Filmer. Both postulate that enzyme subunits exist in one of two conformations, tensed (T) or relaxed (R), and that relaxed subunits bind substrate more readily than those in the tens...oncerted model of allostery postulates that enzyme subunits are connected in such a way that a conformational ...

ATP synthase

...structure, the F 1 particle can be seen to be composed of a cylinder of 6 subunits , alternating alpha and beta subunits, that form a ring around an asymmetri...article to rotate, rotating the gamma subunit of F 1 , while the major F 1 subunits are fixed in place. This rotation forces a conformational change in the F 1...

Cell nucleus

.... Therefore, the regions of DNA that constitute heterochromatin vary between cell types. Nucleoli are densely-stained structures at which ribosome subunits are assembled. ...
Subunits in Biological Dictionary

Tubulin

...ains or filaments that form ... Instead, the polymerized tubulin forms two-dimensional crystalline sheets that ... s of a- and ß- tubulin . These subunits are slightly acidic with an isoelectric point ... Tubulin was long thought to be specific to eukaryote. Eukaryote ... Drosophila has four ß- tu...

Spliceosome

... A spliceosome is a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA (hnRNA) segment. This process is generally referred to as splicing. spliceosome ( ) n. A nucle...

S1 nuclease

...duce single-stranded breaks in double-stranded... A nuclease is an enzyme capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids. Older publications may use terms such as "polynucleotidase" or "nucleodepolymerase". What is S1 nuclease ?...

Ribosome binding site

...-11 to 0 ... structure of the ribosome binding site determines translational efficiency: a ... ... base pairing between one of its internal subunits and the ribosome binding site , ... ribosome binding site on the mRNA, eukaryotic initiation begins with the ... ... adjacent tRNA bind...

Proteins

...rms the backbone of both proteins and synthetic fibers such as Nylon. ... of Proteins ... ... come to proteins , which are also polymeric. The subunits which make-up Proteins are Amino ... Proteins function as enzymes or as structural units in cells. ... Different proteins are made using di...

Proteasome

...on of the proteasome . ... Proteasome Complex ... Many inhibitors of proteasome protease activity are known, some of which are ... Several subunits of the proteasome are glycosylated with GlcNAc (N ... Ubiquitons and Zomes (Ubiquitin and Proteasome ) ... Zomes ( proteasome , COP9 signalosome...
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(Date:4/17/2014)... University of California, San Diego School of Medicine report ... suffered a recent major loss are more likely to ... The study is published in this month,s issue of ... Because compassionate behaviors are associated with better health and ... into ways to improve the outcomes of individuals whose ...
(Date:4/17/2014)... the April issue of Immunity , Kevin J. ... Research, says it,s time to take a fresh look ... sepsis, which kills millions worldwide every year, including more ... into the bloodstream to fight an injury or infection ... maintaining good health without inflammation, wounds and infections ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... MAYWOOD, Il. (April 17, 2014) Doctors who ... disease called lymphangioleiomyomatosis (LAM) can face an agonizing ... progression of the disease and help relieve shortness ... lung transplants, and sirolimus can cause potentially fatal ... said pulmonologist Dr. Daniel Dilling, medical director of ...
(Date:4/17/2014)... YORK, NY (April 16, 2014) The cause of ... a new study proposes that neurons may be mistaken ... immune system, similar to the way autoimmune diseases like ... the body,s cells. The study was published April 16, ... a new, and likely controversial, idea in Parkinson,s disease; ...
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(Date:4/18/2014)... while feeding a world population predicted to reach ... approach to conservation that considers human-altered landscapes such ... and the natural habitat that supports it might ... where at least three-quarters of the land surface ... is vulnerable to human-caused impacts such as climate ...
(Date:4/18/2014)... to the story of how barnyard chickens came to be, ... journal Proceedings of the National Academy of Sciences . ... 200-2300 years ago in Europe, researchers report that just a ... different from the chickens we know today. , The results ... domestic chickens -- such as their yellowish skin -- only ...
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological ... even global scales. But new research from Brown University ... ancient life at the time of an impact. , ... has found fragments of leaves and preserved organic compounds ... in Argentina. The material could provide a snapshot of ...
Breaking Biology News(10 mins):Stanford researchers rethink 'natural' habitat for wildlife 2Stanford researchers rethink 'natural' habitat for wildlife 3Stanford researchers rethink 'natural' habitat for wildlife 4Ancient DNA offers clues to how barnyard chickens came to be 2Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
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