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Substrates in Medical News

New ADDHERE(TM) Adhesive Tie Layer Bonds Acrylic Cap Layers to Substrates of Thermoplastic Polyolefin (TPO) in Production of Sheet for Use in Thermoforming

Proprietary, non-olefinic material brings new levels of gloss, depth of image, and surface durability to high-performance TPO sheet stock MANSFIELD, Texas, Oct. 22 /PRNewswire/ -- Solvay Engineered Polymers, Inc., has introduced its first adhesive tie-layer material for use in the production...

Avipaxin Is First Entrant in Medical Arsenal for Neuro-Endocrine-Immune Connection(C) Product and Testing Protocols

...ed a new product -- Avipaxin -- aimed at decreasing elevated levels of pro-inflammatory cytokines. Avipaxin supports acetylcholine levels by providing substrates for its production and by inhibiting its metabolizing enzyme, acetylcholinesterase. Initial studies at NeuroScience, Inc. revealed a significant decre...

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

... Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator o...

European Prebiotics Market Diversifies Strongly Across New Application Sectors in Food and Beverage Industry, Finds Frost & Sullivan

...ility to improve gut flora composition, immune health and for several other health-promoting properties. "Prebiotics act as food sources or ideal substrates for the growth of probiotic bacteria," explains Dr. Cross. "In the human food market, the prominent market of digestive health products has been posit...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...tion." Skok says that given the deleterious consequences, it is essential that B and T cells tightly regulate the recombinase, the accessibility of substrates for RAG cleavage, and the activities of the DNA damage response and repair machineries. Skok and researchers propose that homologous pairing of allele...

Parkinson's disease medication triggers destructive behaviors

...'s disease, but low doses also are used for restless legs syndrome. They uniquely stimulate brain limbic circuits, which are thought to be fundamental substrates for emotional, reward and hedonistic behaviors. "The 2005 case series alerted us that something bad was happening to some unfortunate people. This ...
Substrates in Medical Technology

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...human immunodeficiency virus (HIV). Our research and development efforts focus on nucleos(t)ide analogs, a class of compounds which act as alternative substrates for the viral polymerase thus inhibiting viral replication. We currently have three clinical-stage product candidates. RG7128, a nucleoside analog for...

Parkinson's Disease Medication Triggers Destructive Behaviors

...'s disease, but low doses also are used for restless legs syndrome. They uniquely stimulate brain limbic circuits, which are thought to be fundamental substrates for emotional, reward and hedonistic behaviors. "The 2005 case series alerted us that something bad was happening to some unfortunate people. Thi...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...abolized by CYP2C9 and CYP3A4, it should be avoided if possible. Tasigna inhibits human P-glycoprotein. If Tasigna is administered with drugs that are substrates of Pgp, increased concentrations of the substrate are likely and caution should be exercised. Tasigna may also induce CYP2B6, CYP2C8, and CYP2C9. Ther...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...abolized by CYP2C9 and CYP3A4, it should be avoided if possible. Tasigna inhibits human P-glycoprotein. If Tasigna is administered with drugs that are substrates of Pgp, increased concentrations of the substrate are likely and caution should be exercised. Tasigna may also induce CYP2B6, CYP2C8 and CYP2C9. There...

Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation

...nch-top environment. Cells for experimentation are grown on the silicon PSD substrates that fit in industry standard 24 well plates for cell culture and storage, ...ndles including the PSD controller, experimental chambers, and cell culture substrates begin at $3,550.00. Advancing the frontiers of excitable cell research, s...

Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

...abolized by CYP2C9 and CYP3A4, it should be avoided if possible. Tasigna inhibits human P-glycoprotein. If Tasigna is administered with drugs that are substrates of Pgp, increased concentrations of the substrate are likely and caution should be exercised. Tasigna may also induce CYP2B6, CYP2C8, and CYP2C9. Ther...
Substrates in Medical Products

Anti-Thyroid Antibody (TA) Test Kit - Monkey Thyroid Substrate

Description:...e diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA...
Company:Inverness Medical Innovations

Autoantibody Screen (AAS) Test Kit - Rat Kidney/Stomach Substrate

Description:...e diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA...
Company:Inverness Medical Innovations

Anti-Nuclear Antibodies (ANA) Hep-2 Substrate

Description:...e diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA...
Company:Inverness Medical Innovations

Anti-Smooth Muscle Antibody (ASMA) Test Kit

Description:...e diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA...
Company:Inverness Medical Innovations

Anti-Mitochondrial Antibody (AMA) Test Kit

Description:...e diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA...
Company:Inverness Medical Innovations

Anti-Native Deoxyribonucleic Acid (nDNA) Test Kit

Description:...e diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate slides, controls, conjugate, mounting medium, phosphate-buffered saline (PBS) and ZORBA...
Company:Inverness Medical Innovations
Substrates in Medical Dictionary

Platelet

...ws, vol.4, no ... Abnormalities in either platelet number or function ... as receptors for components that trigger platelet . activation and as substrates for adhesion ( platelet ... Platelets are irregularly-shaped, colorless bodies that are present in blood. ... The platelets sense the prese...

Lipid

...692-029-5 Find products and compare prices at TheFind.com. Shop online for thousands of great items like the Lipid Complex. (PUFAs) that are substrates of lipid peroxidation that may lead to loss of the ... In particular, they can initiate lipid peroxidation ... surfactant protein a.pdf'> ...
Substrates in Biological News

All eukaryotic kinases share 1 common set of substrates

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death. Dysregulation of protein phosphorylation plays a major role in ...

New journal on advanced glass research to debut

...portation, construction, environmental, optical and defense technologies spheres. From cutting-edge photovoltaic power generation systems to nanosized substrates for repairing or even growing new human tissue, glass-based materials are playing an expanding role in the world's scientific and technical advances. ...

Preclinical work shows how one gene causes severe mental retardation

...fects learning," Ehlers said. "One important aspect of our findings is that sensory manipulations recovered plasticity, suggesting that the underlying substrates for plasticity are intact in mice. If the same thing holds true for the human disease, there may be a chance to improve brain function." ...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

...A (Tue, April 21 3:30 PM - 5:50 PM, Room: 356) White will discuss some of his group's work in manipulating the levels of various insulin receptor substrates in mice. Insulin-like signaling regulates the storage and usage of nutrients, a process best exemplified by insulin's role in keeping blood glucose le...

New high-throughput screening technique makes probing puzzling proteins possible

...hich allow researchers to visibly track the enzymes' activity. Working with substrates is critical to better understand both basic cellular functioning and to ide...his binding interaction better should also further our understanding of the substrates to which the enzyme might bind in normal and cancerous cells. The group...

Scripps research scientists identify blood component that turns bacteria virulent

...S2714-12that was shown to be essential to transporting bicarbonate. As a group, ABC-transporters use the energy of ATP hydrolysis to transport various substrates across cellular membranes. In this case, when the genes that code for the BAS2714-12 ABC transporter were deleted, the rate of bicarbonate uptake insi...
Substrates in Biological Technology

ChemImage Works to Improve Existing Methods of Imaging Untreated Fingerprints on Paper Substrates

PITTSBURGH, June 4 /PRNewswire/ -- Scientists at ChemImage are pleased to report significant improvements in the ability to enhance contrast of untreated fingerprints on paper substrates. Using the CONDOR(TM) Hyperspectral Imaging System, application scientists at ChemImage have been able to appl...

LI-COR Introduces Three IRDye(R) Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Protease Substrates

LINCOLN, Neb., Nov. 12 /PRNewswire/ -- Protease substrates provide a sensitive method to detect protease activity, measure potency of inhibitors and screen compound collections for discovery of drug candidates. LI-COR Biosciences now offers three different IRDye NIR-FRET Protease Substrates: I...

A Microtiter-based Assay for the Determination of ID50s of b-lactamase Inhibitors Employing Reporter Substrates Detected at UV or Visible Wavelengths (MaxLine Application Note #20)

INTRODUCTION β -lactamases are either plasmid or chromosomally encoded bacterial enzymes which hydrolyze β -lactam antibiotics. The majority of β -lactamases produced by clinical isolates are serine active site enzymes. One successful approach to combat...

Pharmasset to Present at Canaccord Adams Conference

...man immunodeficiency virus (HIV). Our research and development efforts focus on nucleoside/tide analogs, a class of compounds which act as alternative substrates for the viral polymerase thus inhibiting viral replication. We currently have three clinical-stage product candidates: RG7128, a nucleoside analog for...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

...ctively inhibits the production of the toxic AB42 peptide without affecting the total amount of AB. As EVP-0962 does not affect other gamma secretase substrates required for normal function, such as Notch, it is predicted to slow the progression of Alzheimer's disease by reducing the disease-associated toxic A...

Nanopillars promise cheap, efficient, flexible solar cells

...elded disappointing results. Light-to-electricity efficiencies were less than one to two percent," says Javey. "Epitaxial growth on single crystalline substrates was often used, which is costly. The nanopillar dimensions weren't well controlled, pillar density and alignment was poor, and the quality of the inte...
Substrates in Biological Products

Anti-UbcH7 Antibody, Unconjugated from CHEMICON

Description:...th the HECT protein, E6-AP and the c-Cbl RING domain. Evidence suggests that this E2 is involved in both the degradation of non-""N-end rule"" protein substrates and of certain N-a -acetylated proteins as well as the degradation of tumor suppressor protein p53....
Company:CHEMICON

LVF Kit: LVF-HL, LVF-CUV-ADP, FHS-LVF, CVD-DIFFUSE from Ocean Optics

Description:...features an excellent transmission band (~90%) and blocking band (99.8%). These filters -- with interference coatings applied to 57 mm x 10 mm quartz substrates -- are especially useful for spectrally shaping the excitation energy from broadband sources used for fluorescence. Features: Excellent transmission...
Company:Ocean Optics

LVF Kit: LVF-UV-HL, LVF-CUV-ADP, FHS-LVF, CVD-DIFFUSE from Ocean Optics

Description:...features an excellent transmission band (~90%) and blocking band (99.8%). These filters -- with interference coatings applied to 57 mm x 10 mm quartz substrates -- are especially useful for spectrally shaping the excitation energy from broadband sources used for fluorescence. Features: Excellent transmission...
Company:Ocean Optics

ReBlot Western Blot Recycling Kit - Trial from CHEMICON

Description:... iodine or other isotopes. It is not recommended for stripping colorimetric substrates (TMB, DAB, 4-chloronapthol, etc.), as it is not possible to effectively remove substrates that precipitate at the reaction site....
Company:CHEMICON

Topoisomerase I (Vaccinia) from Molecular Cloning Laboratories (MCLAB)

Description:...curring DNA Detecting mutant plasmids that differ in length by only one base-pair Increasing restriction endonuclease digestion of resistant DNA substrates by "unwinding" the DNA coils to expose restriction sites ...
Company:Molecular Cloning Laboratories (MCLAB)

GIBCO Cell Dissociation Buffer enzyme free PBS-based from Invitrogen

Description:... and Mg2+-free Hanks' balanced salt solution or Ca2+- and Mg2+-free phosphate-buffered saline for gentle dissociation of mammalian cells from support substrates and each other for studies requiring intact cell surface proteins such as ligand binding flow cytometry and immunohistochemistry (12). These buffers a...
Company:Invitrogen
Substrates in Biological Definition

Anabolism

...occur during starvation , stress and illness. Examples of catabolic processes include breakdown of muscle protein in order to use amino acids as substrates for gluconeogenesis (much like burning furniture in your house as fuel because you are out of firewood), and breakdown of fat in adipose to fa...

Anabolism

...occur during starvation , stress and illness. Examples of catabolic processes include breakdown of muscle protein in order to use amino acids as substrates for gluconeogenesis (much like burning furniture in your house as fuel because you are out of firewood), and breakdown of fat in adipose to fa...

Enzyme

... molecules, often direct or indirect products or substrates of the reaction catalyzed. This provides a means for feedback to keep the products and substrates in proper relative abundance. As a consequence... very little change in net free energy between the substrates and the products, the reaction will normally be ea...

Fermentation

...es" "Preservation of substantial amounts of food through lactic acid , alcoholic, acetic acid , and alkaline fermentations " "Enrichment of food substrates biologically with protein, essential amino acids , essential fatty acids , and vitamins" "Detoxification during food fermentation processing" "A...

Heterotroph

... A heterotroph ( Greek heteron = (an)other and trophe = nutrition) is an organism that requires organic substrates to get its carbon for growth and development. Contrast with autotrophs which use carbon dioxide as sole carbon source. All animals are heterotroph...

Insulin

...ased gluconeogenesis – decreases production of glucose from various substrates in liver; lack of insulin causes glucose production from assorted substrates in the liver and elsewhere increased amino acid uptake – forces ce...
Substrates in Biological Dictionary

Ubiquitin

...ons and Zomes ( Ubiquitin and Proteasome) ... Ubiquitin -like Proteins and Derivatives. Ubiquitin and Ubiquitin -like Protein Cascade Enzymes and substrates ... ...

Site-specific recombination

...in vitro. Arciszewska LK, Sherratt DJ. ... family of enzymes, are required for Xer site - specific recombination in vivo. ... ... between the substrates and products of site - specific recombination raises ... Site - specific recombination of DNA is an integral aspect of a wide range of ... ...

Ribonucleotides

...-specific IFN- production by ... Ribonucleotides are indicated by gray boxes. ... The additional flanking ribonucleotides of the D10R2 and D9R3 substrates were ... Pol µ efficiently polymerizes ribonucleotides on a DNA primer. ... However, elongation of ribonucleotides or with ribonucleotides is...

Proton-motive force

... motive force , delta pH, membrane potential, ... Furthermore, proton motive force was essential for the export process. ... process of the substrates is driven by proton motive force . Publication Types: ... ... of energy by the Proton Motive Force carried out by some ... PROTON MOT...

Peptidyl transferase

...blasticidin S, bruceantin, carbomycin, chloramphenicol, ... sis of the catalytic mechanism of the peptidyl transferase ... Figure 2. Binding of substrates to the Peptidyl Transferase Center ... These events are normally performed in the ribosomal peptidyl transferase center. ... to inhibit pe...

Pathogen

...I give birth to"), infectious agent, or (more commonly) germ, is a biological agent that causes disease or illness to its host. There are several substrates and pathways whereby pathogens can invade a host; the principal pathways have... pathogen n. An agent that causes disease, especially a living mi...
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