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Substitution in Medical News

In the Case of Epilepsy, Generic Drugs and Random Product Substitution are Not Always "Good Medicine"

Nisola LLC launches campaign for stricter regulatory approval requirements and continuity of product supply. New York, NY (PRWEB) May 27, 2009 -- A recent report released by Wolters Kluwer Health predicts that by the end of the year, nearly two-thirds of all drug prescr...

Nephrologists Indicate High Interest in AMAG Pharmaceuticals' Newly Approved Feraheme According to Latest BioTrends Report

...tion. FMC's PhosLo is under mounting pressure from generic versions of the product and Nephrologists are showing little resistance - 80% either allow substitution or prescribe the generic version outright. Shire's Fosrenol is the only brand for which Nephrologists project significant increases in market share. ...

Rochester Medical Reports Third Quarter Results

...d by other companies. Non-GAAP Net Income and constant currency have limitations as analytical tools and should not be considered in isolation or as a substitution for analysis of our results as reported under GAAP. Reconciliations of Net Income and Non-GAAP Net Income, and reconciliations of sales under GAAP an...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... Cardiotoxicity, infusion reaction, myelosuppression, liver impairment, substitution The use of DOXIL may lead to cardiac toxicity. Myocardial damage...uld be reduced in patients with impaired hepatic function Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl ...

Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication

...es if donor funding is reduced or stopped and governments have committed their resources elsewhere. Farag and colleagues point to how this funding substitution "requires the agencies responsible for donor coordination to pay special attention to what happens to the government share of health funding and to un...

‘HairConfirm' Is First Drug Test of Its Kind to Report Low/Medium/High Usage; Now Available at Local Discount Drug Marts

...pering. In two independent studies, hair drug testing uncovered five to ten times more drug users than urinalysis. Urinalysis also carries the risk of substitution of a sample, dilution and addition of a foreign substance designed to skew the results. HairConfirm is now available at a local Discount Drug Mar...
Substitution in Medical Technology

Spherix Announces Positive Phase 2 Study Results

...testinal in nature. Prior Studies with Naturlose A recent controlled animal study demonstrated that, in comparison to sucrose, equivalent substitution of Naturlose as dietary carbohydrate results in less obesity, hyperglycemia, hyperlipidemia, and atherosclerosis (Police SB, Harris JC, Lodder RA, Cas...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

...ons * Severe myelosuppression may occur * DOXIL dosage should be reduced in patients with impaired hepatic function * Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications * Patients with a ...

Comprehensive Safety Tests Published on Ruyan(R) Smoking Alternatives

...a. These products, varieties of replacement cartridges and their accessories are designed, manufactured and sold for the cigarette alternative/smoking substitution market. They allow smokers to satisfy their tobacco cravings in places and situations where they otherwise cannot smoke by law, regulation or common c...

Thrombosis Guidelines Emphasize Difficult Choices for Pregnant Women

... two options for doing this: (1) continuing VKA but performing frequent pregnancy tests to determine when pregnancy has been achieved, followed by the substitution of LMWH or UFH as therapy; or (2) substituting VKAs with LMWH or UFH prior to conception. Although the second option eliminates the potential for feta...

Two DOXIL(R) Studies to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...actions -- Severe myelosuppression may occur -- DOXIL dosage should be reduced in patients with impaired hepatic function -- Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications -- Patients with a histo...

BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU

...od Phe concentrations in subjects with PKU. About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substitution therapy for the treatment of PKU. Pharmacology studies conducted in the PKU mouse model demonstrated that weekly subcutaneous administrations of PEG-P...
Substitution in Medical Products

Blind Performance Specimens

Description:...vides abnormal human urine test results for creatinine, specific gravity and pH. For use in assessing compliance with sample adulteration, dilution or substitution testing guidelines....
Company:Bio-Rad Laboratories

PFC SIGMA Fixed Bearing Knee System Cruciate - Substituting

Description:...lly successful P.F.C. Total Knee System introduced in 1984, P.F.C. Sigma continues a history of innovation. Indicated for procedures where mechanical substitution is required for the posterior cruciate ligament, the cruciate substituting components may be used for primary or revision procedures. The femoral comp...
Company:DePuy Orthopaedics, Inc.
Substitution in Medical Dictionary

Niacin

... Nutrition for A Healthy Life. 11 Vitamins & Minerals For Your Day ... Dietary tryptophan is also converted to niacin in the body... ( See substitution of Different Niacin Preparations under Cautions. ... Information on the role of niacin in detoxification. ... Niacin , when used properly, of...
Substitution in Biological News

Omega-3 fatty acids appear to impact AMD progression

... whole grain versions of pasta and bread, have a milder effect on blood sugar response. Earlier data published by Taylor and Chiu suggests that daily substitution of five slices of whole grain bread for white bread out of a total intake of 250 g of carbohydrate might cut out almost 8% of advanced AMD over five y...

Pliable proteins keep photosynthesis on the light path

...hylls and protein, which differs in naturally occurring reaction center variants. The team may also conduct future experiments to understand the metal substitution limitations of the reaction center and track the protein movements that may be occurring in the reaction center that helps to optimize photosynthesis....

Microbes fuel energy debate

... provide access to new bioenergy alternatives for the marketplace. In the context of a strong global political and economical debate on the gradual substitution of petroleum by renewable alternatives such as biofuels, Demain reviews how microbes can help solve the energy problem, and focuses on the organisms t...

High school students' paper published in prestigious college math journal

...s the Law of Unintended Consequences. Student teams were required to address issues associated with increased corn-derived ethanol production and fuel substitution and relate these matters to dramatic and unanticipated rises in farm commodity pricing, the future of food supplies in developing nations, the effect ...

Synthetic virus supports a bat origin for SARS

...etics to "build" the consensus viral genome and several variations. The consensus synthetic SARS-like bat CoV did not initially grow in culture. But substitution of a single small region from human SARS-CoV the Spike protein receptor binding domain that is critical for viral entry into human cells allowed the...

Carbon sinks: Issues, markets, policy

...and how this baseline rate could be doubled or more through activities including avoided deforestation, afforestation, improved forest management, and substitution of wood for other materials. Brian McPherson will discuss a project designing and deploying several pilot tests to validate the most promising CO ...
Substitution in Biological Technology

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... Cardiotoxicity, infusion reaction, myelosuppression, liver impairment, substitution The use of DOXIL may lead to cardiac toxicity. Myocardial ...d be reduced in patients with impaired hepatic function Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl ...

Shire begins the year with a strong performance

... 577.2 581.5 ________ ________ (1) Following substitution of the convertible bond to Shire plc in 2008, the Company no longer receives a tax deduction on its convertible bond interest, and the interest add ba...

Spherix Announces 2008 Financial Results

...udy showed that mice fed sucrose became obese, hyperglycemic; and hyperlipidemic; and atherosclerosis was increased in these mice as well. Equivalent substitution of D-tagatose did not result in the same extent of these conditions and showed that D-tagatose did not promote substantial weight gain. The fat cells...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

...ignificant impairment of attention, vigilance, information processing or declarative memory as measured by the Leeds Psychomotor Battery, Digit Symbol substitution Test or Word Pair Associates Test. Pharmacokinetic analyses revealed dose-related increases in exposure to ITI-007 and two metabolites with increasin...

BioTrends Releases TreatmentTrends(TM): US Nephrology, an Ongoing Syndicated Publication Providing Insight into Physician Perceptions and Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

...arket dynamics will likely come from the recent introduction of generic calcium acetate from Roxane Laboratories, as very few Nephrologists oppose the substitution of a generic for Fresenius Medical Care's PhosLo. Another recent market shift came with the introduction of Genzyme's Renvela in Q108. Although the ...

EcoSphere(R) Biolatex(TM) Secures Funding from Granholm and Invest Michigan!

...ogy platform provides EcoSphere biolatex products as replacements for petroleum-based paper and paperboard coating binders such as SB and SA Latex. At substitution levels up to 50 percent, the biolatex products are comparable or superior to traditional petroleum-based alternatives and can be specifically formulat...
Substitution in Biological Products

m7G(5)ppp(5)G (Cap Analog) from Ambion

Description:... m7G(5')ppp(5')G (Cap Analog) is used for the synthesis of 5' capped RNA molecules in in vitro transcription reactions. substitution of cap analog for a large portion of the GTP in an in vitro transcription reaction results in the incorporation of the cap structure into a large frac...
Company:Ambion

m7G(5)ppp(5)G (Cap Analog) from Ambion

Description:... m7G(5')ppp(5')G (Cap Analog) is used for the synthesis of 5' capped RNA molecules in in vitro transcription reactions. substitution of cap analog for a large portion of the GTP in an in vitro transcription reaction results in the incorporation of the cap structure into a large frac...
Company:Ambion

RNA Cap Analog, Methylated from EPICENTRE Biotechnologies

Description:... A modified nucleotide structure called a ?cap? is present on the 5?-end of most naturally-occurring eukaryotic mRNAs and many viral RNAs. substitution of Cap Analog for a portion of the GTP present in an in vitro transcription reaction results in the synthesis of transcripts with a cap on the 5'-end ...
Company:EPICENTRE Biotechnologies

RNA Cap Analog, Unmethylated from EPICENTRE Biotechnologies

Description:... A modified nucleotide structure called a ?cap? is present on the 5?-end of most naturally-occurring eukaryotic mRNAs and many viral RNAs. substitution of Cap Analog for a portion of the GTP present in an in vitro transcription reaction results in the synthesis of transcripts with a cap on the 5'-end ...
Company:EPICENTRE Biotechnologies

RNA Cap Analog, Trimethylated from EPICENTRE Biotechnologies

Description:... A modified nucleotide structure called a ?cap? is present on the 5?-end of most naturally-occurring eukaryotic mRNAs and many viral RNAs. substitution of Cap Analog for a portion of the GTP present in an in vitro transcription reaction results in the synthesis of transcripts with a cap on the 5'-end ...
Company:EPICENTRE Biotechnologies
Substitution in Biological Definition

Alcohol

... 8.2.1 Deprotonation 8.2.2 Nucleophilic substitution 8.2.3 Dehydration 8.2.4 Esterification 8....hey can (if activated first) undergo nucleophilic substitution reactions. For more details see the #Chemistry o...2 O (equilibrium to the left) Nucleophilic substitution The OH group is not a good leaving group f...

Genetic code

...where X = any nucleotide) tends to code for hydrophobic amino acids. However, the genetic code is not perfect as minor changes such as the single-base substitution in sickle cell anaemia is disasterous. The hydrophilic glutamate (Glu) is substituted by the hydrophobic valine (Val) which reduces the solubili...

Genetic code

...where X = any nucleotide) tends to code for hydrophobic amino acids. However, the genetic code is not perfect as minor changes such as the single-base substitution in sickle cell anaemia is disasterous. The hydrophilic glutamate (Glu) is substituted by the hydrophobic valine (Val) which reduces the solubili...

Neutral theory of molecular evolution

...silent" or "unexpressed" (see synonymous or silent substitution ). Such changes are presumed to have little or no ...roducing , multicellular organisms, the nucleotide substitution must arise within one of the many sex cells that...re cases they may become "fixed"--meaning that the substitution they carry becomes a universal feature of the popu...

Phospholipid

... amino alcohol formed from palmitate and serine . The amino terminal is acylated with a by a long-chain acyl CoA to yield ceramide . Subsequent substitution of the terminal hydroxyl group by phosphatidyl choline forms sphingomyelin. Sphingomyelin is present in all eukaryotic cell membranes , but is...

Species

...if two population groups are so close that the distinction between them rests on an obscure and microscopic difference in morphology, or a single base substitution in a DNA sequence, then a demonstration of restricted gene flow between the populations will probably be difficult in any case. More typically, on...
Substitution in Biological Dictionary

Substitution

Substitution cipher, in cryptography. Substitution property, in Equality (mathematics)#Some basic logical ... Variable substitution , in first-order logic ... Substitution is automatic conversion of wikitext of a page referring to a template, variable, or parser function when t...

Transversion

... In molecular biology, transversion refers to the substitution of a purine for a pyrimidine or vice versa . It can only be reverted by a spontaneous reversion. Because this type of mutation changes the chem...

Ribonucleotides

...zed next in solution onto a ... use either deoxyribonucleotides (dNTPs) or ribonucleotides ... unable to use ribonucleotides , and the tyrosine substitution ... ribonucleotides ' binding ... Ribonucleotides are found in RNA (ribonucleic acid) and sometimes in DNA. ... The ribonucleotides must also...

Pyrimidine

...5-boronic acid. C16H20BN3O3. Details. B10898 ... D evelopment of purine and pyrimidine analogues as potential anti ... This specific site of substitution on the pyrimidine ring was selected ... Online Shopping at DirectTextBook.com - Save up to 80%, buy or rent. New and used books like Purine and ...

Pribnow box

... TATA HOMOLOGY, HOMEOBOX, PROMOTER, BASE PAIR (bp) ... Roles of the Pribnow box in positive regulation of the ompC and ompF genes ... A base substitution at the Pribnow box renders ompF expression independent of a ... ...

Point Mutation

...ng these point mutations by the use of ... A point mutation or substitution is the most limited type of mutation , whereby a ... Sometimes the expre...on, occurs when a single ... A point mutation results in a base pair substitution after replication and ... Point mutation summary with 3 pages of ...
Other Tags
(Date:7/10/2014)... electronic health record becomes widespread across the United States, ... Care Act, the quantity of clinical data that will ... dramatically increase. Additionally, experts in healthcare have become ... of data for the purpose of gleaning insights that ... care a process that is known as big ...
(Date:7/10/2014)... Fischer HealthDay Reporter THURSDAY, ... ease the hot flashes that often accompany menopause, new research ... 50 percent of menopausal women, said Dr. Taraneh Shirazian, an ... the Icahn School of Medicine at Mount Sinai Hospital in ... than 10 hot flashes a day, and she added that ...
(Date:7/10/2014)... (Boston) Emergency Medical Service (EMS) responders felt better ... receiving focused tactical training according to a new study ... This is the first study to specifically examine the ... scene where a shooter has not yet been neutralized ... , Incidents such as the Columbine High School shooting, ...
(Date:7/10/2014)... the "Mississippi baby" an infant seemingly cured of HIV ... remission of HIV infection in The New England Journal ... after more than two years of not taking antiretroviral therapy ... and researchers involved in the case. , "Certainly, ... child, the medical staff involved in the child,s care, and ...
(Date:7/10/2014)... University of Huddersfield could help to improve the quality ... such as butter, mayonnaise, yoghurt and fruit drinks ... profile for her work. , Katerina gained her MSc ... and now she has embarked on research for a ... she is investigating the potential of carbohydrates extracted from ...
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(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... July 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ... Mr. Gino Pereira was interviewed on July 1 ... Tampa Florida . Mr. Pereira discusses the company,s ... Harris and how the Wocket™ aims to replace a ... Cedric Harris tells Gino he has never ...
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new ... (DW). An Asian OEM has selected FPC1021 for a flagship ... August 2014.   FPC is proud to announce ... planned date for start of mass production in August 2014. ... 5M, for delivery in the first half of July. The ...
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