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Subsets in Medical News

New Analyses Confirm Nexavar's Efficacy and Safety in Multiple Patient Subsets With Liver Cancer

- Subanalyses from the Phase 3 SHARP and Asia-Pacific trials to be presented at 59th Annual Meeting of the American Association for the Study of Liver Diseases - WAYNE, N.J. and EMERYVILLE, Calif., Oct. 31 /PRNewswire-FirstCall/ -- Bayer HealthCare Pharmaceuticals,...

Data from Patient Subsets of e-HEALING, a Worldwide Registry, Support Use of OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) as Alternative to Drug- Eluting Stents

Report of Positive Results with Innovative Pro-Healing Stent is Featured at ESC Congress 2007 VIENNA, Austria, Sept. 3 /PRNewswire/ -- OrbusNeich today announced that post-marketing data from patient subsets of a global registry support the use of the company's Genous(T...

Master Stem Cell for Human Heart Identified

.... Instead, the key seems to be in identifying intermediary points and pathways by which the cells branch off into very specific types of cells and subsets of the major cells so they could be directed to these specific destinations. "This sets up a system where we can now use scientific tools to rigor...

A new take on growth factor signaling in tamoxifen resistance

...l, process of identifying genes associated with given conditions. Dr Loi said, "Although gene expression data has demonstrated its ability to identify subsets of disease and predict outcomes or drug responses, identifying new therapeutic approaches based on whole genome microarray profiling has, to date, bee...

Researchers uncover approach for possibly eradicating HIV infection

... the specific cells where HIV infection persists in patients currently undergoing treatment. They found that the disease is able to survive within two subsets of memory T-cells. Memory T-cells are a portion of the body's immune system and have the ability to learn, detect and attack certain types of infectio...

IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases

...distributed educational approach to synthesize the candidate molecules. Undergraduate and graduate chemistry students from around the world synthesize subsets of these candidate molecules as part of their normal training in synthetic chemistry. Currently students at IUPUI, the University of Indianapolis, an...

New treatment combination proves safe for head and neck cancer patients

...nal chemotherapies. Patients were able to take the drug orally and tolerated it well. Dr. Argiris plans to conduct further studies to identify the subsets of patients most likely to respond to the drug and to examine patients' quality of life while taking the combination therapy. Head and neck cancer...

FDA Approves SAMSCA(TM) (tolvaptan), the First and Only Oral Vasopressin Antagonist to Treat Patients With Clinically Significant Hypervolemic and Euvolemic Hyponatremia

...ss than 130 mEq/L or less than 125 mEq/L, the effects at Day 4 and Day 30 remained significant. This effect was also seen across all disease etiology subsets (e.g., CHF, cirrhosis, SIADH/other). Seven days after withdrawal of SAMSCA, serum sodium levels of patients decreased to levels approximately equival...

A new method for bone-marrow-derived liver stem cells isolation and proliferation

... Great interest has been aroused in the identification and isolation of liver stem cells from bone marrow cells. Several subsets of bone marrow cells have been found to have the potential to differentiate into hepatocytes, however, sorting based on immunological methods is diffi...

APHA Misleads Americans About Fluoridation

...ing water is not protective of health and must be lowered.(2) Agency for Toxic Substances and Disease Registry (2003) This report says "... subsets of the population may be unusually susceptible to the toxic effects of fluoride and its compounds...the elderly, people with osteoporosis, people with...
Subsets in Medical Technology

MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions

CHICAGO, June 21, 2007 /PRNewswire/ -- What and When Data from the PROactive and CHICAGO studies of ACTOS(R) (pioglitazone HCl) will be presented in poster format at the 67th Scientific Sessions of the American Diabetes Association in Chicago: -- Hospitalizations for serious adverse eve...

Data Presented at AUA Demonstrate PROVENGE Significantly Prolongs Survival for Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study

...he primary endpoint was overall survival. In addition to the results described above, the treatment effect was consistent across multiple patient subsets and remained consistent using the log rank test and an unadjusted Cox model (HR=0.766, p-value=0.023), and after adjustment for docetaxel use followin...

New Body of Research Suggests Statin Use Benefits Multiple Areas of Urologic Health

...ted to benign prostatic hyperplasia. "These studies add to a growing body of literature supporting the beneficial effects of statins in certain subsets of patients," said J. Brantley Thrasher, MD, an AUA spokesman. NOTE TO REPORTERS: Experts are available to discuss this study outside normal bri...

Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting

... disorders. Greater analysis of blood cell development in myeloproliferative disorders with the JAK2 V617F mutation led researchers to identify two subsets of patients. The first subset of patients (85 percent) had an overproduction of malignant cells mainly dependent on the late stages of blood cell diff...

EntreMed Presents MKC-1 Phase 2 Data at American Society of Clinical Oncology Annual Meeting

...OR and HIF-1alpha as molecular targets of MKC-1, we will be in a better position to design future clinical studies in defined, less refractory patient subsets that will benefit from MKC-1 treatment. Additionally, based on data from several preclinical models, we believe that by administering MKC-1 on a conti...

Preliminary Phase 2 Results of R788 in Lymphoma Show Benefit in Diffuse Large B-Cell and SLL/CLL

...isease in the treated patients. Furthermore, R788 appears to be well tolerated in this patient population. More studies of the drug candidate in these subsets of NHL are being planned. These results, with additional outcomes and follow-up, will be presented at the 10th International Conference on Malignant L...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

...bron, Barcelona, Spain. "Taken together, the results of the three trials announced today indicate that RAD001 has a promising potential across various subsets of breast cancer." Study results ABSTRACT #530 - "Improved clinical and cell cycle response with an mTOR inhibitor, daily oral RAD001 (everolimus)...

Nexavar Significantly Improves Overall Survival by 47 Percent in Asia-Pacific Liver Cancer Study

...ival was 6.5 months in patients treated with Nexavar versus 4.2 months for those taking placebo. The survival benefit was seen across multiple patient subsets analyzed, including age, extrahepatic spread and/or macroscopic vascular invasion. "Liver cancer in the Asia-Pacific region continues to grow becaus...

Biopure Announces Publication of Phase II Proof-of-Concept Coronary Trial

...bsence of coronary vasoconstriction, despite exposure to undiluted HBOC-201, further supports the potential utility of HBOC-201 in complicated patient subsets such as those with coronary artery disease. In addition, changes in electrocardiograms, indicating severe ischaemia during control coronary artery occ...

Data from Randomized Pilot Study, Real-World Use of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) to be Presented in Symposium at EuroPCR 2008

...led TRIAS HR Pilot with the Genous stent randomized with a drug eluting stent. In addition, de Winter will include interim follow up data from patient subsets in e-HEALING, a monitored, multi-center, worldwide (outside the United States) prospective registry with 5,000 enrolled patients. Dr de Winter is the ...
Subsets in Medical Products

Lymphocyte Subset Panel 4-T-Cell Subsets Percent & Absolute

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Lymphocyte Subset Panel 3-T-Cell Subsets (CD4 & CD8), Absolute Counts Only

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

CD-Chex Plus BC Immunophenotyping Control

Description:... accuracy and reproducibility of all the steps involved in the process of immunophenotyping, including red blood cell lysis. Reference values for five subsets of leukocytes include: T lymphocytes, B lymphocytes, granulocytes, monocytes, and NK cells. CD-Chex® Plus BC CD4 Low offers a depressed CD4 absolu...
Company:Streck

CD-Chex Plus Immunophenotyping Control

Description:... accuracy and reproducibility of all the steps involved in the process of immunophenotyping, including red blood cell lysis. Reference values for five subsets of leukocytes include: T lymphocytes, B lymphocytes, granulocytes, monocytes, and NK cells. CD-Chex Plus is assayed for normal levels of CD34+ cells f...
Company:Streck
Subsets in Medical Dictionary

Incidence

... Incidence (epidemiology), a measure of the risk of developing some new condition ... Incidence (geometry), the binary relations describing how subsets meet ... Online Medical Dictionary and glossary with medical definitions ... In disease epidemiology, the incidence is the number of newly dia...
Subsets in Biological News

New tool isolates RNA within specific cells

... acid) decodes genetic instructions that turn protein molecules on and off in different cell types. The new tagging method, tested in a variety of subsets of Drosophila brain cells, is described in a paper put on line ahead of regular publication by the journal Nature Methods . Instead of scientists nee...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

...ly active TLR-9 and NOD-2 agonists. Signaling pathways activated by these ligands act synergistically to activate a broad range of innate immune cell subsets that are central to the development of innate and adaptive immune responses. ...

When acute hepatitis develops into chronic hepatitis

...sease. To this end, they took blood samples from Indian patients with hepatitis B and compared the extent to which the altered incidence of the T cell subsets in the blood influences the development of the illness and which genes are responsible for this. Guzman's and Geffers's teams were able to show th...

Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA

...reated by alternative splicing, a process that selectively activates alternate splicing sites along the pre-messenger RNA strand to assemble different subsets of RNA nucleotides into a variety of mRNA's. Each mRNA then produces a single protein. The vast majority of genes utilize alternative splicing. A...

New gene-silencing pathway found in plants

...fluences the way in which organisms grow and develop. For instance, although every cell in the human body has the same genetic information, different subsets of the DNA get activated to make an eye different from a toe. RNA polymerases, the enzymes responsible for making RNA from DNA templates, are key pla...

Breast cancer treatment resistance linked to signaling pathway

...epresented the entire spectrum of breast cancer, and researchers identified subsets of patients with high Src activation who expressed low levels of estrogen r... receptor and HER2, also known as triple negative breast cancer, as well as subsets expressing the estrogen or progesterone receptors. These patient sets h...

Colorful spy tactics track live cells supporting cancerous tumors

...mor-associated cells for more than 12 hours, while retaining the high resolution necessary to watch individual cells move in real-time. They saw that subsets of immune cells move differently some migrate along blood vessels, while others remain at the border of the tumor. Additionally, changes in the tumo...

Dartmouth researchers discover gene signatures for scleroderma

...," says Whitfield "Now that we have discovered new subsets at the molecular level, we can begin to map the ge... of clinical heterogeneity and to quantify disease subsets at the gene expression level." The researchers... expression and computational algorithms to select subsets of genes that can classify the patients. The tech...

Mental stress reduces blood flow to the heart in patients with gene variation

... estimated 10 percent of all patients with coronary disease experience detectable mental stress-induced reductions in blood flow to the heart. In some subsets of patients the phenomenon may be even more prevalent, involving up to 40 percent of these patients. UF researchers studied 148 patients with coron...

Ecologists, material scientists pursue genetics of diatom's elegant, etched casing

...to sediments below. This week in the online edition of the Proceedings of the National Academy of Sciences scientists report the discovery of whole subsets of genes and proteins that govern how one species of diatom builds its shell. For oceanographers, the work might one day help them understand how thou...
Subsets in Biological Technology

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

... studies will help investigators better understand the mechanism of therapy resistance so they may develop more effective, personalized treatments for subsets of patients with CML. We are also hopeful that our studies on CML may provide the basis for one day developing commercial laboratory tests that will h...

NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate

...VLPs were robust and higher than the antibody responses to inactivated or live RSV. Further, antibody titers increased with higher VLP doses. subsets of mice that had been immunized with either RSV VLPs via intraperitoneal inoculation or live RSV via intranasal inoculation received a vaccine booster...

James L. Wittliff, Ph.D., FACB, to Present 'Predicting Breast Cancer Outcome with Gene Expression Signatures on the Ziplex(R) System' at the Association for Molecular Pathology Conference, October 30

...ff, "Advantages of the Ziplex automated system to our research include retention of tissue biopsy custody and the rapid, reproducible analyses of gene subsets to investigate breast cancer behavior in order to identify clinically relevant molecular signatures." Dr. Wittliff was among the first investigators...

Monogram and Dana-Farber Cancer Institute Initiate Evaluation of HERmark(TM) Breast Cancer Assay in Metastatic Breast Cancer

...ng as well as response to treatment with Herceptin. "Results from prior studies in metastatic breast cancer have suggested that HERmark can identify subsets of patients with different responses to Herceptin even though they had all been previously assessed as 'HER2-positive' by IHC and/or FISH, tested cent...

BioCryst Reports First Quarter 2008 Financial Results and Clinical Update

...ngoing Phase IIa study at 20mg and 120mg showed similar dose-dependant effects on reduction of peripheral blood lymphocyte counts. Affected lymphocyte subsets in the Phase II study included CD4+, CD8+, CD56+, and CD20+ cells. "While Roche's decision is disappointing, we are very encouraged by the effects o...

Proteolix's Carfilzomib Receives Orphan Drug Designation for Treatment of Multiple Myeloma

...ignation to carfilzomib, a selective blocker of proteasome activity for the treatment of multiple myeloma. The orphan drug designation encompasses all subsets of multiple myeloma and Waldenstrom's macroglobulinemia. "I am very pleased by our receipt of this designation for carfilzomib," said Susan Molineau...

Emergence of Cancer Vaccines Will Be the Key Factor Driving the Pancreatic Cancer Drug Market to More Than Double by 2016

... "Experts argue that the development model for pancreatic therapies needs to be reviewed, that more effort should be directed at identifying responder subsets at an earlier stage of the disease, and that randomized Phase II studies to identify the most promising drug candidates should be more widely implemen...

At 30, biotech is an industry at a crossroads

...d types of lung cancer: small-cell and non-small-cell lung cancer. Each of these types of lung cancer, in turn, can be subdivided further into several subsets - squamous cell carcinoma, etc. New drug therapies are targeting these subsets. The cancer drug market is probably the fastest growing due to improved...

Medical College team seeks stem cell patent

...ved and integrated into the spinal cord, remaining at the site of transplantation and, significantly, not forming tumors. According to Sieber-Blum, subsets of the epidermal neural crest stem cells express markers for the nerve-supporting cells that are essential for proper neuron function. They also may b...

TSKgel ODS-100Z and TSKgel ODS-100V column series provides a universal solution for the analysis of samples containing acidic, basic, polar & non-polar compounds

...ars, many new octadecylsilane (ODS) chemistries have been made commercially available that offer optimized properties for select subsets of compound types. The overriding trends in the release of new stationary phases has shifted toward 1) high purity, metal free silica ...
Subsets in Biological Products

GeneMaths XT from Applied Maths

Description:...sional software for microarray analysis. Its advanced concept of layers and subsets makes it is possible to work with different layers for different data outpu... Cy3 and Cy5, standard deviations, error values, etc., as well as different subsets of genes and/or arrays. Also unique is the full error handling through all ...
Company:Applied Maths

Dynabeads Mouse Pan B (B220) from Dynal Biotech

Description:...ion or depletion of mouse B cells directly from spleen or lymph node cell suspensions. B220 antigen is expressed on mouse B cells and lytically active subsets of lymphokine activated killer cells from all common mouse strains...
Company:Dynal Biotech

CompenFlow Flow Cytometry Compensation Kit 6 m from Molecular Probes (Invitrogen)

Description:... Using multicolor analysis in a modern flow cytometer, a scientist can resolve subsets of cells that are differentially labeled with fluorescent probes. However, the emission spectra of the dyes typically used for cell labeling are broad...
Company:Molecular Probes (Invitrogen)

LabShare 3.0 for Vector NTI Data Management Software from Invitrogen

Description:...lysis. LabShare software contains many security and tracking features to protect your critical sequence information including the ability to partition subsets of data for access under controlled conditions. The central database is also configured to be searched using BLAST. Non-technical personnel can easily...
Company:Invitrogen
Subsets in Biological Definition

Alcohol

...O-H bond in methanol (CH 3 OH) is around 0.96 Å (96 pm ) in length. Primary, Secondary, and Tertiary Alcohols There are three major subsets of alcohols- 'primary' (1), 'secondary' (2) and 'tertiary' (3), based upon the number of carbons the C-OH carbon (shown in red) is bonded to. Ethano...

Taxonomy

...tructure is a single classification, the root node, that applies to all objects. Nodes below this root are more specific classifications that apply to subsets of the total set of classified objects. So for instance in Carolus Linnaeus 's Scientific classification of organisms, the root is the Organism (as...
Subsets in Biological Dictionary

T cell

...ls do not attack healthy parts of the body itself, nor even ... T cell subsets ... different subsets of T cells have been described, each ... Information about T cell...

Segment

... encyclopedia. ... straightaway, straight - a straight segment of a roadway or racecourse ... Segmentation is essentially the identification of subsets of buyers within a ... Of course you can segment by all sorts of variables. ... Compare prices for Segment . Become.com searches billions of web...

Palindromic Sequence

...c subsequences. ... length of palindromic sequence : <select name="min"> <option>4</option> <option>5 ... Palindromic subsets of Concatenated Sequences. Length. Concatenated Prime Sequence . 3 ... The numbers in brackets show the position of the palindromic sequence in a...

Multi-gene family

...ies to explore how ... One path to diversity in a genome involves the proliferation of genes into multi - gene families. ... ... multi - gene subsets were chosen, one upstream of the IGF receptor ( IGF family ' ... differential expression of multi - gene sets ( IGF family ' and IGF signali...

Lymphocytes

... Functionally distinct subsets of lymphocytes correlate with their appearance. Most, but not all large granular lymphocytes are more commonly known as the ... B cells a...

Helper T cell

...se, ... T helper cell - Wikipedia, the free encyclopedia ... Information about helper T cell in the free online ... Helper T cell subsets for immunoglobulin A responses: oral immunization with ... T helper cell summary with 15 pages of encyclopedia entries, essays, summaries, re...

Dendritic cell

...ic cells (arrows) from the spleen of a mouse. ... Dendritic cells have a set of transmembrane receptors that recognize ... Dendritic cell subsets ... These dendritic cells then are seen by the patient's immune system as foreign in ... Dendritic cells specialize in antigen presenta...
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