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Subgroup in Medical News

Researchers Have Identified Subgroup Sensitive to the Drug Cisplatin

Researchers have identified a subgroup of hard-to-treat breast cancers that may be sensitive to the drug cisplatin, rarely used in the treatment of breast tumors. They also have discovered// the molecular basis of this sensitivity, which may help identify patients most likely to benefit from cispla...

FDA Approves New 3000 IU Vial Size for Kogenate(R) FS, antihemophilic factor (recombinant)

...treating diseases. This news release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, fin...

Fox Chase finds that lung cancer patients respond to erlotinib following cetuximab therapy

...hose disease is no longer controlled by cetuximab can respond to erlotinib, Borghaei and colleagues examined the treatment and clinical outcomes for a subgroup of patients who had participated in a Fox Chase clinical trial that tested a combination of carboplatin, paclitaxel and cetuximab as first-line treatm...

Advanced targeted therapies effective as first-line treatment for lung cancer

...toxicity was less common in the gefitinib group than in the chemotherapy group. Additionally, in the gefitinib group, PFS in the mutation-negative subgroup was shorter than that of the mutation-positive group (with a median of 2.1 vs. 8.4 months). There was no difference between these two subgroups in the...

Scientists Track Impact of DNA Damage in the Developing Brain

...e to efficiently repair the single-strand DNA damage. The shutdown triggered a dramatic decline of interneurons throughout the cerebellum. In a subgroup of those cells, the damage triggered apoptosis, or programmed cell death. But the findings suggested the greatest loss occurred as the immature cerebe...

Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer

...orward Looking Statements This news release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, fin...

MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation

... Forward-looking statements This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, fin...

New lung cancer staging system revealed

...n system provides a common language to define the extent of cancer within a subgroup and the corresponding prognosis, the system does not define the process of ...beyond the stage grouping. Therefore, one cannot assume that treatment of a subgroup of patients should change because the new classification has placed them in...

Minimally Invasive Surgery Not Better for Sciatica

..." said study author Dr. Mark P. Arts. Minimally invasive surgery might still be recommended in some cases, Arts noted. "We are still working on our subgroup analysis, but possibly the tubular diskectomy is indicated in obese patients in whom a large incision and exposure is inevitable," he said. But mor...

Family History Key to Psychiatric Disorder Risk

...ecur, whose illness will cause the greatest impairment and who will be the most likely to use treatment resources. Thus, family history may identify a subgroup in need of primary or early intervention and for whom treatments appropriate for recurrent, highly disabling disorder may be needed," the researchers ...
Subgroup in Medical Technology

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

...om SLE." Key Findings from BLISS-52 "The BLISS-52 results support and extend the findings that emerged in the serologically active subgroup of SLE patients at Week 52 in our Phase 2 trial," said David C. Stump, M.D., Executive Vice President, Research and Development, HGS. "We are delight...

New AHRQ Study Finds Mixed Evidence on Use of Radiofrequency Catheter Ablation for Treating Atrial Fibrillation

...ta, such as death, stroke, myocardial infarction, clinically manifested pulmonary vein stenosis, etc., at 5 years post-treatment. The second PAS is a subgroup analysis from an ongoing larger study that will look at the incidence of stroke, and compare the 3-year incidence of stroke between patients treated w...

Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th

...sive and indolent NHL including follow-up data and subgroup analyses of high risk patients from the phase III ...Pixantrone PIX 301 EXTEND Trial Follow-up Data and subgroup Analyses Initial follow-up data in the PIX 30...ts an additional update during late 2009. In subgroup analyses, higher response rates in the pixantrone ...

Alfacell Provides Shareholder Update

...mesothelioma (UMM). We did however; achieve statistical significance with a subgroup of patients who failed a prior chemo therapy. Overall survival was 10.5 mon...r, Division of Thoracic Surgery; Chief of Thoracic Oncology: "The promising subgroup analysis requested by the FDA exhibiting a significant survival advantage f...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

...espectively. Patients continued to receive stable doses of methotrexate, sulfasalazine and/or hydroxychloroquine if receiving them at baseline. subgroup analyses were performed for ACR 20 response at week 14 across disease-modifying anti-rheumatic drug use, number of prior anti-TNF-alpha agents and rea...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

...the 2009 American Society of Clinical Oncology ("ASCO") Annual Meeting, new subgroup analysis data were reviewed from the phase III EXTEND (PIX 301) clinical tr...se levels were solely with a standard anthracycline. An additional new subgroup analysis was highlighted by the ASCO discussant, which demonstrated the cli...

Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506

... Forward-Looking Statements This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, fin...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...5% CI (11.9, 19)]. The median overall survival has not been reached with 33 of 46 patients (72%) still alive. Also of interest was the patient subgroup who had failed both a VEGF receptor inhibitor (sunitinib or sorafenib) and an mTOR inhibitor (either everolimus or temsirolimus). For this group, bes...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...en suggested that reduced estrogen in the body is linked to a decline in cognitive function(6). A new substudy (abstract #510) conducted within a subgroup of patients enrolled in the independent Breast International Group (BIG) 1-98 study (Femara(R) [letrozole tablets] vs. tamoxifen) found that postmenop...

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

... Positive data from subgroup analysis presented at 19th annual European Congres...ndings also presented for the first time include a subgroup analysis of clinical cure and recurrence rates for...ge of 65. The recurrence rates in the BI/NAP1/027 subgroup were similar between fidaxomicin and Vancocin. ...
Subgroup in Medical Definition

European Prospective Investigation into Cancer and Nutrition

..., Norway (7%), Spain (8%), Sweden (10%) and the United Kingdom (17%). One UK centre (Oxford) recruited 27,000 vegetarians and vegans ; this subgroup forms the largest study of this dietary group. Recruitment to the study took place between 1993 and 1999, and follow up is planned for at least ten ye...
Subgroup in Medical Dictionary

Deodorants

...e body odor which is caused by the bacterial breakdown of perspiration. A subgroup of deodorants are "antiperspirants", which prevent odor and red... are substances applied to the body, most frequently the armpit s, to ... A subgroup of deodorants are "antiperspirants", which prevent odor and reduce ... ...
Subgroup in Biological News

Scientists track impact of DNA damage in the developing brain

...nable to efficiently repair the single-strand DNA damage. The shutdown triggered a dramatic decline of interneurons throughout the cerebellum. In a subgroup of those cells, the damage triggered apoptosis, or programmed cell death. But the findings suggested the greatest loss occurred as the immature cerebe...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

...ree subgroups of polyarthritis. There was an older subgroup (average age 11) that included both RF positive an...aring some resemblance to adult RA. A second older subgroup (RF negative) had less severe arthritis and an anti-inflammatory gene expression signature. A third subgroup was comprised mostly of younger patients (average ...

Gene activity reveals dynamic stroma microenvironment in prostate cancer

...ology at BCM and another senior author. "Often in prostate cancer, you don't see much change in the stromal cells," said Ittmann. "However, in this subgroup of patients (in which the stroma become visibly reactive), you see a histologically recognizable change in the appearance of the stroma. Dr. Ayala has...

U of Minnesota research reveals critical role of evolutionary processes in species coexistence

... to understanding species interactions, ecosystems and biodiversity. The work, published in the May issue of Ecology Letters , was conducted by a subgroup of researchers participating in an interdisciplinary working group convened by the National Center for Ecological Analysis and Synthesis (NCEAS) at th...

Personalized treatment for early lung cancer

...cribe a gene signature that might predict which patients will benefit from the treatment. "Because the benefits of vaccination will be limited to a subgroup of patients, strategies to define these patients by means of biomarkers such as a genetic signature are of major clinical relevance, as only these pat...

Researchers identify potential new weapon in battle against HIV infection

...llion) who produce excess of this blood group antigen have dramatically reduced sensitivity to HIV infection. Conversely, another slightly more common subgroup of people who do not produce any Pk (≈ 5 in a million) was found to be much more susceptible to the virus. "This study is not suggesting tha...

American Chemical Society's Weekly PressPac -- Jan. 7, 2009

...ism patients that could eventually provide a clue for the molecular basis of this severe developmental disorder and could be used as a biomarker for a subgroup of patients with autism spectrum disorders (ASD). Their study is in the January 2 issue of ACS' Journal of Proteome Research , a monthly publication....

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

...t cancer recurrence compared to staying on tamoxifen. The aim of the new study was to determine whether CYP2D6 genetic variation would identify a subgroup of patients at higher risk of recurrence within the context of the ABCSG-8 trial. "Among the patients randomized to tamoxifen, poor metabolizers had a...

Healthy or diseased?

...xponents of bioinformatics analyzed data collected in the framework of a pre-clinical metabolomics study in healthy and diabetic mice. In each case, a subgroup of the animals was treated with the diabetes drug RoziglitazoneTM. Then, more than 800 metabolites were quantitatively determined in a blood plasma sa...

Arsenic and new rice

...ded to the mix. They showed that the arsenite was channelled by NIPs and accumulated inside the yeast cells. Further investigations showed that only a subgroup of NIPs had arsenite transport capabilities, and have now been identified as metalloid channels in plants. More surprisingly, the researchers also ...
Subgroup in Biological Technology

Optimer Pharmaceuticals Announces Lower Recurrence Rates for Fidaxomicin Versus Vancocin(R) in Subgroup Analyses from Its Phase 3 Study for the Treatment of CDI

SAN DIEGO, June 2 /PRNewswire-FirstCall/ -- Optimer Pharmaceuticals, Inc. (Nasdaq: OPTR ) announced that additional results from its North American Phase 3 clinical study of fidaxomicin in patients with Clostridium difficile infection (CDI) were presented today by clinical investigator, Mark A...

Glenmark's Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials

...ion of 0.75% in patients receiving 50mg twice daily dose (p<0001) and 0.60 % in patients receiving 100 mg once daily dose (p<.0001). In a subgroup of patients with higher baseline HbA1c of 8.5%-10%, Melogliptin reduced HbA1c from baseline as compared to placebo with a mean average reduction of 0....

Phase 3 Cystic Fibrosis Trial Results Presented at European Conference

...ent with Bronchitol showed an immediate and sustained improvement in lung function (FEV1) over the 26 weeks (p<0.001). -- For the subgroup of patients on concomitant rhDNase there was also a significant improvement in FEV1 from baseline (88mL) and from placebo (109mL) at wee...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

...erapy, was not different between the groups. In contrast to the lack of an observed local effect, patients in the perifosine group, particularly the subgroup of patients who entered the study without prior chemotherapy, showed a trend towards longer survival than patients of the placebo control group despit...

Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma

... has been described for doxorubicin with median LVEF values at a baseline of 58% and at the end of treatment of 59%. Consistent across the primary and subgroup analyses, treatment with pixantrone resulted in superior clinical benefits over standard of care chemotherapy treatment. "We are pleased that the...

Bayer and Onyx Announce Nexavar Data Presentations at 45th American Society of Clinical Oncology Annual Meeting

...vel 2, West Hall C Efficacy and Safety of Sorafenib in Patients with Advanced Hepatocellular Carcinoma : Asia-Pacific Trial subgroup Analyses by Baseline Transamanase / ¿-Fetoprotein Levels Shukui Qin, M.D., Department of Gastroenterology, First Affiliated Hospital of G...

Lilly Set to Unveil More Than 50 Studies at ASCO 2009

... Abstract #8045: Poster Presentation: May 30, 2009, 2:00 p.m. Efficacy of pemetrexed-cisplatin (PC) in East Asian patients (pts): subgroup analysis of a phase III study comparing PC versus gemcitabine-cisplatin (GC) in first-line treatment of advanced non-small cell lung cancer ...

Avian Adenovirus Genotyping Diagnostic Service

...enovirus A based on hexon loop (L1) genotyping. The hexon protein is the major capsid protein of the non-enveloped virion on which type, group and subgroup specific determinants are located. The hexon consists of conserved regions (pedestals), which are located inside the virion, and variable loops which ...

PDHI Launches Short Form of Its ConXus Profile Health Assessment

...ludes assessments for students, children, and Spanish-speaking adults. Employers can deliver both long and short forms to the same population or subgroup and can switch between long and short forms from year to year. Aggregate reports support both versions when deployed within the same population and ti...

Agendia Presents Data Supporting MammaPrint's Predictive and Prognostic Power at 2009 St. Gallen Breast Cancer Conference

...n, E. van Lienen, A. Glas, and R. Bender. Thursday, 12 March 2009 Poster 0071 The 70 Gene-MammaPrint Profile Allows to Identify a subgroup of Good-Prognostic Patients with Primary Breast Cancer and 4-9 Positive Lymph Nodes M. Saghatchian, S. Mook, G. Pruneri, G. Viale, A. Glas, I. ...
Subgroup in Biological Definition

Homeobox

...ption factors, often also homeodomain proteins. Such complexes have a much higher target specificity than a single homeodomain protein. A particular subgroup of homeobox genes are the Hox genes , which are found in a special gene cluster, the HOX cluster . Hox genes function in patterning the body axis. T...

Virus classification

...roup 1: Chronic bee-paralysis satellite virus subgroup 2: Tobacco necrosis satellite virus Sa... satellite RNAs Single-stranded satellite RNAs subgroup 1: Large satellite RNAs subgroup 2: Small linear satellite RNAs ...
Subgroup in Biological Dictionary

Right ventricle

...on,ratios with ... As the right ventricle begins to fail, its ... Double outlet right ventricle (DORV) is a partial abnormality of ... This subgroup of double outlet right ventricle is also closely related to tetralogy of Fallot. ... Answers to your questions about double outlet right ven...
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Breaking Medicine News(10 mins):Health News:Cool Jackets Are For Sale At Fecbek.com 2Health News:Grief Can Weigh on Immune System in Older Folks, Study Says 2Health News:Limited Spots Remain at Becker's Upcoming ASC and Hospital Conferences 2Health News:Carbon Dioxide Production in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Carbon Dioxide Production in the US Industry Market Research Report Now Available from IBISWorld 3Health News:One Dose of Antidepressant Changes Brain Connections, Study Says 2Health News:One Dose of Antidepressant Changes Brain Connections, Study Says 3
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Breaking Biology News(10 mins):Research milestone in CCHF virus could help identify new treatments 2Microplastic pollution discovered in St. Lawrence River sediments 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3
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