Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

...n's in-house discovery efforts. It is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP proteins. In normal human tissues, TRPM8 is expressed predominantly in the prostate, a gland in the male reproducti...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

...n's in-house discovery efforts. It is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP proteins. In normal human tissues, TRPM8 is expressed predominantly in the prostate, a gland in the male reproducti...

Subfamily in Medical Dictionary

Thorax

... protects important parts of the body, such as those that assist in ... mosquito ( mə′skēdō ) ( invertebrate zoology ) Any member of the dipterous subfamily Culicinae; a slender fragile ... The thorax is specialized for locomotion. ... The thorax has to be separated from the abdomen by the diaph...

Swan

... Swans, genus Cygnus, are birds of the family Anatidae, which also includes geese and ducks. Swans are grouped with the closely related geese in the subfamily Anserinae where they form the tribe Cygnini. Sometimes, they are... The Mute Swan (Cygnus olor) is a species of swan , and hence in turn a memb...

Cytomegalovirus

...s HCMV or Human Herpesvirus 5 (HHV-5). CMV belongs to the Betaherpesvirinae subfamily of Herpesviridae, which also includes... From the Centers for Disease C... Overview: Cytomegalovirus (CMV) is a member of Betaherpesvirinae in the subfamily ... Cytomegalovirus ... Patients with primary cytomegalovirus (CMV) ...

Subfamily in Biological News

Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds

...cidating the pathophysiology of mutations in the OPHN1 gene. The protein normally encoded by the OPHN1 gene belongs to what scientists call the Rho subfamily of GTP-binding proteins. "Members of this family are known to be key regulators of the actin cytoskeleton and affect many aspects of neuronal develop...

Diversity among parasitic wasps is even greater than suspected

...rs have dramatically increased nearly doubling the estimated number of species reported of six very species-rich genera of parasitoid wasps. The subfamily to which these wasps belong, Microgastrinae, gets its name from its tiny abdomen. The wasp itself is quite small, about the size of the lead at the ti...

A link between greenhouse gases and the evolution of C4 grasses

...alternative approach to date a large group of grasses. By using a molecular clock technique, the authors were able to determine that the Chloridoideae subfamily of grasses emerged approximately 30 million years ago, right around the time global carbon dioxide levels were dropping. Furthermore, a model of the e...

Present-day species of piranha result from a marine incursion into the Amazon Basin

...ous species of these fish (2). In spite of the evolutionary success of this subfamily of fish, the mechanisms that generated the species richness of this group a... similar to those of present-day piranhas, strongly suggests that this fish subfamily already existed in South Americas hydrographic system 25 million years ago....

New animal and plant species found in Vietnam

...red in the province since 1996. One is a skipper a butterfly with quick, darting flight habitsfrom the genus Zela and the other is a new genus in the subfamily of Satyrinae. According to WWF experts, all of these species are at risk from illegal logging, hunting, unsustainable extraction of natural resour...

A case of mistaken molecular identity

... the concept of molecular mimicry in Chagas disease." Rhodopsin and beta1-adrenergic receptors in heart cells belong to the same class of molecules, a subfamily of the G-protein-coupled receptors, he pointed out. Paveto, an independent researcher at INGEBI--an institute that is home to three HHMI internati...

Cells direct membrane traffic by channel width

...f proteins that form trans-membrane channels in cell walls in all forms of life. They allow for water movement between the cell and its environment. A subfamily of aquaporins allows slightly larger molecules, such as glycerol, to pass, too. In humans, 11 aquaporins have been identified, mostly in the kidney, b...

Scientists track stealth DNA elements in primate evolution

...chanisms, Dr. Batzer and his colleagues examined a subfamily of Alu elements in the human genome known as the A...illas, orangutans, gibbons and siamangs. The AluYb subfamily accounts for approximately 40% of all human-specif... Dr. Batzer's team demonstrated that some AluYb subfamily members have orthologs in all primate genomes test...

Subfamily in Biological Technology

Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio

...Protein 1, aka ABCC1 or ATP-Binding Cassette, subfamily C, Member 1 (4) Cytochrome P450, subfamily IIB, Polypeptide 6 (5) Cytochrome P450, subfamily IID, Polypeptide 6 ...

Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000

...ounds (LOPAC TM ) was used to demonstrate the capability of screening for potential agonists to the β 2-adrenergic receptor, a member of the Gs subfamily of GPCRs. This library consists of 640 well-characterized, pharmaceutically diverse compounds with known drug or drug-like activities. These compounds...

Subfamily in Biological Products

Rabbit Anti-Human Olfactory Receptor, Family 2, Subfamily H, Member 3 Polyclonal Antibody, Unconjugated from IMGENEX

Description: Peptide-affinity Purified Polyclonal Antibody to Olfactory Receptor, Family 2, Subfamily H, Member 3...
Company:IMGENEX

Rat Anti-Human CD66 acd Monoclonal Antibody, Unconjugated, Clone YTH71.3 from GeneTex

Description:... by human neutrophils and cells in some cases of colon carcinoma. Clone YTH71.3 reacts with transfectants containing BGPa, NCA and CGM1a which are CEA subfamily members(2). Immunogen: Human lymphocytes Specificity: human CD66acd...
Company:GeneTex

Mouse Anti-Human NR2F2 Polyclonal Antibody, Unconjugated from Novus Biologicals

Description:... Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
Company:Novus Biologicals

Subfamily in Biological Definition

Virus classification

...on (negative or - polarity). The taxonomy of viruses is similar to that of cellular organisms: Order ( -virales ) Family ( -viridae ) subfamily ( -virinae ) Genus ( -virus ) Species However, the code of nomenclature regulated by the International Committee on Taxonomy o...

Subfamily in Biological Dictionary

Synapomorphy

...of independent evolutionary development? ... A key synapomorphy of the subfamily is an unusual pollen configuration called ... the angiosperms and a strong synapomorphy for most of the subfamily (Nowicke 1994) ... ...

Small nuclear RNA

...vert this formula, in which many ' small RNAs' do not code for proteins, but instead exercise ... Small nuclear RNAs (snRNAs) ... small RNA subfamily contains small ... ...

Paraphyletic

...in all the descendants of that ancestor. ... ( paraphyletic ) (unranked): Sauria. Order: Squamata ( paraphyletic ) ... usually placed in the subfamily Scincinae which seems to be paraphyletic however. ... paraphyletic . adjective (Gr. para: near; phyletikos: bout a tribe) Term applied ... How...