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Stroma in Medical News

Lab Study Finds Protein That May Inhibit Cancer Spread

...ppressor p53 in connective tissue (stroma) surrounding the tumor, which then stimulated production of an inhibitor of blood vessel growth in the tumor stroma and in distant cells, according to the study. "Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, migh...

Potent metastasis inhibitor identified

...unding the tumor. This in turn stimulated production of thrombospondin-1, a natural inhibitor of blood vessel growth (angiogenesis), both in the tumor stroma and in cells at the distant location. "Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, might be an...

New universal breast cancer marker predicts recurrence and clinical outcome

...ient survival. The absence of caveolin-1 in the stroma also appeared to be a marker for drug resistance i...er Center, caveolin-1 is expressed by cells in the stroma called fibroblasts, which are present in the conne...idea that a prognostic biomarker is present in the stroma rather than the epithelial cancer cell is paradigm...

Mayo researchers find potential links between breast density and breast cancer risk

...rily composed of milk glands and ductal cells, and stroma is the connective tissue that supports epithelial ...ity contained much more epithelium (6 percent) and stroma (64 percent) and much less fat (30 percent), compa...t fat. "This shows us that both the epithelium and stroma contribute to density, and suggests that the large...

Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery

...l features and pathophysiology of inherited metabolic genetic disorders. COMMON AND CANCER TYPE-SPECIFIC LOSS-OF-HETEROZYGOSITY (LOH) IN THE TUMOR stroma AND EPITHELIUM OF 3 CARCINOMA TYPES ASSOCIATED WITH CLINICAL OUTCOME A team of researchers led by Charis Eng, M.D., Ph.D., Chair and Director of C...

JCI online early table of contents: March 3, 2008

... bone marrow and stromal cells had to express IFN-gamma and TNF receptors. These data led the authors to suggest that IFN-gamma and TNF acted on tumor stroma to effect bystander killing of ALVs, and they hope that this insight will aid in the development of effective strategies to eliminate established canc...

Scientists discover who is likely to get dry eye syndrome after LASIK surgery

...gery. The PRK has the same goal as LASIK, but the procedures differ. In LASIK a flap of corneal epithelium is cut and lifted to allow the underlying stroma to be shaped by the laser. Then the flap is placed down on the eye. In PRK the corneal epithelium is mechanically removed to allow laser shaping of th...

New target for cancer therapy may improve treatment for solid tumors

...umor growth. We already knew that targeting the stroma is essential for eradicating established large tumors, because the stroma is like the 'root of the tumor," said study author...However, effects of current treatments that target stroma are usually transient and not cancer-specific." ...

Area Around Breast Tumor May Predict Cancer's Spread

...terations in the tumor-suppressing p53 gene in the stroma -- the region surrounding the tumor -- have future implications, the researchers said. "The stroma looks innocent under the microscope, but there's a...e" to patients. Even further down the line, the stroma might provide a new target for drug therapies. ...

Herpes Infects Cornea, Evades Immune Cells

...s coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, vi...he electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect th...hly acidic. But even though the sacs formed by the stroma cells were similar to the phagocyte's sacs, Shukla...
Stroma in Medical Technology

Improved Cornea Surgery Technique Provides Enhanced Transplant Success

...ing keratoplasy). Today, DSAEK (descemet-stripping automated endothelial keratoplasy)---where only endothelial tissue attached to a thin layer of deep stroma is transplanted and the normal structure of the recipient cornea is not disrupted--is increasingly preferred by corneal surgeons. Most patients receiv...
Stroma in Medical Products

Epi-K

Description:...e epithelium from the Bowmans membrane leaving a pristine optical zone for laser ablation. Epi-Lasik preserves the structural integrity of the stroma and is expected to minimize discomfort, shorten the length of visual recovery, and reduce the incidence of haze associated with other surface ab...
Company:Moria S.A.

MEL 80 Excimer Laser

Features:... The exceptionally fast MEL 80's short ablation time reduces procedure time for greater patient comfort Shortened stroma exposure time means faster visual recovery Very small 0.7 mm spot permits the finest corrections without losing the benefits of smooth ablation ...
Company:Carl Zeiss Meditec, Inc.
Stroma in Biological News

Gene activity reveals dynamic stroma microenvironment in prostate cancer

HOUSTON -- (June 9, 2009) As stroma the supportive framework of the prostate gland react to prostate cancer, changes in the expression of genes occur that induce the formation of new structures such as blood vessels, nerves and parts of nerves, said researchers at Baylor College of Medicine in ...

Cancer-causing protein can also help fight the tumors it causes

...ill be less active," says Rechavi. "It's also possible that a tumor could transfer the Ras protein into cells that normally support tumor growth, like stroma cells that grow blood vessels for the tumor. This is why we have to work to understand what is happening." ...

Protein linked to change in tissue that surround and support breast tumors

...e, which seems to increase growth factor responses, is required for cancer to develop, or whether cancer would regress if development of this abnormal stroma was interrupted," she says. ...

Tips from the American Journal of Pathology

...nvironment of human breast cancer. Stromal expression of caveolin-1 correlated with reduced levels of metastasis, and caveolin-1 was not expressed in stroma of patients with poor clinical outcome. In addition, tumor onset in mice was accelerated in the absence of stromal caveolin-1. Caveolin-1 may therefo...

Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer

...nd colleagues showed the potential of the reactive stroma to modulate tumor phenotype and the clinical respo...s found that it is precisely the magnitude of this stroma reaction that was predictive of a response to chem...," Dr Farmer continued. "Patients who had a strong stroma reaction characterized by an increased quantity of...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...ended-wear contact lenses. Inlays are also possible. The cornea contains layers--a top layer of protective epithelial cells, a middle layer called stroma that provides the collagen matrix that gives the cornea its shape, and an innermost endothelial layer. With inlays, some of the epithelial layer can b...

Newly discovered behavior in cancer cells signals dangerous metastasis

... this co-factor could be activated by contact with stroma --the supporting structural cells of a tumor -- because the stroma is where the majority of epithelial-type cancer ce...re observed. Their heavy presence implies that the stroma may have induced the cancer cells to revert to epi...

Study shows how herpes infects cornea, evades immune cells

...s coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, vi...he electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect th...hly acidic. But even though the sacs formed by the stroma cells were similar to the phagocyte's sacs, Shukla...

Links between DNA damage and breast cancer studied

...e can change or disrupt gene expression. The team identified a unique oxidation-induced lesion in the DNA of breast epithelium, myoepithelium and stroma and found that the highest concentrations of this lesion tended to occur in women in the 33- to 46-years age group, a bracket that corresponds to a kn...

New human retrovirus originated in mice

..." Nevertheless, said Ganem, an indirect link to cancer cannot be ruled out, since "in cancer research these days, there is a lot of interest in the stroma as the soil in which cancer arises." He added that the chronic inflammation from infection of stromal tissues may play a role in triggering such cance...
Stroma in Biological Technology

Medarex Announces Presentations at Annual Meeting of the American Association for Cancer Research

..., Peptides, and Protein Therapeutics Session) - Poster session scheduled for Tuesday, April 15, 2008 at 8:00 a.m. -- "Ptk7 as a direct and tumor stroma target in multiple solid malignancies" (Abstract #1526, Targets and Screening Approaches Session) - Poster session scheduled for Sunday, April...
Stroma in Biological Definition

Stroma

This article is about stroma in biology. For the island, see Stroma, Scotland . Stroma can refer to: 1) The connective supportive framework of a biological cell , tissue , or organ . 2) The fluid filled area of a chloroplast outside of the thylakoid membranes wherein the ...

ATP synthase

...P synthase is also present in chloroplasts (CF O F 1 -ATP synthase). The enzyme is integrated into thylakoid membrane; the CF 1 -part sticks into stroma , were dark reactions of photosynthesis ( Calvin cycle ) and ATP synthesis take place. The overall structure and the catalytic mechanism of the chloro...

Calvin cycle

...d by Melvin Calvin and Andy Benson at the University of California, Berkeley . It is one of the light-independent reactions and occurs in the stroma . During photosynthesis, light energy has been converted into chemical energy stored in ATP and NADPH . The light-independent Calvin cycle uses...

Chloroplast

...th four membrane layers. The fluid within the chloroplast is called the stroma , corresponding to the cytoplasm of the bacterium, and contains tiny circ...gh most of their proteins are synthesized by the cell nucleus. Within the stroma are stacks of thylakoids , the sub-organelle where photosynthesis actually...

Chloroplast membrane

...ons and metabolites , but the inner membrane is highly specialised with transport proteins . Within the inner membrane, in the region called the stroma , there is a system of interconecting flattened membrane compartments, called the lamellae , or thylakoid membrane . These are sites of light ab...

Intermembrane space

...with the cytosol in terms of solutes relevent for the functioning of these organelles . Enzymes destined for the mitochondrial matrix or the stroma can bypass the intermembrane space via transport through translocases . These are known as TOM and TIM in mitochondria and TOC and TIC in chlo...
Stroma in Biological Dictionary

Stroma

Stroma (animal tissue), the connective, functionally supportive framework of a ... Stroma , the thick fluid found in between grana, which are stacks of ... Stroma is an island on the northern coast of the Scottish mainland. It is the southernmost of the two islands situated in the Pent...

Thylakoids

... ... ... of Rubisco, and RCA in thylakoids compensates for the reduction of RCA in the ... was subtracted from the average density within the stroma and thylakoids . ... Figure 3 Western analysis of thylakoids from PS1 mutants. ... the 1500 to 1800 cm-1 frequency range for the thylakoids o...

Interstitial cells

...n JJ, Thuneberg L. Interstitial cells of Cajal in human small intestine. ... interstitial or Leydig cells are found in the fibrovascular stroma of the ... interstitial cell tumors are benign but functional tumors and associated with ... Interstitial cells : Wikipedia, the Free Encyc...

Chloroplast DNA

...ed out in specialized organelles called chloroplasts . ... ( DNA ), the stroma contains chloroplast DNA and special ribosomes and RNAs as well. ......hloroplast is enclosed in a double membrane and the area ... ( DNA ), the stroma contains chloroplast DNA and special ribosomes and RNAs as well. ......

Carbon fixation

... The graphic shows the steps in the fixation of carbon dioxide during photosynthesis. ... All the reactions of carbon fixation occur in the stroma of the chloroplast. ... Britannica online encyclopedia article on carbon fixation (biochemistry), The assimilation of carbon into organic co...
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