Statins

Giving Statins to Kids Provokes Debate

Cholesterol-lowering drugs may help young hearts, but long-term use raises concerns SUNDAY, July 26 (HealthDay News) -- Whether cholesterol-lowering drugs called statins should be given to children apparently depends on who you ask. Major health associations in the United States hav...

Many Who Should Use Statins Don't

Survey finds lack of access to medical care a big factor in trend SATURDAY, April 25 (HealthDay News) -- Nearly half of the Americans who meet the criteria for taking cholesterol-lowering statins aren't taking the drug, a national survey indicates. "There is a definite gap between m...

6.5 million more patients might benefit from statins to prevent heart attacks, strokes

Millions more patients could benefit from taking statins, drugs typically used to prevent heart attacks and strokes, than current prescribing guidelines suggest, Johns Hopkins doctors report in a new study. Doctors have long known that statins can help prevent subsequent heart attacks and strok...

Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems

DALLAS, Feb. 19 /PRNewswire-USNewswire/ -- Cholesterol-lowering statins, used by millions of Americans to treat and prevent atherosclerosis, may falsely indicate thyroid problems, according to researchers at Texas Health Presbyterian Hospital Dallas. Their study, "Radioiodine studies, low ser...

Taking Statins Faithfully Lengthens Life

But experts note finding colored by fact that these folks take better care of themselves generally MONDAY, Feb. 9 (HealthDay News) -- A massive Israeli study finds that people with high cholesterol levels who faithfully take statins are less likely to die over four to five years than t...

Got High Cholesterol? Statins Are Not the Only Answer, Says Natural Solutions Magazine

BOULDER, Colo., Feb. 3 /PRNewswire/ -- Eleven million people are currently lowering their cholesterol with statins -- and that number continues to climb as doctors prescribe these pharmaceuticals to those with normal cholesterol as a preventive measure. But these powerful drugs have many side ...

WomenHeart Urges Women to Talk With Doctors About New Study Showing Statins Prevent Heart Attacks, Deaths

WASHINGTON, Nov. 10 /PRNewswire-USNewswire/ -- WomenHeart today urged women to talk with their doctors about heart disease risk factors in light of new research demonstrating the impact of statin therapy (cholesterol-lowering drugs) on cardiovascular events in women. The study, called JUPITER,...

Research Shows Why Statins Don't Work for Everyone

A key protein change can lessen the cholesterol-lowering drugs' effectiveness MONDAY, June 16 (HealthDay News) -- A genetic quirk in the production of one protein helps explain why some people don't get the full cholesterol-lowering benefit of statin drugs, researchers report. Stati...

When statins aren't enough: New trial drug points to better management of coronary heart disease

(PHILADELPHIA) Despite widespread use of cholesterol-lowering drugs, a significant number of cardiac patients continue to suffer heart attacks and stroke. Researchers theorize that high levels of an enzyme found in coronary plaques may be to blame, by making plaques more likely to rupture and bl...

iGuard.org Presents New Data on Statins at FDA Workshop Demonstrating How Patient-Reported Information Can Enhance Drug Safety Knowledge

WASHINGTON, May 7 /PRNewswire/ -- Dr. Hugo Stephenson, founder and CEO of iGuard.org, and specialist in epidemiology and drug safety, today presented new insight about the cholesterol lowering drugs, referred to as "statins" to the U.S. Food and Drug Administration (FDA). Although prescribing ...

More>>

Statins in Medical Technology

New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits

Patients on corticosteroids are one-third less likely to need emergency room treatment or hospitalization when also taking statin medications Study is first in a series to examine factors impacting patient response to asthma medications FRANKLIN LAKES, N.J., March 14 /PRNewswire-FirstCal...

Seniors Can Be Heartened by New Study on Statins

Groundbreaking Research Finds Statins Cut Risk of Heart Attacks, Deaths RESTON, Va., Nov. 13 /PRNewswire-USNewswire/ -- Cardiovascular Disease is the leading cause of death among Americans, costing our healthcare system hundreds of millions of dollars and causing untold suffering. Now there ...

Cleveland Clinic to Lead First Head-to-Head Comparison of the Two Most Potent Statins

Study Designed to Determine Statin Effects on Regression of Atherosclerosis CLEVELAND, Jan. 15 /PRNewswire/ -- Cleveland Clinic researchers will coordinate the first head-to-head comparison of the two most powerful statin medications. The trial intends to begin enrollment as early as next week. ...

Heart Disease Treatment Breakthrough

...e UK from coronary heart disease. It accounts for one in five deaths in men and one in six deaths in women[2]. The four million people who take statins to help lower their cholesterol and chances of suffering a heart attack or stroke could benefit from using Ateronon. The product can be taken alongsid...

New Body of Research Suggests Statin Use Benefits Multiple Areas of Urologic Health

...ed with prostate cancer aggressiveness? Use of statins may be associated with more favorable pathological...tin use and development of erectile dysfunction statins may provide the added benefit of reducing a man's ...ent of urologic outcomes The combined use of statins and non-steroidal anti-inflammatory drugs (NSAIDs)...

New Data for Abbott's TRILIPIX(R) (fenofibric acid) in Combination with Rosuvastatin Calcium Shows Improvement on Key Lipids for Cholesterol Management

...one, TRILIPIX in combination with one of the three most commonly prescribed statins (atorvastatin, simvastatin or rosuvastatin) or statin alone. The clinical ...tion of the gallbladder or pancreas. Women who are pregnant should not take statins and should talk with their healthcare provider about TRILIPIX if they are p...

CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis

...ents during the course of the JUPITER study. ABOUT JUPITER: Results from the primary analysis of JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin), originally presented in November 2008 at the American Heart Association's Annua...

CRESTOR(R) Reduced Risk of Blood Clots in the Veins

...as well tolerated in nearly 9,000 patients during the course of the JUPITER study. ABOUT JUPITER: JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin) was a long-term, randomized, double-blind, placebo-controlled, large-scale study...

Statins Lower Stroke Severity, Improve Recovery

...earchers have shown that patients who were taking statins before a stroke experienced better outcomes and re... "We were trying to determine if the daily use of statins had more of an impact on stroke patients than simp... found it still had quite significant value." statins or reductase inhibitors are enzymes that are widel...

Aching Back? Cholesterol Medication Might Help

... Study finds that using statins may be useful in treatment for degenerative disc disease LAS VEGAS, F..." says Dr. Yang. "Further studies are needed to determine the potentials of statins for regeneration and repair of degenerative disc disorders." In a rel...

Statins in Medical Dictionary

Myositis

... likely to be caused by autoimmune conditions, rather than directly due to infection It is also a documented side effect of the lipid-lowering drugs statins and fibrates. InteliHealth - Featuring Harvard Medical School's consumer health information. ... In inclusion body myositis , the muscle also ....

Statins in Biological News

One size does not fit all

...everity reduced indirectly due to the dampening of the immune response. This issue required further investigation, particularly due to the ability of statins to cross the blood-brain barrier and access the CNS, and the enrichment of cholesterol in the myelin sheath." The objective of the MNI study was to...

Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants

...z, Ph.D., of NUS for his team's examination of how statins cholesterol-lowering drugs may restrict growth a..."Our team aims to characterise the interactions of statins with other proteins known to promote cell death an...rvival, and subsequently explore the potential for statins to fill the gap in novel strategies for more effec...

Statin therapy ineffective in breast cancer prevention

...atory work in animals showed limited activity when statins were given to prevent breast cancer, according to ...nducted laboratory work in animals to determine if statins actually prevent both ER-positive and ER-negative ...sent preclinical studies do not support the use of statins as general breast cancer preventive agents" said L...

Statins may treat blood vessel disorder that can lead to fatal strokes

...tatin drugs that millions of people take to control high cholesterol. If the results of a study in mice are confirmed in a pilot trial with people, statins could provide a safe, inexpensive treatment for cerebral cavernous malformation (CCM), a disorder with no known drug therapy, according to U of U card...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

...ostly high-profile drug withdrawals due to CYP-related DDIs include the antihistamines terfenadine and astemizole, the antihypertensive mibefradil and statins such as cerivastatin. A validated, simple, cost-effective in vivo CYP assay will be useful for profiling drug metabolism prior to performing expensiv...

Statin warning for pregnant women

...end that women who are pregnant should stop taking statins but the advice is based on the knowledge that chol...ital anomalies in children of pregnant women using statins suggested that the detrimental effects of the drug...s may be restricted to fat-soluble or 'lipophilic' statins only. But new research from The University of M...

The genetic heart of the lipids

...d levels, but do not yet improve the prediction of artery or heart disease. Screening for a person with high lipid levels and early treatment with statins is one of the major strategies in the prevention of cardiovascular risk in clinical practice while a healthy diet, weight control and physical activit...

Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants

...ollected the therapeutic proteins grown in the roots, all the remaining material is safely destroyed." Traditional pharmaceuticals, like aspirin or statins for lowering cholesterol, are made by synthesizing and combining chemicals in a factory-like production setting. Therapeutic proteins are biologic mol...

A scientific breakthrough on the control of the bad cholesterol

...are used by more than 25 million people worldwide. statins decrease cholesterol synthesis and increase the nu...k PCSK9 could either be used alone or jointly with statins and would be highly beneficial to patients in whom statins do not work or are unable to take this drug. ...

Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease

...on, vitamin C may be able to reduce CRP as much as statins have done in other studies," said Block. Eviden... the study, known as the Jupiter trial, found that statins reduced cardiovascular mortality and morbidity amo...baseline, levels of CRP were 37 percent lower with statins compared with a placebo. "One of the strengths ...

Statins in Biological Technology

AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support

...tatins, these are deemed to be of limited effectiveness despite some notable successes. CSO Dr. Frank Mattner explains: "Today's therapies with statins act on low density lipoprotein cholesterol (LDLc) and reduce its concentration in the blood. This type of treatment can reduce the likelihood of sever...

Connecticut State Medical Society and Genomas Co-Sponsor Forum on DNA-Guided Medicine and the Path to Personalized Health Care

... Progress Towards DNA-Guided Medicine in Clinical Practice: Case Studies in Cardiology and Psychiatry. Examples in these two therapeutic areas include statins and atypical antipsychotics. Dr. Ruano commented: "We are privileged to partner with the Connecticut State Medical Society to convene the physicians...

Old and new therapies combine to tackle atherosclerosis

...ound that stops blood vessel growth. "We saw that statins sustain the acute inhibition of blood vessel growt...siology. Patients with atherosclerosis often take statins to lower cholesterol. statins also decrease atherosclerotic plaque progression b...

Abbott and AstraZeneca Expand Relationship to Include Co-Promotion of CRESTOR(R)

... New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) in 2009. An NDA for TriLipix for use as monotherapy and in combination with statins has been submitted to the FDA and is currently under review. "This agreement will allow AstraZeneca to increase share of voice for CRESTOR among phy...

Anthera Pharmaceuticals Completes $19 Million Financing; Appoints Christopher S. Henney as Chairman

...cited about Anthera and its late-stage anti-inflammatory platform. We believe the company's lead candidate, Varespladib, has demonstrated synergy with statins and represents a potential breakthrough treatment for people at risk for cardiovascular disease," said Rachel Leheny, Ph.D., Managing Director of Caxt...

Genzyme Reports Strong First-Quarter Growth

...owering agent being developed primarily for patients at significant cardiovascular risk who are unable to achieve target cholesterol levels with statins alone or who are intolerant of statins. The product offers an innovative approach to addressing a serious unmet medical need, and Genzyme be...

Genomas Awarded $1.2 Million NIH SBIR Grant to Develop DNA-Guided System for Management of Statin Therapy

...e grant, entitled "DNA Diagnostic System for Statin Safety and Efficacy," was awarded by the National Institute of General Medical Sciences (NIGMS). statins are the most prescribed drugs in the world. Drugs in this class include atorvastatin (Lipitor(R)), rosuvastatin (Crestor(R)), and simvastatin (Zocor(R...

Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes

...s Statin and Antioxidant Therapy to be Superior to statins Alone in Decreasing Cardiovascular Events in Di...s who had the Hp2-2 phenotype who were also taking statins were randomized to receive either natural source V... those taking combination therapy of Vitamin E and statins compared with statin treatment alone (1.3 percent ...

Abbott Receives FDA Approval for SIMCOR(R) (Niaspan(R) / simvastatin), a Novel Combination Medicine for Comprehensive Cholesterol Management

...e. Liver function tests should be performed on all patients during therapy with Niaspan. Use of Niaspan with other lipid-altering medications called statins may increase the risk of rhabdomyolysis, a rare condition that causes muscles to breakdown. The most common side effect with Niaspan is flushing of th...

New approach may render disease-causing staph harmless

...e inhibitors developed early on as cholesterol lowering agents might also work on this other pathway, he said. Current cholesterol-lowering drugs like statins work in a completely different way and would be ineffective. The researchers began by testing dozens of new compounds for their activity against th...

Statins in Biological Definition

Diabetes mellitus

...betes which include kidney failure (requiring dialysis or transplant), blindness, heart disease and limb amputation. Recent studies show that use of statins might be needed in primary and secondary prevention of cardiovascular complications and mortality. Ideal control of hypertension plays a pivotal r...

Statins in Biological Dictionary

Coenzyme

...d Parkinson's disease. ... Summaries of the latest research regarding Coenzyme Q10. ... The connection between CHF, coenzyme Q-10 (CoQ- 10) and statins is discussed ... CoEnzyme Q-10: Introduction. Description/Source: Coenzyme Q10 is a potent ... 1087 Cellular levels of coenzyme Q10 decline i...