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Src in Medical News

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

...ed that activity of a cancer-related enzyme called src was associated with late-onset bone metastasis. In...e bone marrow and promoted cell survival. Further, src increased the resistance of metastasized breast ca... metastasis tissue. These results demonstrate that src hyperactivity provides breast cancer cells with a ...

Research Reveals Clues to Breast Cancer's Spread

...ors and found that a cancer-related enzyme called src was associated with late-onset bone metastasis. Th...vival of breast cancer cells. They also found that src increased resistance to a key cell death-inducing ...ed. They also noted that drugs designed to inhibit src have recently been developed "that may be worthy o...

Chemo Combo Shows Promise Against Ovarian Cancer

...In some types of ovarian cancers, a pathway called src is involved in the abnormal cell proliferation, sa...more effective in cell lines with higher levels of src expression and src pathway deregulation," Teoh said. Dasatinib, w...

Addition of dasatinib to standard chemo cocktail may enhance effect in certain ovarian cancers

... Cancer Center. "We know that a pathway called src is involved in cell proliferation in certain types...more effective in cell lines with higher levels of src expression and src pathway deregulation." That synergistic effect...

URI scientists reveal mechanism that regulates cancer-causing gene

...es of proteins implicated in numerous cancers: the src and Fibroblast Growth Factor Receptor families of ...t controls them. According to Kemble and Sun, src is a master regulator of cell function, controllin...ision, and death. In normal cells, the function of src is turned off, and it is turned on only when certa...

BLIS™ Announces Alliance with Surgical Review Corporation to Offer Surgical Complication Insurance Coverage for Bariatric Surgery Center of Excellence Designees

...e to advance the quality of bariatric surgery than src and the ASMBS BSCOE designees. "SRC is ex...cy and safety of surgical and related health care. src administers the Bariatric Surgery Center of Excell...bolic and Bariatric Surgery (ASMBS) and launched a src international bariatric surgery COE program in 200...

Atlanta Area Job Board Launches New Local Job Board to Connect Local Employers and Jobseekers

...877.530.5655 or visit AtlantaJobs.com . About src Shaker Recruitment Consultants (SRC), a division ...tering strategic alliances among local newspapers. src offers the creative services, marketing/promotions... inception through the life of the job board.Visit src online at http://www.shaker.com/src About A...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...MF7); somatostatin receptors (SSTr); somatotropin release inhibiting factor (SRIF) receptor (SRIFr); sphingosine kinase (SPHK); spingomyelin synthase; src pathway; stromal derived factor 1 (SDF-1); superoxide dismutase 1, soluble (SOD1); survivin; telomerase reverse transcriptase (TERT, hTERT); telomeras...

Raintree Systems Launches the First Integrated Practice Management and Electronic Medical Records Application Within the Bariatric Surgery Industry

...o offer Centers a real-time tool to monitor their compliance with the Bariatric Surgery Centers of Excellence (BSCOE) requirements. -- To provide src with credible data that can be used to convince consumers, employers, medical professionals, legislators and payors of the value and efficacy ...

Early Phase II results show bosutinib safe, effective for CML

...ct that the low grade and frequency of side effects is probably a result of the drug's specificity in the proteins that it targets. Bosutinib inhibits src and ABL proteins but does not affect platelet derived growth factor receptor or C-Kit, two similar kinases that are affected by other CML drugs. CM...
Src in Medical Technology

Kinex Pharmaceuticals To Present at ASCO 2009 Annual Meeting

...tigator from RPCI will deliver the presentation entitled "Results of a phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket directed src inhibitor, in patients with advanced malignancies." The presentation will provide data from this multi-center Phase 1 trial that utilized the sta...

First Patient Dosed with KX2-391 in Phase 1 Clinical Trial

...Research and Development. KX2-391 targets an important cell signaler called src kinase, a protein linked to the rapid growth and spread of cancer cells. A potential advantage of Kinex's kinase inhibitor is that it disrupts src at a site different from where other currently studied compounds are target...

VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor

...y used for the treatment of the parasitic disease leishmaniasis, is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the src homology PTPase (SHP-1 & SHP-2) and PTP1B. Lenocta has also been demonstrated to augment cytokine signaling and responses in hemopoietic cell lines, w...

Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development

...l Officer of CTI. A new class of thienopyrimidine src inhibitors demonstrates potent growth suppression ... mutation leading to relapse. The study showed the src inhibitors retained potent and non-selective cytot...l line. The data suggest that the thienopyrimidine src inhibitors may represent a new class of drugs with...

VioQuest Pharmaceuticals Completes Enrollment of Phase I Trial of Lenocta(TM)

...s now ready to enroll patients." About Lenocta(TM) Lenocta(TM) is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the src homology PTPase (SHP-1 & SHP-2) and PTB-1B, based on data from several preclinical studies conducted at the Cleveland Clinic. These intracellular enzy...

ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting

...dermal growth factor receptor expression in colon cancer cell lines: implications for combination therapy; #4079 Kopetz et al. Synergistic activity of src and EGFR inhibitors in colon cancer.) ImClone's broad portfolio of investigational fully human IgG1 monoclonal antibodies was featured in 14 AACR pr...
Src in Biological News

Protein that promotes cancer cell growth identified

...n and invasion. The researchers also identified an RXDLL amino acid motif that controls the signaling from the EGF receptor through the protein kinase src to the master cell proliferation regulator protein, MAPK. This same signaling pathway stimulates neuroblastoma cells to migrate and invade neighboring...

Identification of a key molecular pathway required for brain neural circuit formation

... my team discovered provides part of an answer." Their recent work showed that Shh exerts its attractive effect through a group of molecules called src family kinases (SFKs) that, until now, were not known to be linked to Shh function. Remarkably, these novel Shh effector molecules are absolutely requ...

When cancer cells can't let go

...hesions that were particularly sticky. The protein src serves as FAK's helper. FAK and src work together to phosphorylate tyrosines in protei...zation reflects this difference. In control cells, src accumulated in focal adhesions. In FAK's absence,...

Breast cancer treatment resistance linked to signaling pathway

... PHILADELPHIA -- Activation of the src signaling pathway may cause resistance to standard...hich are currently being designed, then inhibiting src signaling while giving standard of care medical tr...have no genetic events to help identify patients. src is one of the oldest known oncogenes, active in ma...

Crossed (evolutionary) signals?

...ween cells by adding phospho-tyrosine modifications, protein tyrosine phosphatases (PTP) are molecules that modify or 'erase' these modifications, and src Homolgy 2 (SH2) molecules 'read' these modifications so the recipient cell gets the message. Without these three molecules to help our cells 'write...

Further breakthroughs for breast cancer patients

...rge increase in the activity of a protein known as src and by stopping this activity resistance to tamox...by treating the cells with a specific inhibitor of src activity, AZD0530. Surprisingly, AZD0530 also made...ug resistance occurring in the first place. The src inhibitor AZD0530 developed by AstraZeneca is curr...

Karen Beemon wins the 2007 Retrovirology Prize

...omes of RNA viruses, describe recombination between viral genomes, characterise sarcoma-specific sequences, and perform structure-function analysis of src proteins. Of particular importance, was her discovery that transformation mechanisms of multiple classes of retroviruses involve aberrant phosphorylat...

Notorious cancer gene may work by destroying messenger

...another molecule, an energy-packing protein called src (pronounced “sark?. Discovered in 1977, src became the first “oncogene??mutated genes that hel...ion. These findings provide insight into how src might contribute to cancer development. The ...

Signal protein shows promise for blocking tumor promoters in skin cells

... cell growth caused by a family of proteins called src kinases. This finding, published online in the Jou...cers. Investigators have known for decades that src kinase proteins can promote tumor formation. src kinase activity is elevated in most skin cancers a...

Tumor cells that border normal tissue are told to leave

...urning off an inhibitor of a major oncogene called src (pronounced sarc), making the tumor cells high in src oncogene activity. (An oncogene is a gene that inc...e study demonstrated that it was the difference in src activity that led to the change in the attachment ...
Src in Biological Technology

Stretching silicon: A new method to measure how strain affects semiconductors

...nergy levels, the researchers needed a wavelength-tunable X-ray source. The src also houses a monochromator, a device that enabled the team to choose a pre...ts techniques for fabricating silicon nanomembranes, the group hopes to use src resources to study strain in other semiconductor materials, as well as to m...

David Hsia, Ph.D. Joins Kinex Pharmaceuticals' Board of Directors

...echnology and compound libraries to identify and develop peptide-competitive kinase inhibitors. The Company's clinical compound KX2-391 is a selective src kinase inhibitor that is currently in Phase 1 trials for oncology. Kinex's pipeline is focused on selective inhibitors for kinase targets that are imp...

Moffitt Cancer Center Receives Prestigious SPORE Grant Worth More Than $10 Million

...ous team members. 1. E2Fs impact on therapeutic efficacy -- Douglas Cress, Ph.D., Jiandong Chen, Ph.D., Bepler 2. -- Antitumor mechanism of src inhibitors -- Eric Haura, M.D., Jin Cheng, M.D., Ph.D., and Jack Pledger, Ph.D. 3. Chemoprevention with enzasataurin -- Bepler and Mark A...

Professor Toh-Ming Lu named fellow of the Materials Research Society

...umerous other honors, including Rensselaers Early Career Award in 1986, the src Invention Award in 1988, the Rensselaer Center for Integrated Electronics F... Faculty Award in 2002, Materials Research Society Medal Award in 2004, and src Faculty Leadership Award in 2005. Lu earned a bachelors in physics from Che...

FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML

...activation of new pathways. SPRYCEL is the first approved oral multiple tyrosine kinase inhibitor that, at nanomolar concentrations, inhibits BCR-ABL, src family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRBeta kinases. SPRYCEL is designed to inhibit the overproduction of leukemia cells in the bone marr...

Systems Medicine (SM), a Subsidiary of Cell Therapeutics, Inc. (CTI), Announces Execution of CRADA with NCI/NIH to Develop Potential Cancer Treatments Targeting the Insulin Growth Factor (IGF) Pathway

... President and CEO of Cell Therapeutics, Inc. "This is another exciting addition to several early stage targeted therapies we are evaluating including src inhibitors and bisplatinates." Daniel D. Von Hoff, M.D., Chief Medical Advisor to SM, Physician-in-Chief and Director of the Clinical Translational R...

Research Tools for Analysis of ZAP-70

...f the CD3 receptor complex leads to the activation of Lck and Fyn which are src family tyrosine kinases 1,2 . These kinases phosphorylate ITAM regions on t...osslinking of the Ig receptor 3 . This activates Lyn, another member of the src family. Through a similar sequence of events, Syk is activated. Syk is foun...

TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins

...associated proteins involved in transducing proliferative or differentiating signals to the nucleus. These signaling proteins each contain modular src homology 2 (SH2) or protein tyrosine binding/interacting domains (PTB/PID), which enable them to directly interact with specific receptors in a ph...
Src in Biological Products

Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

Description:...d mitogen-activated protein kinase 8-interacting protein-1,) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal src homology 3 (SH3) domain. Its SH3 domain is related to the SH3 domains of the tyrosine kinase c-Fyn and the p85 subunit of phosphoinositide-3 kinase (P...
Company:Invitrogen
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(Date:9/16/2014)... therapy and radiation therapy as part of breast ... women with hormone-receptor positive (HR+) invasive breast cancer. ... Cancer Center, however, shows that combination may not ... disease. , The results, which Fox Chase ... Oncology,s 56th Annual Meeting on Sunday, September 14, ...
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