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Spindle in Medical News

Molecule tracking reveals mechanism of chromosome separation in dividing cells

...es before cell division. The apparatus is called a spindle because it looks like a tiny wool-spinner with thin strands of microtubules or spindle fibers sticking out. The lengthening and shortenin...te on each chromosome that mechanically couples to spindle fibers. "Kineochores are also regulatory hubs,"...

From mother to daughters: A central mystery in cell division solved

...n muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle. As happens during muscle contraction, the myosin fila...

Lack of CHFR gene expression sets stage for breast cancer

...nstructions for two new daughter cells. If the spindle doesn't form correctly, genetic material becomes u...containing too many chromosomes. The fact that the spindle is affected is important, because some cancer drugs interact with the mitotic spindle as a way to curb cell division. Research detai...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

...nsors Kenneth E. Prehoda, PhD, and Chris Q. Doe, PhD, at the University of Oregon, Eugene, Oregon, is investigating the molecular mechanism of mitotic spindle orientation during asymmetric cell division of model progenitor stem cells. Failure in this process can lead to aberrant cell division and subsequent...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...ogenase (IMPDH); integrin alpha2; interleukin 6 (IL-6); interleukin 8 (IL-8); placental growth factor (PGF); Janus kinase 2 (JAK2); JAK3; kinesin-like spindle protein (KSP); Lewis y antigen; lymphocyte-specific protein tyrosine kinase (Lck); lymphotoxin (LT) beta receptor (LTBr); mammalian target of rapamyci...

NYP/Columbia physician-scientists present at ASCO 44th annual meeting

... or following reduced-intensity AlloSCT in standard-risk AML. Kinesin spindle Protein (KSP) for Hodgkin's Lymphoma Dr. Owen O'Connor Director of Lymph...e of Physicians and Surgeons A Phase 1 dose-escalation trial of Kinesin spindle Protein (KSP), a drug that targets a unique aspect of cancer cell division,...

Physical Therapists Offer Tips for Proper Bike Fit in Support of National Bike to Work Day

... function the cyclist will have and with less stress on the knee. -- Foot to Pedal. The ball of the foot should be positioned over the pedal spindle for the best leverage, comfort, and efficiency, Moen notes. A stiff-soled shoe is best for comfort and performance. Pedaling is a skilled ac...

Key factor in brain development revealed, offers insight into disorder

...point of cell division. Specifically, Lis 1 makes sure that the mitotic spindle is oriented perpendicular to the top and base components of the neuroepithe...esults in reduced and weakened microtubules and an inability of the mitotic spindle to rotate the microtubules properly in the apical-basal axis. Of note, ...

Cell division studies hint at future cancer therapy

...minants to one side of the mother cell and directs spindle orientation. In work published in Nature Cell B...Cell, he detailed a group of proteins critical for spindle organization and positioning in mammalian cells. ...they cooperate with other proteins to organize the spindle and direct its orientation. These details may e...

'Network' approach identifies potential breast cancer susceptibility gene

...e abnormal spindles, but why this is so has been unclear. The fact that HMMR interacts strongly with BRCA1 on a functional level and is involved in spindle formation suggests a connection. Cells whose centrosomes assemble improperly often develop aneuploidy, a condition in which there is an extra or missi...
Spindle in Medical Technology

CRi Oosight(TM) Instrument Crucial in IVF Breakthrough Demonstrating a Correlation Between Non-Invasive Egg Metrics and Pregnancy

...ts are the first to show a direct link between egg spindle characteristics and pregnancy. "Extrapolatio... of these results would suggest that when a normal spindle is found, the chances of a pregnancy, if a high qu... non-invasive, high-contrast images of the meiotic spindle and zona pellucida without the need for potentiall...

Phase I/II Study of Targeted Gene Delivery In Vivo - Intravenous Infusions of REXIN-G - Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma (ASCO 2008)

...oma, including osteosarcoma, Ewing's sarcoma, leiomyosarcoma, malignant fibrous histiocytoma, chondrosarcoma, fibrosarcoma, liposarcoma, angiosarcoma, spindle cell sarcoma, and malignant mixed Mullerian tumor of ovary, were treated with 1 x 10e11 cfu Rexin-G, administered i.v. over 5 minutes, 2 times a week ...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

...tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR s...

EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer

...oad-acting antitumor effects, including tumor growth inhibition or regression, in multiple preclinical models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Carolyn F. Sidor, M.D., M.B.A., EntreMed...

EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer

...n intracellular target important in cellular trafficking that has been shown to be involved in cell division. MKC- 1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase of the cell cycle, and induce apoptosis in multiple cell lines, consistent with a mechanism i...

Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting

...cs and will present data evaluating ispinesib, a novel inhibitor of Kinesin spindle Protein (KSP), in models of multiple myeloma, data evaluating GSK-923295, a...t 2007 AACR Annual Meeting Ispinesib: Abstract #1435: Kinesin spindle Protein Inhibition for the Treatment of Multiple Myeloma. (Poster dis...

Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer

...tumors as a new development program. ALN-VSP01 is an RNAi therapeutic that is designed to target vascular endothelial growth factor (VEGF) and kinesin spindle protein (KSP), two well-validated genes that are involved in distinct pathways of tumor pathology, cell proliferation and angiogenesis, in a wide vari...

EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers

...g tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. These effects are consistent with mechanis...

Cytokinetics Reports Additional Clinical Trials Data for Ispinesib

...y prostate cancer. Ispinesib is a novel small molecule inhibitor of kinesin spindle protein (KSP), a mitotic kinesin essential for proper cell division. Ispin...om this program, ispinesib and SB-743921, each a novel inhibitor of kinesin spindle protein (KSP), a mitotic kinesin. Ispinesib has been the subject of a broa...
Spindle in Medical Products

ANA SCREEN IgG

Description:...ed DNA (dsDNA), Jo-1, Sm, Sm/RNP, SSA, SSB, and Scl-70. The test is also capable of detecting ANA demonstrating centromere, nucleolar, peripheral, and spindle indirect immunofluorescence antibody (IFA) patterns. This device is for in vitro diagnostic use....
Company:Zeus Scientific, Inc.
Spindle in Medical Definition

Anterior mediastinal mass

... Most common primary anterior mediastinal tumor (20%) in adults but rarely seen in children. It can be classified as lymphocytic, epithelial, or spindle cell histologies, but this is not very significant clinically (2). Tonofibrils seen under electron microscopy can differentiate thymoma from other tum...
Spindle in Medical Dictionary

Lesion

...appears abnormal. Learn about causes. ... However, the meaning of the term " lesion " in this context is unclear. ... The lesion was composed of spindle and oval shaped cells with eosinophilic ... Electron microscopic examination of the lesion did not demonstrate Birbeck granules. ... JOV article...
Spindle in Biological News

Slicing chromosomes leads to new insights into cell division

...e through mitosis, during which the DNA-containing chromosomes separate between the resulting daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell eventually becomes two. "Each cell needs the right number of chromosomes. It's centr...

Scientists deconstruct cell division

...sts have tried for years to unravel the process of spindle assembly. Now, researchers at Carnegie's Departmen...nctions, are essential to regulate assembly of the spindle matrix. "The mechanisms that cells use during d...s adult tissues, such as skin and bones. Forming a spindle requires the assembly of a 'skeleton' from tube-li...

Dartmouth researchers find new protein function

...its own, it hitches a ride on the ends of microtubules which results in a dynamic cross-linking between the arms of chromosomes and the cell's growing spindle of microtubules. If NOD doesn't function properly, then the two cells end up with either both or none of that particular chromosome, which is lethal [...

How chemo kills tumors: research to reduce side effects

...are published in the journal Cancer Cell (August 2008), have shown how different tumours respond to the anti-mitotic drugs which target the mitotic spindle (the structure that separates the chromosomes during cell division) and revealed that the variation in cell behaviour was far greater than previously...

Analysis of RNA role in spreading disease advances study of damaging plant infections

...to look at all of the loops of a viroid RNA and see how each one functions, Ding said. The viroid model used for this research is called the Potato spindle tuber viroid, and its infection was studied in a tobacco-like plant called Nicotiana benthamiana for the experiment. Lead study author Xuehua Zhong, a...

Oosight microscope enables embryonic stem cell breakthrough

...alipovs team to clearly see and remove the meiotic spindle (and the attached genetic material) from 304 femal... the problem was always that you could not see the spindle in the egg, Mitalipov says. The only way to see it...id-crystal polarized light technology to image the spindle noninvasively, with high contrast and quality. ...

Green algae -- the nexus of plant/animal ancestry

...wo lineages. The flagella are equivalent to the cilia and centrioles in animal cells. Centrioles are structures involved in cell division; they form a spindle apparatus, which helps separate genetic material into two new cells during mitosis. Cilia are important to many animal functions. The study identif...

A unique arrangement for egg cell division

...ith the correct number of chromosomes is a bipolar spindle consisting of protein filaments, called microtubules that are part of the cells skeleton. spindle microtubules attach themselves to the chromosomes,...te. They predetermine the bipolar structure of the spindle that is essential to extrude exactly half of the c...

Researchers shed light on shrinking of chromosomes

...o the cell to block the late condensation, more separation defects appeared. “Sometimes chromosomes get stuck and cannot be fully separated by the spindle that normally distributes them into the daughter cells,” says Felipe Mora-Bermúdez, who carried out the experiments in Ellenberg’s lab, “we think that...

Molecular motors and brakes work together in cells

...tal Biology. "This study lets us have a more complete picture." Microtubules are structures that help give shape to many types of cells, form the spindle -- a structure important in cell division -- and act as a railroad, of sorts, upon which molecular motors move protein packages for waste removal and ...
Spindle in Biological Technology

Oncolytics Biotech Inc.'s REOLYSIN(R) Exceeds Primary Statistical Endpoint in U.S. Phase 2 Sarcoma Study

... Chordoma 6* SD ------------------------------------------------------------------------- Unspecified spindle Cell 6* SD ------------------------------------------------------------------------- * patients still on study ...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

...tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR s...

Oncolytics Biotech Inc. Investigators Present Interim U.S. REOLYSIN(R) Phase II Sarcoma Trial Data

...---------- Chordoma 5* SD ------------------------------------------------------------------------- Unspecified spindle Cell 5* SD ------------------------------------------------------------------------- * patients still on study An oral presenta...

JCI online early table of contents: March 6, 2008

...structural components of a cell. Consistent with a role for SBDS in mitotic spindle stability, BMSCs from individuals with SDS exhibited increased abnormal mit... a new approach to the treatment of individuals with SDS. TITLE: Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome AU...

Mouse Brain or Impressionist Painting?

...maging Research at UCSD for his photos of rat tongue and cerebellum; Pat Wadsworth of the University of Massachusetts for her depiction of the mitotic spindle in a diving cell; Earl Nishiguchi of the University of Hawaii for his fruit fly testis image; Jan Schmoranzer of Columbia University for his photo of ...

Chippewa Valley Technical College helps pioneer nanotech program, incubator

...y," Ihlenfeldt said. "We've put out a ton of machine tool people in this region, and they need to know how to operate in an environment where you have spindle speeds up to 40,000 RPM, working with a product that you really can't see, and if you touch it, becomes scrap. We will have a certificate that will gi...

Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27)

... Dissolution. 1 Each individual apparatus (i.e. spindle or basket) must be tested with disintegrating type...ering, deaeration, verification of temperature and spindle speed). Prepare the samples and standards ...d easily for different calibrators, lot numbers or spindle speeds. The Calculation dial...

Assessing Gene Function with siRNA Libraries

...s likely corresponds to activation of the well-studied spindle assembly checkpoint, which monitors the correct, functional interactions between spindle microtubules and kinetochores in preparation for metap...
Spindle in Biological Definition

Mitotic spindle

The mitotic spindle is a structure of the eukaryotic cytoskeleton involved in mitosis and meiosis . It consists of a bundle of microtubules joined at the ends but spread out in the middle, vaguely resembling an American football in shape. The spindle is aligned perpendicularly to the p...

Anaphase

...te poles of the cell (opposite ends of the nuclear spindle ). Anaphase is preceded by metaphase , by the e...ying along a surface known as the metaphase plate. spindle fibres (microtubules containing γ-tubulin) extend from the spindle poles to the centromeres . The point of contact i...

Centriole

...on they are located in (close to the nucleus) is known as the centrosome . Centrioles are important in the cell division process, organizing the spindle upon which the chromosomes are pulled apart. Some animal cells may be able to separate without centrioles. Centrioles assist the cell through the ...

Centromere

...omosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis . It is also the site of the pri...

Centrosome

...rosomes migrate to opposite poles of the cell. Between them is formed the spindle , a bundle of microtubules that will function later as the foundation for... spindle. When the centrioles are destroyed, for example by a laser , the spindle nonetheless forms and cell division procedes normally. ...

Chromatid

... mitosis or meiosis . Each chromosome consists of two exactly identical (" sister ") chromatids. After they have been pulled apart by the mitotic spindle , chromatids are called "chromosomes". Sister chromatids are joined at a point called the centromere . In non-gametic, non-dividing human cells, the...

Cytoskeleton

...ith dyneins and kinesins they transport organelles like mitochondria or vesicles .) the axoneme of cilia and flagella the mitotic spindle synthesis of the cell wall in plants. The prokaryotic cytoskeleton The cytoskeleton was previously considered to be a feature only of euka...

Eukaryote

...several bundles called chromosomes , which are separated by a microtubular spindle during nuclear division. In addition to asexual cell division, most eukary...r derived from it. Centrioles may also be associated in the formation of a spindle during nuclear division. Some protists have various other microtubule-sup...

Meiosis

...eoli and nuclear envelope and the formation of the spindle fibres (including their attachment to chromosomes)...ear envelope has already dispersed into vesicles. spindle fibres ( microtubules ) attach only to one kineto...hase I includes the disappearance of spindles and spindle fibres as well as the uncoiling of the chromatids ...

Mitosis

...mitotic spindles . By increasing the length of the spindle (growing the microtubules), the centrioles push ap...ch chromosome - one for each chromatid. When the spindle grows to sufficient length, the microtubules begin...this process by generating a signal - the mitotic spindle checkpoint - that tells the cell to wait before p...
Spindle in Biological Dictionary

Mitotic spindle

In cell biology, the spindle apparatus is the structure that separates the chromosomes into the daughter cells during cell division. It is part of the cytoskeleton in eukaryotic cells. Depending on the type of cell division,... Mitosis is the process in which a eukaryotic cell se...

Telophase

..., respectively. ... Telophase is also marked by the dissolution of the kinetochore ... In telophase , the daughter chromosomes arrive at the spindle poles and are eventually redistributed into chromatin. ... fourth fluorescence image of telophase . ... Mitosis, process in which a cell's nucleu...

Spindle Fibers

... In cell biology, the spindle apparatus is the structure that separates the ch... cell division,... Encyclopedia article about spindle fibers . Information about spindle fibers in the Columbia Encyclopedia, Computer D...

Sister Chromatids

... ... Is the choice between sister chromatid and homologous chromosome in the two ... At meiosis I, sister chromatids attach to the same spindle pole while homologous ... Cohesin is localized on paired sister chromatids and dissociates from them, as ... In mitotic cells, sister chroma...

Reflex arc

...rve ... The Reflex Arc . How a Stimulus Elicits a Response. A. Knee-Jerk ... called a simple reflex arc . Follow the sensory neuron. from the spindle (receptor) to ... A reflex arc refers to the neural pathway that a nerve impulse follows. ... It is the simplest reflex arc and the in...

Proprioception

... Proprioception is defined as "sensing the motion and position of the body" ... SENSORY ORGANS FOR PROPRIOCEPTION . Muscles and Tendons. Muscle spindle fibers ... This resource paper explains what proprioception is and how it works. ... Proprioception metaphorically is called the "sixth sense,...

Prophase

...owly wrap... Genetics: stages of mitosis ... Prophase - Wikipedia, the free encyclopedia ... Mitosis: Prophase ... In prophase the mitotic spindle forms and the chromosomes condense. ... Aspects of the topic prophase are discussed in the following places at Britannica. ... Zoology informa...

Prometaphase

...ng from the centrosomes at the poles (ends) of the spindle reach the chromosomes,... ... stages are proph...vided into five phases. In prophase the mitotic spindle forms and the chromosomes condense. In prometa... enters prometaphase , during which the mitotic spindle ... Prometaphase I embryos contained reticul...

Microtubules

...centrosome with their plus ... These clusters of microtubules are called spindle fibers. ... The Cell - A Molecular Approach is a basic text that provide... to determine cell shape, and provide a ... Microtubules also form the spindle fibers for separating chromosomes during mitosis. ... Biology4Kids.co...

Kinetochore

... The kinetochore is the protein structure on chromosomes where the spindle fibers attach during division to pull the chromosomes apart. Promet...ears. Microtubules emerging from the centrosomes at the poles (ends) of the spindle reach the chromosomes,... Keywords - chromatin component, assembles th...
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