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Sphingosine in Medical News

Deciphering the body's healing secrets

...explains. Publishing in Blood , Professor Gamble and her team found that this process, called differentiation, is partly controlled by the enzyme sphingosine kinase-1. "We found that high levels of SK-1 keep the cells as EPCs whereas a decrease in the amount of SK-1 allows the cell to differentiate to fu...

Drug Impedes Body's Deadly Reaction to Flu Virus

...kill that may cause the person to perish, a new study says. The compound sphingosine analog AAL-R, when administered directly into the lungs of mice, helped mit...SARS, in which pulmonary infiltration is severe." They plan to study how sphingosine analog AAL-R receptors work and test combination therapy, such as adding Ta...

UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases

...e patient's CD4 T cells did not move out of her lymph nodes as they would in a normal immune system because her body created antibodies to one type of sphingosine 1-phosphate (S1P) receptor. S1P is critical to appropriate immune responses since it regulates T- and B-cell movement throughout the body by interacti...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...transcription 3 (STAT3); SLAM family member 7 (SLAMF7); somatostatin receptors (SSTr); somatotropin release inhibiting factor (SRIF) receptor (SRIFr); sphingosine kinase (SPHK); spingomyelin synthase; Src pathway; stromal derived factor 1 (SDF-1); superoxide dismutase 1, soluble (SOD1); survivin; telomerase reve...
Sphingosine in Medical Technology

Data to be presented at AAN Meeting -Study results of drug candidate for MS

...wed by complete or partial restoration of functions. Preclinical studies FTY720's previously known activity is based on its ability to bind to the sphingosine 1-phosphate receptor-1 (S1P-R1) on circulating lymphocytes (white blood cells). This activity reversibly traps a proportion of lymphocytes in the lymp...
Sphingosine in Biological News

Scientists uncork a potential secret of red wine's health benefits

...trol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to en...

Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection

...ed in the study. In the research report, Goetzl and colleagues explain how they discovered that the antibodies produced by this patient blocked the sphingosine 1-phosphate (S1P) receptor on T cells. The S1P receptor is a cell-surface antenna that receives signals telling T cells to leave the lymph nodes and p...

ASBMB taps 8 scientists for top awards

...el is one of the founders of the paradigm that sphingolipid metabolites serve as signaling molecules, and the sphingolipid signal that she discovered, sphingosine 1-phosphate (S1P), is now the most thoroughly characterized mediator in this field. Susan Lindquist , an HHMI Investigator, member of the Whitehe...

Potential new therapeutic molecular target to fight cancer

...nia Commonwealth University Massey Cancer Center have identified the enzyme sphingosine kinase 2 as a possible new therapeutic target to improve the efficacy of ch...hers examined human colon and breast cancer cells and established a role of sphingosine kinase 2 (SphK2), an enzyme that forms the potent lipid mediator sphingosin...

JCI table of contents: Aug. 16, 2007

... indistinguishable in wild-type mice and in mice lacking a protein known as sphingosine 1–phosphate receptor 2 (S1P2R). By contrast, damage to the retina, in the f...e presence of an abnormal blood vessel network. TITLE: Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retina ...

VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells

...actor, which plays a critical role in breast cancer progression, stimulates sphingosine kinases - SphK1 and SphK2 - a family of enzymes that forms the potent lipid...etter understand the functions of these enzymes. "Our work suggests that sphingosine kinases are potential new targets in cancer therapy," she said. ...
Sphingosine in Biological Products

Rabbit Anti-Human Sphingosine 1-phosphate receptor Edg-1 Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: Sphingosine 1-phosphate receptor Edg-1...
Company:GenWay Biotech, Inc.

SphingoBeads from Echelon Biosciences Inc.

Description:...are designed for protein pull-down experiments to identify and characterize sphingosine binding proteins. An order of Sphingobeads contains 1 mL of agarose beads with 10 nmol of sphingosine bound through the terminus of the alkyl chain; enough for several binding e...
Company:Echelon Biosciences Inc.
Sphingosine in Biological Definition

Phospholipid

... known as phosphoglycerides. There is only one type of phospholipid with a sphingosine backbone; sphingomyelin . Phospholipids are a major component of all biol...ound in the liver. Sphingomyelin The backbone of sphingomyelin is sphingosine , an amino alcohol formed from palmitate and serine . The amino termi...
Sphingosine in Biological Dictionary

Rhodopsin

...ells, and blue, red, and green ... The European Bioinformatics Institute ... The rhodopsin -like GPCRs themselves represent ... Rhodopsin . EDG-1 sphingosine 1-phosphate receptor. Opioid receptor ... A description of the current concept of the chromophores of vision ... HISTORICAL CONCEPT OF RHODOPSIN...
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