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specificity in Medical News

Influenza: Insights into cell specificity of human vs. avian viruses

Rotterdam, The Netherlands Researchers have identified which sites and cell types within the respiratory tract are targeted by human versus avian influenza viruses, providing valuable insights into the pathogenesis of these divergent diseases. The report by van Riel et al, Human and avian influen...

Study Determines Breast-Specific Gamma Imaging Has Higher Specificity Than MRI in Patients With Equivocal Mammograms

Dilon high-resolution camera superior to conventional gamma imaging for both detecting breast cancer and screening high-risk patients. NEWPORT NEWS, Va., Oct. 2 /PRNewswire/ -- Recently published study results in The Breast Journal indicate that Breast-Specific Gamma Imaging (BSGI) may be ...

Diagnostic tools and innovative therapies improve patient prognosis

...phology. "Based on abnormal cell prevalence counts in sputum from patients with cancer, we estimate that the LuCED test demonstrates near-perfect specificity (no false positives) while maintaining sensitivity that exceeds 90 percent for patients with lung cancer cells in their sputum," says Michael Meyer, M...

Pelosi, Democratic Leaders Remarks Today at News Conference on Legislative Accomplishments

... As you see, we take great pride in the advancements that we have made for the American people and we present it to you with all of the commitment and specificity that will make a difference in the lives of the American people and take our country in a New Direction. "One other pillar of the President's ...

Urine Test for Chlamydia Shown Effective in Men

... chain reaction test using urine samples from more than 1,200 men, ages 16 to 73. The rapid test had a high level of sensitivity (82.6 percent) and specificity (98.5 percent) and provided results within an hour. Quick availability of results means that male patients can be offered treatment while still at a c...

Colon capsule endoscopy diagnoses 64 percent of total polyps detected by conventional colonoscopy

...ule, the Pamplona-based hospital centre obtained 88% of the locating of these lesions with respect to the 100% of the usual colonoscopy. As regards specificity (coincidence between lesions detected and real lesions), the Hospital gave the second best result with 92% of hits only one point less than the best....
specificity in Medical Technology

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

EMERYVILLE, Calif., July 17 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) announced today that a study of the gene regulation in multiple cell lines by several of their estrogen receptor beta (ERb) candidates will be published in Public Library of Science One. ...

New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring

...garding the repeatability of clinical results, risks related to our belief that Masimo SpHb and PVI will provide a sufficient level of sensitivity and specificity to facilitate continuous measurement capabilities and deliver clinical improvement over alternative hemoglobin and fluid assessment measurement capabi...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...ladelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses that would be protective against tuberculosis and have the poten...

Advanced Life Sciences Announces Outcome of FDA's Anti-Infective Drugs Advisory Committee Review of Restanza(TM) (cethromycin)

...ne-resistant bacteria. Restanza's demonstrated potency and ability to overcome bacterial resistance may be due to its mechanism of action resulting in specificity for its bacterial target. In addition to its utility in CAP, Restanza is also being investigated for the prophylactic treatment of inhalation anthrax ...

AdvanDx Launches Fast, 90 Minutes Protocol for All CE-IVD Marked PNA FISH(R) Tests in Europe

...e 100% equivalent while maintaining the very high (>95%) sensitivity and specificity versus slower, conventional laboratory methods. Since the first produc...around Time and minimal Hands-on Time Close to 100% sensitivity and specificity versus conventional, slower laboratory methods Molecular method re...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...killing of tumor cells leading to the regression of established tumors. Antibody-drug conjugates comprising a non-cleavable linker had greatly reduced specificity and efficacy. In addition to demonstrating potent anti-tumor efficacy, conjugates using a cleavable linker also showed a more favorable toxicity and s...
specificity in Medical Products

C. Difficile Tox A/B II

Description:... samples that are toxin A-/B+. It's easy to perform, produces no indeterminates and provides results in one hour or less. The relative sensitivity and specificity of the test are 92.2% and 100%, respectively, when compared to tissue culture....
Company:Inverness Medical Innovations

TOX A/B QUIK CHEK

Description:...difficile toxins A and B in fecal specimens. The test uses antibodies specific for toxins A and B of C. difficile and yields >90% sensitivity and >99% specificity compared to tissue culture. Because the test detects both toxin A and toxin B, the risk of false negative results due to A-/B+ strains is greatly redu...
Company:Inverness Medical Innovations

Hemoccult ICT

Description:...uct line. An immunochemical FOBT (iFOBT) with high specificity and sensitivity, Hemoccult ICT is clinically prove...tional guaiac-based FOBTs. Because of its superior specificity for lower GI bleeding, Hemoccult ICT is an ideal s...reening tool for colorectal cancer (CRC), and this specificity also reduces the number of false positive test res...
Company:Beckman Coulter, Inc.

Hemoccult ICT Fecal Occult Blood Test

Description:...uct line. An immunochemical FOBT (iFOBT) with high specificity and sensitivity, Hemoccult ICT is clinically prove...tional guaiac-based FOBTs. Because of its superior specificity for lower GI bleeding, Hemoccult ICT is an ideal s...reening tool for colorectal cancer (CRC), and this specificity also reduces the number of false positive test res...
Company:Beckman Coulter, Inc

PK® CMV-PA Systems & Controls

Description:...Microplate System, the PK CMV-PA System uses CMV antigen attached to a gelatin particle for the detection of cytomegalovirus. Relative sensitivity and specificity of the CMV assay as compared to EIA measures 99.8% and 99.3% respectively. The use of a gelatin particle as the carrier provides excellent lot-to-lot ...
Company:Olympus America Diagnostics

SHBG IRMA Test

Description:... Human sex hormone-binding globulin (SHBG) is a serum glycoprotein which binds several sex steroids with relatively high specificity and low capacity, including testosterone and dihydrotestosterone (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specif...
Company:Diagnostic Systems Laboratories, Inc.
specificity in Medical Definition

Central tolerance

... tolerant (non-reactive) in a number of ways : Negative selection ( apoptosis ) Anergy (non-responsiveness) Receptor editing (changing the specificity of the autoreactive cell) [4] Division to a regulatory lineage Genetic defects in these processes lead to autoimmunity, such as in the human ...

Muscle atrophy

...tion by the proteasome . Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others - specificity is gained by coupling targeted proteins to an "E3 ubiquitin ligase ". Each E3 ubiquitin ligase binds to a particular set of substrates, causing the...

Positive predictive value

...e → Negative predictive value ↓ Sensitivity ↓ specificity A worked example the Fecal occult blood (FOB) screen test is ... False positive rate (α) = FP / (FP + TN) = 18 / (18 + 182) = 9% = 1 - specificity False negative rate (β) = FN / (TP + FN) = 1 / (2 + 1) = 33% = 1 - sensit...
specificity in Medical Dictionary

ELISA

...thod ... ELISA can also be adapted to measure the concentration of antibodies. In this case, ... ... Immunosorbent Assays ( ELISAs ) combine the specificity of antibodies with the ... One of the most useful of the immunoassays is the two antibody sandwich' ELISA . ... Elisa - Definition of Elisa ...

ABO incompatibility

... In ABO hemolytic disease of the newborn maternal IgG antibodies with specificity for the ABO blood group system pass through the placenta to the fetal circulation where they can cause hemolysis of fetal red blood cell...
specificity in Biological News

Unique dual target specificity of kinase inhibitor key for success against cancer

Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. ...

Moving to the US increases cancer risk for Hispanics

...ology at the University of Miami Miller School of Medicine. "Targeted interventions for cancer prevention and control should take into account the specificity of each Hispanic subgroup: Cubans, Puerto Ricans or Mexicans," added Pinheiro, who is the study's lead researcher. Pinheiro received support from the ...

New DNA and RNA aptamers offer unique therapeutic advantages

... NY, August 5, 2009A novel class of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and are currently in clinical development as treatments for a broad range of common diseases, as described in a comprehensive review article published...

Nanodiamonds deliver insulin for wound healing

...dence of infection. Ho says this ability to release therapeutics from the nanodiamonds on demand represents an exciting strategy towards enhancing the specificity of wound treatment. In their studies, Ho and his colleagues showed that the insulin was very tightly bound to the nanodiamonds when in an aqueous s...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

...ng pathway confers specific physiological outcomes such as proliferation, differentiation and cell migration," notes Dr. Catling. "We hypothesize that specificity is conferred by the action of input- and output-specific 'scaffolding' molecules that assemble the pathway around growth factor receptors." The sup...

A urine test for appendicitis?

...al inflammation. It had an "area under the curve" value of 0.97, indicating near-perfect sensitivity (with almost no false-negatives) and near-perfect specificity (almost no false-positives). LRG was strongly elevated in diseased appendices, even when those appendices appeared normal on imaging, and the amount o...
specificity in Biological Technology

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

ST. LOUIS, April 28 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced the global release of MISSION(R) esiRNA, a pool of gene-specific siRNA that provides a novel and powerful approach to RNAi screening in mammalian cells. Unlike traditional synthetic RNAi, esiRNA ( htt...

Publication in Clinical Cancer Research Confirms Ability of Peregrine's Bavituximab to Target Tumor Blood Vessels with Excellent Specificity

- Data Further Supports High Degree of Tumor Targeting Specificity for Bavituximab, Currently in Phase II Cancer Trials in Combination with Chemotherapy - - Imaging Study Also Suggests Potential Utility of Anti-PS Agents for Molecular Imaging ...

Improve Amplification Specificity with Hot Start PCR Enzyme

SureStart Taq DNA polymerase utilizes ultra-pure Taq2000 DNA polymerase SureStart Taq DNA polymerase features a modified version of Taq2000 DNA polymerase with hot start capability. Using SureStart Taq, hot start is in- corporated into PCR protocols previ...

Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer

Measure mutations in any tissue with the Big Blue transgenic rodent mutation assay Johan G. de Boer Barry W. Glickman Centre for Environmental Health, University of Victoria, Victoria, BC Canada With Stratagenes Big Blue transgenic rodent mutation assay,* which carrie...

Greater Amplification Specificity with New Hot Start PCR Enzyme

SureStart Taq DNA polymerase makes hot start simple and efficient Jonathan Eads Frances Bai Ronda Allen Holly Hogrefe ...

Advanced Life Sciences Receives Complete Response Letter From FDA for Restanza(TM) (Cethromycin) in Community Acquired Pneumonia

...ne-resistant bacteria. Restanza's demonstrated potency and ability to overcome bacterial resistance may be due to its mechanism of action resulting in specificity for its bacterial target. In addition to its utility in CAP, Restanza is also being investigated for the prophylactic treatment of inhalation anthrax ...
specificity in Biological Products

Goat Anti-Cholesterol Oxidase Polyclonal Antibody, Unconjugated from GeneTex

Description:... Product Goat polyclonal to Cholesterol Oxidase Immunogen Cholesterol Oxidase (Microorganism). Reactivity / specificity Cross-reacts with bacteria. Not yet tested in other species. Background Information Cholesterol oxidases exist as both type I and type II oxidases ...
Company:GeneTex

Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex

Description:...t Goat polyclonal to BRF2 Immunogen Synthetic peptide: QAARQAATSVPNPP, corresponding to C terminal amino acids 406-419 of Human BRF2. Reactivity / specificity Cross-reacts with Human. Not yet tested in other species. Background Information BRF2 is one of the multiple subunits of the RNA polymerase III tra...
Company:GeneTex

Rabbit Anti-Human Rab3A Polyclonal Antibody, Unconjugated from Assay Designs/Stressgen Bioreagents

Description:... This antibody detects an ~25 kDa band, corresponding to the expected molecular mass of Rab3A, on immunoblots. The antibody specificity is confirmed in peptide inhibition immunoblotting studies....
Company:Assay Designs/Stressgen Bioreagents

Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex

Description:... Product Mouse monoclonal [SPM278] to 67kD Laminin Receptor, prediluted Immunogen Small cell lung carcinoma N592 live cells (Human). Reactivity / specificity Cross-reacts with Human. Not yet tested in other species. Background Information Laminin, one of the major glycoproteins of basement membrane, disp...
Company:GeneTex

Ultrastreptavidin (USA) Horseradish peroxidase (HRP) 150 Test, Murine, Detection Kit (SIGNET) from Covance Research Products, Inc

Description:...indirect labeling technique, the avidin-biotin chemical bonding principle and Signets unique formulation of ultra Streptavidin to provide sensitivity, specificity and reliablility. Signet reagents will achieve excellent quality immunostaining in both manual and automated protocols. Signets USA Detection reage...
Company:Covance Research Products, Inc

Ultrastreptavidin (USA) Horseradish peroxidase (HRP) 500 Test, Rabbit, Detection Kit (SIGNET) from Covance Research Products, Inc

Description:...indirect labeling technique, the avidin-biotin chemical bonding principle and Signets unique formulation of ultra Streptavidin to provide sensitivity, specificity and reliablility. Signet reagents will achieve excellent quality immunostaining in both manual and automated protocols. Signets USA Detection reage...
Company:Covance Research Products, Inc
specificity in Biological Definition

Antibody

...iable fragment (scFv), which retains the original specificity of the parent immunoglobulin. A crude estimation...he same time. However, they are identical in their specificity for antigen, conferred by their variable region. T...tained. Monoclonal antibodies have much greater specificity than polyclonal antibodies . See also ...

Sticky end/blunt end

...gurations resulting from the breaking of double-stranded DNA . DNA exhibits a stabilizing interaction between complementary base pairs , providing specificity to the pairing of two strands of DNA. If two complementary strands of DNA are of equal length, then they will terminate in a blunt end , as in the f...

DNA

...thymine (T), cytosine (C), and guanine (G). In a DNA double helix, two polynucleotide strands can associate through the hydrophobic effect . specificity of which strands stay associated is determined by complementary pairing . Each base forms hydrogen bonds readily to only one other -- A to T and C ...

Endosymbiont

...shown there to be great diversity in Symbiodinium . In some cases there is specificity between host and Symbiodinium clade. More often, however, there is a eco...dinium in reef ecology and the current state of research: FLEXIBILITY AND specificity IN CORAL-ALGAL SYMBIOSIS: Diversity, Ecology, and Biogeography of Symbiodin...

Endosymbiont

...shown there to be great diversity in Symbiodinium . In some cases there is specificity between host and Symbiodinium clade. More often, however, there is a eco...dinium in reef ecology and the current state of research: FLEXIBILITY AND specificity IN CORAL-ALGAL SYMBIOSIS: Diversity, Ecology, and Biogeography of Symbiodin...

Enzyme

... 2.1 Rate of enzyme mediated reactions 2.2 specificity 2.3 Kinetics 2.4 Metabolic pathways 2.5 Q... mediated reactions depends on many factors. specificity Figure 2: An enzyme catalyzes the re... the enzyme and substrate are responsible for this specificity (Fig. 2). Kinetics In 1913, Leonor Michae...
specificity in Biological Dictionary

Wobble base pair

... the GU wobble base pair , but never a standard. Watson–Crick pair . ... The presence of a G3.U70 wobble base pair is essential for the specificity of ... and slide due to the wobble base pair , but no recognizable distortion of the ... ... base pair cognate or wobble interaction fro...

Substrate

..... Pronunciation of substrate . substrate synonyms. substrate usage examples and substrate quotes. ... specificity: However, the substrate specificity of the ... ...

Saturation mutagenesis

... mutagenesis of N-acetylneuraminic acid lyase for the ... Here, we used structure-guided saturation mutagenesis to produce variants of NAL ... specificity Based on Combinatorial Saturation Mutagenesis and. Logical Redesign of the Castor ... saturation mutagenesis at positions known to affect sub...

RNase

...ls, it has to be "turned on" ... RNase - Biological definition of RNase from A Dictionary of Biology at Encyclopedia.com ... Each RNase has a specificity for a different cleavage site. ... EPICENTRE develops and manufactures reagents and kits for genomics, proteomics, ... Ribonuclease R ( RNase R)...

Rhizobia

...estoration and reconstruction ... Sesbania rhizobia showed extremely high specificity to rhizobiophages. ... Rhizobia bacteria establish symbiotic relatio...New Zealand, investigating native and exotic legumes (plants) Chapter 5: specificity of Symbioses in New Zealand Rhizobia ... Rhizobia fix Nitrogen from the...

Polyadenylation

...A molecule. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for... Cleavage and polyadenylation specificity factor (CPSF) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule in the process...
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(Date:9/18/2014)... York and London. (PRWEB) September 18, 2014 ... of Computer Aided Engineering software, today announced its new ... will be utilizing the CD-adapco simulation tool, STAR-CCM+® in ... team just announced its participation in the 35th America’s ... the 35th edition of the America’s Cup is sustainability, ...
(Date:9/18/2014)... parents eat more vegetables and drink less sugar, according ... Columbia. But it,s still not enough, the study goes ... when it comes to eating healthier at school , ... of socioeconomic status, may inform a child,s diet. , ... some post-secondary education were 85 per cent more likely ...
(Date:9/18/2014)... in German . ... have won the ,International Space Station Research Competition, with ... prize, the scientists will see the International Space Station ... involves crystallizing two proteins of the hepatitis C virus ... the International Space Station is scheduled to lift off ...
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(Date:9/17/2014)... the Copenhagen Centre for Social Evolution and Yale University ... birth weight and -length can partially predict the likelihood ... autism and schizophrenia later in life. The study analyzed ... hospital diagnoses for up to 30 years, and adjusted ... is published today in the Proceedings of the ...
(Date:9/17/2014)... at UTSouthwestern Medical Center have found that the most ... apoE3, helps repair the lining of blood vessels. Individuals ... benefit of this repair, putting them at higher risk ... identified one mechanism by which apoE3 promotes a healthy ... detrimental," said Dr. Philip Shaul , Professor of ...
(Date:9/17/2014)... complex social behavior by studying nonhuman mammals and primates, ... With their unusually large brains relative to their body ... social environment---not merely in a large population of cooperating ... dynamic setting of alliances and competitors. The same is ... and social carnivores, like hyenas and lions. , A ...
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