Influenza: Insights into cell specificity of human vs. avian viruses
Rotterdam, The Netherlands Researchers have identified which sites and cell types within the respiratory tract are targeted by human versus avian influenza viruses, providing valuable insights into the pathogenesis of these divergent diseases. The report by van Riel et al, Human and avian influen...
Study Determines Breast-Specific Gamma Imaging Has Higher Specificity Than MRI in Patients With Equivocal Mammograms
Dilon high-resolution camera superior to conventional gamma imaging for both detecting breast cancer and screening high-risk patients.
NEWPORT NEWS, Va., Oct. 2 /PRNewswire/ -- Recently published study
results in The Breast Journal indicate that Breast-Specific Gamma Imaging
(BSGI) may be ...
Diagnostic tools and innovative therapies improve patient prognosis
...phology.
"Based on abnormal cell prevalence counts in sputum from patients with cancer, we estimate that the LuCED test demonstrates near-perfect
specificity (no false positives) while maintaining sensitivity that exceeds 90 percent for patients with lung cancer cells in their sputum," says Michael Meyer, M...
Pelosi, Democratic Leaders Remarks Today at News Conference on Legislative Accomplishments
... As you see, we take great pride in the advancements that we have made for the American people and we present it to you with all of the commitment and
specificity that will make a difference in the lives of the American people and take our country in a New Direction.
"One other pillar of the President's ...
Urine Test for Chlamydia Shown Effective in Men
... chain reaction test using urine samples from more than 1,200 men, ages 16 to 73.
The rapid test had a high level of sensitivity (82.6 percent) and
specificity (98.5 percent) and provided results within an hour. Quick availability of results means that male patients can be offered treatment while still at a c...
Colon capsule endoscopy diagnoses 64 percent of total polyps detected by conventional colonoscopy
...ule, the Pamplona-based hospital centre obtained 88% of the locating of these lesions with respect to the 100% of the usual colonoscopy.
As regards
specificity (coincidence between lesions detected and real lesions), the Hospital gave the second best result with 92% of hits only one point less than the best....
specificity in Medical Technology
Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity
EMERYVILLE, Calif., July 17 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) announced today that a study of the gene regulation in multiple cell lines by several of their estrogen receptor beta (ERb) candidates will be published in Public Library of Science One.
...
New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring
...garding the repeatability of clinical results, risks related to our belief that Masimo SpHb and PVI will provide a sufficient level of sensitivity and
specificity to facilitate continuous measurement capabilities and deliver clinical improvement over alternative hemoglobin and fluid assessment measurement capabi...
CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas
...ladelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) vaccine technology with
specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses that would be protective against tuberculosis and have the poten...
Advanced Life Sciences Announces Outcome of FDA's Anti-Infective Drugs Advisory Committee Review of Restanza(TM) (cethromycin)
...ne-resistant bacteria. Restanza's demonstrated potency and ability to overcome bacterial resistance may be due to its mechanism of action resulting in
specificity for its bacterial target. In addition to its utility in CAP, Restanza is also being investigated for the prophylactic treatment of inhalation anthrax ...
AdvanDx Launches Fast, 90 Minutes Protocol for All CE-IVD Marked PNA FISH(R) Tests in Europe
...e 100% equivalent while maintaining the very high (>95%) sensitivity and
specificity versus slower, conventional laboratory methods.
Since the first produc...around Time and minimal Hands-on Time
Close to 100% sensitivity and
specificity versus conventional, slower laboratory methods
Molecular method re...
Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer
...killing of tumor cells leading to the regression of established tumors. Antibody-drug conjugates comprising a non-cleavable linker had greatly reduced
specificity and efficacy. In addition to demonstrating potent anti-tumor efficacy, conjugates using a cleavable linker also showed a more favorable toxicity and s...
specificity in Medical Products
C. Difficile Tox A/B II
Description:... samples that are toxin A-/B+. It's easy to perform, produces no indeterminates and provides results in one hour or less. The relative sensitivity and
specificity of the test are 92.2% and 100%, respectively, when compared to tissue culture....
Company:Inverness Medical Innovations
TOX A/B QUIK CHEK
Description:...difficile toxins A and B in fecal specimens. The test uses antibodies specific for toxins A and B of C. difficile and yields >90% sensitivity and >99%
specificity compared to tissue culture. Because the test detects both toxin A and toxin B, the risk of false negative results due to A-/B+ strains is greatly redu...
Company:Inverness Medical Innovations
Hemoccult ICT
Description:...uct line. An immunochemical FOBT (iFOBT) with high
specificity and sensitivity, Hemoccult ICT is clinically prove...tional guaiac-based FOBTs. Because of its superior
specificity for lower GI bleeding, Hemoccult ICT is an ideal s...reening tool for colorectal cancer (CRC), and this
specificity also reduces the number of false positive test res...
Company:Beckman Coulter, Inc.
Hemoccult ICT Fecal Occult Blood Test
Description:...uct line. An immunochemical FOBT (iFOBT) with high
specificity and sensitivity, Hemoccult ICT is clinically prove...tional guaiac-based FOBTs. Because of its superior
specificity for lower GI bleeding, Hemoccult ICT is an ideal s...reening tool for colorectal cancer (CRC), and this
specificity also reduces the number of false positive test res...
Company:Beckman Coulter, Inc
PK® CMV-PA Systems & Controls
Description:...Microplate System, the PK CMV-PA System uses CMV antigen attached to a gelatin particle for the detection of cytomegalovirus. Relative sensitivity and
specificity of the CMV assay as compared to EIA measures 99.8% and 99.3% respectively. The use of a gelatin particle as the carrier provides excellent lot-to-lot ...
Company:Olympus America Diagnostics
SHBG IRMA Test
Description:... Human sex hormone-binding globulin (SHBG) is a serum glycoprotein which binds several sex steroids with relatively high
specificity and low capacity, including testosterone and dihydrotestosterone (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specif...
Company:Diagnostic Systems Laboratories, Inc.
specificity in Medical Definition
Central tolerance
... tolerant (non-reactive) in a number of ways :
Negative selection ( apoptosis )
Anergy (non-responsiveness)
Receptor editing (changing the
specificity of the autoreactive cell) [4]
Division to a regulatory lineage
Genetic defects in these processes lead to autoimmunity, such as in the human ...
Muscle atrophy
...tion by the proteasome . Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others -
specificity is gained by coupling targeted proteins to an "E3 ubiquitin ligase ". Each E3 ubiquitin ligase binds to a particular set of substrates, causing the...
Positive predictive value
...e
→ Negative predictive value
↓
Sensitivity
↓
specificity
A worked example
the Fecal occult blood (FOB) screen test is ...
False positive rate (α) = FP / (FP + TN) = 18 / (18 + 182) = 9% = 1 -
specificity
False negative rate (β) = FN / (TP + FN) = 1 / (2 + 1) = 33% = 1 - sensit...
specificity in Medical Dictionary
ELISA
...thod ... ELISA can also be adapted to measure the concentration of antibodies. In this case, ... ... Immunosorbent Assays ( ELISAs ) combine the
specificity of antibodies with the ... One of the most useful of the immunoassays is the two antibody sandwich' ELISA . ... Elisa - Definition of Elisa ...
ABO incompatibility
... In ABO hemolytic disease of the newborn maternal IgG antibodies with
specificity for the ABO blood group system pass through the placenta to the fetal circulation where they can cause hemolysis of fetal red blood cell...
specificity in Biological News
Unique dual target specificity of kinase inhibitor key for success against cancer
Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. ...
Moving to the US increases cancer risk for Hispanics
...ology at the University of Miami Miller School of Medicine.
"Targeted interventions for cancer prevention and control should take into account the
specificity of each Hispanic subgroup: Cubans, Puerto Ricans or Mexicans," added Pinheiro, who is the study's lead researcher. Pinheiro received support from the ...
New DNA and RNA aptamers offer unique therapeutic advantages
... NY, August 5, 2009A novel class of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and
specificity and are currently in clinical development as treatments for a broad range of common diseases, as described in a comprehensive review article published...
Nanodiamonds deliver insulin for wound healing
...dence of infection. Ho says this ability to release therapeutics from the nanodiamonds on demand represents an exciting strategy towards enhancing the
specificity of wound treatment.
In their studies, Ho and his colleagues showed that the insulin was very tightly bound to the nanodiamonds when in an aqueous s...
Grant supports LSUHSC research on how like cell receptor systems determine very different functions
...ng pathway confers specific physiological outcomes such as proliferation, differentiation and cell migration," notes Dr. Catling. "We hypothesize that
specificity is conferred by the action of input- and output-specific 'scaffolding' molecules that assemble the pathway around growth factor receptors."
The sup...
A urine test for appendicitis?
...al inflammation. It had an "area under the curve" value of 0.97, indicating near-perfect sensitivity (with almost no false-negatives) and near-perfect
specificity (almost no false-positives). LRG was strongly elevated in diseased appendices, even when those appendices appeared normal on imaging, and the amount o...
specificity in Biological Technology
Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening
ST. LOUIS, April 28 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced the global release of MISSION(R) esiRNA, a pool of gene-specific siRNA that provides a novel and powerful approach to RNAi screening in mammalian cells. Unlike traditional synthetic RNAi, esiRNA ( htt...
Publication in Clinical Cancer Research Confirms Ability of Peregrine's Bavituximab to Target Tumor Blood Vessels with Excellent Specificity
- Data Further Supports High Degree of Tumor Targeting
Specificity for Bavituximab, Currently in Phase II Cancer Trials in Combination with Chemotherapy -
- Imaging Study Also Suggests Potential Utility of Anti-PS Agents for Molecular Imaging ...
Improve Amplification Specificity with Hot Start PCR Enzyme
SureStart Taq DNA polymerase utilizes ultra-pure
Taq2000 DNA polymerase
SureStart Taq DNA polymerase
features a modified version of Taq2000 DNA polymerase
with hot start capability. Using SureStart Taq, hot start is
in- corporated into PCR protocols previ...
Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer
Measure mutations in any tissue with the Big Blue transgenic
rodent mutation assay
Johan G. de Boer Barry W. Glickman
Centre for Environmental Health, University of Victoria, Victoria, BC Canada
With Stratagenes Big Blue transgenic rodent mutation
assay,* which carrie...
Greater Amplification Specificity with New Hot Start PCR Enzyme
SureStart Taq DNA polymerase
makes hot start simple and efficient
Jonathan Eads Frances Bai Ronda Allen
Holly Hogrefe
...
Advanced Life Sciences Receives Complete Response Letter From FDA for Restanza(TM) (Cethromycin) in Community Acquired Pneumonia
...ne-resistant bacteria. Restanza's demonstrated potency and ability to overcome bacterial resistance may be due to its mechanism of action resulting in
specificity for its bacterial target. In addition to its utility in CAP, Restanza is also being investigated for the prophylactic treatment of inhalation anthrax ...
specificity in Biological Products
Goat Anti-Cholesterol Oxidase Polyclonal Antibody, Unconjugated from GeneTex
Description:... Product Goat polyclonal to Cholesterol Oxidase Immunogen Cholesterol Oxidase (Microorganism). Reactivity /
specificity Cross-reacts with bacteria. Not yet tested in other species. Background Information Cholesterol oxidases exist as both type I and type II oxidases ...
Company:GeneTex
Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex
Description:...t Goat polyclonal to BRF2 Immunogen Synthetic peptide: QAARQAATSVPNPP, corresponding to C terminal amino acids 406-419 of Human BRF2. Reactivity /
specificity Cross-reacts with Human. Not yet tested in other species. Background Information BRF2 is one of the multiple subunits of the RNA polymerase III tra...
Company:GeneTex
Rabbit Anti-Human Rab3A Polyclonal Antibody, Unconjugated from Assay Designs/Stressgen Bioreagents
Description:... This antibody detects an ~25 kDa band, corresponding to the expected molecular mass of Rab3A, on immunoblots. The antibody
specificity is confirmed in peptide inhibition immunoblotting studies....
Company:Assay Designs/Stressgen Bioreagents
Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex
Description:... Product Mouse monoclonal [SPM278] to 67kD Laminin Receptor, prediluted Immunogen Small cell lung carcinoma N592 live cells (Human). Reactivity /
specificity Cross-reacts with Human. Not yet tested in other species. Background Information Laminin, one of the major glycoproteins of basement membrane, disp...
Company:GeneTex
Ultrastreptavidin (USA) Horseradish peroxidase (HRP) 150 Test, Murine, Detection Kit (SIGNET) from Covance Research Products, Inc
Description:...indirect labeling technique, the avidin-biotin chemical bonding principle and Signets unique formulation of ultra Streptavidin to provide sensitivity,
specificity and reliablility. Signet reagents will achieve excellent quality immunostaining in both manual and automated protocols.
Signets USA Detection reage...
Company:Covance Research Products, Inc
Ultrastreptavidin (USA) Horseradish peroxidase (HRP) 500 Test, Rabbit, Detection Kit (SIGNET) from Covance Research Products, Inc
Description:...indirect labeling technique, the avidin-biotin chemical bonding principle and Signets unique formulation of ultra Streptavidin to provide sensitivity,
specificity and reliablility. Signet reagents will achieve excellent quality immunostaining in both manual and automated protocols.
Signets USA Detection reage...
Company:Covance Research Products, Inc
specificity in Biological Definition
Antibody
...iable fragment (scFv), which retains the original
specificity of the parent immunoglobulin.
A crude estimation...he same time. However, they are identical in their
specificity for antigen, conferred by their variable region. T...tained. Monoclonal antibodies have much greater
specificity than polyclonal antibodies .
See also
...
Sticky end/blunt end
...gurations resulting from the breaking of double-stranded DNA . DNA exhibits a stabilizing interaction between complementary base pairs , providing
specificity to the pairing of two strands of DNA. If two complementary strands of DNA are of equal length, then they will terminate in a blunt end , as in the f...
DNA
...thymine (T), cytosine (C), and guanine (G).
In a DNA double helix, two polynucleotide strands can associate through the hydrophobic effect .
specificity of which strands stay associated is determined by complementary pairing . Each base forms hydrogen bonds readily to only one other -- A to T and C ...
Endosymbiont
...shown there to be great diversity in Symbiodinium . In some cases there is
specificity between host and Symbiodinium clade. More often, however, there is a eco...dinium in reef ecology and the current state of research: FLEXIBILITY AND
specificity IN CORAL-ALGAL SYMBIOSIS: Diversity, Ecology, and Biogeography of Symbiodin...
Endosymbiont
...shown there to be great diversity in Symbiodinium . In some cases there is
specificity between host and Symbiodinium clade. More often, however, there is a eco...dinium in reef ecology and the current state of research: FLEXIBILITY AND
specificity IN CORAL-ALGAL SYMBIOSIS: Diversity, Ecology, and Biogeography of Symbiodin...
Enzyme
...
2.1 Rate of enzyme mediated reactions
2.2
specificity
2.3 Kinetics
2.4 Metabolic pathways
2.5 Q... mediated reactions depends on many factors.
specificity
Figure 2: An enzyme catalyzes the re... the enzyme and substrate are responsible for this
specificity (Fig. 2).
Kinetics
In 1913, Leonor Michae...
specificity in Biological Dictionary
Wobble base pair
... the GU wobble base pair , but never a standard. Watson–Crick pair . ... The presence of a G3.U70 wobble base pair is essential for the
specificity of ... and slide due to the wobble base pair , but no recognizable distortion of the ... ... base pair cognate or wobble interaction fro...
Substrate
..... Pronunciation of substrate . substrate synonyms. substrate usage examples and substrate quotes. ... specificity: However, the substrate
specificity of the ... ...
Saturation mutagenesis
... mutagenesis of N-acetylneuraminic acid lyase for the ... Here, we used structure-guided saturation mutagenesis to produce variants of NAL ...
specificity Based on Combinatorial Saturation Mutagenesis and. Logical Redesign of the Castor ... saturation mutagenesis at positions known to affect sub...
RNase
...ls, it has to be "turned on" ... RNase - Biological definition of RNase from A Dictionary of Biology at Encyclopedia.com ... Each RNase has a
specificity for a different cleavage site. ... EPICENTRE develops and manufactures reagents and kits for genomics, proteomics, ... Ribonuclease R ( RNase R)...
Rhizobia
...estoration and reconstruction ... Sesbania rhizobia showed extremely high
specificity to rhizobiophages. ... Rhizobia bacteria establish symbiotic relatio...New Zealand, investigating native and exotic legumes (plants) Chapter 5:
specificity of Symbioses in New Zealand Rhizobia ... Rhizobia fix Nitrogen from the...
Polyadenylation
...A molecule. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for... Cleavage and polyadenylation
specificity factor (CPSF) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule in the process...