Indevus Pharmaceuticals Announces Definitive Merger Agreement With Endo Pharmaceuticals

...of the upper arm and is specifically designed to provide a continuous release of octreotide, a long-acting octapeptide that mimics the natural hormone somatostatin to block release of growth hormone (GH), over a six-month period. About Indevus Pharmaceuticals Indevus Pharmaceuticals, Inc. is a specialty ...

Medical Futures partners with Norgine for MOVIPREP(R) in Canada

...rption and lower side effects. PEGALAX(TM): osmotic laxative with electrolytes for the treatment of chronic constipation. SANVAR(R): somatostatin analogue for the treatment of esophageal variceal bleeding. Norgine is an independent, successful European specialty pharmaceutical company ...

CCNY researchers demonstrate effectiveness of contrast agent Cytate in detectcing prostate cancer

...en (ICG), an FDA-approved near-infrared dye, and a somatostatin receptor ligand. somatostatin is a small cyclic neuropeptide that is believed to...revious studies had shown that Cytate could target somatostatin receptor-rich pancreas tumors in animal model beca...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...Ron; SH2-containing protein-tyrosine phosphatase 1 (SHP-1); signal transducer and activator of transcription 3 (STAT3); SLAM family member 7 (SLAMF7); somatostatin receptors (SSTr); somatotropin release inhibiting factor (SRIF) receptor (SRIFr); sphingosine kinase (SPHK); spingomyelin synthase; Src pathway; strom...

Medical Futures signs North American licensing rights to New Biologic agent for Ulcerative Colitis

...em that delivers sterile lidocaine powder into the epidermis of the skin that provides topical, local analgesia in one minute. SANVAR(R) is the only somatostatin analogue to have demonstrated statistically significant benefits in the treatment of esophageal variceal bleeding in association with endoscopic thera...

Ranbaxy to Market Debiopharm's New Drug in India

...tal hypertension, Ranbaxy said in a statement Monday. Sanvar (vapreotide acetate) is a synthetic octapeptide analogue of the naturally-occurring somatostatin hormone. Sanvar can be used in combination with specific treatment such as sclerotherapy or band ligation. Under the agreement, Ranbaxy will hav...

Novel Technique For Targeting Small-Cell Lung Cancer

... sensitivity of endoscopic imaging. Conjugation of somatostatin analogs with fluorescent agents enables tumor dete... novel backbone cyclic peptides, which function as somatostatin receptor (SSTR) binding, tumor-targeting vectors. They synthesized novel somatostatin analogs, based on backbone cyclic peptides, and co...

Somatostatin in Medical Technology

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

...minal discomfort. Patients with carcinoid syndrome currently have limited therapeutic options, and the standard of care includes chronic therapy with somatostatin analogues, which are delivered by injection. With current therapy, the gastrointestinal symptoms return over time in the vast majority of patients, h...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...array of therapeutic strategies for fighting cancer, including novel targeted agents, monoclonal antibodies, deacetylase (DAC) inhibitors, multiligand somatostatin analogs and novel cytotoxics. Sandostatin LAR important safety information Sandostatin LAR is a long-acting, injectable depot formulation of ...

New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors

...LAR is a long-acting, injectable depot dosage form of octreotide acetate, a somatostatin analog which exerts similar pharmacologic effects on the human body as the natural hormone somatostatin. However, octreotide is even more potent than somatostatin at inhibiting growth hormone, glucagon and insulin. Based on these attribut...

Sanvar(R) (Debio 8609) for Esophageal Variceal Bleeding

...ide acetate) is a synthetic octapeptide analogue of the naturally-occurring somatostatin hormone. It has similar pharmacological properties to native somatostatin, but exhibits a longer duration of action. It is the only somatostatin analogue to have demonstrated statistically significant benefits in the ear...

RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors

...analogue that exerts similar pharmacologic effects on the human body as the natural hormone somatostatin. However, octreotide is even more potent than somatostatin at inhibiting growth hormone, glucagon and insulin. Based on these attributes, octreotide has been used to treat the diarrhea and flushing associated ...

Indevus Pharmaceuticals Reports Positive Results of Phase II Octreotide Implant Trial

...patented Hydron technology to deliver effective levels of octreotide for six months. Octreotide is a synthetic peptide that mimics the natural hormone somatostatin to block release of GH. In the recently completed six-month trial, the octreotide implant effectively suppressed levels of GH and IGF-1 at rates simil...

Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice

...ress pancreatic specific factors as well as hormones insulin, glucagons and somatostatin in physiological proportions. These studies also demonstrated that MDIs fun.... These insulin producing islet-like clusters express insulin, glucagon and somatostatin characteristic hormones found in pancreatic islets and function in a glucos...

Somatostatin in Medical Products

hGH IRMA Test

Description:...he anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplitude of GH rel...
Company:Diagnostic Systems Laboratories, Inc.

hGH, Ultra-Sensitive ELISA Test

Description:...he anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplitude of GH rel...
Company:Diagnostic Systems Laboratories, Inc.

Placental Growth Hormone ELISA Test

Description:...he anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplitude of GH rel...
Company:Diagnostic Systems Laboratories, Inc.

Bioactive hGH ELISA Test

Description:...he anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplitude of GH rel...
Company:Diagnostic Systems Laboratories, Inc.

hGH ELISA Test

Description:...he anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplitude of GH rel...
Company:Diagnostic Systems Laboratories, Inc.

Somatostatin in Biological News

Suppressing growth hormone in early adulthood may prevent cancer

..., he said. Although additional research is needed, he said, drugs in the somatostatin class are currently available to suppress growth hormone and IGF-1 in people, so somatostatin analogs could be given as preventative measures to lower plasma IGF-1 befor...

Somatostatin in Biological Technology

The development of a somatostatin sst4 receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: somatostatin • receptor binding assay • LEADseeker • SPA Imaging Beads Somatostatin (SS) is a neurotransmitter/hormone with a wide range of biological actions (1–3) and a reduction in cortical SS levels has been re...

Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome

...minal discomfort. Patients with carcinoid syndrome currently have limited therapeutic options, and the standard of care includes chronic therapy with somatostatin analogues, which are delivered by injection. With current therapy, the gastrointestinal symptoms return over time in the vast majority of patients, h...

Calvert Research Licenses Novel Technology to Treat Age Related Macular Degeneration from Tulane University

...central vision, and eventual blindness. The preclinical stage compounds licensed by Calvert T1 combine the known anti-proliferative effects of a somatostatin peptide analog with a cytotoxic drug chemically linked to the peptide, resulting in a dual mechanism drug candidate designed to specifically target an...

Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million

...growth in revenue for TP-5 pre-filled injections, contributing to the total increase in TP-5 as a whole.'' Mr. Xueyun Cui continued, ''Sales of somatostatin for injection (3mg) accounted for 8% of total sales in 2008, increasing 39% to $961,266 in 2008 from $692,888 in 2007. This was a result of increased ...

The birth of biotech: San Francisco, Boston, Geneva or Chicago?

...entist Stanley Cohen and University of California at San Francisco scientist Herbert Boyer. Boyer initially worked on human recombinant insulin and somatostatin (a precursor to the human growth hormone). While public and very successful, Genentech unfortunately is still largely owned by Hoffman LaRoche, which ...

Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements

...ting the expression of genes containing SRE and AP-1 or NF-kB binding elements in their promoter, while the CRE element found in somatostatin promoter is very specific to PKA. 7,8-12 MEKK, a protein kinase known to activate the stress signaling pathways and the MAP kin...

Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems

...apable of activating the expression of genes containing SRE and AP-1 or NF- k B binding elements in their promoter, while the CRE element found in somatostatin promoter is very specific to PKA. 19-21 MEKK, a protein kinase known to activate the stress signaling pathways and the MAP kinase pathway, also ...

Somatostatin in Biological Products

Rabbit Anti-Somatostatin 28 Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to somatostatin 28 ( Abpromise for all tested applications). entrezGeneID: 6750 SwissProtID: P61278...
Company:Abcam

Somatostatin in Biological Definition

Hormone

...e stimulating hormone (MSH or α-MSH) neuropeptide Y oxytocin parathyroid hormone (PTH) prolactin (PRL) renin secretin somatostatin thrombopoietin thyroid-stimulating hormone (TSH) thyrotropin-releasing hormone (TRH) Steroid hormones : Glucocorticoids c...

Neurotransmitter

...ecretins: secretin motilin glucagon vasoactive intestinal peptide (VIP) growth hormone-releasing factor (GRF) Somatostatins: somatostatin Tachykinins : neurokinin A neurokinin B neuropeptide A neuropeptide gamma substance P Biogenic amines : acetylcho...