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Solubility in Medical News

FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

...reland, a subsidiary of Elan Corporation plc (NYSE: ELN ). The NanoCrystal(R) Technology is a proven, robust, drug optimization technology, enabling solubility for many poorly water-soluble compounds. More information is available at www.elandrugtechnologies.com . (This press release contains "forwa...

Horse Study: RBC Life Sciences' Antioxidant, Microhydrin, Reduced Lactic Acid Buildup and Improved Hydration During Strenuous Exercise

...face area--bonding absorbed water as well as minerals. Specific silicate interactions play a substantial role in nutrient bioavailability by enhancing solubility properties, improving ion and water transport and also providing free radical antioxidant protection. About RBC Life Sciences RBC Life Sciences ...

Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting

...ealth" properties, making Fleximer(R) materials and their conjugates long-circulating and non-immunotoxic. Fleximer(R) molecules are characterized by solubility in water, with stability in common manufacturing procedures. Mersana's investors include Fidelity Biosciences, ProQuest Investments, Rho Ventures, Ha...

U-M researcher's idea jells into potential new disease-detection method

...ted by particular cue ---in this case, the presence of nitric oxide and oxygen. Other research groups have achieved similar feats with materials whose solubility changes when exposed to triggers (for example, a change in pH). But McNeil had the idea of promoting the process, known as stimuli-induced gelation, b...

NeurogesX Reports Fourth Quarter and Year-End 2008 Results

...ovel prodrugs of acetaminophen, have completed in vivo and in vitro preclinical studies, in which they demonstrated approximately 10 times greater solubility in water versus acetaminophen. NGX-1576, a novel prodrug coupling acetaminophen to a liver protectant, has been evaluated in vitro and in ...

Frost & Sullivan Lauds OVATION Pharmaceuticals for Its Business Model and Ability to Sustain Growth

...ocaine and methamphetamine dependence where there continues to be a significant unmet need for effective pharmacological therapy. Having overcome solubility issues plaguing others attempting to bring to market an intravenous (IV) reformulation of the oral antiepileptic carbamazepine, OVATION's IV carbamaze...
Solubility in Medical Technology

Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

...land, a subsidiary of Elan Corporation plc (NYSE: ELN ). The NanoCrystal((R)) Technology is a proven, robust, drug optimization technology, enabling solubility for many poorly water-soluble compounds. More information is available at www.elandrugtechnologies.com . (This press release contains "forward...

Archimedes Pharma Announces Successful Proof-of-Concept Results on Two Intranasal Development Projects

...ability to both patients and physicians combined with ease/speed of use and rapid onset of action. Archimedes' unique formulation is based on enhanced solubility providing a stable, high strength solution, allowing a wide range of doses to be administered in a small spray volume using conventional, approved nas...

Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery

...n. We also will examine the ability of the PCT SPS to facilitate biochemical studies of mitochondrial constituents that are often otherwise limited by solubility concerns. If successful, this work would facilitate drug development in the above diseases, generally aid research into the roles that mitochondria pl...

Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)

... by increasing drug circulation time in the bloodstream, decreasing immunogenicity and dosing frequency, increasing bioavailability and improving drug solubility and stability. It can also be used to modify pharmaceutical agents to preferentially target certain systems within the body. It is a technique in whic...

Significant Anti-Tumor Activity of NKTR-102 in Patients With Refractory Solid Tumors; Interim Data Published in ASCO 2008 Proceedings

...asing drug circulation time, improving pharmacokinetics, decreasing immunogenicity and dosing frequency, increasing bioavailability and improving drug solubility and stability. "The impressive Phase 1 results with NKTR-102 represent a major advancement for our small molecule PEGylation platform," said Howard ...

NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting

... by increasing drug circulation time in the bloodstream, decreasing immunogenicity and dosing frequency, increasing bioavailability and improving drug solubility and stability. It can also be used to modify pharmaceutical agents to preferentially target certain systems within the body and reduce penetration of ...
Solubility in Medical Products

Hemoglobin S, Evaluationwith reflex to RBC Solubility

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

SICKLEDEX

Description:... SICKLEDEX detects the presence of Hemoglobin S in patient samples. Each test requires 2ml of reconstituted solubility buffer and 20l of anticoagulated whole blood or 20l of sickle cell hemoglobin control. Each test kit contains two bottles of phosphate buffer with Sap...
Company:Streck

Sickle-Chex Hemoglobin S Control

Description:...nd negative whole blood control to test for the presence of Hemoglobin S in solubility tests and hemoglobin electrophoresis. Sickle-Chex is compatible with Streck SICKLEDEX and other manufacturers' solubility kits. Sickle-Chex is packaged in a 2.5ml plastic squeeze dropper vial. The ...
Company:Streck
Solubility in Medical Dictionary

Uric acid

...ls of uric acid . ... Uric acid is the end-product of purine nucleotide metabolism in man. ... At the normal acidic region, uric acid solubility is strongly increased by urinary pH. ... Read how this simple inexpensive test has been shown to be highly predictive of one's risk for heart di...

Ammonia

...onia n. A colorless, pungent gas, NH 3 , extensively used to manufacture fertilizers and a wide variety of nitrogen-containing organic and high solubility of ammonia in water. ... is established between dissolved ammonia gas and ammonium ions. ... words, ammonia is a weak base. ... Ammonia is...
Solubility in Biological News

Natural-born divers and the molecular traces of evolution

...strial relatives, and they have speculated that this may help improving the solubility of the molecule. This is important as divers may contain 10 times more myo...itat preference. "This work will contribute to our understanding of protein solubility in general", explains Dr.Berenbrink. "It will also allow the analysis of na...

University awarded £1.7M to develop nanotechnology for use in health care

... Pharmacology will apply nanotechnology techniques to develop new approaches for future drug development. Many medicines currently in use have poor solubility and have to be administered in large doses to ensure that enough of the drug is absorbed into the body to be effective. Scientists, working closely wi...

Engineers develop method to disperse chemically modified graphene in organic solvents

...ed by industry to determine the solvents most likely to dissolve certain materials or to create good colloids, the researchers have developed a set of solubility parameters for chemically modified graphenes," Ruoff added. "We believe that this approach will have exceptional utility for technology transition in ...

October 2008 GEOLOGY and GSA TODAY media highlights

...t water depths. The Black Sea is an archetype of recent marine anoxic (oxygen free) environments. The author's isotope results confirm that molybdenum solubility is strongly related to the amount of dissolved sulphide in the water column. Further, molybdenum isotopes indicate that there is a well-defined thresh...

'Buckyballs' have high potential to accumulate in living tissue

...plicates efforts to understand how they might be dispersed by water in the environment. "Typically, buckyballs are not found in water because their solubility is so low, but the same could be said of DDT," Jafvert said. "DDT is found in sediment, so you would assume buckyballs would also end up in sediments....

Improved technique determines structure in membrane proteins

...ion structural information, and thereby be able to better understand the function of the proteins." Solid-state NMR spectroscopy relaxes the need for solubility of the sample. In solution NMR spectroscopy, molecules are allowed to tumble randomly in the magnetic field. In solid-state NMR spectroscopy, molecule...
Solubility in Biological Technology

NeurogesX Reports Second Quarter 2009 Results

...el prodrugs of acetaminophen, have been evaluated in in vivo and in vitro preclinical studies and have demonstrated approximately 10 times greater solubility in water versus acetaminophen. NGX-1576, a novel prodrug coupling acetaminophen to a liver protectant, has been evaluated in vitro and in vi...

Champions Biotechnology Partners with Do-Coop Technologies to Advance Its Novel Oncology Compound Into Biomerk Tumorgraft(TM) Testing

...ent in Champions' drug development pipeline. Using Neowater((R)), a novel proprietary water-based nanotechnology, Do-Coop has been able to improve the solubility and activity of SG410. SG410 is an antimitotic inhibitor that was shown in Biomerk Tumorgraft models to target microtubule associated protein...

Mersana Reports Preliminary Phase 1 Results of XMT-1001 in Patients with Advanced Solid Tumors

...ealth" properties, making Fleximer(R) materials and their conjugates long-circulating and non-immunotoxic. Fleximer(R) molecules are characterized by solubility in water, with stability in common manufacturing procedures. About Mersana Therapeutics, Inc. Mersana Therapeutics employs its biodegradable...

NeurogesX Reports First Quarter 2009 Results

..., novel prodrugs of acetaminophen, have been evaluated in in vivo and in vitro preclinical studies and demonstrate approximately 10 times greater solubility in water versus acetaminophen. NGX-1576, a novel prodrug coupling acetaminophen to a liver protectant, has been evaluated in vitro and in ...

Zymes Omega Solutions Bottles and Launches the World's First Omega-3 Enhanced Water

...ith an average particle size of 25 nanometers, thus allowing for the formulation to be crystal clear in water. Zymes Omega Solutions, a leader in the solubility and stability of omega-3 fatty acids, offers formulation services and private label solutions in select categories. The technology is also available ...

Sigma-Aldrich Signs Agreement With CPC Scientific for the Distribution of PEPscreen(R) Custom Peptide Libraries

...duce almost all commercially available peptide modifications. All peptides are delivered with full documentation including HPLC, Mass Spectrometry and solubility information plus a 100% Customer Satisfaction Guarantee. The Company has in-house AAA capabilities. For more information about CPC Scientific, pleas...
Solubility in Biological Products

Bacterial system service from Abgent

Description:... Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. Expected yield and timeline: 2-5 mg/L in 4 weeks....
Company:Abgent

LIC Duet™ Trx•Tag™ Ek Adaptor from Novagen

Description:...Trx•Tag coding sequence. The Trx•Tag is a 109 aa sequence that encodes thioredoxin. Fusion to this sequence has been demonstrated to enhance solubility of many proteins that are typically insoluble in E. coli ...
Company:Novagen

LIC Duet™ GST•Tag™ Ek Adaptor from Novagen

Description:...tion codon and an N-terminal GST•Tag coding sequence. The GST•Tag sequence has been reported to enhance the production and in some cases the solubility of its fusion partners. The GST•Tag is a multi-purpose tag that can be used for purification, quantification, and detection of fusion protein wit...
Company:Novagen

Freedom EVO 150 from Tecan

Description:...LDI spotting Protein crystallization and crystallization set-up Protein solubility Recombinant protein purification Drug Discovery Compound synthesis ... brain barrier permeability Skin permeability Eye irritation Compound solubility Cytochrome P450 inhibition Cell migration, invasion assays Metabolite...
Company:Tecan

Nepehloskan Ascent w/ 1st dispenser from Thermo Scientific

Description:...ent in microplates. Nepheloskan measures light scattering and offers an ultra-sensitive technique for particle quantification. This makes it ideal for solubility testing in drug discovery, immunoprecipitation, and microbial growth applications among others....
Company:Thermo Scientific

SOS Soluble Protien Service from Genlantis

Description:... SOS Protein solubility Service We deliversoluble protein or No Charge t...ology yields the best soluble protein results 24 solubility optimization parameters applied on each clone subm...s on your most insoluble clones The new protein solubility Optimization Service (SOS) uses proprietary tools ...
Company:Genlantis
Solubility in Biological Definition

Alcohol

...n form hydrogen bonds to one another and to other compounds. Two opposing solubility trends in alcohols are: the tendency of the polar OH to promote solubility in water, and of the carbon chain to resist it. Thus, methanol, ethanol, an...

Amine

...he chemical reactions shown in this article represent the lone electron pairs on the nitrogens in the amines. These lone pairs also contribute to the solubility of simple amines due to hydrogen bonding between water molecules and the lone electron pairs. Also, a halogenoalkane can react with an am...

Chromatography

...tionary phase to separate the components in a mixture. Components of a mixture may be interacting with the stationary phase based on charge, relative solubility or adsorption. There are two theories of chromatography, the plate and rate theories. Retention The retention is a measure of the speed at wh...

Genetic code

...titution in sickle cell anaemia is disasterous. The hydrophilic glutamate (Glu) is substituted by the hydrophobic valine (Val) which reduces the solubility of -globin. This causes haemoglobin to form linear polymers linked by the hydrophobic interaction between the valine groups causing sickle cell deform...

Ethyl alcohol

...K (241C, 465.53F) 63 bar Δ fus H 4.9 kJ/mol Δ fus S 31 J/molK Δ vap H 38.56 kJ/mol solubility Soluble in water Acid-base properties pKa 15.9 pH 7.0 (Neutral) Liquid properties Δ ...

Genetic code

...titution in sickle cell anaemia is disasterous. The hydrophilic glutamate (Glu) is substituted by the hydrophobic valine (Val) which reduces the solubility of -globin. This causes haemoglobin to form linear polymers linked by the hydrophobic interaction between the valine groups causing sickle cell deform...
Solubility in Biological Dictionary

Diffusion

... ... Facilitated diffusion depends on carrier proteins imbedded in the membrane to ... Rate of Diffusion = gradient x temp X surface area · solubility ... Hydrophilic molecules cannot participate in simple diffusion because they ... Definition and other additional information on Diffusion from...
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