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Smallpox in Medical News

Scientists discover how smallpox may derail human immune system

GAINESVILLE, Fla. University of Florida researchers have learned more about how smallpox conducts its deadly business discoveries that may reveal as much about the human immune system as they do about one of the world's most feared pathogens. In findings to be published this week in the onlin...

Japanese Researchers Develop New Smallpox Vaccine

No serious side effects are found in latest test, study reports,, TUESDAY, March 10 (HealthDay News) -- A third-generation tissue-cultured smallpox vaccine shows promise, Japanese researchers report. "The threat of smallpox bioterrorism has prompted reconsideration of the need for s...

NIH awards LIAI major grant to test safety of new smallpox treatment

SAN DIEGO (May 8, 2008) The La Jolla Institute for Allergy & Immunology (LIAI) has received a $7.1 million grant from the National Institutes of Health (NIH) to fund safety and effectiveness testing of an antibody treatment that quickly fights the smallpox virus. The treatment could be the natio...

Bavarian Nordic Reports Positive Data from First EUA Enabling Study with IMVAMUNE(R) Smallpox Vaccine Candidate

WASHINGTON, DC, November 29 /PRNewswire-FirstCall/ -- Bavarian Nordic reports the successful completion of a large, placebo-controlled Phase II trial in 745 healthy subjects who received either one or two doses of IMVAMUNE(R) next-generation smallpox vaccine candidate. The results of this stud...

Genetic Variations Leads to Fever After Smallpox Vaccination

St. Louis researchers have identified common DNA variations that underlie susceptibility to fever after smallpox vaccination. Most of the eight genetic alterations the scientists identified increased the likelihood of fever after smallpox vaccination. A few, however, reduced fever risk. The s...

Study Finds That Lincoln Suffered from Smallpox During Gettysburg Speech

US President Abraham Lincoln delivered his famous Gettysburg Address, he was in the early stages of a deadly form of smallpox, a new study by two University of Texas researchers, has revealed. Some historians, who recognized that Lincoln was ill, following his Gettysburg speech, asserted t...

Toddler Infected With Rare Side Effect Of Smallpox Vaccination Recovering

The quote there is nothing as lovely as the feet of those who bring good tidings, could not be more apt . There is finally, good news from the University of Chicago Comer Childrens Hospital, which was witness to one of the most horrific side effects of the smallpox vaccine, and unfortunately, on...

HHS Buys Next Generation Smallpox Vaccine

WASHINGTON, HHS Secretary Mike Leavitt announced today that HHS has awarded a contract for $500 million to Bavarian Nordic A/S of Copenhagen, Denmark to manufacture and deliver 20 million doses of a next generation modified vaccinia Ankara (MVA) smallpox vaccine. The vaccine would be recom...

New Smallpox Vaccine Contract: Five Years in the Making

On December 13, 2002, fifteen months after the 9/11 terrorist attacks, President George W. Bush went to Room 450 of the Dwight D. Eisenhower Executive Office Building next door to the White House and said: "We know that smallpox still exists in laboratories, and we believe that regimes host...

New Evidence Links Smallpox Vaccination Side Effects to Genetic Factors

Boffins have found new evidence that supports the link between genetic factors and certain adverse reactions related to smallpox vaccination . Immunization with live virus particles, as in the smallpox vaccine, is sometimes found to cause reactions that range from fatigue to serious illness...

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Smallpox in Medical Technology

The Government of Canada Procures IMVAMUNE(R) Smallpox Vaccine for the Country's Biological Preparedness

KVISTGARD, Denmark, December 1 /PRNewswire-FirstCall/ -- Following a Request for Proposal issued in 2007 with the intent to procure an MVA-based, third generation smallpox vaccine, Public Works and Government Services Canada, on behalf of the Canadian Department of National Defence, has awarde...

Albemarle Optimizes Smallpox Drug Candidate for SIGA

Fine Chemistry Services unit demonstrates pilot production for "fast track" drug BATON ROUGE, La., May 5 /PRNewswire-FirstCall/ -- Two American companies are teaming up for second-round test-phase production of a FDA-designated "fast track" drug candidate to trea...

Chimerix Initiates a Multi-dose Clinical Trial of the Company's Lead Compound, CMX001, for the Treatment for Smallpox Infection

RESEARCH TRIANGLE PARK, N.C., Dec. 11 /PRNewswire/ -- Chimerix, Inc., a biotechnology company developing orally available antiviral therapeutics, announced today that the Company has initiated a multi-dose trial with its lead drug candidate, CMX001, an oral treatment for smallpox infection. Th...

Aethlon Medical to Present at the 2009 RedChip Small-Cap Investor Conference on June 16, 2009

...rd Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and Vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers representing: The U.S. Army Medical Research Institute of Infectious Disease...

BN ImmunoTherapeutics Updates on Phase I/II Studies With Breast Cancer Vaccine

...vectors. Bavarian Nordic has ongoing contracts with the US government for the late-stage development and procurement of the company's third-generation smallpox vaccine, IMVAMUNE(R). Bavarian Nordic is listed on the OMX NASDAQ under the symbol BAVA. For more information, please visit: http://www...

Bavarian Nordic Reports Successful Safety Data From Phase II Study With IMVAMUNE(R)

... emergency. In support of using IMVAMUNE(R) as a smallpox vaccine in individuals otherwise contraindicated t...who are excluded from vaccination with traditional smallpox vaccines. The complete data set from this trial ...h a history of previous exposure to a conventional smallpox vaccine). This announcement does not change Bava...

AlphaVax Continues to Expand the Use of Its Vaccine Platform

...warded a second grant to continue development of a smallpox vaccine based on AlphaVax's proprietary vector pla...he first grant period demonstrated that AlphaVax's smallpox vaccine, which expresses four, highly conserved po... working with the U.S. Government to advance a new smallpox vaccine that has an excellent safety profile and i...

BN ImmunoTherapeutics Starts Clinical Trials With Prostate Cancer Vaccine

...vectors. Bavarian Nordic has ongoing contracts with the US government for the late-stage development and procurement of the company's third-generation smallpox vaccine, IMVAMUNE(R). Bavarian Nordic is listed on the OMX Nordic Exchange Copenhagen under the symbol BAVA. For more information, please visit: ...

GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2007 Financial Results

...ightly binding Ab. GeoVax studies in non-human primates clearly show this Ab correlates with protection. -- GeoVax vaccines use an attenuated smallpox vaccine to provide pulses of HIV proteins (antigen) to stimulate protective anti-AIDS vaccine responses. Pulses of antigen from the GeoVax...

GeoVax Labs, Inc. Third Quarter Financial Results and Operational Update

...ly binding Ab. GeoVax studies in non-human primates clearly show this Ab correlates with protection. * GeoVax vaccines use an attenuated smallpox vaccine to provide pulses of HIV proteins (antigen) to stimulate protective anti-AIDS vaccine responses. Pulses of antigen from the Ge...
Smallpox in Medical Definition

Anthrax Vaccine Immunization Program

...g up to the 2003 invasion of Iraq , all military personnel were required to get anthrax vaccination [6] (in addition to their other vaccinations of smallpox and other diseases and viruses like Japanese encephalitis, Pneumococcal, Tetanus, among others [7] ). While some military personnel had questions...

Artificial induction of immunity

...cs. Contents 1 Variolation and smallpox 2 Vaccination 3 Germ theory ...References Variolation and smallpox See main articles variolation and smallpox . Typical site of inoculation in Eu...
Smallpox in Medical Dictionary

Smallpox

Smallpox is an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the... Smallpox is an acute contagious disease caused by va...

Vaccine

...ng > Vaccine Shortages. Advanced Search ... Information about the smallpox vaccine from the American Academy of Family Physicians. ... was wiped ou...finitely will not be the first office to offer the vaccine . ... ... smallpox Vaccine . 18 ... Studies Conducted with ACAM2000 Vaccine , and Master and...

Vaccination

... and ... Also, immunity develops rapidly after vaccination against smallpox (see above) ... Complications of vaccination ... Vaccination is contra...... Vaccinated people can transmit vaccinia virus ... Complications of smallpox vaccination , Maryland 1968. ... Global Insight's unique perspective ...

Pustules

...d bumps on the skin that are filled with pus ( pustules ) ... Pustules may be localized to the palms and soles (palmoplantar pustulosis) ... smallpox (also called variola) is the only disease that has been completely ... usually happens before typical pustules developed Reprinted with permission...

Inoculation

...ave. Buy.com books: new ~ used ~ paperbacks ~ NYTBS at the cheapest prices. Inoculation , however, was not without risk. ... For a discussion of smallpox inoculation and its introduction into Europe and ... City fathers in Boston immediately outlawed the use of inoculation . ... Some writers aga...
Smallpox in Biological News

New study indicates smallpox vaccination effective for decades

New York, December 1, 2008 Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population. Under such circumstances, the supply of smallpox vaccine may be insufficient for universal admin...

Most people believe smallpox not an extinct disease

The vast majority of Scottish people interviewed in the streets of Edinburgh are unaware of one of the greatest achievements of medical science the eradication of smallpox from the world over 40 years ago. A poll sponsored by the Society for General Microbiology (SGM), in conjunction with the Edi...

New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed

Smallpox is older than thought, according to results of a new technique reported in the Sept. 24 issue of the Proceedings of the National Academy of Sciences by researchers from Lawrence Livermore National Laboratory and the Centers for Disease Control (CDC). The researchers created a molecular...

Innovative smallpox vaccine research study to be conducted at Case Medical Center

University Hospitals Case Medical Center (UHCMC) and Case Western Reserve University School of Medicine are part of a nationwide research study to determine the safety and effectiveness of a new smallpox vaccine geared toward adults ages 18 to 34 who have never been vaccinated against the disease....

Genetic factors are linked to fever following smallpox vaccination

New evidence supports the link between genetic factors and certain adverse events related to smallpox vaccination. The study, published in the July 15th issue of The Journal of Infectious Diseases, now available online, may have implications for predicting adverse events from other live vaccines....

Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack

Mass vaccination would not be necessary in the event of a large-scale smallpox bioterrorist attack in the United States, according to a study led by researchers at Fred Hutchinson Cancer Research Center that appears online in the International Journal of Infectious Diseases. Instead, the current ...

Defective immune system response to smallpox vaccine detailed in new study

Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have identified a defect in the immune response of people with the skin condition atopic dermatitis that puts them at risk of developing serious complications ...

Serious adverse reactions to smallpox vaccine appear to be limited

There was a low rate of life-threatening adverse reactions to the smallpox vaccine administered to potential first responders to a bioterrorism incident, possibly attributable to rigorous vaccine safety screening and educational programs, according to a study in the December 7 issue of JAMA. Rout...

Researchers develop new testing methods for potential monkeypox or smallpox outbreak

Researchers at the Vaccine and Gene Therapy Institute (VGTI) at Oregon Health & Science University have developed new diagnostic methods to better detect future monkeypox or smallpox outbreaks. The research also sheds new light on the 2003 monkeypox outbreak in the Midwest -- monkeypox is close...

LIAI scientists make major finding on potential smallpox treatment

Research could lead to treatment that would help stop a smallpox outbreak Researchers at the La Jolla Institute for Allergy & Immunology (LIAI) have made a major advancement toward protecting society against a smallpox outbreak by identifying an antibody in humans that quickly fights the sma...

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Smallpox in Biological Technology

New study indicates smallpox vaccination effective for decades

New York, December 1, 2008 Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population. Under such circumstances, the supply of smallpox vaccine may be insufficient for universal admin...

New study indicates smallpox vaccination effective for decades

New York, December 1, 2008 Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population. Under such circumstances, the supply of smallpox vaccine may be insufficient for universal admin...

Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks

Data published in February issue of Clinical and Vaccine Immunology ANN ARBOR, Mich., Feb. 26 /PRNewswire/ -- Scientists at NanoBio Corporation and the University of Michigan have demonstrated their nasally delivered vaccinia vaccine can protect animals against 77 times the potentially letha...

Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine in Persons With Atopic Dermatitis/Eczema

WASHINGTON, October 10 /PRNewswire-FirstCall/ -- The National Institutes of Allergy and Infectious Diseases (NIAID) has extended an existing contract (RFP-2) with Bavarian Nordic to include the initiation of a larger Phase II study with IMVAMUNE(R), the company's investigational smallpox vacci...

FDA Approves ACAM2000(TM) Vaccine for Protection Against Smallpox

Highly Successful Collaboration With CDC to Ensure US's Preparedness Against the Threat of a Smallpox-Related Public Health Emergency CAMBRIDGE, England and CAMBRIDGE, Massachusetts, September 3 /PRNewswire-FirstCall/ -- Acambis plc (Acambis) (LSE: ACM), a leading vaccine company, announc...

First genetically engineered malaria vaccine to enter human trials

...is approach to vaccine development using a weakened form of the whole organism that causes a particular disease has proven successful in eradicating smallpox and controlling diseases such as flu and polio. Professor Cowman said the research team, which includes Dr Matthew O'Neill and Dr Alex Maier from th...

Chimerix, Inc. Appoints Kenneth I. Moch Chief Operating Officer

...and is currently being developed as a biodefense agent for the treatment of smallpox and complications associated with smallpox vaccination, as well as for the treatment of infections that cause morbidit...

Thomson Reuters Examines Highly Cited Research in Bioterrorism

...per has now been cited more than 400 times. The third most-cited paper, published in 1999 and garnering more than 375 citations, discusses the use of smallpox as a biological weapon. For the complete rankings of total citations and citation impact in the bioterrorism field, as well as a rundown of the m...

The Court Supports Bavarian Nordic's Decision to Start Patent Infringement Case Against Oxford BioMedica

...ian Nordic owns several United States patents relating to an attenuated strain of the company's core technology, MVA-BN(R), which is the basis for its smallpox vaccine, IMVAMUNE(R). MVA-BN(R) also holds promise as a vector for delivering recombinant vaccines. Bavarian Nordic has asserted four US patents as a ...

Bavarian Nordic Announces its Interim Report for the Period 1 January to 31 March 2009

...from the delivery of IMVAMUNE(R) to the United States under the RFP-3 contract and billing of the continuation of the RFP-2 contract and contracts for smallpox vaccines already entered with other countries. Forward-looking statements This announcement includes "forward-looking statements" that i...
Smallpox in Biological Definition

Edward Jenner

... , England , famous for his work introducing the smallpox vaccine . Jenner's early education included a... achievements. In Jenner's time, the practice of smallpox inoculation was commonplace in England. However ...-called ' cowpox ' protected one from contracting smallpox . (It has been theorized that the romantic image o...

Louis Pasteur

... not new: this had been known for a long time for smallpox . Inoculation with smallpox was known to result in far less scarring and great...time this had generally replaced the use of actual smallpox material in inoculation. The difference with chick...

Outbreak

... pandemic (a global epidemic). Major human epidemic viruses include influenza , Human Immunodeficiancy Virus ( HIV ), measles , and rubella . smallpox has been eradicated as a major epidemic virus, however emerging viruses and engineered viruses pose a significant challenge for the future. HIV is n...

Vaccine

...pox , which, when administered to humans, provided them protection against smallpox . Contents showTocToggle("show","hide") 1 Types of vaccine...ltiply to vast numbers. Vaccines have contributed to the eradication of smallpox , one of the most contagious and deadly diseases known to man. Other disea...

Virus classification

... Family Plasmaviridae Family Polyomaviridae - e.g. Simian virus 40 Family Poxviridae - e.g. Cowpox virus , Variola virus ( smallpox ) Family Rudiviridae Family Tectiviridae Unassigned genera Mimivirus ; type species: Acanthamoeba polyphaga mimivirus ...

Virus

...aused by any one of a variety of related viruses; smallpox ; AIDS , which is caused by HIV ; and cold sores... in a laboratory. Much concern revolves around the smallpox virus, which has devastated numerous societies thr...istory, and today is extinct in the wild. In fact, smallpox has been used in a crude form of biological warfar...
Smallpox in Biological Dictionary

Synapton

...ar Genetics and Physics of Complex System, Weizmann ... Horesh O, Simchen G, Friedmann A: Morphogenesis of the synapton during yeast meiosis. ... smallpox Vaccine, Vaccinia Vaccine. Snap Back® Sodium Bicarbonate ... Synagis™ Synalar® Synalgos®-DC. Synapton ® Synemol® Synercid® Synthroid® Syntocinon® ......

Mycelium

...D Talks Mycologist Paul Stamets lists 6 ways the mycelium fungus can help save the universe: cleaning polluted soil, making insecticides, treating smallpox and ... ... Suppliers. Find a reliable & professional Mycelium manufacturer or supplier. ... Mushroom Extract and Mycelium Powder ... Cordy...
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