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Smac in Medical News

Smac-ing lung cancer to death

...ath machinery. When that machinery is switched on, smac is released from the mitochondria and triggers the...earchers have developed small-molecule mimetics of smac that can enter the cell and trigger apoptosis. The...molecules do their damage without the need for the smac signal from the mitochondria. In earlier studies, ...
Smac in Medical Technology

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...pm Synergistic anti-tumor effect with Nathalie combination of a novel small Bruey-Sedano, molecule smac mimetic compound PhD, (SM-164) and agonist TRAIL-R Ascenta monoclonal Abs (mapatumumab & ...
Smac in Biological News

Synthetic compound promotes death of lung-cancer cells, tumors

...y cells unaffected. In those studies, however, the smac mimic only killed cancer cells when it was introdu...ound that 22 percent of them were sensitive to the smac mimic alone, without having to add TNFa. The researchers also found that the smac mimic alone was effective against some types of br...
Smac in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...cade of protein signaling that activates enzymes called caspases to initiate breakdown of the cancer cell. AT-406 is thought to mimic the activity of smac (second mitochondria-derived activator of caspases) by binding to XIAP and preventing it from inhibiting caspase activation. Upon binding, AT-406 ind...

Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS

... (GX15-070), an innovative pan Bcl-2 inhibitor, and GMX1777, a novel inhibitor of NAD+ synthesis, and preclinical studies for its Telomere Capping and smac Mimetic programs. Potential treatment indications for the full scope of pipeline programs span a broad range of hematological and solid tumors, includ...
Smac in Biological Definition

Apoptosis

...apoptotic stimulus, IAP activity is relieved after smac (Second Mitochondria-derived Activator of Caspases...hondrial protein, is released into the cytosol . smac binds to IAPs, and in doing so "inhibits the inhib... But before we go on to a short description of how smac is released, lets take a look at two well-studied ...
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(Date:7/9/2014)... The liver is one of the most important organs ... that we utilize our food properly this is ... removed from our organism this is its detoxification ... and unhealthy food all damage the liver. The resulting ... deposits, cirrhoses, and life-threatening liver failure. According to the ...
(Date:7/9/2014)... studies linking older age with kidney and heart disease ... donation among older adults. However, in the first study ... Perelman School of Medicine at the University of Pennsylvania ... enjoy similar life expectancy and cardiovascular health as very ... In light of the ever increasing organ transplant waitlists, ...
(Date:7/9/2014)... has risen dramatically in Western societies. One frequently cited ... and have fewer infections than previous generations, thereby delaying ... researchers at Sahlgrenska Academy, University of Gothenburg, monitored children ... the immune system in relation to allergic disease. All ... Vstra Gtaland Region, half of them on farms that ...
(Date:7/8/2014)... awarded up to $15 million by the Defense Advanced ... aiming to help brain-injured people restore lost memory functions. ... psychology and physics will collaborate to create, surgically implant, ... Memory is the process in which neurons in certain ... retrieve it. Certain types of illnesses and injuries disrupt ...
(Date:7/8/2014)... found to be three times higher when auditors were ... auditors present, according to a study in a major ... "Quantification of the Hawthorne effect in hand hygiene compliance ... study," published today on-line in the BMJ Quality ... Srigley, who did the study as part of her ...
Breaking Medicine News(10 mins):Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3
(Date:7/9/2014)... Sexual selection refers to species, selection for traits that ... of natural selection enhances opportunities to mate, the tail ... at the University of California, Riverside have now found ... a placenta are linked. Describing the life histories ... family Poeciliidae, the researchers found that species with placentas ...
(Date:7/9/2014)... (TCGA) Research Network have identified novel mutations in ... most common subtype of lung cancer. Knowledge of ... possible therapeutic targets for this disease and potentially ... mutations because many potent cancer drugs that target ... funded and managed by the National Cancer Institute ...
(Date:7/9/2014)... With grilling season upon us, many backyard cooks are ... fatty hot dogs. But low fat can sometimes mean ... addressing the texture problem in low-fat wieners that are ... study was published in ACS, Journal of Agricultural ... colleagues note that hot-dog consumers have come to expect ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Study identifies novel genomic changes in the most common type of lung cancer 2Study identifies novel genomic changes in the most common type of lung cancer 3
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