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Smac in Medical News

Smac-ing lung cancer to death

...ath machinery. When that machinery is switched on, smac is released from the mitochondria and triggers the...earchers have developed small-molecule mimetics of smac that can enter the cell and trigger apoptosis. The...molecules do their damage without the need for the smac signal from the mitochondria. In earlier studies, ...
Smac in Medical Technology

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...pm Synergistic anti-tumor effect with Nathalie combination of a novel small Bruey-Sedano, molecule smac mimetic compound PhD, (SM-164) and agonist TRAIL-R Ascenta monoclonal Abs (mapatumumab & ...
Smac in Biological News

Synthetic compound promotes death of lung-cancer cells, tumors

...y cells unaffected. In those studies, however, the smac mimic only killed cancer cells when it was introdu...ound that 22 percent of them were sensitive to the smac mimic alone, without having to add TNFa. The researchers also found that the smac mimic alone was effective against some types of br...
Smac in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...cade of protein signaling that activates enzymes called caspases to initiate breakdown of the cancer cell. AT-406 is thought to mimic the activity of smac (second mitochondria-derived activator of caspases) by binding to XIAP and preventing it from inhibiting caspase activation. Upon binding, AT-406 ind...

Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS

... (GX15-070), an innovative pan Bcl-2 inhibitor, and GMX1777, a novel inhibitor of NAD+ synthesis, and preclinical studies for its Telomere Capping and smac Mimetic programs. Potential treatment indications for the full scope of pipeline programs span a broad range of hematological and solid tumors, includ...
Smac in Biological Definition

Apoptosis

...apoptotic stimulus, IAP activity is relieved after smac (Second Mitochondria-derived Activator of Caspases...hondrial protein, is released into the cytosol . smac binds to IAPs, and in doing so "inhibits the inhib... But before we go on to a short description of how smac is released, lets take a look at two well-studied ...
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(Date:11/27/2014)... According to a recent report by iData Research ... the surgical robotics market may find significant ... field dominated by Intuitive. These companies are expected to ... by 2020. , “The MIS robotic device market ... President of iData. “System sales for the da Vinci ...
(Date:11/27/2014)... Luciana Lagana and her husband ... Omadox, a feature film that received 9 awards at the ... ensemble cast. It is also an official selection of the ... a successful cinematic career for James Noel, a young filmmaker ... enjoy experimental mystery, filmed in glorious black and white, watching ...
(Date:11/27/2014)... 27, 2014 Cambrionix Ltd today announced that ... 50, a ranking of the 50 fastest-growing technology companies in ... over the last five years. Cambrionix Ltd grew 2989 ... first in the region of Cambridgeshire and East and first ... Says:, “This award is recognition of the hard work put ...
(Date:11/27/2014)... Acapulco, Guerrero (PRWEB) November 27, 2014 ... the time individuals allot to sleep has lessened, ... televisions and laptops, the quality of sleep has ... workers falls asleep on the job (Reference: ... American worker’s productivity index by an incalculable amount, ...
(Date:11/27/2014)... Blood-borne pathogens raise the risk of ... procedures in place to counter this. However, it doesn’t ... tainted with menstrual blood are taken as seriously. ... sanitary way to handle tampons and menstrual pads while ... Calif. , He then created a prototype of the ...
Breaking Medicine News(10 mins):Health News:U.S. Robotic Surgery Market Set to Diversify and Grow: Intuitive Surgical’s ‘da Vinci’ Robot Revenues to Increasingly Rely On Procedures and Services 2Health News:Luciana Lagana and Gregory Graham Join the Award-Winning Cast of the Black-and-White Experimental Mystery Feature Film Omadox. 2Health News:Luciana Lagana and Gregory Graham Join the Award-Winning Cast of the Black-and-White Experimental Mystery Feature Film Omadox. 3Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 2Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 3Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 4Health News:Research Shows Surprising Number of US Workers Affected by Lack of Sleep 2
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
(Date:11/6/2014)... -- A groundbreaking paper from a team of Florida ... of how plants could adapt to and survive environmental ... published in the latest issue of the journal ... (the complex of DNA and proteins) is organized in ... that some genes are turned on and others are ...
(Date:11/5/2014)... Fidel Santamaria, associate professor of biology in the ... researchers in the nation selected to receive a ... Grant for Exploratory Research (EAGER). The funding supports ... support researchers to create new technology that will ... Santamaria, complex behaviors in neuroscience are broken into ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
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