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Smac in Medical News

Smac-ing lung cancer to death

...ath machinery. When that machinery is switched on, smac is released from the mitochondria and triggers the...earchers have developed small-molecule mimetics of smac that can enter the cell and trigger apoptosis. The...molecules do their damage without the need for the smac signal from the mitochondria. In earlier studies, ...
Smac in Medical Technology

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...pm Synergistic anti-tumor effect with Nathalie combination of a novel small Bruey-Sedano, molecule smac mimetic compound PhD, (SM-164) and agonist TRAIL-R Ascenta monoclonal Abs (mapatumumab & ...
Smac in Biological News

Synthetic compound promotes death of lung-cancer cells, tumors

...y cells unaffected. In those studies, however, the smac mimic only killed cancer cells when it was introdu...ound that 22 percent of them were sensitive to the smac mimic alone, without having to add TNFa. The researchers also found that the smac mimic alone was effective against some types of br...
Smac in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...cade of protein signaling that activates enzymes called caspases to initiate breakdown of the cancer cell. AT-406 is thought to mimic the activity of smac (second mitochondria-derived activator of caspases) by binding to XIAP and preventing it from inhibiting caspase activation. Upon binding, AT-406 ind...

Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS

... (GX15-070), an innovative pan Bcl-2 inhibitor, and GMX1777, a novel inhibitor of NAD+ synthesis, and preclinical studies for its Telomere Capping and smac Mimetic programs. Potential treatment indications for the full scope of pipeline programs span a broad range of hematological and solid tumors, includ...
Smac in Biological Definition

Apoptosis

...apoptotic stimulus, IAP activity is relieved after smac (Second Mitochondria-derived Activator of Caspases...hondrial protein, is released into the cytosol . smac binds to IAPs, and in doing so "inhibits the inhib... But before we go on to a short description of how smac is released, lets take a look at two well-studied ...
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