Smac-ing lung cancer to death
...ath machinery. When that machinery is switched on, smac
is released from the mitochondria and triggers the...earchers have developed small-molecule mimetics of smac
that can enter the cell and trigger apoptosis. The...molecules do their damage without the need for the smac
signal from the mitochondria. In earlier studies, ...
Smac in Medical Technology
Smac in Biological News
Synthetic compound promotes death of lung-cancer cells, tumors
...y cells unaffected. In those studies, however, the smac
mimic only killed cancer cells when it was introdu...ound that 22 percent of them were sensitive to the smac
mimic alone, without having to add TNFa. The researchers also found that the smac
mimic alone was effective against some types of br...
Smac in Biological Technology
Smac in Biological Definition
...apoptotic stimulus, IAP activity is relieved after smac
(Second Mitochondria-derived Activator of Caspases...hondrial protein, is released into the cytosol . smac
binds to IAPs, and in doing so "inhibits the inhib... But before we go on to a short description of how smac
is released, lets take a look at two well-studied ...