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Sirtuins in Medical News

Anti-Aging Powers of Enzyme Sirtuins

In the recent years, scientists discovered a family of enzymes called sirtuins, which can dramatically extend life in organisms// as diverse as yeast, worms, and flies. Now, a new study from scientists at The Wistar Institute points to another strategy for activating sirtuins to unleash their...

Wistar Institute team finds key target of aging regulator

...ts have long known that a class of proteins called sirtuins promotes fitness and longevity in most organisms r...le-celled yeast to mammals. At the cellular level, sirtuins protect genome integrity, enhance resistance to ad... role in maintaining long lifespan in yeast. Since sirtuins deacetylate many different proteins, these results...

Cocaine Spurs Long-Term Change in Brain Chemistry

... The process showed, for the first time, that a family of genes called the sirtuins are activated by chronic cocaine use and fuel addiction-related behaviors i...s brain region," Nestler said. "We showed that blocking the activity of the sirtuins reduced both cocaine's rewarding effects and the motivation to self-adminis...

Pharmion and MethylGene Present Favorable Clinical Data From Combination MGCD0103/Vidaza(R) Study in Myelodysplastic Syndromes and Acute Myelogenous Leukemia at The 49th American Society of Hematology (ASH) Meeting

...ral preclinical programs: MGCD290, an HDAC inhibitor in combination with azoles for fungal infections; an HDAC program for Huntington's disease; and a sirtuins program for cancer. MethylGene's development and commercialization partners include Pharmion Corporation, Taiho Pharmaceutical and EnVivo Pharmaceutic...

Pharmion and Methylgene Report Favorable Results for Phase 2 MGCD0103 Single- Agent Studies in Relapsed or Refractory Lymphomas at the 49th American Society of Hematology (ASH) Meeting

...eral preclinical programs: MGCD290 an HDAC inhibitor in combination with azoles for fungal infections; an HDAC program for Huntington's disease; and a sirtuins program for cancer. MethylGene's development and commercialization partners include Pharmion Corporation, Taiho Pharmaceutical and EnVivo Pharmaceutic...

Researchers Pinpoint Link Between Caloric Restriction and Longevity

...selves. Two members of a family of genes called sirtuins were required for this effect to occur, the author... essentially dead, but if the mitochondria and the sirtuins are active, the cells will live." This suggests...he question of whether pharmacologic activation of sirtuins is necessarily a good idea -- cell death is nature...

Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find

... being figured out. His team found that providing a newly discovered vitamin activates the yeast anti-aging gene product Sir2, which resembles sirtuins found in humans. The new work builds on Brenners prior discovery of the vitamin, termed NR (nicotinamide riboside), a natural product found in milk. L...

Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find

...ll being figured out. His team found that providing a newly discovered vitamin activates the yeast anti-aging gene product Sir2, which resembles sirtuins found in humans. The new work builds on Brenner’s prior discovery of the vitamin, termed NR (nicotinamide riboside), a natural product found in milk. ...

Cell Survival Depends on Chromosome Integrity

...that removing from yeast cells two proteins called sirtuins — Hst3p and Hst4p — causes cells to become hyperse... normal state. The cells require proteins like the sirtuins Hst3p and Hst4p to act as guideposts to help ident...am hopes to further understand what controls these sirtuins to remove acetyl groups and how hyperacetylation c...

Restriction of Carbohydrates to Prevent Alzheimer's Disease

...use plaque buildup in the brain (the main characteristic of AD). Beta-amyloid peptides activate SIRT1, a member of a broad family of proteins known as sirtuins which influence a variety of functions including metabolism and aging. Dr. Pasinetti and colleagues used an experimental mouse model to demonstra...
Sirtuins in Medical Technology

Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Acute Myelogenous Leukemia

...sine kinases. In addition, MethylGene's preclinical programs include: MGCD290 an HDAC inhibitor in combination with azoles for fungal infections and a sirtuins program for cancer. MethylGene's development and commercialization partners include Pharmion Corporation, Taiho Pharmaceutical and EnVivo Pharmaceutic...

Pharmion and MethylGene Announce Orphan Drug Designation Granted by the European Medicines Agency (EMEA) for MGCD0103 for the Treatment of Acute Myelogenous Leukemia

...sine kinases. In addition, MethylGene's preclinical programs include: MGCD290 an HDAC inhibitor in combination with azoles for fungal infections and a sirtuins program for cancer. MethylGene's development and commercialization partners include Pharmion Corporation, Taiho Pharmaceutical and EnVivo Pharmaceutic...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

...eral preclinical programs: MGCD290 an HDAC inhibitor in combination with azoles for fungal infections; an HDAC program for Huntington's disease; and a sirtuins program for cancer. MethylGene's development and commercialization partners include Pharmion Corporation, Taiho Pharmaceutical and EnVivo Pharmaceutic...

Resveratrol Studies Suggest Broad Implications for SIRT1 Activation in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease

...lzheimer's Disease and Amyotrophic Lateral Sclerosis (ALS), neurodegenerative diseases which have been associated with reduced mitochondrial function. sirtuins are a recently discovered class of enzymes that appear to affect the aging process in mammals and increase the number and function of mitochondria. ...
Sirtuins in Biological News

Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery

...of the journal Nature Reviews Drug Discovery . sirtuins are a family of enzymes which target genes that co...ew highlights the molecular mechanism of action of sirtuins with a view towards diseases where SIRT1 activatio...aged by early data that indicates a role for other sirtuins in multiple therapeutic areas," continued Dr. West...

Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging

...man clinical studies in the first half of 2008. sirtuins are a recently-discovered family of enzymes that p...ral defense against disease. There are seven human sirtuins (SIRT1-7). sirtuins are attractive drug targets because some have a sp...

Jefferson scientists find aging gene also protects against prostate cancer development

...ugs against the disease. SIRT1 is a member of a family of enzymes called sirtuins that have far-reaching influence in all organisms, including roles in metabolism, gene expression and aging. “We know that sirtuins play a role in aging, and that the risk for prostate cancer increases with ...

Novel Enzyme Shows Potential As An Anti-HIV Target

...ion. Acetylation and deacetylation enzymes can also target other proteins. Of the three classes of deacetylases known to modify human histones, the sirtuins (SIRT1?) appear to preferentially target a number of nonhistone proteins. Ott and colleagues first tested the ability of all seven SIRT proteins to de...
Sirtuins in Biological Technology

GlaxoSmithKline to Acquire Sirtris Pharmaceuticals, a World Leader in 'Sirtuin' Research and Development

.... Westphal commented, "We have built a dynamic and scientifically-driven organisation. We expect this transaction will accelerate our vision to target sirtuins to treat diseases of metabolism and ageing and deliver tremendous value to patients, our shareholders and our employees. We look forward to working wi...

Growing old together: Yeast, worms and people may age by similar mechanisms

...east in part, by genetic factors. Previous studies have implicated a number of conserved genes in model organisms as regulators of aging, such as the sirtuins and insulin/IGF1 receptors. However, no investigations to date have quantified the degree to which aging-related genes are conserved across the genom...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

...ort in development of sirtuin inhibitors - sirtuins implicated in tumor development and growth - Si...cancer targets within a related family of enzymes. sirtuins (including SIRT1) have been shown to deacetylate h...rant gene silencing in cancer cells. Inhibition of sirtuins allows reexpression of silenced tumor suppressor g...
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