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Sirtuin in Medical News

GlaxoSmithKline Acquires Sirtris Pharmaceuticals, Inc., a World Leader in Sirtuin Research and Development

LONDON, PHILADELPHIA and CAMBRIDGE, Mass., June 6 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE: GSK ) announced today that it has completed its acquisition of Sirtris Pharmaceuticals, Inc. (Sirtris) for approximately USD720 million (or approx. GBP362 million) through a cash tender offer an...

Researchers Gain Insights Into Aging in Mice

...e findings, published in the Jan. 9 issue of Cell , link pathways involving the SIRT6 and NF-kappa B, or NF-kB, protein molecules. SIRT6, part of the sirtuin family of proteins, regulates life span in some simple organisms, and NF-kB regulates production of certain genes involved in aging. It has previously...

Resveratrol: Thousands of Bottles of Wine, High-Dose Pills Not Required; Mega-doses May Induce Side Effects

...e not been tested in humans for long-term use. Advertising claims by resveratrol supplement makers that their pills exert greater stimulation of the sirtuin 1 DNA-repair gene should also be regarded with caution since an animal study shows over-stimulation (greater than 7.5 fold) of this gene induces heart...

Cigarettes leave deadly path by purging protective genes

...bstructive pulmonary disease (COPD) and lung cancer. By identifying the sirtuin (SIRT1) genes role in pulmonary disease, scientists also hope to find ways ...tigate what pathways lead to the depletion of SIRT1. Researchers found that sirtuin also plays a role in regulating the entire chemical signaling system that p...

Pharmion to Present Clinical Data on Key Hematology Products at American Society of Hematology (ASH) Annual Meeting

...pigenetic therapies includes three developmental programs: Vidaza and oral azacitidine, both DNA demethylating agents; MGCD0103, a HDAC inhibitor; and sirtuin inhibitors, Pharmion's newest epigenetic research program. Pharmion currently markets Vidaza, the parenteral formulation of Azacitidine, in the U.S. a...

Researchers Pinpoint Link Between Caloric Restriction and Longevity

...ro Imai, an assistant professor of molecular biology and pharmacology at the Washington University School of Medicine, in St. Louis. The mammalian sirtuin family contains seven members, one of which, SIRT1, had previously been implicated in mammalian aging. "What we publish now is there are two more [sir...

Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find

...more complex, but animal studies indicate potential. Perhaps the best known sirtuin activator is the red wine compound resveratrol. Overfed mice on high dose r...pan. While resveratrol and NR work through different mechanisms to increase sirtuin activity, Brenner said, the two compounds could be complementary or synergi...

Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find

...more complex, but animal studies indicate potential. Perhaps the best known sirtuin activator is the red wine compound resveratrol. Overfed mice on high dose r...pan. While resveratrol and NR work through different mechanisms to increase sirtuin activity, Brenner said, “the two compounds could be complementary or synerg...

Anti-Aging Powers of Enzyme Sirtuins

...agerly searching for drug candidates able to boost sirtuin activity. The public-health benefits of such an "a...o known as niacin, binds to a specific site on the sirtuin molecule to inhibit its activity. This observation...to target it, it should be very specific for these sirtuin molecules." Marmorstein's research on sirtui...
Sirtuin in Medical Technology

Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone

...ers have been hearing a lot about resveratrol in the past four years, since an Ivy League university discovered it activated a longevity gene known as sirtuin 1, advice concerning dosage has been confusing at times. A 2006 mouse study suggested consumers would have to drink about 750 to 1500 bottles o...

Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged

...ie diet. Nature 2006 Nov 16; 444(7117):337-42] The Sirtuin1 gene does not appear to be the "holy grail" of longevity by itself, as once claimed. The sirtuin family of genes works in tandem with other genes, such as FOXO1 and PGc1alpha. [Interaction of aging-associated signaling cascades: inhibition of NF-k...

Resveratrol Studies Suggest Broad Implications for SIRT1 Activation in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease

...mpany focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that activation of SIRT1, a member of the sirtuin family of enzymes, was shown to protect against neurodegenerative diseases such as Alzheimer's Disease and Amyotrophic Lateral Sclerosis in animal mod...
Sirtuin in Biological News

Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery

CAMBRIDGE, MA [October 1, 2008] Sirtris, a GSK company focused on discovering and developing small molecule drugs to treat diseases of aging such as Type 2 Diabetes, announced today that it published a new review article on the growing body of sirtuin research and its potential to treat diseases ...

Resveratrol prevents fat accumulation in livers of 'alcoholic' mice

...that alcohol inhibits two molecules that play a role in cell signaling and the breakdown of fats in the liver: AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1). When alcohol inactivates AMPK and SIRT1, it allows fat to accumulate. Resveratrol does the opposite -- activating AMPK and SIRT1, and helpi...

Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging

... because some have a specialized function in mitochondrial activity which may be therapeutically beneficial for metabolic and other diseases of aging. sirtuin therapeutics offer the potential for a novel class of drugs that can treat diseases of aging in a new way. ...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...s limited. But no one knew exactly how it was controlled or what else it might need in order to launch the sugar-making process. Sirtuin1, like its sirtuin relatives, is best known for removing molecular "decorations" on proteins that help organize DNA and restrict access to genes. It turns out that sirtu...

Computational verification of protein-protein interactions by orthologous co-expression

...s limited. But no one knew exactly how it was controlled or what else it might need in order to launch the sugar-making process. Sirtuin1, like its sirtuin relatives, is best known for removing molecular "decorations" on proteins that help organize DNA and restrict access to genes. It turns out that sirtu...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...s limited. But no one knew exactly how it was controlled or what else it might need in order to launch the sugar-making process. Sirtuin1, like its sirtuin relatives, is best known for removing molecular "decorations" on proteins that help organize DNA and restrict access to genes. It turns out that sirtu...

Future diabetes drugs may target new protein interaction

...s limited. But no one knew exactly how it was controlled or what else it might need in order to launch the sugar-making process. Sirtuin1, like its sirtuin relatives, is best known for removing molecular "decorations" on proteins that help organize DNA and restrict access to genes. It turns out that sirtu...
Sirtuin in Biological Technology

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

- Third epigenetic anticancer program at Pharmion - Leading effort in development of sirtuin inhibitors - Sirtuins implicated in tumor development and growth - Significant opportunity to explore combination epigenetic therapies BOULDER, Colo. and MONTREAL, Aug. 20...

GlaxoSmithKline to Acquire Sirtris Pharmaceuticals, a World Leader in 'Sirtuin' Research and Development

...lass of enzymes that are believed to be involved in the ageing process. Sirtris Pharmaceuticals has established a drug discovery capability to exploit sirtuin modulation for the treatment of human disease, an approach that has the potential to generate multiple clinically and commercially important products....

Pharmion Corporation Announces 2007 Operating Results

... of patients in the dose escalation study for oral Azacitidine and the initiation of our research collaboration program with MethylGene Inc. targeting sirtuin inhibitors. Selling, general and administrative expenses totaled $143.2 million for the full year 2007 and $50.0 million for the fourth quarter of 2...
Sirtuin in Biological Products

Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Sirtuin 7 (SIRT7) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: Other Recommended Storage: Long term: -20C; Short term: +4C...
Company:Lifespan Biosciences
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(Date:10/2/2014)... -- Genes may interact with stress to trigger heart disease ... risk occurs in about 13 percent of people, but only ... people reduce their heart disease risk through simple measures such ... Duke University researchers said. The study authors analyzed genetic ... between variations in the EBF1 gene and higher levels of ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, ... roses -- literally -- may face an increased risk of dying ... study of over 3,000 older Americans, researchers found those who were ... more than three times as likely to die in the next ... In fact, anosmia -- the inability to distinguish odors -- was ...
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(Date:10/1/2014)... researchers hope to take a healthy salad up a ... of breast cancer in leafy greens. , "In the ... either by eating the salad or making a pill ... of biomedical engineering at Case Western Reserve School of ... G. Komen breast cancer organization is funding the research ...
(Date:9/30/2014)... Evidence of the environmental effects of moorland burning is ... the subject, with the aim of relieving tensions on ... , The EMBER (Effects of Moorland Burning on the ... burning on moorland, which is practised predominantly to support ... impacts on peat hydrology, peat chemistry and physical properties, ...
(Date:9/30/2014)... WASHINGTON, D.C., September 30, 2014--Sea monkeys have captured the ... of their easily observable life cycle -- sold as ... and mate given little more than a tank of ... a shorter-term pattern: Like other zooplankton, brine shrimp vertically ... conditions, coming closer to the surface at night and ...
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