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Simvastatin in Medical News

Tianyin Pharmaceutical Co., Inc. Receives Chinese SFDA Approval for Simvastatin Tablets

-- This Approval Creates New Growth Opportunities for the Company -- Company Expects to Exceed Its FY2008 Make Good Target of $5.6 million CHENGDU, China, July 31 /Xinhua-PRNewswire-FirstCall/ -- Tianyin Pharmaceutical, Co., Inc. (OTC Bulletin Board: TYNP), a manufacturer and supplier of ...

Abbott's Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study

Six Percent of Patients Discontinued Combination Therapy Due to Flushing ORLANDO, Fla., Nov. 4 /PRNewswire-FirstCall/ -- New data released today showed that Abbott's SIMCOR(R), an investigational, fixed-dose combination of Abbott's proprietary extended-release niacin, Niaspan(R), and simvastat...

Ranbaxy Gets USFDA Nod For Simvastatin

Pharma major Ranbaxy Laboratories Ltd has received approval from the USFDA for manufacturing and marketing cholesterol-lowering Simvastatin Tablets in the US market. // The company said it has received the approval for marketing the drug in strengths of 80mg with 180 day exclusivity. Si...

For Treatment of Dyslipidemia, Surveyed Physicians are Increasingly Switching Patients to a More Potent Statin Following the ENHANCE and SEAS Trials

...e taken action as a result of the SEAS and ENHANCE trials. The ENHANCE trial showed that Vytorin was no more effective than the less expensive generic simvastatin in reducing carotid intima-media thickness. The report's survey results indicate that Vytorin was moved to a less favorable tier in 30 percent of both...

Statins May Cause Muscle Damage in Some Patients

...dy's ability to repair muscles. Muscle cells exposed to increasing doses of simvastatin (Zocor) showed less ability to multiply and, therefore, heal and regenerate... In the new study, 41 percent of those experiencing myopathy were taking simvastatin (Zocor); 31 percent were taking pravastatin (Pravachol); 17 percent were ta...

Genomas Presents Drug-Specific Genetic Determinants of Statin Safety and Efficacy at the XV International Symposium on Atherosclerosis

...ions in daily life activities, and reduction in regimen adherence. In this study, 442 outpatients treated with atorvastatin, rosuvastatin and/or simvastatin were studied in lipid clinics at Hartford Hospital (Hartford, CT) and the University of California, San Francisco . Researchers genotyped 384 SNPs (s...

Abbott's TRILIPIX(R) (Fenofibric Acid) in Combination With Rosuvastatin Calcium Helps Patients With Mixed Dyslipidemia and Type 2 Diabetes Meet American Diabetes Association Lipid Targets

...ntrolled studies where patients received TRILIPIX alone, TRILIPIX in combination with one of the three most commonly prescribed statins (atorvastatin, simvastatin or rosuvastatin) or statin alone. The clinical program also included a 52-week, long-term, open-label extension study. Important Safety Infor...

One Pill Might Prevent Heart Disease

...ne in The Lancet . The polypill contains generic versions of the blood pressure medications atenolol, hydrochlorothiazide and rampiril, as well as simvastatin (Zocor) and aspirin. It is designed to attack three major risk factors of cardiovascular disease -- high blood pressure, high blood cholesterol and fo...

Cholesterol Drugs Linked to Increased Fatigue

...or diabetes into three groups and gave them daily doses of 20 milligrams of simvastatin (Zocor), 40 milligrams of pravastatin (Pravachol), or a placebo for six mon... took place between 2000 and 2005. The researchers found that people on simvastatin reported reduced energy and activity levels, while those on pravastatin rep...

Sanofi-aventis Delivers 2008 Results Above Guidance

...urrently proceed only with those that target oncology patients. - Concerning Life Cycle Management, the combination of Plavix(R) with simvastatin and Plavix(R) with irbesartan will not be pursued. The Plavix(R) plus aspirin combination project has been discontinued in the United Stat...
Simvastatin in Medical Technology

New Data for Abbott's TRILIPIX(R) (fenofibric acid) in Combination with Rosuvastatin Calcium Shows Improvement on Key Lipids for Cholesterol Management

...ntrolled studies where patients received TRILIPIX alone, TRILIPIX in combination with one of the three most commonly prescribed statins (atorvastatin, simvastatin or rosuvastatin) or statin alone. The clinical program also included a 52-week, long-term, open-label extension study. TRILIPIX Indications ...

Michael J. Fox Foundation Awards $2.9 Million for Two New Parkinson's Disease Clinical Trials

...ove effective in PD. One funded team will investigate the potential of simvastatin (marketed under the trade name Zocor), a drug currently used to treat high ...Randomized, Placebo-controlled, Multiple Crossover (n-of-1), Pilot trial of simvastatin on the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease Pati...

Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe

...atin are still in progress: (i) SHARP (ezetimibe + simvastatin vs placebo in 9,000 patients; recruitment complete...ow-up continuing) and (ii) IMPROVE-IT (ezetimibe + simvastatin vs placebo + simvastatin in 11,000 patients; recruitment continues towards ...

Results From the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) Study

...nsive cholesterol lowering with the combination of simvastatin (40 mg daily) and ezetimibe (10 mg daily) in patie...nsive cholesterol lowering with the combination of simvastatin (40 mg daily) and ezetimibe (10 mg daily) or match...afety. Compared with placebo, the combination of simvastatin and ezetimibe reduced LDL-cholesterol by an averag...

/C O R R E C T I O N -- Prof Terje Pedersen, SEAS Study Principal Investigator & Head of Steering Committee/

...se go to: http://clients.mediaondemand.net/pedersen Professor Terje Pedersen (Ulleval University Hospital, Oslo, Norway), lead investigator for the simvastatin and Ezetimibe in Aortic Stenosis (SEAS) Study, will provide an update on the study on Monday the 21st July. Also present in London will be Sir Richa...

Phase III Study of Abbott's Investigational TriLipix(TM) in Combination With AstraZeneca's CRESTOR(R) Meets Primary Endpoints on Key Lipids

...riLipix Clinical Development Program TriLipix was studied alone and in combination with three of the most commonly prescribed statins (atorvastatin, simvastatin and rosuvastatin) in 2,698 patients with mixed dyslipidemia. The clinical program also includes a 52-week, long-term, open-label extension study. More...

Abbott's Phase III Studies of Investigational TriLipix(TM) (ABT-335), in Combination With Statins, Meets Primary Endpoints on Improving LDL, Triglycerides and HDL

...ing fenofibric acid combined with atorvastatin and simvastatin met their primary endpoints. Combination therapy s... that TriLipix in combination with atorvastatin or simvastatin improved all three key lipids -- LDL, HDL and trig...escribed statins -- rosuvastatin, atorvastatin and simvastatin -- were evaluated in three randomized, multi-cente...

ReachMD Broadcasts First-of-its-Kind Physician Peer-Peer Discussion on ENHANCE Trial

...ntroversial debate over effects of simvastatin vs. Ezetimibe/Simvastatin CHICAGO, Feb. 4 /PRNew...NCE (Effect of Combination Ezetimibe and High-Dose simvastatin vs. simvastatin Alone on the Atherosclerotic Process in Patients w...

ImpactRx Tracks Decline in Zetia and Vytorin Prescribing

...was designed to determine if ezetimibe (Zetia) and simvastatin used in combination was more effective than simvastatin alone in slowing the growth of plaque in the carot...isen dramatically since ENHANCE was released, with simvastatin now garnering two- thirds of those changes from Vy...

Zetia Does Not Reduce Carotid Plaque Size When Added to Zocor

... unusual condition known as heterozygous familial hypercholesterolemia. Vytorin cut "LDL levels by 58 percent, compared to a 41 percent reduction with simvastatin alone. However, the researchers found that "the average thickness of the carotid artery plaque increased by 0.0111 of a millimeter in patients taking ...
Simvastatin in Biological News

One size does not fit all

...lation. "The results of our study indicate that simvastatin has in fact, a slightly deleterious effect on myel... but also in oligodendrocyte number as a result of simvastatin treatment. The findings also suggest that simvastatin inhibits CNS remyelination by blocking oligodendro...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

...nally the investigators determined the effects of varying concentrations of simvastatin on SCs in different states (i.e., undergoing differentiation or differentia...e proliferating cells was reduced by 50% (equivalent to the availability of simvastatin in circulation from a 40 milligram dose per day used in some patients). Spe...

Statin does not appear helpful for children with learning disabilities caused by genetic disorder

... Use of simvastatin by children with neurofibromatosis type 1 (NF1), a...randomized trial to study the effect of the statin simvastatin on cognitive function of 62 children with NF1. The participants received simvastatin or placebo treatment once daily for 12 weeks. A...

Statin treatment improves spatial memory in mouse models of Alzheimer's

...week, with as much food and water as they wished, then divided into four groups. Half the “Alzheimer’s mice?and half the normal mice received 10 mg/kg simvastatin for seven days, while half of each group only received saline. Each day the mice had two swimming trials in the water maze, giving them a chance to le...

Patients can report statins' adverse effects on new web site

...ol-lowering drugs are among the most prescribed drugs in the United States. According to Consumer Reports, two such drugs ?atorvastatin (Lipitor) and simvastatin (Zocor) ?were #1 and #2 best-selling drugs in the country in 2004, with 75 million prescriptions for Lipitor alone. Although pharmaceutical companies ...

Statins stop hepatitis C virus from replicating

...vastatin. When the statins were tested alone, all except pravastatin inhibited HCV replication. Fluvastatin had the strongest effect. Atorvastatin and simvastatin had moderate effects while lovastatin had a weak effect. While pravastatin exhibited no anti-HCV activity, it did work as an inhibitor for HMG-CoA red...

Statins have neutral effect on risk of cancer

...s continue, "?the patients in our meta-analysis were primarily treated with simvastatin and pravastatin. As such, we evaluated pravastatin alone and simvastatin alone on cancer incidence and death and found no impact." "Statins have ...
Simvastatin in Biological Technology

Abbott Annual Meeting Highlights Outstanding 2007 Results, International Growth and Near-Term Pipeline

...ate response to conventional therapy. -- SIMCOR(R), a fixed-dose combination of Niaspan(R) (Abbott's proprietary niacin extended-release) and simvastatin that targets both "good" and "bad" cholesterol in a single pill, was also approved by the FDA in the first quarter. -- Abbott broadened its l...

Abbott Receives FDA Approval for SIMCOR(R) (Niaspan(R) / simvastatin), a Novel Combination Medicine for Comprehensive Cholesterol Management

...nts with complex lipid disease when treatment with simvastatin or Niaspan monotherapies are not considered adequa...1000/20mg had additional lipid improvements beyond simvastatin 20-mg treated baseline, with additional LDL reduct...rease in LDL and an 8 percent increase in HDL with simvastatin 20mg alone. Furthermore, SIMCOR reduced triglyceri...

Schering-Plough Reports Financial Results for 2007 Fourth Quarter, Full Year

... at risk for heart disease. Clinical studies have demonstrated that VYTORIN lowered patients' LDL cholesterol more than rosuvastatin, atorvastatin and simvastatin at the doses studied and was able to get more patients to their goal. OBS Integration The company reviewed progress in the integration of OBS sinc...
Simvastatin in Biological Definition

Diabetes mellitus

...orative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lance...364: 685-96 MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. La...
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