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Simian in Medical News

Vaccine Shields Monkeys From Simian Form of HIV

Scientists inject antibody-coding genes directly into muscles SUNDAY, May 17 -- Raising hopes for the development of an AIDS vaccine that might actually work, researchers report they were able to protect monkeys against infection with simian immunodeficiency virus (SIV), the primate ve...

Yerkes researchers propose ambitious new strategies for AIDS vaccine research

...ity, believe conventional vaccine strategies should not be the only avenue explored in the development of an effective AIDS vaccine. Based on studying simian immunodeficiency viruses (SIVs) in African nonhuman primates, they propose an additional new approach to the AIDS vaccine research agenda in a comment...

AIDS-like Illness Found in African Chimps

...tional Park for nine years, watching what happened to those infected with a simian equivalent of HIV. Their findings appear in the July 23 issue of Nature...ent with the end stages of AIDS in humans. Chimps appear to transmit the simian equivalent of HIV just like humans, Hahn said: They spread it through sex. ...

New HIV Drug May Help Those Resistant to Therapy

... the drugs. In the study, researchers tested the effectiveness of a molecule called D-1mT and anti-retroviral therapy (ART) in macaque monkeys with simian immunodeficiency virus (SIV), which is similar to HIV in humans. After six days of treatment, only three of the macaques had detectable SIV levels, an...

OHSU vaccine research targets HIV in the slower, early stage of infection

...prevent the spread of the virus." To determine whether they could proactively "educate" the immune system, scientists used a monkey model of AIDS - simian immunodeficiency virus (SIV) the monkey counterpart to HIV. They introduced an altered monkey form of cytomegalovirus (CMV) programmed to express SIV...

Possible AIDS Treatment Shows Promise in Monkeys

... In the new study, Amara and colleagues injected nine monkeys with an antibody that blocks a kind of "don't kill me" signal that cells infected with simian immunodeficiency virus (SIV) send to immune cells. When the SIV-infected cells emit the signal, "the killer cell thinks, 'You are not my enemy. You...

Hopes for AIDS Vaccine Still Alive Despite Setbacks

...up led by pathologist David Watkins has successfully tested a vaccine that has provided monkeys with protection from up to 20 different strains of the simian equivalent of HIV, using only T-cell mediated immunity. Similar experiments have panned out well in pathologist Louis J. Picker's lab at the Oregon...

Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce

...tory (CSHL) has discovered new details about how a simian strain of the AIDS virus replicates. The findings ...ssor, led a team that studied a virulent strain of simian immune-deficiency (SIV) virus called SIVsm/mac, na...al machineries in order to reproduce. HIV and its simian cousin SIV are members of a viral subspecies calle...

World AIDS Vaccine Day 2008

...ogens that can stimulate the production of these antibodies in humans. Finally, non-human primates immunized with a live, but weakened form of the simian equivalent of HIV are protected from infection. For safety reasons, we cannot immunize humans with weakened HIV, but scientists are actively studying ...

Progression of SIV infection in monkeys raises

.... The study, Acute Loss of Intestinal CD4+ T Cells is Not Predictive of simian Immunodeficiency Virus Virulence, challenges current thinking regarding AID...ression to full-blown AIDS in humans, some non-human primates infected with simian immunodeficiency virus (SIV) do not develop AIDS after such a depletion. Af...
Simian in Medical Technology

Novel Vaccine Approach Offers Hope in Fight Against HIV

...sfer technology that produces molecules that block infection, the scientists protected monkeys from infection by a virus closely related to HIV -- the simian immunodeficiency virus, or SIV -- that causes AIDS in rhesus monkeys. "We used a leapfrog strategy, bypassing the natural immune system response ...

GeoVax Starts Injections for Phase 2a Human HIV/AIDS Vaccine Trial in USA

...l vaccinate infected people who are already on drugs to test the safety and immunogenicity of the vaccine in infected people. Therapeutic trials of a simian immunodeficiency virus (SIV) prototype of the GeoVax HIV vaccine in SIV infected primate animal models have held high promise that the GeoVax vaccine ...

Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study

... causes gonorrhea. Vaginally applied PRO 2000 has been found to afford protection in mouse models for genital herpes infection and gonorrhea, and in a simian model for vaginal HIV infection. Prior to initiation of the HPTN 035 trial, PRO 2000 had undergone extensive safety testing in several clinical trial...

GeoVax Reports Progress on Its AIDS Vaccine Technology

...peutic Human Clinical Trials in Planning Stages GeoVax also announced summary data from a pilot study on therapeutic vaccination in simian immunodeficiency virus (SIV) infected non-human primates with the SIV prototype for the GeoVax AIDS vaccine. In this small pilot study, conducted by D...
Simian in Medical Dictionary

Simian crease

...palmar creases that people typically have.... simian crease - Overview, A simian crease is a single line that runs across the ... The term " simian crease " is not used much anymore since it tends...

Retrovirus

..., unlike most other viruses and all cellular organisms, carry their ... simian Retrovirus Laboratory, California Regional Primate Research Center, ... simian type D retrovirus (SRV) is enzootic in many populations of Asian monkeys ...
Simian in Biological News

Novel vaccine approach offers hope in fight against HIV

...transfer technology that produces molecules that block infection, the scientists protected monkeys from infection by a virus closely related to HIVthe simian immunodeficiency virus, or SIVthat causes AIDS in rhesus monkeys. "We used a leapfrog strategy, bypassing the natural immune system response that w...

Potential new HIV drug may help patients not responding to treatment

...rrow in The Journal of Immunology . Scientists looking at monkeys with the simian form of HIV were able to reduce the virus levels in the blood to undetectab...ys with a molecule called D-1mT alongside Anti-Retroviral Therapy (ART). simian Immunodeficiency Virus (SIV) is very similar to Human Immunodeficiency Viru...

ASU researchers receive NIH awards for studies of malaria and emergent disease

...iversity of California at Davis and the Fred Hutchinson Cancer Center in Seattle, will examine the evolution, recombination, emergence and exchange of simian retroviruses between human and nonhuman primates. Escalante will also explore the dynamics of nonhuman malarial parasites as part of his vivax-macaque...

Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS

... undertaken to identify the source of the virus. These studies led to the discovery that chimpanzees and sooty mangabeys are infected in the wild with simian immunodeficiency viruses (SIV), whose transmission to humans and macaques leads to AIDS. Surprisingly, the natural hosts for the AIDS viruses, suc...

Simian foamy virus found in several people living and working with monkeys in Asia

...f Washington scientists has found that several people in South and Southeast Asian countries working and living around monkeys have been infected with simian foamy virus (SFV), a primate virus that, to date, has not been shown to cause human disease. The findings provide more evidence that Asia, where inter...

Big brains arose twice in higher primates

...atural History, and colleagues determined that the brains of the ancestors of modern Neotropical primates were as small as those of their early fossil simian counterparts in the Old World. This means one of the hallmarks of primate biology, increased brain size, arose independently in isolated groupsthe pla...

UC Davis researchers discover how HIV turns food-poisoning into lethal infection

...ether, they developed a novel technique that allowed them to study early intestinal responses to Salmonella infection in rhesus macaques infected with simian immunodeficiency virus (SIV), an established model for HIV infection. We found that animals that had no SIV infection were able to generate immedia...

Penn researchers find monkeys able to fend off AIDS-like symptoms with enhanced HIV vaccine

...HIV in macaque monkeys provides the animals with greater protection against simian HIV (SHIV) than an unmodified vaccine. This multi-year study found that the...ukin-15 effectively boosts the effects of a vaccine derived from the DNA of simian HIV. The study illustrates that DNA vaccine effectiveness can be improved b...

Jefferson scientists find rabies-based vaccine could be effective against HIV

...es-based vaccines in preventing disease in rhesus macaques. One was a glycoprotein on the surface of HIV, while the other was an internal protein from simian immunodeficiency virus (SIV). They used the latter because HIV does not cause disease in monkeys. The idea was that such rabies?vehicles, or "ve...

Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps

...ome with the genomes of other organisms is crucial to identifying what makes the human genome unique." The rhesus, because of its response to the simian immunodeficiency virus (SIV), is widely recognized as the best animal model for human immunodeficiency virus (HIV) infection. The rhesus genome seque...
Simian in Biological Technology

GeoVax Labs, Inc. Provides Clinical Studies Update

... started on drugs within six months of testing positive for HIV," stated McNally. He continued, "You will recall that trials conducted using a simian immunodeficiency virus (SIV) prototype of the GeoVax HIV vaccine in SIV-infected primate animal models have held high promise that the GeoVax vaccine ...

GeoVax Labs, Inc. Announces Six Month Financial Results and Provides Operational Update

...t to FDA approval. - Planning for Therapeutic Human Trials -- GeoVax reported summary data from a pilot study on therapeutic vaccination in simian immunodeficiency virus (SIV) infected non-human primates with the SIV prototype of GeoVax's AIDS vaccine. In this small pilot study, ...

JCI table of contents: April 22, 2008

...ri, these data also have implications for PPAR-gamma agonists, which are currently used to treat individuals with type 2 diabetes. TITLE: Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPAR-gamma/STAT5 signaling pathway in macaques AUTHOR CONTACT: Stphane Prost...

Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System

...rimate colony for the viruses of greatest concern: simian retrovirus (SRV), simian T-cell leukemia virus (STLV), herpes B, and simian immunodeficiency virus (SIV). To minimi...

Whole Gel Eluter Purification of a Functional Multiprotein DNA Replication Complex, Rev A

...5; containing complex was shown to have a high specific in vitro simian virus 40 (SV40) origin dependent DNA replication activity. We ha...l, E. F., A 21S enzyme complex from HeLa cells that functions in simian virus 40 DNA replication in vitro, Biochemistry, 29 , 63626374 ...

New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter

...lian cell types. Figure 5 illustrates the high-intensity fluorescence that resulted upon delivery of hrGFP to human, rodent, and simian cells. To further demonstrate the high transduction efficiency of this retroviral vector, we analyzed the fluorescence profile o...
Simian in Biological Products

Mouse Anti-Simian Virus 5 Monoclonal Antibody, Unconjugated from AbD Serotec

Description:... MOUSE ANTI simian VIRUS 5 Immunogen: simian virus 5...
Company:AbD Serotec

Mouse Anti-Simian Virus 5 Monoclonal Antibody, FITC Conjugated from AbD Serotec

Description:... MOUSE ANTI simian VIRUS 5:FITC Immunogen: simian virus 5...
Company:AbD Serotec

Mouse Anti-RFC1 Monoclonal Antibody, Unconjugated, 1320 from GeneTex

Description:...nformation Replication factor C is a multisubunit, DNA polymerase accessory protein required for the coordinated synthesis of both DNA strands during simian virus 40 DNA replication in vitro. It consists of five different subunits known as p140, p40, p38, p37, and p36. RFC is a DNA-dependent ATPase that bi...
Company:GeneTex
Simian in Biological Definition

Down syndrome

...ous diseases , heart problems, poor eyesight, and hearing problems. Other physical characteristics associated with the disorder include presence of a simian crease . Early educational intervention, screening for common problems such as thyroid functioning, medical treatment where indicated, a conducive f...

Retrovirus

...nretrovirus ; type species: Walleye dermal sarcoma virus Genus Lentivirus ; type species: Human immunodeficiency virus 1 ; others include simian , Feline immunodeficiency viruses Genus Spumavirus ; type species: Chimpanzee foamy virus These were previously divided into three sub...

Virus classification

...dae Family Nimaviridae Family Papillomaviridae Family Phycodnaviridae Family Plasmaviridae Family Polyomaviridae - e.g. simian virus 40 Family Poxviridae - e.g. Cowpox virus , Variola virus ( smallpox ) Family Rudiviridae Family Tectiviridae Unassigned...
Simian in Biological Dictionary

Viral oncogene

..., Viral :: physiology :: [Transcriptional repressive activity of mutated E2 protein of human papillomavirus 2 (HPV-2) ... Human RALA (v-ral simian leukemia viral oncogene homolog A (ras related)) See all paths ... Viral . Bacterial. Bovine. Canine. Chicken/Avian. Feline. Hamster ... Raf1 ...

Transformed phenotype

... ... ... Control of Transformed Phenotype in Hybrids between SV40- Transformed and Normal Human Cells ... Genetics of Cell Transformation by simian Virus 40. ... ... the goal of genetic transformation is to change an organism's traits ( phenotype ). Before any ... transformation ) phenotype...

Okazaki fragments

... detection of short Okazaki fragments together with a known replication speed ... Essentially all of the Okazaki fragments on replicating simian virus 40 (SV40)DNA could be grouped into one of three classes. A combination of spectroscopic and calorimetric techniques was used to determine c...

Gene expression

...ly ... ectopic expression experiments: What happens if the gene is expressed aberrantly? ... high level gene expression in mammalian cells. simian virus 40 early ... TaqMan® Gene Expression Master Mix. TaqMan® Universal PCR Master Mix. TaqMan® PreAmp Master Mix ... View All TaqMan® Gene...

Endonuclease

...e the phosphodiester bond within a ... Restriction endonucleases (Restriction Enzymes) cleave DNA at specific sites, ... Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae" ... new site-specific endonuclease StuI from Streptomyces ... W...
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