Gene silencer and quantum dots reduce protein production to a whisper
More than 15 years ago scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells.
Now scientists at the U...
Turning back the Clock in Inherited Anemias
...s also a professor of pediatrics at Harvard Medical School and chair of pediatric oncology at Dana-Farber. "It's pretty clear that this gene is a silencer
of fetal hemoglobin. If you could knock it down to a low level, you could turn on fetal hemoglobin."
"The discovery of a single gene tha...
Study reveals how stem cells decide to become either skeletal or smooth muscle
...on. The current findings suggest, however, that myocardin has a second role, independent of its partnership with CARG-SRF, where it serves as a potent silencer
of gene expression for the stem cell to skeletal muscle gene program.
With its dual action, myocardin is an early example of the efficiency and e...
Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
...s the presence of two sequence elements in the Trop-2 cytoplasmic tail, the signalling engine of Trop-2, which act as, respectively, an enhancer and a silencer
of metastatic propensity. This may be the key to the identification of signalling molecules that promote or inhibit the formation of metastases.
Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
...ream splicing site sometimes silenced it and sometimes did not.
Using bioinformatics techniques, the researchers organized the 89 unique intronic silencer
sequences they found into four distinct clusters, while the 47 unique exonic silencers formed two clusters. That more than 130 potential mRNA's could ...
Depression model leaves mice with molecular scar
...n mice exposed to this animal model of depression, silencer
molecules turned off a gene for a key protein in t...a a process called methylation. Methyl groups, the silencer
molecules, attach themselves to the histones, turn...ne. Notably, imipramine was unable to remove these silencer
molecules, suggesting that they remained a latent ...
Gene keeps neural cells on correct developmental path
... created the acronym to describe how REST quiets the nerve genes. The protein is also known by the name Anderson gave it, NRSF, for neuron-restrictive silencer
Since then, they and others have found that REST locks down neuronal genes in other cells by grabbing onto the DNA and cementing in other m...
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...A ( siRNA ) for the induction of RNA interference (RNAi) in a variety of organisms. siRNA Synthesis. Premium quality siRNAs ... Made-to-order silencer
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Ribosomal DNA genes
...nes , all of which are essential for normal ... gene often make the 12S RNA in human cells look similar to bacterial ribosomal RNA. ... ... silencer
gene , SIR2, in regulation of recombination in ribosomal DNA . ... An unusual form of transcriptional silencing in yeast ribosomal DNA . Gen...