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Silence the gene, save the cell: RNA interference as promising therapy for ALS
Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease. Their results will be published in the April issue of Nature Medicine, and in the...Used in a new way, RNA interference permanently silences key breast cancer gene
In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive. The study, presented at...Restoring silenced suppressor gene kills lung-cancer cells
A new study suggests that restoring a gene often silenced in lung cancer causes the cells to self-destruct. The findings could lead to a new strategy for treating the disease. The research focused on a gene known as WWOX, which is lost or silenced in a large majority of lung cancers, and in cancers of the breast, ovary, prostate, bladder, esophagus and pancreas. The work was led by scient...Tool developed to silence genes in specific tissues using RNAi
Researchers at The University of Texas M. D. Anderson Cancer Center say they have jumped a significant hurdle in the use of RNA interference (RNAi), believed by many to be the ultimate tool to both decode the function of individual genes in the human genome and to treat disease. Reporting in the journal Genes and Development, investigators have developed a simple way to use the RNAi appro...Freedom of expression is great, but silence is golden ?at least when it comes to amoebae, which are intestine-dwelling parasites that cause life-threatening dysentery in many parts of the world. Three years ago, scientists at the Weizmann Institute accidentally discovered a way to silence the expression of a key amoebic gene, one which codes for a toxic protein that kills human intestinal cells i...
Silence at Biology Products
Silencer siRNA Starter Kit from Ambion
Description:The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure successful gene knockdown experiments....Company:Ambion
Magnetofection - SilenceMag from OZ Biosciences
Description:Last innovation from Magnetofection technology, SilenceMag is the most efficient siRNA delivery system available. Simple, rapid and easy to use, SilenceMag is serum compatible and non toxic. Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA.SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (p...Company:OZ Biosciences
Magnetofection - SilenceMag from OZ Biosciences
Description:Last innovation from Magnetofection technology, SilenceMag is the most efficient siRNA delivery system available. Simple, rapid and easy to use, SilenceMag is serum compatible and non toxic. Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA.SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (p...Company:OZ Biosciences
Magnetofection - SilenceMag from OZ Biosciences
Description:Last innovation from Magnetofection technology, SilenceMag is the most efficient siRNA delivery system available. Simple, rapid and easy to use, SilenceMag is serum compatible and non toxic. Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA.SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (p...Company:OZ Biosciences
Silencer CellReady siRNA Transfection Optimization Kit from Ambion
Description:Prior to siRNA library screening, optimal siRNA transfection parameters must be identified and verified for each cell type used. The Silencer CellReady siRNA Transfection Optimization Kit, which was developed specifically for optimizing transfection conditions in 96 well plates, dramatically simplifies this process....Company:Ambion
Silence at Biology Technology
Fluorescently Labeling Long dsRNA with the Silencer siRNA Labeling Kit
Although the <A href="http://www.ambion.com/catalog/CatNum.php?1632"> siRNA Labeling Kits were developed for labeling siRNA, they can be readily adapted for labeling long dsRNA. The following protocol can be used for this application. See "<A href="#visualizing">Visualizing In...Silencer Validated siRNAs are single siRNA duplexes that have been verified by real-time RT-PCR to reduce the expression of a number of important human genes. The cut-off for siRNA validation is a >70% reduction in target gene expression 48 hours post-transfection, though the average reduction in target gene expression in the inital set...
pSilencer 4.1-CMV: Versatile Vectors for Expression of siRNA, miRNA, and mRNA
4.1-CMV plasmid vectors are designed for long-term gene silencing experiments in a broad range of cell lines. The vectors carry an RNA polymerase II-type CMV promoter (human cytomegalovirus immediate-early promoter) and an optimized SV40...Selecting siRNA Sequences to Incorporate into the pSilencer Vectors
The first step in preparing a plasmid for siRNA experiments is to identify target sequences in the gene of interest that are susceptible to siRNA-induced degradation. We have found that a little more than half of the siRNAs provide at least a 50% reduction in target mRNA levels and approximately 1 out of 4 siRNAs...Iezzi M, Kouri G, Fukuda M, Wollheim CB (2004) Synaptotagmin V and IX isoforms control Ca J Cell Sci In a recently published paper in the Journal of Cell Science, Iezzi and colleagues used Ambions...
Silence at Medicine News
Australian Scientists 'Silence' Cancer Gene
This new treatment claims to treat the cancer by 'gene silencing.' This process apparently turns off a single gene in a cancer cell responsible for the continued development and spread of the cancer. This means that the other genes // are left unharmed. If successful, this new method promises to beat the conventional methods of treating cancer which include radiation and chemotherapy. These two t...Scientist proved that the brain is always alert even if there is no sound (silence). The brain is activated in people when they are listening out for a sound. Pierre Fonlupt and Julien Voisin conducted the research at Inserm, France's national research institute. He studied the brain activity of 11patients who were at rest with the help of Magnetic Resonance Imaging. // It showed that...
Silence Puts Comfort For Digestive Syndrome
Irritable bowel syndrome, by which 15% of Americans were suffered, was caused by distinctly personal habits and when medication doesn't help, there's often little left// to do but to suffer in silence. Others like constipation, bloating, diarrhea and gas, flatulence make their lives miserable, limiting some of their day-to-day activities. Researches believe that the most basic of treatm...Commonplace Sugar Compound Silences Seizures
Though in clinical use for decades, a small, sweet-tasting compound is revealing a startling new face as a potential cure for epilepsy.// 2-deoxy-glucose, or 2DG, has long been used in radio labeling, medical scanning and cancer imaging studies in humans. But now, researchers at the University of Wisconsin-Madison have found the substance also blocks the onset of epileptic seizures in...Intervention Needed to Break 'Silence' on Reproductive Health
There is "enormous silence" in India around adolescent sexual and reproductive health issues, and this can be overcome through involvement of parents, in-laws, spouses// and elders, says a new report by the International Center for Research on Women (ICRW) and partners. More than half the population in India is younger than 25, and many adolescents, particularly unmarried girls, suff...Silence at Medicine Products
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(Date:10/13/2008)...URGH, Oct. 13 /PRNewswire/ -- Today,s autism resea...from genetics to functional magnetic,resonance ima...negie,Symposium on Cognition, "Development and Bra...inent autism researchers will present their latest...ss the direction of future,study that will continu...
(Date:10/13/2008)...S PINK! KEEP WARM THIS WINTER WITH THE VIPER RESPO...TY & REMOTE START SYSTEM, VISTA, Calif., Oct. 13 ...wholly-owned subsidiary of DEI Holdings Inc. (Nasd...ancer with the availability of Responder LE,Specia...stems from Viper,supporting Susan G. Komen for th...
(Date:10/13/2008)...rruption to shipments or service to new or existin...-FirstCall/ -- Cardiac Science,Corporation (Nasdaq...worldwide voluntary field corrective action of cer...factured between August 2006 and March 2007. Some,...mponent whose performance,doesn,t match the factor...
(Date:10/13/2008)... Oshkosh is one of six sites included in national ...rest survival rates, OSHKOSH, Wis., Oct. 13 /PRNe...tp://www.advancedcirculatory.com ) announced today...n funding from the National Institutes,of Health (...in combination,on those who experience cardiac arr...
Breaking Medicine News(10 mins):Health News:Carnegie Mellon International Autism Symposium to Feature Groundbreaking Research, Oct. 17-18 2Health News:Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month 2Health News:Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month 3Health News:Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs 2Health News:Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs 3Health News:Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques 2[0] Carnegie Mellon International Autism Symposium to Feature Groundbreaking Research, Oct. 17-18[0] Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month[0] Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs[0] Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques
(Date:10/10/2008)... identified stem cells with the capacity to build ...ue of the journal Cell, a Cell Press publication...n renew themselves, transplants of the progenitor ...can restore normal fat tissue in animals that are ...ight into the causes of obesity, a condition chara...
(Date:10/10/2008)...tober 7, 2008 The world,s top scientists and clin... Philadelphia to present their latest research fin...Society of Human Genetics (ASHG) from Tuesday, Nov... the Pennsylvania Convention Center., Founded in ...organization for human genetics,specialists world...
(Date:10/10/2008)...port on a previously unknown relationship between ...mitochondria a cell,s energy makers. Stem cells wi...pacity to differentiate and are more likely to for... in JBC, could lead to methods of enriching the be...e and may provide some insights into the role of s...
(Date:10/10/2008)...IS Investigators from the Herman B Wells Center f...hool of Medicine are focusing on a family of blood...g the toxic effects of chemotherapy in children an...the development of targeted therapies for leukemia... , The researchers, led by Kristin T. Chun, Ph.D...
Breaking Biology News(10 mins):Fat-regenerating 'stem cells' found in mice 2The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 2The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 3The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 4The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 5On the trail of a targeted therapy for blood cancers 2Medifast Inc to Present at the Canaccord Adams Diabetes 26 Obesity Conference 20901 1Medifast Inc to Present at the Canaccord Adams Diabetes 26 Obesity Conference 20901 2Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598 2296 1Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598 2296 2Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598 2296 3Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598 2296 4Study of anti CD20 therapy effective B cell depletion 20898 1Study of anti CD20 therapy effective B cell depletion 20898 2Katzen Eye Group Announces a New Option in Vision Correction Technology for Patients 20895 1Katzen Eye Group Announces a New Option in Vision Correction Technology for Patients 20895 2| Copyright © 2003-2008 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |