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Sialic in Medical News

Drugs against winter vomiting disease one step closer

...e of these chains is characterised in that it has a monosaccharide known as sialic acid at its end. The thesis also shows that the virus binds to such sugar c...inding structures. "Our results suggest that the sugar chains that have sialic acid are important for infection by the virus, but this must be confirmed. ...

St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease

...ysosomes destined for lysosomal exocytosis is by cutting off a sugar called sialic acid from a structural protein of the lysosomal membrane, known as LAMP-1. ...l membrane and release their content outside the cell. When NEU1 strips the sialic acids off LAMP-1, this protein is rapidly turned over so that its total amo...

Ashwell receptor reduces mortality during sepsis

...ccus makes an enzyme called sialidase, which removes sugar molecules called sialic acid from host cells, and helps facilitate spread of the pathogen through t... sepsis, the researchers found that the pneumococcal sialidase also removes sialic acid from circulating host factors involved in blood coagulation, including...

$450,000 sweetener in colon cancer battle

...eensland said the compounds target a unique sugar, sialic acid, believed to give cancer cells their deadly a... a consistent link between the amount of the sugar sialic acid on the surface of cancer cells, and the abili...or spread to other parts of the body," he said. sialic acid is found in cells throughout the body, giving...

Nervous Systems of Insects may Offer Clues on Neurodegenerative Diseases

... understand this. This led to a second research project, which involves studying mutant flies that lack the ability to add the terminal sugar, sialic acid, to specific proteins of the central nervous system. Mutant flies exhibit abnormal mating behavior, have defects in their ability to fly and clim...

Mouse Model Points to Strategy for Treating Rare Muscle Disease & Kidney Disorders

...GNE gene, which codes for two enzymes that produce sialic acid, a sugar important to muscle development and ...idence that impairment of the enzymes that promote sialic acid production causes low sialic acid levels in muscle proteins. They hypothesized ...

Hybrid Molecule Causes Cancer Cells to Self-Destruct

...ily penetrates a cell’s surface, then is split apart by enzymes inside the cell. Once inside the cell, ManNAc is processed into another sugar known as sialic acid that plays key roles in cancer biology, while butyrate orchestrates the expression of genes responsible for halting the uncontrolled growth of ca...

An All Important Breakthrough Reached In Understanding T cell response For Parasitic Diseases

...-sialidase (or 'ts') family of genes. 'The function of the ts genes is crucial for the parasite,' said Tarleton, 'because the parasite must have sialic acids to invade cells and infect the host. But since it doesn’t have it, it must steal it from the host cells.' The problem is that T. cruzi potential...

Single Sugar Enables Antibody to Treat Inflammation

...tibodies in the IVIG solution carry a sugar called sialic acid that is required for its protective ability. ...'s how they discovered that just the very terminal sialic acid on the Fc portions of the IgG molecule were t...mmatory activity. When the researchers removed the sialic acid, the molecule retained its structure and its ...

Human Diseases May Have Clue In Human-Chimp Genome Difference

...r finding of the first truly human-specific protein in the September issue of Science. Siglecs are molecules that serve as binding receptors for sialic acids, which are sugars found on the surface of all higher animal cells. Comparing human and chimpanzee genome sequences, the researchers noted that a...
Sialic in Medical Products

Lipid Associated Sialic Acid

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Sialic in Medical Dictionary

Epididymis

...in therapy could be beneficial for the amelioration of fluoride induced ... sialic acid: sialic acid in the epididymis of both control and treated animals ... ,med...
Sialic in Biological News

Researchers find chink in the armor of viral 'tummy bug'

...dies by sticking to certain types of sugars called sialic acids on the surface of our stomach cells. They th... led to the conclusion that some viruses depend on sialic acid to infect the body while others were thought to cause infection independent of sialic acid. "Unsuccessful attempts to reduce rotaviru...

American Chemical Society's Weekly PressPac -- July 9, 2008

.... But antibody-based tests can be expensive and require refrigeration to remain stable. Their solution involved development of artificial forms of sialic acid, a sugar molecule found on the surface of cells that flu viruses attach to when they attack humans. In laboratory tests, the researchers showed t...

Sugar linkage could lead to better treatment for autoimmune diseases

...on the tip of this glycan is a specifically linked sialic acid. All the sialic acid on IVIG was converted to the active linkage t...Understanding and analyzing the exact structure of sialic acid was the contribution of the UNH Glycomics Cen...

'Invisible' bacteria dupe the human immune system

...apture the molecule used to make the cloak, called sialic acid. The researchers have now discovered an en...tivity that helps in the more efficient capture of sialic acids released from our cell surfaces. As well as using the sialic acid to make the invisibility cloak other bacteria...

Story ideas from Molecular & Cellular Proteomics

... of the cell surface proteins that are attached to sialic acid, which is the outside portion of some of the ...he number of protein-sugar structures that contain sialic acid in the blood plasma of a control individual a...d contained a significantly higher number of these sialic acid-containing structures than the control indivi...

Changes in amino acids in the 1918 influenza virus cut transmission

...ated in of the surface of the influenza virus, and sialic acid, a cellular molecule that is recognized by he...his process is the binding of the hemagglutinin to sialic acid containing molecules in the cell surface. There are two primary ways sialic acids are associated with molecules in the cell su...

Hybrid molecule causes cancer cells to self-destruct

...ily penetrates a cell's surface, then is split apart by enzymes inside the cell. Once inside the cell, ManNAc is processed into another sugar known as sialic acid that plays key roles in cancer biology, while butyrate orchestrates the expression of genes responsible for halting the uncontrolled growth of ca...

A single sugar found responsible for an antibody's ability to treat inflammation

...tibodies in the IVIG solution carry a sugar called sialic acid that is required for its protective ability. ...'s how they discovered that just the very terminal sialic acid on the Fc portions of the IgG molecule were t...mmatory activity. When the researchers removed the sialic acid, the molecule retained its structure and its ...

Researchers add crucial information on how the body's T cells react to parasitic diseases

...ns-sialidase (or "ts") family of genes. "The function of the ts genes is crucial for the parasite," said Tarleton, "because the parasite must have sialic acids to invade cells and infect the host. But since it doesn't have it, it must steal it from the host cells." The problem is that T. cruzi potential...

Minor mutations in avian flu virus increase chances of human infection

...tors containing complex glycans-carbohydrates-that in turn contain terminal sialic acids. Avian viruses prefer binding to ?2-3-linked sialic acids on receptors of intestinal epithelial cells, while human viruses are ...
Sialic in Biological Technology

High-Tech 'Smart' Face Mask Helps Hong Kong Families Combat Swine Flu

... a terminal sialic acid residue on the surface of the human cell membrane. The binding agent in the BioFriend(TM) textile mimics the binding action of sialic acid on influenza viruses. Typical face masks (including standard surgical masks and N95s) do not kill airborne pathogens. They are based on a ...

Australia: Face Mask That Kills Swine Flu Readied for Australian Pandemic Fight

... Many viruses, including influenza viruses, are known to bind to a terminal sialic acid residue on the surface of the human cell membrane. The binding agent in the BioFriend(TM) textile mimics the binding action of sialic acid on influenza viruses. Typical face masks (including standard su...

Hong Kong Biotech Company, Filligent, Announces CE Certification of Its Revolutionary, Anti-Infective Medical Face Mask, the BioMask

... Many viruses, including influenza viruses, are known to bind to a terminal sialic acid residue on the surface of the human cell membrane. The binding agent in the BioFriend(TM) textile mimics the binding action of sialic acid on influenza viruses. Typical face masks (including standard su...

Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn

... core structure with extensions and branches composed primarily of sialic acid, galactose and N-acetylglucosamine. Figure...This glycoform was found to have a typical structure including one sialic acid, two galactoses and two N-acetylglucosamines (GlcN) (labeled ...
Sialic in Biological Products

Glycoprotein Isolation Kit WGA from Pierce Biotechnology, Inc.

Description:...A lectin, recognizes a-linked mannose and terminal glucose residues while WGA lectin, selectively binds to N-Acetyl glucosamine (GlcNAc) groups and to sialic acid. High recovery Equivalent or greater glycoprotein recovery versus competitor kits and lectin resins Fast Glycoprotein purification in...
Company:Pierce Biotechnology, Inc.
Sialic in Biological Definition

Glycoprotein

...yproline , serine , or threonine . Possible carbohydrates include glucose , glucosamine , galactose , galactosamine , mannose , fructose , and sialic acid . The sugar group can assist in protein folding or improve its stability. Glycoproteins are often used in proteins that are at least in part ...

Stem cell

...ted with nonhuman molecules from the culture medium used to grow the cells, for example, mouse cells and other animal cells. The nonhuman cell-surface sialic acid can compromise the potential uses of the embryonic stem cells in humans--according to scientists at the University of California, San Diego [7]...
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