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Shutdown in Medical News

Pennsylvania Government's Partial Shutdown Ends

The budget impasse that existed in the Pennsylvania government after a deal was struck between the legislator and the governor on Monday night More than 24,000 state workers returned to work after they were sent back home without pay. "This is an agreement where all sides can say that they a...

South Africa Facing Major Economic Shutdown as Health Workers are Sacked En Masse

South Africa could experience a total economic shutdown as some 2 million public servants take to the streets over an ongoing wage dispute . 'It's going to be a total shutdown tomorrow in public services and the economy. It's gonna be a massive strike involving marches in major cities and pickets ...

Nuvo Announces 2009 second quarter financial results

...une 30, 2009 compared to $0.8 million for the comparable quarter in 2008. The decrease in gross margin is primarily attributable to the planned 8 week shutdown of the Pennsaid manufacturing facility to prepare for the U.S. launch of Pennsaid. For the six months ended June 30, 2009, gross margin on product sal...

West Announces Second Quarter 2009 Results

...d full reimbursement for, among other things, severance-related employee costs, inventory on hand, leases and other facility costs associated with the shutdown of operations at the former Exubera(R) device manufacturing facility. During the first and second quarters of 2008, we received contract settlement p...

Scientists Track Impact of DNA Damage in the Developing Brain

... the enzyme. The result was a mouse whose nervous system lacked Xrcc1 and so was unable to efficiently repair the single-strand DNA damage. The shutdown triggered a dramatic decline of interneurons throughout the cerebellum. In a subgroup of those cells, the damage triggered apoptosis, or programmed ce...

MDS Nordion Continues to Urge Government of Canada to Complete MAPLE Project to Address Critical Medical Isotope Shortage

...are not a guarantee of future impact or performance and are inherently subject to risks and uncertainties. The actual impact to the Company of the NRU shutdown could differ materially from that currently anticipated due to a number of factors, including, the actual timing of a return to full production and ot...

Government of Canada supports research to help address medical isotope shortage

...rnment of Canada is supporting research to find alternatives to nuclear-produced Technetium-99m, the principal medical isotope affected by the current shutdown at the Chalk River nuclear reactor. Health professionals use medical isotopes in combination with imaging technologies to diagnose and treat condition...

MDS Reports Second Quarter 2009 Financial Results

... related to NRU-supplied isotopes, MDS expects the financial impact of this shutdown to reduce MDS Nordion's adjusted EBITDA by approximately $4 million for eve...is out of service. MDS is assessing plans to reduce costs over the extended shutdown period. MDS Nordion continues to deliver positive EBITDA from sterilization...

MDS Nordion Urges Government of Canada to Complete MAPLE Project to Address Current Medical Isotope Supply Shortage

...d increasingly important field of nuclear medicine. "The current NRU shutdown - and the shutdown of November 2007 - illustrates the fragility and unpredictability of the gl...

MDS Nordion Provides Update on AECL's Medical Isotope Supply Disruption

... press release issued by AECL on May 18, 2009, the shutdown is a result of a heavy water leak that has been id...deration. MDS Nordion expects the impact of this shutdown to begin to be felt this week. The NRU produces ap...he actual impact to the Company of the maintenance shutdown could differ materially from that currently antici...
Shutdown in Medical Technology

Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer

... GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti-tumoral immune attack. About Jennerex Jennerex is a clinical-stage biopharmaceutical company focused on the development and...

Jennerex Completes the Treatment of First Patient Cohort in Phase 1 Trial With Intravenous Delivery of JX-594 Oncolytic Virus

... GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti-tumoral immune attack. About Jennerex Jennerex Biotherapeutics was established in San Francisco and in Ottawa in 2006 with Dr. David K...

Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus

... GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti-tumoral immune attack. About Jennerex Jennerex is a clinical-stage biopharmaceutical company focused on the development and commercial...

Jennerex Publishes Promising Results from Cancer Clinical Trial of JX-594 in Lancet Oncology

... GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti-tumoral immune attack. About Jennerex Jennerex is a clinical-stage biopharmaceutical company focused on the development and commercial...

Study Shows Metabolic Strategy of Stressed Cell

...h issue of "Chemistry and Biology." The researchers studied the response to decreased CoA in a mouse model by blocking CoA production. Following the shutdown of CoA production, the cells quickly recycled CoA from other jobs so it could concentrate all its efforts on a single task: extracting life-supporting...

Major Manufacturer of Unapproved and Adulterated Drugs

... of five years and to provide reports to FDA analyzing compliance with CGMP and labeling requirements. The decree also allows FDA to require recall or shutdown in the event of future violations and provides for damages of $5,000 per day and $1,000 per violation, up to a maximum of $5 million per year, if the ...
Shutdown in Medical Products

Digit Finger Oximeter

Description:... rate and pulse strength measurements on patients from pediatric to adult. Its pocket-size with a large LED display, one button keypad and auto power shutdown after 8 seconds when not in use, makes it ideal for emergency, hospital or clinical environments, or for home use. The Digit Finger Oximeter is avail...
Company:Smiths Medical MD, Inc.

GR 4.22 Powerful Programmable Refrigerated Floor-standing Centrifuge.

Description:...ors, large choice of accessories, microprocessor control, lifetime reproducibility, informative display, display in 4 languages, imbalance detection & shutdown (JOUAN patented pendulum system), guard barrier, dual lid interlock, current and temperature limitation, rugged motor, tough steel casing with chemica...
Company:ThermoFisher Scientific

GR 4.12 Powerful Refrigerated Floor-Standing Centrifuge.

Description:...le space saver, very powerful, high capacity rotors, large choice of accessories, analog controls, large bright digital display, imbalance detection & shutdown (JOUAN patented pendulum system), guard barrier, dual lid interlock, current and temperature limitation, rugged motor, tough steel casing with chemica...
Company:ThermoFisher Scientific

G 4.12 Powerful Ventilated Floor-Standing Centrifuge

Description:...le space saver, very powerful, high capacity rotors, large choice of accessories, analog controls, large bright digital display, imbalance detection & shutdown (JOUAN patented pendulum system), guard barrier, dual lid interlock, current and temperature limitation, rugged motor, tough steel casing with chemica...
Company:ThermoFisher Scientific

Digit Finger Pulse Oximeter

Features:...ED display allows for use in a wide range of light and dark environments Two "AAA" cell batteries provide power for 1,400 spot-checks Auto power shutdown after 8 seconds when not in use conserves batteries Low battery indicator flashes when 30 minutes of battery time remains ...
Company:Invacare Corporation

Model 5200 Warming Unit

Features:... Automatic temperature step-down and automatic shutdown Highest air flow rate at 55 CFM Fast warm-up (38 °C in 30 seconds) Smooth, durable housing accommodates easy cleaning Quiet operation (Le...
Company:Nellcor

WarmTouch Model 5300 Warming Unit

Features:... Automatic temperature step-down from boost (45C) to high (43C) to warm very cold patients. Automatic shutdown at 50C to assure patient safety. Provides outstanding patient warming and safety throughout the hospital. Highest air flow rate of any convective ...
Company:Nellcor

Digistim 2 Plus Nerve Stimulator

Features:...p assembly), battery, and 6 foot leads with alligator clips are included. Low power consumption. Double-burst stimulation output mode. Automatic shutdown indicated by audible signal after 20 minutes of nonuse. Adjustable volume on beep-tone. ...
Company:CCR Medical

LP440

Features:...ow aspiration sequence enhancing volume equality in every well for both 96- and 384-well formats. No limitation of the wash and waste bottles. Minimum shutdown time. Automatic rinsing for cleaning the internal tubing and needles to facilitate daily maintenance. Self-Calibration of the dispensed volume, liquid...
Company:Adil Instruments

COULTER AcT 5diff OV (Open Vial)

Features:...inable patient and action ranges for enhanced flexibility 60 sample-per-hour throughput for streamlined workflow One-step setup, operation and shutdown speeds workflow Zero daily maintenance saves time and labor Random access testing for complete workflow flexibility CBC or CBC/Diff mode a...
Company:Beckman Coulter, Inc.
Shutdown in Biological News

Scientists track impact of DNA damage in the developing brain

...n by the enzyme. The result was a mouse whose nervous system lacked Xrcc1 and so was unable to efficiently repair the single-strand DNA damage. The shutdown triggered a dramatic decline of interneurons throughout the cerebellum. In a subgroup of those cells, the damage triggered apoptosis, or programmed ce...

Researchers identify gene linked to aggressive progression of liver cancer

...tes multiple intracellular signaling pathways that are known to be involved in HCC progression. So, strategies to inhibit AEG-1 that could lead to the shutdown of these pathways, either by small molecules or by siRNAs, might be an important therapeutic modality for HCC patients," said principal investigator D...

Researchers find nature's shut-off switch for cellulose production

...gh rinds of corn stalks, vascular elements to conduct water and fibers for strength," he said. The researchers said that delaying or preventing the shutdown of both primary and secondary cellulose production might enhance total plant biomass. "Most biofuel researchers believe that cellulose utilization ...

Moderate use averts failure of type 2 diabetes drugs in animal model

...in G. Nichols, Ph.D., the Carl F. Cori Professor and professor of cell biology and physiology. "We've shown in a mouse model that whatever causes this shutdown doesn't kill the insulin-making beta cells of the pancreas or stop them from making insulin. Instead, it somehow stops them from secreting insulin." ...

Researchers discover critical detail of cellular defense against genetic mistakes

...st search for detail, Maquat and colleagues determined that the delivery of a given faulty mRNA to the degradation machinery requires first the active shutdown (translational repression) of protein building based on that mRNA. In the studys key finding, experiments revealed that repression of protein synthesi...

Botched production of insulin molecule may lead to diabetes

...mprehensive Diabetes Center, explains that this chain reaction can start with just a few misfolded proinsulin molecules. It can then lead to beta cell shutdown and an insulin shortage. The misfolded proinsulin does not get exported from the factory, and neither does the normally folded proinsulin made after i...

Researchers shed light on mechanism of action used by anti-cancer drug

...n the ER stress response, and which helps to resolve stresses associated with increased protein loads. The net effect of these actions was to induce a shutdown of protein synthesis accompanied by a dramatic increase in cell death. “The notion that sorafenib acts by inhibiting protein synthesis and reduc...

New mechanism for nutrient uptake discovered

...thor Wolf Frommer. "Imagine a large animal marking its territory. A sudden flow of ammonia could be toxic to the plant. If it weren't for a rapid-fire shutdown plants could die. The conservation of this feature in the related transporters in bacteria, fungi, plants, and animals suggests that an ancient organi...

A wolf in sheep's clothing: Plague bacteria reveal one of their virulence tricks

...the configuration looked just like one formed by some of the host's own signaling proteins. And it's this mimicry, he found, that leads to a signaling shutdown and deregulation of the cell's normal structure. After establishing this effect, Prehna set about disrupting it by mutation. Using the structure t...

Molecular 'on/off switch' controls immune defenses against viruses

...rugs that could mimic viral effects on RIG-I to spur antiviral response or, conversely, mimic viral effects on LGP2 to shut down RIG-I activity. RIG-I shutdown would be necessary in cases when the immune system's response to a virus is dangerously overactive, which happened in many flu cases during the 1918 p...
Shutdown in Biological Technology

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

...gators' hypothesis that rapamycin is active only on mTORC1 and inhibition of mTORC2 by either Erlotinib or Perifosine is necessary to achieve complete shutdown of mTOR signaling pathway. The following abstract was presented yesterday: Abstract 2822: Evidence implicating Bim activation/inducti...

IDM Pharma Reports 2008 Financial Results

...07 to terminate its participation in the UVIDEM development program. The $3.5 million includes $3.2 million of severance benefits and $0.6 million of shutdown costs, offset by $0.3 million of proceeds from the sale of fixed assets. Interest income decreased to $0.1 million for the three months ended Dec...

White Paper Details How DNA Sequencing Services Can Prevent Cleanroom Shutdowns at Medical Device and Pharmaceutical Manufacturers

... AGAWAM, Mass., March 3 /PRNewswire/ -- Contamination by an unknown organism often calls for total shutdown of a cleanroom's operation until that organism can be identified and eliminated. Such shutdowns can have catastrophic effects on the schedules and pr...

Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic

...herapies such as chemotherapy and radiation. Simultaneously, a therapeutic cascade is initiated by product replication resulting in tumor vasculature shutdown and anti-tumoral immune attack. In addition, these products are "armed" with immune-stimulatory GM-CSF that destroys cancers by complementary and syn...

White Paper Details How DNA Sequencing Services Can Prevent Cleanroom Shutdowns at Medical Device and Pharmaceutical Manufacturers

... AGAWAM, Mass., Nov. 11 /PRNewswire/ -- Contamination by an unknown organism often calls for total shutdown of a cleanroom's operation until that organism can be identified and eliminated. Such shutdowns can have catastrophic effects on the schedules and pro...

Jennerex Completes $8.3 Million Series B Financing and Appoints Dr. Cal Stiller as Director

... GM-CSF complements the cancer cell lysis work of the product candidate, leading to a cascade of events resulting in tumor necrosis, tumor vasculature shutdown and an anti- tumoral immune attack. About Jennerex Jennerex is a clinical-stage biopharmaceutical company focused on the development and commercia...

Strong Double-Digit Net Sales Growth and Solid Earnings Growth Highlight First Quarter for Bristol-Myers Squibb Company

...tive: Downsizing and streamlining of worldwide operations $- $- $- $11 $- $11 Accelerated depreciation and other shutdown costs 96 - - - - 96 Process standardization implementation costs - 15 - - - ...

Cryolife Once Again Severely Maims an Innocent Knee Surgery Patient

...nother of the Keenan Law Firm's clients, first alerted the nation of the unregulated cadaver tissue billion dollar industry. Brian's death led the FDA shutdown in 2002 of Cryolife's tissue business and the passage of 900 plus pages of safety regulations which at the time of passage were insufficient and creat...

Hurricane Katrina: Many disaster recovery systems were outdated

...o look at what to do after a manmade or natural disaster. One is to look at disaster recovery, which from a traditional sense is to have an orderly shutdown of systems. This was how most organizations looked at their information technology systems in the 1980s and 1990s. Most consulting firms and those at ...

Connecture's Maynard finds IT business opportunity in adversity

... W aukesha, Wis. - As the web-centric business sector continued its crash in 2001, the directors of an East Coast company were contemplating the shutdown of their Wisconsin-based business unit. Their decision was only delayed when the events of Sept. 11 forced postponement of the board meeting in New Yo...
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