Penn researchers find key to Sonic hedgehog control of brain development
...in some cancers.
"Elucidating the regulators of shh
expression in the forebrain will not only improve ...a type of holoprosencephaly.
A decrease in the shh
protein by 50 percent predisposes humans to cranio...acial problems such as holoprosencephaly. Too much shh
can lead to tumor formation....
Stem cells give clues to understanding cancer and make breakthrough in childhood leukaemia
...o send important signals between cells. We have shown that interfering with shh
signalling decreases the size of tumours, which is proof of principle that ...g cancer in the laboratory with chemicals that inhibit the activity of the shh
pathway and lead to the inhibition of Gli-1. We take tumour samples and gro...
Researchers Develop Mouse Model Of Brain Tumor
...sel and colleagues have shown through the above-mentioned model that Ink4c inactivation collaborates with a mutation in a gene called Patched (Ptc1, a shh
receptor) to trigger the development of this tumor. "Preliminary data suggest that INK4c protein expression is diminished in a significant cohort of h...
Focused Treatment For Childhood Cancer
... on those tumors that have that particular molecular pathway active," says Pomeroy.
Recently developed compounds that can block the uncontrolled shh
signaling found in the tumors could potentially be used as a therapy in children with medulloblastoma. Researchers also found that the clinical outcom...
Shh in Medical Dictionary
...ice supplies like quill brand desktop calculator; 8- digit at Medical Arts Press. posted to d2d4 digit female length twins by naturecure to ... shh
and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. ... check digit ( ′chek ′dijət ) ( computer s...
Shh in Biological News
Identification of a key molecular pathway required for brain neural circuit formation
...tanford University, Frdric Charron discovered that shh
acted as an axonal attractant for brain and spinal cord neurons. "How exactly shh
elicited this effect has remained unknown so far,"...rt of an answer."
Their recent work showed that shh
exerts its attractive effect through a group of mo...
James Briscoe awarded 2008 EMBO Gold Medal
Briscoe and his group discovered a novel mechanism that allows cells to integrate the time of exposure and the concentration of the morphogen shh
to subsequently mount a graded response. In other words, different concentrations of the morphogen activate a signal within the receiving cell for dif...
Wisconsin researchers describe how digits grow
...ehog (SHH) plays an important role in determining the form and number of digits, and many believe that other secondary signaling centers downstream of shh
also are involved in establishing a particular digit's identity.
In a 2000 paper published in Science, Fallon and graduate student Randall Dahn sh...
Molecular mechanism of feather formation found
...ather-the function of these two proteins interact. shh
up-regulates its own expression and that of Bmp2, and Bmp2 then signals the down-regulation of shh
expression. This dynamic signaling interaction fit...esults suggested that a simple interaction between shh
and Bmp2 is sufficient to model the creation and p...
Shh in Biological Definition
...ignaling molecule Sonic hedgehog (Shh), and it is this gradient that directs cells to form patterns in the embryonic neural tube: cells that receive shh
in a receptor in their membranes called Patched1 (Ptc1) survive and proliferate; but, in the absence of Shh, one of the ends of this same Ptc1 recepto...