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Serine in Medical News

E. coli persists against antibiotics through HipA-induced dormancy

...sociate professor of biochemistry and molecular biology. While other types of phosphorylation occur in bacteria, HipA phosphorylates proteins at their serine or threonine amino acids. This kinase activity is more commonly associated with eukaryotic cells, which make up animals, plants and fungi, and are gen...

Work with fungus uncovering keys to DNA methylation

...n is important for DNA methylation," Selker said. The new paper by Adhvaryu and Selker shows that PP1 is important to remove phosphates attached to serine 10 of H3, the site immediately adjacent to the site that DIM-5 needs to methylate, leading to DNA methylation. In an accompanying article in the s...

JCI table of contents: June 20, 2008

...eumatoid arthritis. One mechanism by which neutrophils protect us is to internalize microorganisms and destroy them using proteins known as neutrophil serine proteases (NSPs), but whether NSPs have a role in noninfectious chronic inflammation has not been clearly determined. However, using mice lacking two ...

A new finding in liver transplantation and antifibrinolytics?

...formed by a team led by Professor Wang Xuehao, is to be published in the March 7, 2008 issue of the World Journal of Gastroenterology. Aprotinin, a serine protease inhibitor, is used increasingly often in surgeries during operations such as cardiac surgery and liver transplantation to reduce bleeding and...

Pathway to cell death redefined in landmark study

... for Alzheimers and Parkinsons diseases. The work appears on the Sept. 21 cover of the journal Cell. This remarkable molecular trigger, SRP-6, is a serine protease inhibitor or serpin, and targets the cells digestive center, the lysosome. The authors report that the family of intracellular serpins may he...

Pathway to cell death redefined in landmark study

... for Alzheimers and Parkinsons diseases. The work appears on the Sept. 21 cover of the journal Cell. This remarkable molecular trigger, SRP-6, is a serine protease inhibitor or serpin, and targets the cells digestive center, the lysosome. The authors report that the family of intracellular serpins may he...
Serine in Medical Technology

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

...-in period) in treatment-naive patients with HCV genotype 1. About the HCV SPRINT-1 Study In this Phase II study, known as HCV SPRINT-1 (HCV serine Protease Inhibitor Therapy-1), boceprevir (800 mg TID) was evaluated in three treatment regimens: 4 weeks of PEGINTRON (1.5 mcg/kg once weekly) and R...

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

...presentation at a future medical meeting. About the Boceprevir HCV SPRINT-1 Study In this Phase II study, known as HCV SPRINT-1 (HCV serine Protease Inhibitor Therapy-1), boceprevir (800 mg TID) was evaluated in three treatment regimens: 4 weeks of PEGINTRON (1.5 mcg/kg once weekly) and R...

Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients

... compared to the no lead-in arms (7 and 11 percent, respectively). About the HCV SPRINT-1 Study In this Phase II study, known as HCV SPRINT-1 (HCV serine Protease Inhibitor Therapy-1), boceprevir (800 mg TID) was evaluated in three treatment regimens: 4 weeks of PEGINTRON (1.5 mcg/kg once weekly) and RE...

Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients

...re between 9 and 19 percent for patients in the boceprevir arms, compared to 8 percent for the control arm. In the study, known as HCV SPRINT-1 (HCV serine Protease Inhibitor Therapy-1), boceprevir (800 mg TID) was evaluated in three treatment regimens: 4 weeks of PEGINTRON (1.5 mcg/kg once weekly) and RE...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

...dy. Pivotal Study in Patients Who Failed Prior Treatment The primary objective of this pivotal study, known as HCV RESPOND-2 (Retreatment with HCV serine Protease Inhibitor Boceprevir and PEGINTRON/REBETOL) is to evaluate the efficacy of 36- and 48-week regimens of boceprevir (800 mg TID) in combination...

Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL

...represent 16 percent of the patients enrolled and 7 percent of patients in the study are cirrhotic. In the ongoing study, known as HCV SPRINT-1 (HCV serine Protease Inhibitor Therapy-1), boceprevir (800 mg TID) is being evaluated in three treatment regimens: 4 weeks of PEGINTRON (1.5 mcg/kg once weekly) a...
Serine in Medical Products

Ghrelin, Total ELISA Test

Description:... Ghrelin is a 28 amino-acid lipophilic peptide with a labile octanoic acid side chain at the serine residue three, that is primarily expressed in specialized enterochromaffin cells located mainly in the mucosa of the fundus of the stomach (1) and has...
Company:Diagnostic Systems Laboratories, Inc.

Prostate Specific Antigen (PSA) - Rapid Test

Description:... Prostate specific antigen (PSA) is a serine protease that is found only in the prostate within the epithelial cells of the acini and ducts. Normal PSA concentration in whole blood or serum is 0....
Company:Bio-Quant, Inc.

OneStep PSA InstaTest

Description:... Prostate specific antigen (PSA) is a serine protease that is found only in the prostate within the epithelial cells of the acini and ducts. Normal PSA concentration in whole blood or serum...
Company:Bio-Quant, Inc.

Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-48 Myeloperoxidase

Description:...A were directed against an antigen in the azurophil granules of the cytoplasm of human neutrophils (8) and later that the principal antigen was a 29kD serine protease identical to proteinase 3 or myeloblastin (9,10,11). When detected by antigen specific assays these autoantibodies are termed 29kD-ANCA or PR...
Company:ALPCO Diagnostics
Serine in Medical Dictionary

Protein C

...in C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by thrombin into activat...C in inhibiting factors Va and VIIIa. ... Activated Protein C is a serine protease which functions to inactivate Factors Va and VIIIa. ... normal lev...

Factor XII

... Hageman factor is a plasma protein also known as factor XII . It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease class. In humans, factor XII is encoded by the F12 gene. factor XII ( ′faktər ′twelv ) ( biochemistry ) A blood clotting factor ...

Alpha-1 antitrypsin

... generally known as serum trypsin inhibitor. Alpha 1 - antitrypsin is also referred to as alpha - 1 proteinase inhibitor (A1PI) because it is a serine protease... Alpha 1 - antitrypsin deficiency is a genetic disorder caused by defective production of alpha 1 - antitrypsin (A1AT), leading t...
Serine in Biological News

New piece found in the puzzle of epigenetics

...nd how specific amino acids of this region are modified biochemically. Thus, it is absolutely essential for the synthesis of snRNA that the amino acid serine at position 7 of this repeat sequence is provided with an additional phosphate group. If this is lacking, mRNA will be produced, but not any snRNA. Th...

Why 'lazy Susan' has a weak heart

...ey discovered the crucial change in the amino acid serine 195, which was lost through mutation. This single ...of zebrafish, the researchers are confident that a serine 195 mutation will have a similar affect in human h...atients. A targeted modification of the amino acid serine could increase the activity of the actin-myosin co...

Meyskens honored with AACR-Prevent Cancer Foundation award

...predictors of preventive effectiveness. Currently, Meyskens is continuing the clinical development of the Bowman-Birk inhibitor, a soybean-derived serine protease inhibitor, being tested as a human cancer-preventive agent. Meyskens received a Bachelor of Science degree from the University of San Fran...

A genetic cause for iron deficiency

...with more than one chronically iron-deficient member. They found a variety of mutations in a gene called TMPRSS6 (the acronym stands for transmembrane serine protease S6) in all of these families, as well as several patients without a family history of the disorder. Although IRIDA is quite rare, the aut...

Evolution with a restricted number of genes

... is still largely enigmatic. The groups of Dirk Eick and Shona Murphy have now shown a differential requirement for phosphorylation of the amino acid serine at position 7 of CTD in the processing and maturation of specific gene products. These results provide the groundwork for the discovery of further pie...

Pathogens use previously undescribed mechanism to sabotage host immune system

...othreonine lyases and explain the enzymes differential activities towards different MAPK substrates, explains Dr. Shao. Further, as phosphorylation of serine and threonine residues is widely used as a regulatory mechanism in mammalian cells, the researchers speculated that phosphoserine or phosphothreonine ...
Serine in Biological Technology

Affitech and Omeros Enter Into Antibody Discovery and Development Agreement

...ies for Omeros' MASP-2 program. MASP-2, or mannan-binding lectin-associated serine protease-2, mediates activation of the complement system via the lectin pat...flammatory therapeutics." About MASP-2 Mannan-binding lectin-associated serine protease-2 (MASP-2), a novel pro-inflammatory protein target, is involved i...

A Microtiter-based Assay for the Determination of ID50s of b-lactamase Inhibitors Employing Reporter Substrates Detected at UV or Visible Wavelengths (MaxLine Application Note #20)

...946; -lactamases produced by clinical isolates are serine active site enzymes. One successful approach to combating the serine active site β -lactamases is the use of β...; -lactamases). These enzymes are not sensitive to serine β lactamase inhibitors and have a much broade...

DELFIA Protein Kinase assays.

... Protein kinases use ATP to phosphorylate certain amino acid residues (tyrosine, serine or threonine) on their substrates. In receptormediated signalling the phosphorylation forms an important secondary messenger system. Phosphorylation c...

DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging

...re washed twice with PBS and blocked using 1% BSA (in PBS) for 30 minutes. For the detection of phosphorylated H2AX, the mouse monoclonal anti-phospho serine 139 H2AX antibody (Chemicon, 05-636) at 2 μg/mL in 1% BSA block was used. 53BP1 was detected using the anti-53BP1 rabbit polyclonal antibody (Nov...

Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS

...ptides are seen in addition to small peaks representing residual Pbf (Arg-protecting group). These are due to released Pbf attacking, for example, the serine residue. Small contributions from cationization with sodium and potassium are also observed. Figure 3 shows the MH+ region of the completed ...

Quantitative Analysis of GFP in Plant Extracts Using the VersaFluor Fluorometer System

... for eukaryotes, or altered spectral properties. One form, GFP-S65T incorporates a threonine amino acid substitution in place of serine at position 65, which results in red-shifted fluorescence characteristics. 1 This form is one that has been proven to be very beneficial ...
Serine in Biological Products

Rabbit Anti-ATF4, phospho (Ser245) Polyclonal Antibody, Unconjugated from Abcam

Description:...pho S245) ( Abpromise for all tested applications). Antigen: Synthetic phosphopeptide derived from human ATF4 around the phosphorylation site of serine 245. Entrez GeneID: 468 SWISS Protein ID: P18848...
Company:Abcam

Rabbit Anti-MKK6, phospho (Ser207) Polyclonal Antibody, Unconjugated from Abcam

Description:...spho S207) ( Abpromise for all tested applications). Antigen: Synthetic phosphopeptide derived from human MKK6 around the phosphorylation site of serine 207 (V-D-S P -V-A). Entrez Gene ID: 5608 Swiss Protein ID: P52564...
Company:Abcam

Rabbit Anti-Jun B, phospho (Ser79) Polyclonal Antibody, Unconjugated from Lab Vision

Description:...ation, diverge. Antigen: The antibody was produced against synthesized phospho- peptide derived from human JunB around the phosphorylation site of serine 79....
Company:Lab Vision

Mouse Serpin A1 from R&D Systems

Description:... Recombinant Mouse Serpin A1/alpha-1-Antitrypsin, CF Protein Family: Coagulation, serine Protease Regulators...
Company:R&D Systems

Goat Anti-Human TFPI Polyclonal Antibody, Unconjugated from R&D Systems

Description:... Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, serine Protease Regulators...
Company:R&D Systems

Anti-PEBP Polyclonal Antibody, unconjugated, Clone ZLK.17 from Invitrogen

Description:...BP) does not share significant homology with other serine protease inhibitors. PEBP is expressed in the cen...in is exerting inhibitory activity against several serine proteases including thrombin, neuropsin, and chymotrypsin. serine proteases are involved in many processes during de...
Company:Invitrogen
Serine in Biological Definition

Amino acid

...ilic 146.15 5.65 2.17 9.13 R Arg Arginine basic 174.20 10.76 1.82 8.99 12.48 S Ser serine hydrophilic 105.09 5.68 2.19 9.21 T Thr Threonine hydrophilic 119.12 5.60 2.09 9.10 V...

Genetic code

...UG (Leu/L) Leucine , Start UCU (Ser/S) serine UCC (Ser/S) serine UCA (Ser/S) serine UCG (Ser/S)...

Cytotoxic T cell

... plasma membrane ; this causes ions and water to flow into the target cell, making it expand and eventually lyse . T C also release granzyme , a serine protease , that can enter target cells via the perforin-formed pore and induce apoptosis (cell death). Most T C cells have present on the cell su...

Genetic code

...UG (Leu/L) Leucine , Start UCU (Ser/S) serine UCC (Ser/S) serine UCA (Ser/S) serine UCG (Ser/S)...

Glycoprotein

...The carbohydrate is usually attached to the protein in a posttranslational modification , at either asparagine , hydroxylysine , hydroxyproline , serine , or threonine . Possible carbohydrates include glucose , glucosamine , galactose , galactosamine , mannose , fructose , and sialic acid . Th...

Lipase

...mage below) and employ a chymotrypsin-like hydrolysis mechanism involving a serine nucleophile, an acid residue (usually aspartic acid), and a histidine. S...Turkenburg, L. Christiansen, B. Huge-Jensen, L. Norskov, and et al. 1990. A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Natu...
Serine in Biological Dictionary

Glycoprotein

...ies, research information, and more. ... Search " Glycoprotein " ... Shop for Reelin Glycoprotein - Books at Shop.com. Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin... Lifestyle, fitness & health information about Glycoprotein ....
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