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Selectivity in Medical News

Selective attention increases both gain and feature selectivity of the human auditory cortex

On Sept. 19, a research report by Helsinki University of Technology, Laboratory of Computational Engineering scientists will appear in the online, open-access journal PLoS ONE, showing that selective attention increases both gain and feature selectivity of the human auditory cortex. The ability...

EntreMed Reports Second Quarter 2009 Financial Results

...evelopment collaborations." About ENMD-2076 ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. Preclinical studies with ENMD-2076 demonstrated significant antitumor activity, including tumor regression,...

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

... the gastrointestinal symptoms associated with Bezielle treatment. We believe Bezielle may be an important new anticancer agent because its biological selectivity allows it to kill cancer cells without affecting normal cells. This also leads to a dramatically lower side effect profile." Bezielle ...

Arena Pharmaceuticals Announces Second Quarter 2009 Financial Results and Recent Developments

...DA, and the submission of the BLOOM-DM results as a supplement to the NDA; the development, advancement, therapeutic indication, tolerability, safety, selectivity and efficacy of lorcaserin; the protocol, design, scope, enrollment and other aspects of the lorcaserin trials; the potential of lorcaserin in managin...

With Autism, Diet Restrictions May Do More Harm Than Good

...d into five groups: constipation; diarrhea; abdominal bloating, discomfort or irritability; gastroesophageal reflux or vomiting; and feeding issues or selectivity (people with autism often stick with the same food choices and have other "ritualistic tendencies" in eating). The frequency of GI symptoms was ab...

Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009

...oratory. Clinical Toxicology LC/MS/MS is now widely used in confirmation analysis in clinical toxicology. The sensitivity, speed, selectivity and simple sample pre-treatment requirements have led to LC/MS/MS methods being adopted as the preferred choice for many important applications. At AA...
Selectivity in Medical Technology

GenVec Announces New Research at AACR on Selectivity and Mechanism of Action of TNF-Based Anti-Cancer Therapy

GAITHERSBURG, Md.--(BUSINESS WIRE)--Apr 17, 2007 - GenVec, Inc. (Nasdaq:GNVC) announced today data from two studies presented at the 97th annual meeting of the American Association of Cancer Research (AACR) that further support the use of adenovector systems to deliver the gene for tumor necrosis f...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

...ective drugs. The study determines the relative ER selectivity and pattern of gene expression of the three classe...therapy. The study also demonstrates the cell type selectivity of Menerba (MF101) and Liquiritigenin, two of Bion...ssential that new drug candidates demonstrate drug selectivity and tissue specificity in order to minimize advers...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... a specially designed proprietary assay, our team of researchers was able to discover and optimize a small molecule capable of demonstrating exquisite selectivity for the LMP7 immunoproteasome subunit," said Susan Molineaux, Ph.D., Chief Scientific Officer at Proteolix. "This selective inhibition of the immunop...

Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk

...uch forward-looking statements include statements about the BLOOM results; the development, advancement, therapeutic indication, tolerability, safety, selectivity and efficacy of lorcaserin; the FDA's guidance, process and requirements; the potential of the lorcaserin Phase 3 program and its results to meet the ...

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

...s web site at www.entremed.com . About ENMD-2076 ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. Preclinical studies with ENMD-2076 demonstrated significant antitumor activity, including tumor regression,...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

...d is known to cause 60% of melanomas, the most deadly form of skin cancer, and approximately eight percent of all solid tumours. PLX4032's potency and selectivity is expected to result in a treatment that is both effective and well tolerated. Malignant melanoma is the most serious type of skin cancer, with ...
Selectivity in Medical Products

VersaFluor Cuvette Fluorometer

Description:...and simple way to quantitate DNA, RNA, and proteins, to detect apoptosis, and to perform reporter enzyme assays with the high level of sensitivity and selectivity that fluorescent detection offers....
Company:Bio-Rad Laboratories

CUSA EXcel Ultrasonic Surgical Aspirator

Features:...o reduce noise in the OR. Enters a quiet "resting" state when not in use. Unique TissueSelect function maintains fragmentation while maximizing selectivity for surgeon control. CEM nosecones add electrosurgery functionality. Laparoscopic mode for effective minimally invasive procedures. Powerful...
Company:Integra Radionics, Inc.

Apogee Elite Two-in-One Laser System

Features:...ng in healthier, more radiant looking skin. Choose the wavelength that provides optimal results for the removal of unwanted hair. Pulse duration selectivity allows you to customize treatments according to your patients aesthetic needs. The Apogee Elite delivers high fluences from large spot sizes ensuri...
Company:Cynosure, Inc

In-Time Retrieval Device

Features:...Device features a steerable nitinol corewire that can be rotated, advanced, and retracted independently of the microcatheter shaft for enhanced vessel selectivity and precise device positioning. Shapeable Corewire Tip: The corewire tip is shapeable and extends 3cm distally from the retrieval basket. The corew...
Company:Boston Scientific Corporation

Proteomelab™ XL-A/XL-I Protein Characterization System

Features:... The ProteomeLab XL-A is configured with a scanning UV/Vis detection system that provides sensitivity for low-concentration work and selectivity for optimizing detection based on the sample's maximum absorbance. The addition of Rayleigh Interference Optics provides the capability to measure the...
Company:Beckman Coulter, Inc.
Selectivity in Medical Dictionary

Antimicrobial

... (microbistatic).... 2 Antimicrobial Activities. 3 Immunomodulatory Activities. 4 Determination of AMP action ... 8 Factors that determine the selectivity of antimicrobial peptides ... Antimicrobial Test Laboratories is a Microbiology Laboratory Specializing in Antimicrobial Testing and Disin...
Selectivity in Biological News

Biomass as a source of raw materials

... made of six carbon atoms with some hydroxy (-OH) groups attached. With the new process, the phenolic components of bio-oil can be converted with high selectivity to cycloalkanes (ring-shaped alkanes) and methanol. The researchers were able to demonstrate this with various model substances. As catalyst, they use...

American Chemical Society's weekly PressPac -- May 6, 2009

...ge resins that are frequently used in reactors is selective for cobalt but has the unique ability of disregarding iron-based ions. The polymer's high selectivity increases its appeal, the researchers add, for use in decontamination processes in reactors that utilize a variety of structural materials. JS ART...

6 young ASU faculty earn NSF Career awards

...ecular weight. Biosensors typically use molecular probes such as DNA, RNA, enzymes and antibodies to capture specific molecules. These probes offer selectivity but have many limitations. For example, the reagents that are used are expensive, the probes have limited life spans and the systems require highly tr...

Study unravels why certain fishes went extinct 65 million years ago

...ion. Although the two groups of fishes are not related to each other, their fates may end up being similar. The paper is called "Ecomorphological selectivity among marine teleost fishes during the end-Cretaceous extinction" and will appear in issue 13 of PNAS. In it, Friedman describes the results of his st...

A pocketful of uranium

... atoms of uranyl. This NikR mutant only binds to DNA in the presence of uranyl, not in the presence of nickel or other metal ions. This confirms its selectivity for uranyl and may make it useful for the detection of uranyl and nuclear waste bioremediation. It also represents the first step towards developing p...

Tufts University Prof. Maria Flytzani-Stephanopoulos named as AAAS Fellow

... metals, it's like starting from scratch again to understand their chemistry and tailor their catalytic properties to optimize both their activity and selectivity for a large number of reactions of interest to clean and sustainable energy production." This year 486 members were selected as Fellows because of ...
Selectivity in Biological Technology

Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform

EMERYVILLE, Calif., Jan. 2 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) announced today results describing predictable estrogen regulatory elements that can be used to identify estrogenic drugs that are safer. The data, published in Molecular and Cellular Endocrinology, showed tha...

Novel Bonding Chemistry Imparts Enhanced Polar Selectivity to TSK-GEL ODS-100V Reversed Phase Columns

Introduction While full coverage C18 phases have been responsible for the growth of HPLC as a reliable high efficiency technique, it has become apparent in recent years that such column types are not suited for reliable analysis o...

Improved Quantitative Selectivity of Clenbuterol in Human Urine using High Resolution on the TSQ Quantum Mass Spectrometer

Mark Churchill 1 , Mark Harrison 1 , John Henninge, 2 and Hanne Lund 2 1 Thermo Finnigan, Stafford House, 1 Boundary Park, Boundary Way, Hemel Hempstead, HP2 7GE, UK; 2 Aker University Hospital, Hormone Lab...

Rapid heating prepares energy-saving zeolite for greater role in industrial separations

...tion rate for paraxylene that is about two orders of magnitude higher than that of orthoxylene." "A considerable increase in paraxylene/orthoxylene selectivity was observed for RTP-treated membranes," the researchers wrote in Science , "resulting in an attractive combination of paraxylene permeance and mixtu...

Sanofi-aventis Announces Second Quarter 2009 Results

...e rates. Research and development expenses rose by 1.6% to euro 1,108 million. At constant exchange rates, they were down by 2.5%, reflecting selectivity in R&D projects and cost savings. Selling and general expenses increased by 5.9%, or 1.5% at constant exchange rates, to euro 1,895 milli...

DuPont and Arzeda Collaborate to Develop Improved Crops to Increase Productivity

...essing global problem of agricultural productivity." Arzeda's groundbreaking technology integrates the power of chemical catalysis, the high selectivity of biological macromolecules, and the speed of computational design to rapidly design and screen novel enzymes that don't exist in nature and are curr...
Selectivity in Biological Products

Human, Porcine Endothelin-1 from Biotrend Chemikalien GmbH

Description:... Endothelin-1 (human, porcine) Endogenous potent vasoconstrictor peptide. Displays selectivity for the endothelin ETA receptor and modulates vascular tonus. ET-1, ET-2, and ET-3 are the products of three distinct endothelin genes. ET-2 and ET-3 ...
Company:Biotrend Chemikalien GmbH

Varian 1200L LC/MS from Varian, Inc.

Description:...liquid chromatography analytical needs. The Atmospheric Pressure Ionization (API) interface and the Transmission Quadrupole Analyzer provide superior selectivity and sensitivity for pharmaceutical, clinical, toxicological, environmental, and other Liquid Chromatography applications....
Company:Varian, Inc.

LabChip 3000 Drug Discovery System from Caliper Life Sciences

Description:... Phosphatases; Proteases; Lipid-modifying Enzymes; and G-protein coupled receptors (GPCRs). Caliper's most recent introduction, KiSS (Kinase selectivity Screening) offers lead optimization and secondary screening laboratories a simple, affordable approach to kinase profiling....
Company:Caliper Life Sciences

MIDAS TRAQ System with 4000 Q TRAP LC/MS/MS System from Applied Biosystems

Description:...e, to provide a rapid solution for high sensitivity validation of protein biomarkers. Eliminate extensive sample preparation with high instrument selectivity and sensitivity. Build methods quickly using MIDAS Workflow Designer Software. Reduce assay development hasslesthere is no need for protein stan...
Company:Applied Biosystems

Cardiovascular/Renal Profile from Novascreen-a Caliper Life Sciences Company

Description:... Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
Company:Novascreen-a Caliper Life Sciences Company

Gastrointestinal Profile from Novascreen-a Caliper Life Sciences Company

Description:... Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential GI liabilities of compounds....
Company:Novascreen-a Caliper Life Sciences Company
Selectivity in Biological Definition

Chromatography

...in the column, leading to broader peaks. Less time on the column then translates to narrower peaks in the resulting chromatogram and thence to better selectivity (it's easier to differentiate one peak from another) and sensitivity (tall, narrow peaks can be easier to discriminate from noise than shorter, broade...

Ion channel

...these helices move about and open the pore. Two of these six helices are separated by a loop that lines the pore and is the primary determinant of ion selectivity and conductance in this channel class and some others. The channel subunits of one such other class, for example, consist of just this "P" loop and tw...

Lipase

...e 343:767-70. Carriere, F., C. Withers-Martinez, H. van Tilbeurgh, A. Roussel, C. Cambillau, and R. Verger. 1998. Structural basis for the substrate selectivity of pancreatic lipases and some related proteins. Biochim Biophys Acta 1376:417-32. Diaz, B. L., and J. P. Arm. 2003. Phospholipase A(2). Prostagland...

Peptide

...microbial peptides generally disrupt the membranes of a target cell, causing lysis of the cell. How this occurs, and what determines the activity and selectivity of these peptides, is currently only known approximately. It has also been documented that when certain food proteins such as gluten , casein , ...

Peptide

...microbial peptides generally disrupt the membranes of a target cell, causing lysis of the cell. How this occurs, and what determines the activity and selectivity of these peptides, is currently only known approximately. It has also been documented that when certain food proteins such as gluten , casein , ...
Selectivity in Biological Dictionary

Sigma Factor

.... Britannica online encyclopedia article on sigma factor (biochemistry), ...the genetic information has been transcribed. The way in which this selectivity is achieved ... We wanted to study the role of the group 2 sigma factors in Synechocystis. ... The role of the housekeeping sigma factor , S...
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