Segregation

Study finds segregation decreases access to surgical care for minorities

CHICAGO (June 11, 2009) New research published in the June issue of the Journal of the American College of Surgeons reveals that in counties with the highest levels of segregation, an increase in the African-American or Hispanic population was associated with a decrease in the availability and ...

CSHL scientists discover link between control of chromosome duplication and segregation

Cold Spring Harbor, N.Y. Before a cell can divide into two, first it must duplicate its genetic material--the DNA packed in its chromosomes. The two new sets of chromosomes then have to be separated from one another and correctly distributed to the resulting "daughter" cells, so that both daughte...

17 of America's Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences

... Jenn i fer G . D eL u c a, Ph. D . C olora d o St a te U n iv e r s i t y Mechanisms of mitotic chromosome segregation P a tr i ck J. Pad d iso n , Ph. D . Fred Hu t ch i nson Ca n cer R esea r ch Ce n ter Stem cell and cance...

Grandson of Slaves Wins Experience of a Lifetime, Heads to Washington, D.C. to Attend Presidential Inauguration Events

... Returning to the South after serving duty, Bouey found that nothing had changed. There were no jobs for him, and segregation was still a major fact of life. In June of 1946, Bouey couldn't take it any longer, and moved to Chicago with $10 in ...

Med school discovery could lead to better cancer diagnosis, drugs

... His paper on the discovery has been published in the journal Proceedings of the National Academy of Sciences . "The correct timing of chromosome segregation during cell division is necessary to ensure normal, healthy growth," Wang said. "Now we have discovered a previously undetected layer of regulation in...

First Two Non African-American Graduates of Meharry Medical College to Receive Awards at 2008 Fall Convocation

...ial Distinguished Service Medal on his behalf. The admission of Drs. Lachman and Gorman to Meharry Medical College during the days of rigid racial segregation in America speaks volumes about the academic health center as a national treasure and of the strong moral and ethical character of the College's fifth...

NEWSWEEK: Media Lead Sheet/September 1, 2008 Issue (on newsstands Monday, August 25, 2008).

...n for the United States. "Many have discoursed on what an Obama victory could mean for America. We would finally be able to see our legacy of slavery, segregation and racism in the rearview mirror. Our kids would grow up thinking of prejudice as a nonfactor in their lives," he writes. However, "if Obama loses, o...

Georgia to Offer More Community Living Alternatives for Individuals With Disabilities

...the fullest extent possible. "In this voluntary compliance agreement with the Federal Government, Georgia promises a serious effort to end the illegal segregation of its citizens with disabilities and to provide appropriate community alternatives," said Sue Jamieson, the attorney with the Atlanta Legal Aid Socie...

Lack of CHFR gene expression sets stage for breast cancer

...tically unstable cells loaded with too many chromosomes, which can lead to cancer. "Our findings show that loss of CHFR disrupts normal chromosome segregation in breast cells during cell division and creates genomic instability, which can drive genetic mechanisms that accelerate the development of cancer," s...

Racial Disparities Widespread in Kidney Patient Outcomes

... Studies find mistrust, cultural barriers, segregation of care contribute to inequalities WEDNESDAY, June 4 (HealthDay...es: lack of patient trust; cultural and communication barriers; residential segregation that groups minorities in communities with lower quality health care; lower...

Segregation in Medical Technology

Isogen Launches Major New Facility to Address Global Biopharma Demand

...e process development, analytical laboratory services and pharmaceutical engineering consulting. Isogen's Advanced Sterile Filling offers full product segregation and isolator-based sterile processing. The facility meets global regulatory standards and operates according to cGMP. Isogen's industry subject matter...

Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer

...omosomes are equally separated during cell division. Anaphase-promoting complex (APC) is one such checkpoint regulatory protein involved in the proper segregation of chromosomes during cell division. This complex monitors the timing of cell division and provides sufficient time for cells to segregate chromosomes...

EntreMed Commences Continuous Dosing Clinical Trial For MKC-1

...ients in multiple Phase 1 and 2 clinical trials. MKC-1 has been shown to induce apoptosis, inhibit mitotic spindle formation, and prevent chromosome segregation in the M-phase (mitosis) of the cell cycle. Furthermore, MKC-1 inhibits the PI3K-Akt-mTOR signaling pathways, which may occur through inhibition of th...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

...in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR signaling pathways, which may occur through...

EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model

...n in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR signaling pathways, which may occur through...

EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer

...llular trafficking that has been shown to be involved in cell division. MKC- 1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase of the cell cycle, and induce apoptosis in multiple cell lines, consistent with a mechanism in which MKC-1 blocks the nuclear uptake of...

EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers

...n in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. These effects are consistent with mechanisms resulting from MKC-1 binding to multipl...

Segregation in Biological News

Surface tension drives segregation within cell mixtures

What does a mixture of two different kinds of cells have in common with a mixture of oil and water? The same basic force causes both mixtures to separate into two distinct regions. That is the conclusion of a new three-dimensional computer model of the cell sorting process produced by Shane Hut...

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

Lars Jansen's work on the formation of the centromere, a key cellular structure in powering and controlling chromosome segregation and accurate cell division, has just earned him a paper in Nature Cell Biology and a prestigious EMBO installation grant, of 50,000 euro per year, for a maximum of f...

Separating the good from the bad

...their left-handed brethren, impelling the microbes in opposite directions. This finding and the possibility of quickly and cheaply implementing the segregation of two-handed objects in the laboratory could have a big impact on industries like the pharmaceutical industry, for which the separation of right-hand...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators

...phen C. Harrison, PhD, at Harvard Medical School, Boston, Massachusetts, is studying the structure of kinetochores, protein complexes that mediate the segregation of chromosomes during cell division. Discrepancies in the distribution of chromosomes in divided cells occur in many cancers and diseases such as Dow...

February 2009 Geology and GSA Today media highlights

...osits have caused them to be regarded differently in geological research than older, generally more lithified strata. This has been exacerbated by the segregation of the Quaternary research community into different schools of geology and geography, producing redundant nomenclature, multiple classification approa...

Dartmouth researchers find new protein function

... HANOVER, NH A group of Dartmouth researchers has found a new function for one of the proteins involved with chromosome segregation during cell division. Their finding adds to the growing knowledge about the fundamental workings of cells, and contributes to understanding how cell f...

Keeping chromosomes from cuddling up

...J. Sweeney and Peter J. Knepler, both at the UA, and Bosco published their paper, "Condensin II Resolves Chromosomal Associations to Enable Anaphase I segregation in Drosophila Male Meiosis," in the October 2008 issue of PLoS Genetics. Sweeney and Knepler were UA undergraduates when they conducted the research. ...

December 2008 Geology and GSA Today media highlights

...sulfide trace element data, and gold occurrence, the data demonstrate that metamorphism has gradually homogenized the early sulfur, accompanied by the segregation of quartz and the release of gold from the lattice of early pyrite and its re-precipitation as inclusions in later pyrite. The sulfur isotopic composi...

Scripps research team defines new painkilling chemical pathway

...so induced other effects associated with the cannabinoid receptors, namely hypothermia and decreased movement. "This really does suggest a sort of segregation of labor, if you will," says Cravatt of the differential effects of elevating AEA versus 2-AG as part of the overall function of the cannabinoid syste...

Cancer signatures uncovered

...l group of cancers that present as a transition phenotype between these two extremes and displays both characteristics. According to Kohane, "This segregation of tumors into three groups with distinct expression patterns is surprising. Clearly, the developmental trajectory provides a meaningful background fo...

Segregation in Biological Technology

Telik Reports Preclinical Results at AACR Annual Meeting

...lly Active Aurora Kinase/ VEGFR Inhibitors; Abstract # 1764 Aurora kinases are Ser/Thr kinases that play an important role in chromosome alignment, segregation and cytokinesis during mitosis. Over-expression of Aurora kinases has been demonstrated in both solid tumors and leukemia and is considered to be ass...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

...in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR signaling pathways, which may occur through...

CBDM.T, The Market and Business Intelligence Company Reviews The Biomanufacturing Market

...bout 10 to 15%. Pharmaceutical biomanufacturing could account for more than 20% of the global contract manufacturing market in 2012. If we analyze the segregation of production capacity between CMOs (Contract Manufacturing Organisations) and product development companies, the "build versus buy" decisio...

Managing SOX in the age of SOA

...cess to financial applications that have been exposed as Web services. segregation of roles Segregation of roles is a core technique of internal controls ...hine-to-machine authorization, it may be impossible to establish clear role segregation in an SOA. If the "user" of a Web service-based financial application is ac...

Companies still neglect network security

... be thinking about it in terms of an ice storm in Wisconsin. Is it going to happen? Yeah." Running the gauntlet Practices such as establishing segregation of duties, identifying what employees can have access to sensitive information, and controlling what can be copied onto a USB flash drive should be sp...

Auditors paying more attention to IT woes

...ent involved access to programs and data (includes segregation of duties). 31 percent were related to progra... faithfully executing these procedures. Inadequate segregation of duties, both within IT and the business, was al...f these findings was wide: change control, backup, segregation of duties, etc. Vendors and SAS-70 Out of ...

Technology helps but the best way to reduce Sarbox cost is with people

...ees. Wrong skill sets for position. Poor training. Overwhelming workloads. Excessive staff turnover. Poor accountability. Weak segregation of duties. Poor supervision. Floored by 404 These challenges are nothing new. However, they are coming to the forefront largely due to se...

Testing Compressed Air Lines for Microbiological Contamination

... design the facility whereby the air compressor is segregated from the area where the product is assembled for logical hygienic reasons. However, this segregation may lead to a false sense of security because it is possible that the environmental air source that feeds into the compressor may contain biological f...

SNPs Powerful Tools for Association Studies

... and the putative disease allele. Under such circumstances, only a higher density map, such as a SNP map, will be able to follow the recombination and segregation of alleles (also seeChoosing SNPs for an Association Study below). This density is defined by the observed average size of co-inheritance blocks, gene...

Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

...cteristic of genotoxic compounds and analysis of micronuclei formation resulting from DNA strand breakage (clastogens) or interference with chromosome segregation (aneugens) is an important component of toxicology screening of new drug candidates. Manual scoring of micronucleus assays is time consuming and subje...

Segregation in Biological Definition

Eugenics

...ative" eugenics). "Negative" eugenic policies in the past have ranged from segregation to sterilization to even genocide . "Positive" eugenic policies have be...migration restriction and sterilization as primary methods, Goddard favored segregation in his The Kallikak Family , Grant favored all of the above and more -- ...

Mendelian inheritance

...have had the impact it made on the world of genetics. Mendel's law of segregation Mendel's law of segregation essentially has three parts. Alternative versions of genes account for...

Mitosis

...ents in mitosis In biology , mitosis is the process of chromosome segregation and nuclear division that follows replication of the genetic material in e...ch to kinetochores, they begin to line up in the middle of the cell. Proper segregation requires that every kinetochore be attached to a microtubule before separat...

Mitosis

...ents in mitosis In biology , mitosis is the process of chromosome segregation and nuclear division that follows replication of the genetic material in e...ch to kinetochores, they begin to line up in the middle of the cell. Proper segregation requires that every kinetochore be attached to a microtubule before separat...

Segregation in Biological Dictionary

Segregation

Racial segregation is the separation of different racial groups in daily life, such as eating in a restaurant, drinking from a water fountain, using a rest room, attending school, going to the movies, or in the rental or... Racial segregation in the United States, as a general term, included...

Post-meiotic segregation

Anti- Post Meiotic Segregation Increased 2. Species Reactivity. Key Applications. Host ... Anti- Post Meiotic Segregation Increased 2 - Data Sheet ... Anti- Post Meiotic Segregation Increased 2 - Data Sheet. Catalogue Number: AB3247 - AB3247.pdf ... Español. Português. 日本語. 中文 © 1...

Segregating

...equested from Ed Coe (email) (please state ... segregation n. The act or process of segregating or the con... the mentally ill ... abuse, neglect and unneeded segregation . ... Dynamic instability and bipolar stabilization drive plasmid segregation . ... tion of a DNA- segregating system from puri...

Mendelian inheritance

...eritance . ... Mendelian inheritance describes three laws or basic principals of ... Mendelian Inheritance from Answers.com. Mendels Law of segregation Biology from About.com ... A brief, readable, introduction to the basic principles of genetics and heredity. Reviews older theories of inheritan...

Kinetochore

...... kinetochore A disc of proteins located on the centromere, ... 7. Kinetochore assembly. 8. Assembly of the mitotic spindle. 9. Chromosome segregation ... A number of other kinetochore proteins have been identified whose depletion ... Cell cycle articles relating to ' kinetochore ' ... The k...

Homozygous

.... HancockHorses.com, portal website for Hancock bred horses. ... This is consistent with the homozygous lethal roan gene theory. ... law of segregation principle of heredity seed shape nbsp nbsp nbsp nbsp nbsp independent assortment: Definition of homozygous . Definition of the word homozygo...

Heteroduplex

... a unique ... Thus a heteroduplex joint initiated at one end of the duplex DNA grows by ... arrangement of heteroduplex DNA in the postmeiotic segregation products reveals ... to generate noncrossover products in which heteroduplex is unrepaired. ... Assembly of the MutL·MutS· heteroduplex complex...

Hereditary Unit

...... 1. There are hereditary traits controlled by units (the term gene' was ... Although the individual hereditary units follow the laws of segregation and ... The presence of hereditary units in the cytoplasm was first hypothesized in 1902 ... Encyclopedia article about Genes. Information a...

Genetic linkage

...edirect to Genetic Linkage ? 9 Tooo much redundant ... Genetic Linkage Analysis Software. This is a list of genetic linkage ... for segregation analysis, linkage calculations, genetic counseling, and related ... Genetic Linkage Evidence. Why Study Ashkenazim? Educational Materials....

Diakinesis

...progressed past diakinesis and exhibited several different alterations. ... The events of diplotene– diakinesis prepare chromosomes for their segregation ... Diakinesis bivalents must be condensed, resolved, and reorganized into a ... diakinesis - Hutchinson encyclopedia article about diakinesi...