Secretion

Aspirin-like compounds increase insulin secretion in otherwise healthy obese people

Aspirin-like compounds (salicylates) can claim another health benefit: increasing the amount of insulin produced by otherwise healthy obese people. Obesity is associated with insulin resistance, the first step toward type 2 diabetes. Aspirin and other salicylates are known to reduce blood gluc...

Natural secretion marks difference between mole and melanoma

A protein naturally produced and secreted by the body can make the difference between your average mole and melanoma, which killed more than 8,000 people in the United States last year, reveals a new study in the February 8 issue of the journal Cell, a publication of Cell Press. If this natura...

Natural Secretion Marks Difference Between Ordinary Mole and Melanoma

IGFBP7 protein may prove a targeted treatment for metastatic cancers, study suggests THURSDAY, Feb. 7 (HealthDay News) -- An anti-cancer protein that's naturally produced and secreted by the body can make the difference between a common mole and deadly melanoma skin cancer, a new study...

Insulin regulates the secretion of the antiaging hormome Klotho

Boston, MA--Dr. Carmela Abraham, a professor of biochemistry and medicine at Boston University School of Medicine (BUSM), reports this week in the Proceedings of the National Academy of Sciences new findings on Klotho, an anti-aging gene that is associated with life span extension in rodents and h...

Cholesterol and Insulin Secretion -bound by a Gene

Scientists have conducted a study, the first of its kind to link cholesterol with Type// 2 Diabetes. The experiment was performed on mice, yet scientists say the findings may be applicable to humans too. The cause for Type 2 diabetes is still unknown. There are varied theories on this. ...

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

...vanced prostate cancer. As a receptor antagonist, FIRMAGON reversibly binds to the GnRH receptors in the pituitary gland, immediately suppressing the secretion of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and subsequently, testosterone levels.(4) FIRMAGON also reduces levels of prosta...

Secretion in Medical Technology

Wacker Validates Scalability of Anticalin(R) Production With E.coli Secretion Technology and Will Produce Pieris First Clinical Candidate PRS-050

FREISING-WEIHENSTEPHAN and JENA, Germany, July 17 /PRNewswire/ -- Pieris AG, a bio-pharmaceutical company developing Anticalins(R), a novel class of targeted human protein therapeutics, and Wacker Biotech GmbH, a full-service contract manufacturer of biopharmaceuticals, announced yesterday a s...

New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion

CHICAGO, March 31 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. (Nasdaq: CVTX ) announced today that preclinical research presented at the American College of Cardiology 57th Annual Scientific Session in Chicago showed that ranolazine increased glucose-stimulated insulin secretion (GSIS) in...

Study Shows GSK's Novel Diabetes Treatment SYNCRIA(R) (albiglutide) Improves Glucose Control and Reduces Weight

...elevation in blood sugar levels. However, GLP-1 is rapidly degraded, resulting in its short duration of action. In people with type 2 diabetes, GLP-1 secretion in response to a meal is reduced. Albiglutide is the only medication which fuses modified human GLP-1 to human albumin, a protein found in the blood ...

Lilly Announces Positive Phase II Data on Investigational Medicine for Patients with Type 2 Diabetes

...HbA1C). In this study, LY2189265 showed an insulinotropic (stimulating the secretion of insulin) effect, suggesting it produced the desired outcome in participa...gar in patients with type 2 diabetes by enhancing glucose-dependent insulin secretion from the pancreas. Diabetes: A Global Epidemic Researchers say ne...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...017)(1). This important benefit was seen in patients with functioning tumors (i.e., tumors that are associated with carcinoid syndrome due to the secretion of various hormones that cause symptoms, such as diarrhea or flushing) and non-functioning (non-secreting) tumors. In an analysis of patients with non...

Cystic Fibrosis - Orphan Drug Designation for Innovative Treatment Against Lung Infections by Axentis Pharma AG

...e is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications represent the most serious manifestation of the disease ­ and the reason for the high mortality rate...

Secretion in Medical Products

Cytology, Breast Nipple Secretion

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Vasopressin (AVP) RIA Test

Description:...or pituitary for storage and eventual release. AVP secretion is regulated by changes in blood osmolality and al...se in arterial blood pressure. A deficiency in AVP secretion or action is a characteristic of polyuria, a condi... and can result from a number of factors including secretion of AVP by malignancy, disorders of the central ner...
Company:Diagnostic Systems Laboratories, Inc.

Ghrelin, Total ELISA Test

Description:...sitive energy balance and in chronic obesity, but elevated during fasting and in anorexia nervosa. These data further support the hypothesis that the secretion of Ghrelin not only has effects opposite to leptin, but is also regulated antipodal to leptin. Whether increased Ghrelin levels in anorexia nervosa r...
Company:Diagnostic Systems Laboratories, Inc.

Aldosterone RIA Test

Description:...st potent mineralocorticoid in humans. Aldosterone secretion appears to be stimulated primarily through the ren...um chloride concentrations lead to increased renin secretion and activation of angiotensin, with angiotensin II...y hyperaldosteronism as a result of elevated renin secretion [3,6]. Abnormally low aldosterone...
Company:Diagnostic Systems Laboratories, Inc.

Renin IRMA Test

Description:... cause vasoconstriction. In addition, angiotensin II stimulates aldosterone secretion from the adrenal gland, resulting in increased renal tubular sodium reabsorption and concomitant secretion of potassium and hydrogen [1]. Renin plasma levels are useful in the diagno...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione EIA Test

Description:...t ~(less than or equal to) 20% of testosterone [1]. However, serum androstenedione levels often exceed testosterone in both normal and disease states. secretion and production rates also exceed those of testosterone in women in whom significant extra-adrenal conversion of androstenedione to testosterone occurs...
Company:Diagnostic Systems Laboratories, Inc.

Secretion in Medical Dictionary

Venom

...IMDb: Movies, TV, Celebs, and more... Sins of the Fathers Chapter 10: Venom Returns (1996) TV episode, Played by Hank ... venom n. A poisonous secretion of an animal, such as a snake, spider, or scorpion, usually ... venom or zootoxin, any of a variety of poisonous ... Venom Group Members: Mant...

Urogenital

... Radiology Urogenital ... 3. The Urogenital Apparatus - Human Anatomy ... The urogenital apparatus consists of (a) the urinary organs for the secretion ... Urogenital Disorders. Search. Query. A Well Timed High Five A Well ... Overview of Urinary/ Urogenital System Disorders. Analgesic Nephropa...

Urine output

... in which polyuria due to decreased collecting tubule water ... The urine output in normals ... INTRODUCTION The syndrome of inappropriate secretion of drug_l_z/277759 Antidiuretic hormone antidiuretic hormone (SIADH) ... cases, the urine output does not ... A noticeable and consistent ...

Stomach acid test

...fasting, fluid is all that remains in the stomach . ... Gastric acid secretion test After not eating for a period of time, fluid is all ... What is Sto...f cells in the stomach to ... Stomach Acid Test (Gastric Acid secretion Test ) information center covers description, preparation, risks, expectat...

Prolactin

...uitary hormone that stimulates and maintains the secretion of milk. ... 7.1 Conditions associated with elevated prolactin secretion ... Describes how prolactin testing is used,...e anterior pituitary in 1933 (1) ... Prolactin secretion ... Prolactinoma -- part of the Endocrine Reso...

Peripheral

...eripheral nerve stimulator plus ON-Q Cbloc ... Tolerance at Peripheral Opioid Receptors: The first step in pain treatment is ... Opioid secretion and Peripheral Pain Control ... Can you reverse the effects of peripheral neuropathy or, at least, stop it from getting worse? ... Can that ...

Secretion in Biological News

Microbes and their hosts -- exploring the complexity of symbiosis in DNA and cell biology

...bacterial group in the article "Prevalence of Genes Encoding the Type Three secretion System and the Effectors AexT and AexU in the Aeromonas veronii Group." The...pticemia and meningitis. The authors demonstrate the presence of the type-3 secretion factors AexT and AexU in a variety of Aeromonas veronii strains and propose...

DuoCort: New chronotherapy for adrenal insufficiency

...rtisone dosing closely resembles the physiological secretion pattern. The data is published today in the Europe...ical release profile that mimics the bodys natural secretion pattern of cortisol to improve outcomes for patien...single-dose administration that mimics the natural secretion pattern of cortisol. The new DuoCort therapy showe...

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...d expression of gastrin, a hormone that stimulates secretion of gastric acid; however, the role of gastrin in c...ection from mucosal damages caused by gastric acid secretion induced by gastrin itself, and thus either too muc...cter bacteria that colonize the stomach when acid secretion is suppressed, since bacterial overgrowth likely c...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

...nd repeated injection of large number of stem cells, we thought it would be a good method to deliver MSCs," Lee said. "We hypothesized that MSCs, via secretion of these functionally synergistic trophic factors, would be able to rescue the failing heart even when delivered away from the myocardium. "This stu...

Cocaine: Perceived as a reward by the brain?

... sniffing cocaine triggers high levels of dopamine secretion in a central region of the brain called the striat...the relationship between the intensity of dopamine secretion and the frequency of drug use has been demonstrate...nsitivity to addiction that leads to the increased secretion of dopamine? This question is not easy to answer, ...

Yale team identifies key to potential new treatment for allergy-induced asthma

...hma cases reported in recent decades. Scientists know that asthma involves an immune response to inhaled allergens that results in inflammation, mucus secretion and bronchial constriction. But limitations of existing treatments aimed at the immune system suggest that additional physiological mechanisms may be ...

Secretion in Biological Technology

AEterna Zentaris Acquires All Assets from Ardana for Growth Hormone Secretagogue Compound, AEZS-130

...ication protecting the use of AEZS-130 for the diagnostic of growth hormone secretion deficiency. Ardana had developed AEZS-130 up to the initiation of Phase 3...s in the United States for use as an oral diagnostic test of growth hormone secretion deficiency. In addition to the diagnostic indication, AEZS-130, based on re...

Chronic Lung Disease - Axentis Pharma Attracts Investment Interest

...e is caused by a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications represent the most serious manifestation of the disease - and the reason for the high mortality rate ...

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

...nd characterized this unique peptide in a variety of preclinical studies. In these studies, researchers have demonstrated that HIP stimulates insulin secretion in human pancreatic ductal tissue devoid of islets. HIP was also shown to stimulate new islet formation with a 3-fold increase in islet numbers in va...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

...d the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent insulin secretion and release of incretin hormones such as GLP-1, and thus may preserve beta cell health. This novel dual mechanism may provide a unique therapeutic ben...

Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opportunities

...d the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent insulin secretion and release of incretin hormones such as GLP-1, and thus may preserve beta cell health. This novel dual mechanism may provide a unique therapeutic ben...

FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes

... GIP are excreted in the digestive tract following food intake, and stimulate the beta-cells in the pancreas --- thereby stimulating increased insulin secretion --- and it has also been confirmed that they improve the functioning of the beta cells themselves. Furthermore it is known that because GLP-1 suppress...

Secretion in Biological Products

pPIC9K from Invitrogen

Description:...indicates that multiple copies of the kanamycin resistance gene and the gene of interest are integrated into the genome (1). The pPIC9K vector directs secretion of expressed proteins while proteins expressed from pPIC3.5K remain intracellular....
Company:Invitrogen

Mast Cell Degranulation colorimetric Assay Kit from CHEMICON

Description:... Degranulation, the secretion of cytoplasmic granules, is a key step in the inflammatory response of leukocytes (e.g. basophils, neutrophils, eosinophils, and mast cells). In addit...
Company:CHEMICON

Secretion in Biological Definition

Antibiotic

...emonstrated interesting anti-bacterial effects from various bacterial secretions, the German scientist E. de Freudenreich in 1888 isolated a bacterial secretion and noted its antibacterial properties. Pyocyanase, secreted by Bacillus pyocyaneus, retarded the growth of other bacteria in situ and was toxic to ma...

Cartilage

...artilage is composed of cells , fibers and a matrix. Cells Chondrocytes are the only cells found in cartilage. They are responsible for the secretion and maintenance of the matrix. The matrix immediately surrounding the chondrocytes is referred to as the territorial matrix and stains darker than t...

Digestion

... to secrete pepsinogen and hydrochloric acid . secretion of gastrin is stimulated by food arriving in stomach. The secretion is inhibited by low pH . Secretin - is in the duodenum and signals the secretion of sodium bicarbonate in the pancreas and it sti...

Flagellum

... sequence similarity to components of the type III secretion systems , but the components of bacterial and arch... which are assembled through the action of type II secretion systems (the nomenclature of pili and protein secretion systems is not consistent). These differences...

Foot and mouth disease

...oot-and-mouth disease is characterized by high fever that declines rapidly after two or three days; blisters inside the mouth that lead to excessive secretion of stringy or foamy saliva and to drooling; and blisters on the feet that may rupture and cause lameness. Adult animals may suffer weight loss from w...

Hormone

...to the target cells; the action of hormones is determined by the pattern of secretion and the signal transduction of the receiving tissue. Hormone actions va...from production, on the metabolism and excretion of hormones. Hormone secretion can be stimulated and inhibited by: Other hormones ( stimulating or r...

Secretion in Biological Dictionary

Tracheae

... This experiment suggests that the tracheae are not particularly sensitive to ... In electrically stimulated tracheae , tachykininergic neural secretion was ... In tracheae from ovalbumin-sensitised animals, repeated administration of ... ... to the integrity of the tracheae , microorganisms ente...

Signal Sequence

...Signal Sequence ... The signal sequence is then cleaved from the polypeptide when it ... Gene design of signal sequence for the effective secretion ... Signal peptide A signal peptide is a short (3-60 amino acids long) peptide chain ... sources refer to signal peptides as only t...

Semen

...e Preparation Normal results Abnormal results Resources Semen Analysis Definition Semen analysis evaluates a man's semen n. A viscous whitish secretion of the male reproductive organs, containing spermatozoa and consisting of secretions of the testes, seminal from Stay Free!, a magazine focussed on...

Secretin

...ls of the duodenum in the crypts of Lieberkühn. Its primary effect is to regulate the pH of the duodenal contents via the control of gastric acid secretion and buffering with bicarbonate. It was the first... Human secretin receptor is a G protein-coupled receptor which binds secretin and is the l...

Proton-motive force

...VE FORCE ... ... the FliI ATPase and proton motive force in bacterial flagellar protein ... posted to flagella proton - motive - force secretion by biomcgary on 2008-01-23 20: ... Energizing porters by proton - motive force . Nelson N. J Exp Biol 1994 Nov;196:7-13 ... The existence of pr...

Proton pump

...up of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available today. The group... Proton pump inhibitors (PPIs) are a group of medications that prevent the ... Proton Pump Inhibitors - What A...