Scientists explain how insulin secreting cells maintain their glucose sensitivity
Scientists at the leading Swedish medical university Karolinska Institutet have now disclosed the mystery how the insulin-secreting cells maintain an appropriate number of ATP sensing ion channel proteins on their surface. This mechanism, which is described in the latest number of Cell Metabolism,...
Menin Gene Mutation made Insulin Secreting Cells to Proliferate
Acute loss of a protein named menin – involved in tumor-suppression or cell-proliferation-suppressing function resulted in the proliferation of pancreatic islet cells, which again affected blood sugar// regulation - researchers at the University of Pennsylvania School of Medicine reports.
DNA-damaged cells communicate with neighbors to let them know they're in trouble
...ignaling process was activated inside the cultured human cells within minutes of the DNA damage, it took 24 to 48 hours for the damaged cells to start secreting
the inflammatory signals.
"We think the cell is giving itself time to repair its DNA before alerting the immune system that there's a problem," sa...
CU-Boulder study shows brain's immune system may cause chronic seizures
...foundly increase the excitability of the neurons that they are near.
"In our new study, we showed for the first time that glial cells moving in and secreting
these cytokines cause the neurons in the area to become excitable enough to cause seizures."
The results of the study appear in the July issue of t...
Lab Study Finds Protein That May Inhibit Cancer Spread
Researchers at Children's Hospital Boston had found previously that metastatic tumors prepare "landing places" for cancer in other organs by secreting
certain proteins that encourage tumor growth and attract feeder blood vessels. In the new study, they found that non-metastatic tumors secrete a prote...
Potent metastasis inhibitor identified
... the Vascular Biology Program at Children's, has been finding that metastatic tumors prepare landing places in distant organs for their metastases, by secreting
certain proteins that encourage tumor growth and attract feeder blood vessels. Now, he and his colleagues show that non-metastatic tumors secrete a pr...
Plant communication: Sagebrush engage in self-recognition and warn of danger
...rch is in its early stages, the scientists suspect that the plants warn their own kind of impending danger by emitting volatile cues. This may involve secreting
chemicals that deter herbivores or make the plant less profitable for herbivores to eat, he said.
What this research means is that plants are "cap...
Obesity and diabetes double risk of HF -- patients with both conditions 'very difficult' to treat
... with heart failure," says Professor McMurray. An even more "intriguing" suggestion, he added, is that adipose cells might act as an endocrine tissue, secreting
substances which may have a harmful effect on heart tissue and blood vessels.
The relationship between diabetes and heart failure is also a subject...
Study in Nature Medicine establishes major new treatment target in diseased arteries
...tion, immune cells often mistakenly contribute to disease, in some cases by secreting
chemicals called cytokines that kill cells outright, and that also signal f...ce the early 1990s," Berk said. "We had to determine that vessel walls were secreting
something in response to ROS, then prove it was CypA, then prove CypA was r...
BELLUS Health reports results for first quarter of fiscal 2009
...decreases glycemic levels in obese diabetic Zucker rats, when compared to the control group, while preserving 40% more pancreatic islet cells (insulin secreting
cells) as compared to the control group, and have shown some protective effect on renal function.
Research tax credits and grants amounted to $30...
Secreting in Medical Technology
Secreting in Medical Products
Description:...ion is strong evidence against GH deficiency, with exceptions being some GH deficient children with craniopharyngiomas and adults who have a prolactin secreting
tumor accompanied with GH deficiency and prolactin excess....
Company:Nichols Institute Diagnostics
Secreting in Medical Dictionary
...s, ... synovia . Dictionary: syn·o·vi·a (sĭ-nō'vē-ə) Home > Library > ... ... a. [Cf. F. synovial .] (Anat.) Of or pertaining to synovia ; secreting
synovia ... synovia . ... membrane which secretes synovia and surrounds synovial ... Synovia , an Information and Communications Technolog...
...milies, and health care providers who treat them. A pituitary tumor is an abnormal growth of pituitary cells. ... prolactinoma-a prolactin secreting
pituitary tumor that is common and usually treatable. ... Pituitary adenomas are the fourth most common intracranial tumor after gliomas, ...
...ssels are central to moderating blood's tendency to clot. The endothelial cells of intact vessels prevent thrombus ("clot") formation by secreting
tissue plasminogen activator... Hemostasis , the arrest of bleeding from an injured blood vessel, requires the ... and Table 1: Hemostasis...
... Apocrine glands — a portion of the secreting
cell's body is lost during secretion. ... Holocrine glands — the entire cell disintegrates to secrete its ... Exocrine glands are gla...
...elium, whereas the ... ... the liver serves as an exocrine gland , secreting
bile into the small intestine ... The salivary glands are more typical exocrine glands , secreting
saliva into the ... SUNY Downstate Medical Center is one of the natio...
...that consists of the endocrine glands and functions to regulate body ... are stored in endocrine cells in secretory ... endocrine ( ) adj. secreting
internally. Of or relating to endocrine glands or the hormones secreted by them ... cells with endocrine function scattered among ... Descri...
...especially of a ... Information about diaphoresis in the free online English ... diaphoresis - the process of the sweat glands of the skin secreting
a salty ... Sweating - excessive; Perspiration - excessive; Diaphoresis . Definition Return to top ... Hyperhidrosis is a medical condition in wh...
Secreting in Biological News
Finding the constant in bacterial communication
...hough they have no sensory organs, bacteria can get a good idea about what's going on in their neighborhood and communicate with each other, mainly by secreting
and taking in chemicals from their surrounding environment. Even though there are millions of different kinds of bacteria with their own ways of sensi...
Lice can be nice to us
...es throughout their lives.
The researchers speculate that the louse is able to exert some kind of immuno-suppressive effect, possibly directly by secreting
some substance into the mice from its saliva, or indirectly by transmitting bacteria or other pathogens.
Professor Bradley said: "Much like laborat...
Mollusks taste memories to build shells
...e shell's edge grows.
Bands parallel to the growing edge can be explained by inhibition of future activity. Pigment secreted on one day can inhibit secreting
cells for a few days, resulting in an on/off pattern that produces a series of bands.
The most interesting patterns, however, are waves of activity...
Time (and PPAR-beta/delta) heals all wounds
...e skin is reconstructed.
Chong et al. found that PPARβ/δ-deficient fibroblasts made wild type keratinocytes hyperproliferative in OTCs by secreting
extra doses of several growth factors. The fibroblasts were stimulated to produce these growth factors by keratinocyte-released cytokine IL-1 - unders...
Moderate use averts failure of type 2 diabetes drugs in animal model
...aking insulin. Instead, it somehow stops them from secreting
When they stopped receiving the drug, beta cells began secreting
insulin again hours later. Nichols and co-author M...lem seems to lie somewhere between the trigger for secreting
insulin, which was hyperactivated while they were ...
Green tea may delay onset of type 1 diabetes
...he EGCG-fed group.
"It's kind of counterintuitive why would there be proliferation of the glandular cells occurring when the present cells are not secreting
saliva?" says Dr. Kevin Gillespie, first author of the study he conducted for his master's research project at MCG.
The proliferation phenomenon al...
When under attack, plants can signal microbial friends for help
...can send out an S.O.S. to the roots for help, and the roots will respond by secreting
an acid that brings beneficial bacteria to the rescue.
The finding quash...roots in the plants that had Bacillus in the soil. The roots responded by secreting
a carbon-rich chemical--malic acid.
All plants biosynthesize malic acid,...
Response to immune protein determines pathology of multiple sclerosis
...dly and the prognosis is particularly bleak.
MS ensues when the body's T cells invade the brain and trigger nerve-damaging inflammation, in part by secreting
proteins called cytokines. According to the new study, lead by Washington University scientist John Russell, the brain's response to one particular im...
Ripple effect: Water snails offer new propulsion possibilities
...by an animal, or in the lab) to generate propulsive forces and move. Some freshwater and marine snails crawl by "hanging" from the water surface while secreting
a trail of mucus. The snail's foot wrinkles into little rippling waves, which produces corresponding waves in the mucus layer that it secretes between...
UNC scientists turn human skin cells into insulin-producing cells
...ny other fetal or adult cell type, and then inducing them to differentiate, or transform, into cells that perform a particular function in this case, secreting
Several recent studies have shown that cells can be returned to pluripotent state using "defined factors" (specific proteins that control...
Secreting in Biological Technology
iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming
...ancreatic development, and metabolic disease, Dr. Melton recently published successful in-vivo reprogramming of exocrine pancreatic cells into insulin secreting
cells without reversion to a pluripotent stem cell state.
Dr. Corey Goodman was a professor at Stanford University and the University of C...
Assembling cells into artificial 3-D microtissues, including a tiny gland
... a step further.
They have assembled different types of genetically engineered cells into synthetic microtissues that can perform functions such as secreting
and responding to hormones, promising more complex biological capabilities than a single cell alone could produce.
"This is like another level of h...
Cyntellect Launches CellXpress(TM) System to Boost Productivity of Biopharmaceutical Process Development
...d cells, leaving
behind cells that are efficiently secreting
biopharmaceutical proteins. The
process is initiat...ied clone that is very likely to
generate a highly secreting
cell lines. The imaging and purification
processes...rs (vs. weeks) -- Isolating ten-fold more highly secreting
clones than traditional methods -- Selectin...
US College Students Needing TB Testing Now Have the Benefit of QFT(TM)
...The T-cells of these individuals are
sensitized to TB, and respond to stimulation with peptides simulating those
expressed by the TB causing bacteria, secreting
a cytokine called
interferon-gamma. QFT accurately measures the interferon-gamma response in
a sensitive enzyme assay. QFT is unaffected by previous B...
More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
...pposing responses to vaccines. Upon receipt of vaccines some individuals
develop substantial inflammation leading to autoimmune destruction of
cells, type 1 diabetes. Other individuals produce
increased cortisol, an immune suppressing hormone, to suppress the vaccine
induced inflammation. The...
Novocell Reports Successful Use of Stem Cells to Generate Insulin in Mice
...nior author of the publication. "It
also provides strong evidence that hES cell-derived endoderm cells are able
to generate glucose-responsive insulin secreting
cells that are
functionally similar to adult human beta cells."
Current cellular therapy for diabetes is performed by transplanting
Immune system protein starves 'staph' bacteria
...apon neutrophils employ as they wage battle in the abscess. First, neutrophils try to gobble up the bacteria. If they fail and die (staph is expert at secreting
toxins that kill neutrophils), then they spill their guts, which are filled with metal-binding calprotectin sponges that soak up the metals.
Swiss Experts Recommend QuantiFERON(R)-TB Gold for Tuberculosis Infection Screening Prior to Initiating anti-TNF-a Therapy
...The T cells of these
individuals are sensitized to TB, and respond to stimulation with peptides
simulating those expressed by the TB causing bacteria, secreting
called interferon- a. QFT(TM) accurately measures the interferon-a response
in a sensitive enzyme assay. QFT(TM) is unaffected by previous ...
RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs
producing active TSP1 began to form exponentially growing
tumors. These tumors were composed of cells secreting
unusually high amounts of the angiogenic stimulator, vascular
endothelial growth factor (VEGF), which were s...
Uses and Applications of FuGENE 6 Transfection Reagent
...ols. Consider repeating the experiment
with a secreted reporter gene assay such as SEAP, hGH, or a standard -gal
control vector. Cells secreting
SEAP should show little to no evidence of
The culture may be contaminated with myco...
Secreting in Biological Products
Bovine IFN gamma ELISPOT Kit from Endogen
Description:...issection microscope or automated ELISPOT reader) and then compared to the number of cells added to the microplate. This allows the frequency of cells secreting
the cytokine to be calculated. One spot is equal to one molecule-secreting cell....
Secreting in Biological Definition
...urrounding the colony of mold . Having previously studied the ability of the enzyme lysozyme to kill bacteria, Fleming realized that the mold was secreting
something that stopped bacterial growth. He knew that this substance might have enormous utility to medicine. Although he was unable to purify the co...
...cular mass 1,5 kD, rich with cysteine and structurally completely different from other immunoglobulin chains. This chain is formed in the antibodies secreting
cells. The dimeric form of IgA in the outer secretions has also a polypeptide of the same molecular mass (1,5 kD) that is called the secretory chain a...
...hat are specific for them, get activated, so they start to secrete cytokines . The cytokines then activate cytotoxic lymphocytes T (CTL), antibodies secreting
lymphocytes B , macrophages and other cells.
Endogenous antigens are antigens that have been generated within the cell...
...rm of hydroxylapatite. The matrix is initially laid down as unmineralized osteoid (manufactured by osteoblasts). Mineralisation involves osteoblasts secreting
vesicles containing alkaline phosphatase. This cleaves phosphate groups and acts as the foci for calcium and phosphate deposition. The vesicles then...
.... Chondrification is the process in which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondrocytes and begin secreting
the materials that form the matrix.
Two types of growth can occur in cartilage: appositional and interstitial.
... get their energy by breaking down organic molecules, and cannot synthesize organic molecules from inorganic substances (as plants do). They feed by secreting
exoenzymes into the surrounding substrate . Exoenzymes act like the digestive enzymes of animals , breaking apart large organic molecules, but f...
...creas was removed, the Minkowski's animal keeper noticed a swarm of flies feeding on the dog's urine. On testing the urine they found that the dog was secreting
sugar in its urine, demonstrating for the first time the relationship between the pancreas and diabetes. In 1901 another major step was taken by Eugen...
...tering the blood, then reabsorbing some necessary fluid and molecules while secreting
other, unneeded molecules. Reabsorption and secretion are accomplished with...amids : The conical segments within the internal medulla. They contain the secreting
apparatus and tubules and are also called malpighian pyramids .
... to man-made pollutants . Hence, they have potential as pollution indicator organisms. When growing on mineral surfaces, lichens slowly degrade it by secreting
acids that dissolve the minerals, contributing to the process of weathering by which rocks are slowly turned into soil.
Secreting in Biological Dictionary
... cells ... differentiate into plasma cells that secrete these soluble BCRs, which we now call antibodies. ... of clones of plasma cells secreting
antibodies against the ... Protein produced by a plasma cell that is generated in reaction to a foreign ... Single tumor comprised of malig...
... of multicellular animals ... Leydig cell ( ′līdig ′sel ) ( histology ) One of the interstitial cells of the testes; thought to produce ... secreting
cell in the interstitial area, between ... Definition of Interstitial cells in the Online Dictionary. Meaning of Interstitial cells . .....
...y target... exocrine gland n. An externally secreting
gland , such as a salivary gland or sweat glan...tions directly or through a exocrine ( ) adj. secreting
externally, directly or through a duct: exocrine ... ... the liver serves as an exocrine gland , secreting
bile into the small intestine ... The salivary...
... into the corpus luteum following ovulation is generally not a ... After ovulation the granulosa and luteal cells turn into the hormone secreting
corpus luteum . ... Here is a closer look at the cells that make up the Corpus Luteum . ... The corpus luteum prepares the uterus in ...
...e adrenal glands secrete adrenaline to help your body respond to stress, but ... And rightly so—the adrenal glands are arguably best known for secreting
the ... (Click to enlarge) adrenal gland top: cross section of a right adrenal gland bottom: placement of adrenal glands relative to ki...