Study Shows a Link Between Schizophrenia & Genetic Mutations
LOS ANGELES, July 20 /PRNewswire/ -- A link between schizophrenia
and ultra-rare variants in microRNA genes on the X-chromosome has been identified. Mutations in a subset of these regulatory RNA genes may strongly predispose to schizophrenia. The recently published study in PLoS ONE by ...
International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
The July 1, 2009 advance online edition of the journal Nature includes three companion papers describing the results of genome-wide association studies (GWAS) of schizophrenia. Schizophrenia
is an elusive and severe psychiatric disorder that affects up to 70 million people worldwide. The causes o...
Possible Gene Regions for Schizophrenia Located
Immune function genes also in the same area, researchers say
WEDNESDAY, July 1 (HealthDay News) -- Immune function may play a role in schizophrenia, say scientists who found that schizophrenia
patients have genetic variations on a section of chromosome 6 that contains numerous genes as...
Animal model for schizophrenia identifies a novel approach for treating cognitive impairments
Philadelphia, PA, 9 June 2009 - Researchers have been seeking a safe and effective way to treat cognitive impairments associated with schizophrenia
by enhancing N-methyl-D-aspartate (NMDA) glutamate receptors. Functional deficits in NMDA receptors may contribute to the underlying neurobiology of ...
Schering-Plough Announces European Filing of SYCREST(R) (asenapine) for the Treatment of Schizophrenia and Bipolar I Disorder
KENILWORTH, N.J., June 2 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today announced that the European Medicines Agency (EMEA) has validated (accepted for review) the company's Marketing Authorization Application (MAA) for SYCREST(R) (asenapine) sublingual tablets for the ...
'Singing brains' offers epilepsy and schizophrenia clues
Studying the way a person's brain 'sings' could improve our understanding of conditions such as epilepsy and schizophrenia
and help develop better treatments, scientists at Cardiff University have discovered.
Research by a team working in Cardiff University's Brain Research Imaging Centre (CUB...
Hollow mask illusion fails to fool schizophrenia patients
Patients with schizophrenia
are able to correctly see through an illusion known as the 'hollow mask' illusion, probably because their brain disconnects 'what the eyes see' from what 'the brain thinks it is seeing', according to a joint UK and German study published in the journal NeuroImage . The...
A Drug That Receives Regulatory Approval for Cognitive Impairment Associated With Schizophrenia Would Earn a Higher Patient Share in the United States Than in Europe
A Therapy's Effect on Executive Function and Functional Capacity are the Attributes that Most Influence Psychiatrists' Prescribing Habits, According to a New Report from Decision Resources
WALTHAM, Mass., Feb. 17 /PRNewswire/ -- Decision Resources, one of the world's leading research and advi...
New Research Study in Houston, Texas Seeks Improved Quality of Life for People in the Future with Schizophrenia
Jason Baron, M.D. of Med Labs Research leads research for local patients
Houston, TX, February 10, 2009: Imagine going through the day without the ability to concentrate and focus on the things you enjoy and important tasks that you need to complete. Think what it wou...
Johns Hopkins researchers discover new schizophrenia gene
Researchers at the Johns Hopkins University School of Medicine are one gene closer to understanding schizophrenia
and related disorders. Reporting in the Jan. 9 issue of the American Journal of Human Genetics , the team describes how a variation in the neuregulin 3 gene influences delusions assoc...
Schizophrenia in Medical Technology
Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry
- Improvement Was Noted At Day 3 And All Subsequent Study Visits -
FORT LEE, N.J., June 3 /PRNewswire/ -- Dainippon Sumitomo Pharma Co., Ltd., (DSP) announced today that positive results from a phase 2 clinical trial for lurasidone in the treatment of patients with schizophrenia
have been pu...
Lilly Announces Inconclusive Phase II Study Results for mGlu2/3 at the International Congress on Schizophrenia Research
SAN DIEGO, March 29 /PRNewswire-FirstCall/ -- Eli Lilly and Company (NYSE:
LLY ) announced today inconclusive Phase II clinical trial results from Study
HBBI investigating LY2140023 monohydrate, also known as mGlu2/3, for the
treatment of patients suffering from acute schizophrenia. In Stud...
Omeros Receives $3.1 Million Milestone Payment from The Stanley Medical Research Institute for Schizophrenia Program
SEATTLE, Jan. 28 /PRNewswire/ -- Omeros Corporation today announced that it was awarded $3.1 million in a second tranche of equity and grant funding from The Stanley Medical Research Institute (SMRI) to support late-stage preclinical development of the Company's proprietary product candidates for ...
U.S. FDA Issues Complete Response Letter for SAPHRIS(TM) (ASENAPINE) in the Acute Treatment of Both Schizophrenia and Bipolar I Disorder
Schering-Plough expects to respond to agency during first quarter
KENILWORTH, N.J., Jan. 14 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today announced that the U.S. Food and Drug Administration (FDA) has issued a complete response letter for SAPHRIS(TM) (asenapine) s...
FDA Issues a Complete Response Letter for Lilly's Olanzapine LAI for Treatment of Schizophrenia in Adults
INDIANAPOLIS, Jan. 7 /PRNewswire-FirstCall/ -- Eli Lilly and Company
(NYSE: LLY ) announced today that it received a complete response letter from
the U.S. Food and Drug Administration (FDA) for olanzapine long-acting
injection (LAI) for acute and maintenance treatment of schizophrenia
Schering-Plough Unveils Top-Line Study Results for SAPHRIS(TM) (asenapine) Demonstrating Efficacy in Long-Term Schizophrenia Relapse Prevention
Company's R&D Update Today Unveils Rich Development Pipeline of Compounds Meeting Important Medical Needs
KENILWORTH, N.J., Nov. 24 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today revealed top-line results of a long-term Phase III clinical study of its psych...
Olanzapine Long-Acting Injection (LAI) Shown to Maintain Treatment Benefit in Schizophrenia for up to Six Months
BARCELONA, Spain, Sept. 2 /PRNewswire-FirstCall/ -- Final results from
a 24-week study presented today at a major medical meeting in Barcelona
suggest that investigational olanzapine long-acting injection (LAI)
therapeutic doses showed a maintenance of treatment benefit for up to six
Olanzapine Long-Acting Injection (LAI) Data Presented at First Annual Schizophrenia International Research Society Conference
Efficacy and safety data were generally consistent with oral olanzapine with the exception of injection-related events
VENICE, Italy, June 23 /PRNewswire-FirstCall/ -- Results from
olanzapine long-acting injection (LAI) clinical trials showed that the
efficacy and safety profile of...
Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
NEW YORK, Feb. 15 /PRNewswire/ -- Intra-Cellular Therapies, Inc. (ITI),
announced the presentation of preclinical data on ITI-007, its
first-in-class dual 5HT2A receptor antagonist/dopamine receptor
phosphoprotein modulator (DPPM) for the treatment of schizophrenia, and
ITI-002, ITI's family o...
FDA Advisory Committee Supports Efficacy and Safety of Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment
INDIANAPOLIS, Feb. 6 /PRNewswire-FirstCall/ -- The U.S. Food and Drug
Administration's (FDA) Psychopharmacologic Drugs Advisory Committee voted
that, with appropriate labeling around excessive sedation events,
Zyprexa(R) long-acting injection (olanzapine LAI) has been shown to be
Schizophrenia in Medical Definition
Neurobiological Brain Disorder
... purposes and special educational services, others, such as pediatric-onset schizophrenia
and bipolar disorder, are not globally accepted as such, resulting in a gre...ngering Psychiatric Symptoms From Hyperthyroidism
Protein Biomarkers for schizophrenia
Studied in Cerebrospinal Fluid ...
...o television (Becker, 2004). Another example is schizophrenia
, the risk for which may be considerably reduced i..., Gamazo-Garran, Soutullo and Ortuno (2002)
Narcissistic/Poor maternal parenting/escapism/ ...chopharmacology, 12, 259-263.
Green, M.F. (2001) schizophrenia
Revealed: From Neurons to Social Interactions. New...
Schizophrenia in Medical Dictionary
, from the Greek roots skhizein and phrēn, phren- is a psychiatric diagnosis that describes a mental disorder characterized by abnormalities in the perception or expression of reality. Distortions in perception... Disease description, signs and symptoms, treatment, and related ...
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Schizophrenia in Biological News
LSUHSC research helps link schizophrenia to specific DNA region
New Orleans, LA For the first time, an international group of researchers has found genetic evidence linking schizophrenia
to a specific region of DNA on chromosome 6. This is the same area where key genes for immune function are located. The LSUHSC research team was led by Nancy Buccola, APRN,...
Researchers discover link between schizophrenia and diabetes
AUGUSTA, Ga. People with schizophrenia
are at increased risk for type 2 diabetes, Medical College of Georgia researchers have found.
In a study of 50 people newly-diagnosed with schizophrenia
or a related psychotic disorder with no other known risk factors, 16 percent had either diabetes or an...
MU brain imaging center provides research for autism, schizophrenia and Parkinson's disease
Recently, the University of Missouri Department of Psychological Sciences introduced an addition to their field of research with the opening of the Brain Imaging Center (BIC). The BIC will allow MU researchers to conduct behavioral research on diseases that can have tremendous impact, including Pa...
Brain-nourishing molecule may predict schizophrenia relapse
A factor that helps optimize brain formation and function may also provide clues about whether patients suffering with schizophrenia
are headed toward relapse, researchers say.
Over the next two- and one-half years, they are regularly measuring levels of brain-derived neurotrophic factor, or BD...
Advances in the field of schizophrenia research: New genetic factors identified Schizophrenia
is one of the most serious mental illnesses and is accompanied by symptoms that include delusions and blunted affect. Environmental as well as genetic factors form a complex interplay that leads to the illness. Two papers published in the Internet editions of the professional journal...
Protein marker for schizophrenia risk
A protein found in immune cells may be a reliable marker for schizophrenia
risk, report researchers in a new proteomics study appearing in the July issue of Molecular and Cellular proteomics.
is a severe and complex psychiatric illness that affects about 1% of the population. D...
Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
NEW YORK Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia
and possibly other brain...
Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
Philadelphia, PA, January 8, 2008 Schizophrenia
is a developmental disorder with a large genetic component contributing to increased risk. Available antipsychotic medications treat some of the symptoms of schizophrenia, but are typically effective in only a subset of patients. Unfortunately, it...
How schizophrenia develops: Major clues discovered Schizophrenia
may occur, in part, because of a problem in an intermittent on/off switch for a gene involved in making a key chemical messenger in the brain, scientists have found in a study of human brain tissue. The researchers found that the gene is turned on at increasingly high rates during n...
A genetic basis for schizophrenia
Chicago, Illinois, July 21, 2009 Schizophrenia
is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD ...
Schizophrenia in Biological Technology
Schering-Plough Submits Response to FDA for SAPHRIS(TM) (asenapine) in the Acute Treatment of Both Schizophrenia and Bipolar I Disorder
Response submitted within one month of FDA complete response letter
KENILWORTH, N.J., Feb. 20 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today announced that it has responded to the U.S. Food and Drug Administration (FDA) complete response letter for SAPHRIS(TM) (ase...
Asenapine Meets Primary Endpoint in Long-Term Schizophrenia Relapse Prevention Trial
KENILWORTH, N.J., Oct. 23 /PRNewswire-FirstCall/ -- Schering-Plough
Corporation (NYSE: SGP ) today announced that its novel psychopharmacologic
agent asenapine has met the primary endpoint in a long-term schizophrenia
relapse prevention trial. Asenapine, which is administered as a
Galenea and Otsuka Pharmaceutical Extend & Expand Schizophrenia Research Collaboration
CAMBRIDGE, Mass. and TOKYO, Oct. 6 /PRNewswire/ -- Galenea Corp. and
Otsuka Pharmaceutical Co., Ltd. announced today the extension and expansion
of their research and development collaboration. The two companies have
been working together since January 2005 to discover and develop novel
Topline Findings from Comparative Analysis of INVEGA(TM) and Quetiapine in Schizophrenia to be Postered at the 20th Annual U.S. Psychiatric and Mental Health Congress
TITUSVILLE, N.J., Oct. 8 /PRNewswire/ -- Preliminary results from a
clinical study comparing INVEGA(TM) (paliperidone) Extended-Release Tablets
to quetiapine (marketed as Seroquel(R)) and placebo in patients with
recent, acute exacerbation of schizophrenia
will be the subject of a poster
FDA Approves RISPERDAL(R) to Treat Adolescents with Schizophrenia and Children and Adolescents with Bipolar Mania
TITUSVILLE, N.J., Aug. 22 /PRNewswire/ -- The U.S. Food and Drug
Administration (FDA) today approved RISPERDAL(R) (risperidone) for the
treatment of schizophrenia
in adolescents ages 13-17 and for the short-term
treatment of bipolar mania associated with manic or mixed episodes of
bipolar I di...
SAPHRIS(R) (asenapine) Meets Primary Endpoint in Long-Term Extension Study in Patients With Predominant, Persistent Negative Symptoms of Schizophrenia
KENILWORTH, N.J., July 24 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today announced that its investigational agent SAPHRIS(R) (asenapine) met the primary endpoint over one year of treatment in an extension study in patients with predominant, persisten...
Phase 3 Data Demonstrate Efficacy and Tolerability of Paliperidone Palmitate, an Investigational Long-Acting Therapy for the Treatment of Schizophrenia
Results of Two Trials Identify Potential Initiation Dosing Regimen
TITUSVILLE, N.J., Dec. 10 /PRNewswire/ -- Paliperidone palmitate, an investigational long-acting therapy (LAT) demonstrated statistically significant symptom control compared with placebo according to the results of a 13-w...
ChemDiv and Avineuro Extend Collaboration on Alzheimer's Disease and Schizophrenia
SAN DIEGO, Nov. 21 /PRNewswire/ -- ChemDiv Inc. and Avineuro
Pharmaceuticals Inc. have extended the term of their research and development
collaboration including formulation, safety and early clinical development
studies in areas of neurodegenerative and psychiatric disorders. R&D services
Incorrectly cleaved protein leads to schizophrenia
Leuven, Belgium Schizophrenia
is a disease that strikes an average of 4000 Belgians every year. The causes of this psychiatric disorder are not yet clear. But now, VIB researchers connected to the Katholieke Universiteit Leuven have discovered that a disturbed cleavage of the Nrg-1 protein lies a...
Memory Pharmaceuticals Initiates Phase 2a Trial of MEM 3454 in Cognitive Impairment Associated with Schizophrenia
MONTVALE, N.J., Dec. 20 /PRNewswire-FirstCall/ -- Memory
Pharmaceuticals Corp. (Nasdaq: MEMY ) today announced dosing of the first
subject in a randomized, double-blind, placebo-controlled Phase 2a clinical
trial of MEM 3454, the Company's lead nicotinic alpha-7 receptor partial
agonist, in c...
Schizophrenia in Biological Definition
... cortex to treat their patients. Others may use this knowledge to search for biological causes for common mental illnesses, such as depression and schizophrenia
Many psychologists focus largely on the mental processes of their patients. Biological psychologists work on the basis that there is an organic...
...ly, only the symptoms of these diseases can be treated, but stem cell research may offer a cure. Mental illnesses , such as clinical depression , schizophrenia
, bipolar disorder , and post-traumatic stress disorder , are now recognized as having a biological basis in the brain. These disease can be treate...
...ein in wheat and rye) is suspected of being related to the development of schizophrenia
in some cases. (See British Medical Journal, February 21, 2004.)
Alz... Obes Rev. 2004 Feb;5(1):13-9.
William Eaton et al Coeliac disease and schizophrenia
British Medical Journal, February 21, 2004.
Janssen I, Katzmarzyk PT, Ro...
Schizophrenia in Biological Dictionary
...hat are expressed as a group and their ... and prevents the read through of RNA polymerase into the three structural genes . ... Patients with schizophrenia
carry rare structural gene mutations that impact upon neurodevelopment pathways and may contribute to overall disease phenotype, say US ... Psy...