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Scaffold in Medical News

Frost & Sullivan Lauds Pioneer Surgical Technology for Development of Tissue Scaffold E-Matrix

MOUNTAIN VIEW, Calif., March 19 /PRNewswire/ -- Based on its recent analysis of the field of orthopedic tissue engineering, Frost & Sullivan recognizes Pioneer Surgical Technology, Inc. with the 2009 North American Technology Innovation of the Year Award for its development of the E-Matrix(TM)...

MIT Creates 3-D Scaffold for Growing Stem Cells

Stem cells grew, multiplied and differentiated into brain cells on a new three-dimensional scaffold of tiny protein// fragments designed to be more like a living body than any other cell culture system. An MIT engineer and Italian colleagues will report the invention-which may one day replace...

Improved Bone Grafts With Bioactive cement scaffold

American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST) have developed a new technology for implants// that will enhance the construction or repair of bones in the face, skull and jaw. The novel technology will enable a method for making scaff...

ReGen Biologics Clarifies Recent Press about the Menaflex Device

...Gen's Menaflex(TM) device is a resorbable collagen scaffold used in arthroscopic surgery to address the most c...rce and repair the damaged meniscus by providing a scaffold that is replaced by the patient's own tissue. ...agen meniscus implant employs proprietary collagen scaffold technology to facilitate tissue growth, thereby re...

New Collagen Meniscus Implant Opens New Vista for Knee Repair

...maged meniscus and literally becomes part of the body. There are no artificial devices. The collagen implant is a temporary template and serves as a scaffold for tissue re-growth." Many patients with healthy knees, but who are missing a portion of their meniscus, will benefit from a segmental re-grow...

Dr. Benjamin Raab of Naperville, IL Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler

...mal fillers with the key difference being its lasting effect. The unique microspheres in Artefill are not absorbed by the body and therefore provide a scaffold for the patient's own collagen stimulation to generate long lasting natural feeling results. This is different from temporary dermal fillers that are ...

Study identifies potential fix for damaged knees

...stigators from Hospital for Special Surgery have shown that a biodegradable scaffold or plug can be used to treat patients with damaged knee cartilage. The stud...e data has been encouraging to support further evaluation of this synthetic scaffold as a cartilage repair technique," said Asheesh Bedi, M.D., a fellow in spor...

Positive CHMP Opinion for JAVLOR(R) in Metastatic Treatment of Bladder Cancer After Failure of a Prior Platinum-Containing Regimen

... Pierre Fabre Research Center, vinflunine is a new bi-fluorinated MTI (Microtubule inhibitor) obtained by chemistry exploiting the reactivity of Vinca scaffold in superacidic media. Such strategy, finalized in collaboration with experts at the University of Poitiers (France), enabled the selective introductio...

University of Leeds wins $18 million funding to improve the quality of our old age

...velop products which regenerate inside the body, replacing damaged tissue. iMBE directors Professors John Fisher and Eileen Ingham have designed donor scaffold products which provide a matrix into which the recipient's own cells can migrate when implanted. These are providing a long-term solution for the repl...

Frost & Sullivan Selects Bone Solutions for Technology Leadership of the Year Award

... tricalcium phosphate. This compound provides an osteoconductive, biologic scaffold onto which new bone can form during the window of healing. The Mg gives th...arriers for other materials that may promote bone formation and providing a scaffold for bony ingrowth. Biomechanically, cements do not offer adhesive propertie...
Scaffold in Medical Technology

Osteotech Completes Enrollment for DuraTech(TM) BioRegeneration Matrix Clinical Trial

...ioRegeneration Matrix Utilizing Osteotech's HCT platform, DuraTech is an engineered nano-structure human collagen material that provides a porous scaffold to facilitate cellular in-growth and healing. The DuraTech BioRegeneration Matrix is the lead product in Osteotech's collagen platform and is designed...

Applying Clinical Findings to the Practice of Medicine

...clinical strategy induced bone regeneration by providing an osteoconductive scaffold and by releasing osteoinductive factors. An osteoconductive scaffold is a material that mimics the normal tissue that the bone cells attach to a...

Osteotech Initiates Pivotal Clinical Trial for DuraTech(TM) BioRegeneration Matrix

...eration Matrix Utilizing Osteotech's collagen technology, DuraTech is an engineered nano-structure human collagen material that provides a porous scaffold for rapid cellular in-growth to facilitate healing. The DuraTech BioRegeneration Matrix is the lead product in Osteotech's collagen platform and is de...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

...cancer activity in preclinical studies. A novel and proprietary molecular scaffold has been developed using computational modeling allowing for the design of ... tumor growth reduction in the same model. "Semafore's proprietary kinase scaffold and our new multi-targeted kinase inhibitors add significant value to our p...

Idenix Pharmaceuticals Advances HCV Discovery Program to Clinic

...ease inhibitor discovery program to support IND-enabling pharmacology and toxicology studies. Both IDX136 and IDX316 are based on Idenix's proprietary scaffold B and were developed through SAR (structural activity relationship) approaches aided by high-resolution co-crystal structures with the HCV protease. I...

Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair

...ersus Repair of a Mammalian Bladder Using Autologous Cell and Biodegradable scaffold Technologies," was co-authored by Tengion scientists Manuel J. Jayo, D.V.M....al -- in which either a Tengion Neo-Bladder Augment or a biodegradable mesh scaffold alone was surgically implanted following partial, trigone-sparing cystectom...

Preclinical Data Demonstrate Ability to Regenerate an Entire Bladder With Tengion Neo-Bladder Replacement(TM)

...s technology to regenerate an entire urinary bladder. Neo-Bladder Replacements were produced from autologous bladder cells seeded onto a biodegradable scaffold and were then surgically implanted into 23 large mammals. In this study: -- Tengion's Neo-Bladder Replacement was able to regenerate an entire ...

CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model

...rial The unique properties of extracellular matrix biomaterials were discovered at Purdue University. The decellularized matrix material serves as a scaffold to allow adjacent tissues to deliver cells and nutrients to the matrix, which then differentiate into tissue-specific cells. The ECM material is gradu...

Tengion Launches Third Phase 2 Clinical Trial of Regenerated Human Bladder

...nstructed using the patient's healthy cells from the biopsy. After approximately four to eight weeks, expanded cells will be seeded on a biodegradable scaffold to produce the Neo-Bladder Augment. Approximately one week later, a surgeon will surgically implant the Neo-Bladder Augment back into the patient's na...

Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ

...the-art manufacturing facility using cells taken from a small biopsy of each patient's bladder. Each neo-bladder construct consists of a biodegradable scaffold seeded with cells cultured by Tengion scientists from the patient's own (i.e., autologous) healthy cells. A surgeon implants the neo-bladder construct...
Scaffold in Medical Products

Osteomesh Bioresorbable Implant for Craniofacial Surgery

Description:...gnals that are required for bone growth and remodeling. The mesh is malleable and can be easily cut to any shape. The mesh offers a rigid yet flexible scaffold with sufficient mechanical strength that supports bone in-growth and it degrades as bone regeneration and remodeling takes place. Long term clinical t...
Company:Osteopore International

Osteoplug Bioresorbable Implant for Trephination Burr Holes

Description:...on mushroom, allows a snap fit into burr holes and requires no fixation by screws, unlike titanium plates. It has superior mechanical strength and the scaffold architecture minimizes potential injuries to the exposed brain through the burr holes. Its interconnecting porous matrix architecture allows it to be ...
Company:Osteopore International

Collagen Meniscus Implant

Description:...return to a more active lifestyle. The CMI is a resorbable type I collagen scaffold designed to minimize progressive degenerative changes in the knee after a p...it is a biocompatible, bioresorbable material that is designed to provide a scaffold for tissue growth when implanted in the knee. The surgeon sutures the CMI i...
Company:ReGen Biologics

TruFit® CB

Description:... TruFit® CB Plugs use OBIs proprietary PolyGraft® material technology which provides a scaffold for tissue repair that is both biologically friendly and biomechanically stable. A patented composite of polylactide-co-glycolide, calcium sulfate an...
Company:OsteoBiologics, Inc.

Conduit TCP Granules Bone Graft

Description:...ed of Tricalcium Phosphate, which is similar to the mineral phase that comprises 70% of human bone. TCP is an osteoconductive material that provides a scaffold that allows the attachment of bone forming cells and allows for the development of vascular networks within granules as well as between each granule. ...
Company:DePuy Orthopaedics, Inc.

Ocu-pore Porous Orbital Implants

Description:...atible ceramic matrix similar in nature to that found in human cancellous bone. The product provides a macro porous structure that serves as an ideal scaffold allowing rapid and complete soft tissue penetration throughout the entire implant. The device is permanent and will not resorb. Once integrated the de...
Company:Ceramisys

POPmesh™

Features:... - At a mere 19g/m2, POPmesh is 56.4% lighter than the leading polypropylene mesh Enhanced Patient Comfort - POPmeshs structure creates a pliable scaffold with soft edges to reduce irritation risk Superior Handling & Drapability - The POPmesh knit structure allows for multi-dimensional elasticity, makin...
Company:Caldera Medical

EBI OsteoGen-M

Features:... placement against decorticated bone Increases contact between cathode and host bone to enhance application of current Provides an electrified scaffold for stimulating bone growth Totally implanted to assure patient compliance No special surgical instrumentation required Generator has 6-mo...
Company:Biomet, Inc.

EBI OsteoGen™-M (Mesh Cathode)

Features:... placement against decorticated bone Increases contact between cathode and host bone to enhance application of current Provides an electrified scaffold for stimulating bone growth Totally implanted to assure patient compliance No special surgical instrumentation required Made from biocompa...
Company:Biomet, Inc.

Symphony I/C Graft Chambers

Features:...ontains 100% cancellous chips and DBM particles, undiluted with inert carriers. Autologous Graft Carrier - Provides graft handling characteristics, a scaffold for cellular ingrowth and attachment, and a measurable increase in growth factor concentration. LifeNet Quality which enhances safety, reliably inacti...
Company:DePuy Orthopaedics, Inc.
Scaffold in Biological News

MIT: New tissue scaffold regrows cartilage and bone

CAMBRIDGE, Mass.--MIT engineers and colleagues have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints. The scaffold could offer a potential new treatment for sports injuries and other cartilage damage, such as arthritis, s...

Scientists discover a molecular scaffold that guides connections between brain cells

Brain cells known as neurons process information by joining into complex networks, transmitting signals to each other across junctions called synapses. But neurons dont just connect to other neurons, emphasizes Z. Josh Huang, Ph.D., in a lot of cases, they connect to very specific partners, at par...

MIT creates 3-D scaffold for growing stem cells

Stem cells grew, multiplied and differentiated into brain cells on a new three-dimensional scaffold of tiny protein fragments designed to be more like a living body than any other cell culture system. An MIT engineer and Italian colleagues will report the invention-which may one day replace the u...

Bioactive cement scaffold may improve bone grafts

A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST). Described in recent and upcoming jour...

Navigating in the ocean of molecules

...aceutical substances. The program, which is called scaffold Hunter, acts as a tool for navigating chemical spa...way through this sea of possibilities. The program scaffold Hunter generates a map of the chemical space based...e the molecules to their characteristic scaffolds. scaffold Hunter then orders these structures in a kind of f...

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

...p at Stanford University School of Medicine, provides new insights into the scaffold of proteins that ensures accurate segregation of chromosomes during cell di...he chromosome that directs this attachment by controlling the assembly of a scaffold of proteins (called the kinetochore), which tether the chromosome to the sp...

Structural biology scores with protein snapshot

...s of function but would not usually affect protein folding, whereas key residues for folding would be located elsewhere in the protein to underpin the scaffold for the active site. "Our study shows that you can't make that assumption," he said. Sanders cautions that investigators cannot simply predict the...

Capturing the birth of a synapse

...ecules on the membrane of another neuron. In turn, neuroligins recruit at least two other key proteins (PSD-95 and NMDA receptors) to begin building a scaffold to hold the synapse components in place. The moment of locking is captured in a video (link below) that will appear with the paper's final version at ...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

... His goal for the three-year term of the grant is to demonstrate the feasibility of this approach in laboratory rats. "What we want to do is make a scaffold a material that the bone-forming cells can enter that supplies them with the proper directions for how much bone they should be forming and how fast...

Non-wovens as scaffolds for artificial tissue

... vessels in the laboratory. The research scientists place cells on a porous scaffold material, for example a non-woven made of polymer fibers. The cells can the...n the artificial cartilage is inserted in the patient's knee the supporting scaffold is gradually resorbed and only the cartilage tissue remains. While it i...

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Scaffold in Biological Technology

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

...actions. Each map describes multi-step signaling covering the full spectrum of cellular signaling from ligand-receptor interaction through enzymes and scaffold proteins to transcription factors. The donated maps describe the role of interferons and cytokines in the immune response, development (via a variety ...

Heart disease: Research off the beating patch

...n Inc. San Francisco) made from microscopically thin fibers that serve as a scaffold to which the cells can adhere. The group's latest achievements have attra...work shows that we can put living cells onto a biodegradable, 3-dimensional scaffold in a way that not only allows them to survive, but to spontaneously beat in...

BioSyntech Reports Positive Results from Pivotal Trial for BST-CarGel(R) Cartilage Repair Device

..., "This randomized controlled study performed under good clinical practice guidelines is a well run study with robust data that will have an impact on scaffold directed cartilage repair in the coming years. I congratulate the Company on this early stage histological data and the rigor of the study design." ...

ETEX Corporation Announces FDA Clearance of Small Size Beta-bsm(TM) Injectable Paste and Gamma-bsm(TM) Moldable Putty

...: http://www.newscom.com/cgi-bin/prnh/20080424/NETH117LOGO ) Beta-bsm(TM) and Gamma-bsm(TM) set hard to provide an optimal osteoconductive scaffold that mimics the nanocrystalline structure of human bone. Smaller sizes were developed in direct response to the needs of the small bone market. Both h...

Stemedica Signs Scientific Advisory Board Agreement with Leading Pediatric Burn & Wound Care Researcher

...t of pediatric burns and chronic wounds. Her methodology included using a proprietary cell formulation administered through an all natural, gauze-like scaffold construct. During the clinical trials, pediatric burn patients treated with whole cell bioengineered tissue showed significant clinical improvement o...

Osteotech Reports Fourth Quarter and Full Year 2008 Financial Results; Company Plans Three Product Launches and Unveilings in 2009; Will Provide 2009 Guidance During Conference Call on March 5, 2009 at 9:00 a.m. EST

... In April 2008, Osteotech received FDA clearance to market its Plexur P(R) Biocomposite in spinal applications. Plexur P is a porous, resilient scaffold which allows for the rapid absorption and retention of cells to facilitate bone growth. In March and July 2008, Osteotech received FDA clearan...

Biomerix Corporation Announces FDA Clearance and Market Launch of REVIVE(TM) for Use in Soft Tissue Repair Procedures

...U.S. Food and Drug Administration (FDA) 510(k) clearance to market REVIVE(TM). Constructed using the Biomerix Biomaterial(TM), REVIVE acts as a tissue scaffold facilitating rapid tissue ingrowth and can be utilized in a variety of soft tissue repair procedures, including the repair of inguinal hernias. ...

Serica Technologies Receives FDA 510(k) Clearance for SeriScaffold(TM) Technology for Soft Tissue Repair

...iScaffold (TM) silk-based, long term bioresorbable scaffold technology. "We are delighted to receive FDA ...ution as an off-the-shelf, long-term bioresorbable scaffold for support and repair of weakened or damaged conn...ld could be used as a sophisticated tissue repair scaffold for the approximately 60,000 women who, according ...

Frost & Sullivan Presents CorMatrix Cardiovascular Inc. with 2008 Healthcare Innovation Award for the Treatment of Cardiovascular Disease

...l product enhances the patient's recovery after surgery by facilitating efficient tissue repair." The company's ECM Technology(TM) product acts as a scaffold into which the patient's own cells migrate and integrate, stimulating the body's innate wound-healing mechanisms to repair tissue at the site of impla...

Frost & Sullivan Acknowledges ISTO Technologies' Role in Developing Advanced Biologic Products for Bone Healing

...Frost & Sullivan Research Analyst Pramodh Ishwarakrishnan. "The unique InQu scaffold creates a microenvironment that is both biocompatible and conducive to new bone formation." These two major components of the scaffold have specific contributions to the overall healing process. PLGA, while giv...
Scaffold in Biological Definition

Human Genome Project

...esent the exact sequence of each and every individual's genome. It is the combined genome of a small number of anonymous donors. The HGP genome is a scaffold for future work in identifying differences between individuals. Most of the current effort in identifying differences between individuals involves s...

Nucleosome

...r the structure of chromatin is poorly understood, but it is classically suggested that the 30 nm fiber is arranged into loops along a central protein scaffold to form transcriptionally active euchromatin . Further compaction leads to transcriptionally inactive heterochromatin . ...

Ribosome

...s, peptide transfer, can occur in the presence of rRNA alone, albeit at a slower rate. This suggests that the protein components of ribosomes act as a scaffold that may enhance the ability of rRNA to synthesise protein. The structure and function of ribosomes, and their attendant molecules, known as the tr...
Scaffold in Biological Dictionary

Skeleton

... human skeleton consists of both fused and individual bones supported and supplemented by ligaments, tendons, muscles and cartilage. It serves as a scaffold which supports organs, anchors muscles, and protects organs such... View the skeletons of a human, chimpanzee, and baboon and gather information ...

Secondary Structure

... however, describe specific atomic... The functional form of single stranded RNA molecules frequently requires a specific tertiary structure . The scaffold for this structure is provided by secondary structural elements which are hydrogen bonds within the... This 1996-1997 Protein Secondary St...

Proteome

...covery through the use of their proprietary proteomic technologies. Home scaffold 2 scaffold Q+ Proteomics Links FAQs Downloads. Home | Contact Us | Partners ... Copyri...

Microtubules

... actin filaments and microtubules . ... Microtubules are slender cylindrical structures that exhibit a cytoplasmic ... Microtubules act as a scaffold to determine cell shape, and provide a ... Microtubules also form the spindle fibers for separating chromosomes during mitosis. ... Biology...

Kinase

... IPR010440 Lipopolysaccharide kinase ... IPR016477 Fructosamine/Ketosamine-3 - kinase ... The European ... associated guanylate kinase (MAGUK) scaffold protein ... Guanylate kinase /L-type calcium channel region. Zona occludens protein ZO-3 ... ...

Biological tissues

... of Soft Biological Tissues page for The Physical and Engineering Sciences Center at Sandia National Laboratories California The shape of the scaffold determines the shape of the tissue as it grows. ... of work done in printing electronics, printing biological tissue , and musclebots... ...
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