STAT3

Cell Protein Could Help Spur Malignancy

...SDAY, June 25 (HealthDay News) -- A protein called stat3 plays a major role in the change of normal cells i...lity that inhibiting the mitochondrial function of stat3 could be a promising cancer therapy in the future,...made the discovery about the mitochondrial role of stat3 by analyzing tumors caused by the Ras oncogene, wh...

New oncogene gives valuable insight into hepatocellular tumors in humans

...target the IL-6 binding site in GP130. Also demonstrated was the fact that the expression of the most frequent GP130 mutants in HEP3B cells activates stat3 in absence of IL-6. The researchers searched for possible interaction and cooperation of GP130 activation with other pathways altered in hepatocellula...

New Clues to Stopping Colitis-Linked Cancer

...e edition of Cancer Cell . The findings suggest that targeting IL-6 and stat3 mught be a way to stop or treat CAC, said lead researcher Michael Karin, a ...ty and a member of its cancer center. For example, when researchers removed stat3 from intestinal epithelial cells, the development of colitis-associated can...

2 immune-system proteins linked to colitis-associated cancer

...s are largely mediated by the transcription factor stat3 in cancer cells. Their latest study which is also...irst to establish the cancer-promoting function of stat3 in a validated mouse model of human cancer will b...he first genetic evidence for the critical role of stat3 in cancer using a mouse model of human cancer, als...

Immune Molecule Key to Preventing Organ Rejection

...his colleagues found that when HLA-G dimer binds with its inhibitory receptor ILT4, it triggers a signaling pathway in which immune molecules IL-6 and stat3 play a major role. "Biologically, this is an interaction that requires several important suppressive molecules," said Horuzsko, corresponding autho...

Immune molecule that plays a powerful role in avoiding organ rejection identified

...f Sciences details that when HLA-G dimer binds with its inhibitory receptor, ILT4, it triggers a signaling pathway in which immune molecules IL-6 and stat3 play a major role. "Biologically this is an interaction that requires several important suppressive molecules," says Dr. Horuzsko, the study's corresp...

Blocking signaling protein prevents prostate cancer spread, Jefferson scientists find

...o Dr. Nevalainen, previous studies have shown that stat3 is very active in metastatic prostate cancer, and ...se prostate cancer cells to overproduce the normal stat3 protein by delivering it through a virus vehicle. ... lacking a working immune system, they showed that stat3 caused a 33-fold increase in metastases. "This...

Scientists Discover How Stomach Tumors Form

...ors in the stomach by increasing activation of the stat3 protein, a known player in inflammation-associated carcinogenesis. Excessive stat3 activity is often found in gastric and other types of cancer. The underlying cause of the stat3 issue had previously been unknown. "The clear l...

Discovery of good -- and bad -- liver stem cells raises possibility of new treatment

...he current study indicate that use of the agent, a stat3 inhibitor, dramatically inhibited liver cancers in...ls and found that only 1 in 40 mice bred without a stat3 gene developed liver cancer. But with the stat3 gene intact, 70 percent of mice developed the canc...

Gene Plays 'Jekyll-and-Hyde' Role in Deadly Brain Cancer

... Study finds stat3 can act as tumor suppressor, keeping bad cells in ...THURSDAY, Feb. 7 (HealthDay News) -- A gene called stat3 acts like "Jekyll and Hyde" in glioblastoma brain ... over decades. Previous research has shown that stat3 is an oncogene in several types of glioblastoma. A...

STAT3 in Medical Technology

RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds Significant Promise for Treating Breast Cancer

IRVING, Texas--(BUSINESS WIRE)--May 15, 2007 - Reata Pharmaceuticals, Inc. today announced the publication of an article in the May 2007 issue of the journal Cancer Research showing that RTA 402, the company's Phase 2 development candidate for cancer, was highly effective in a rigorous animal model...

EntreMed to Highlight ENMD-2076 Kinase Inhibitor at 2008 AACR Annual Meeting

...ddition, EntreMed scientists are scheduled for the following poster presentations: -- "ENMD-1198 Antitumor Activity and Inhibition of HIF-1alpha, stat3 and NFkappaB Signaling Pathways are Dependent on Microtubule Isotype Expression and Targeting," Monday, April 14, 2008 from 1:00 PM - 5...

Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer

... with only mild, transient side effects, inhibits the activity of NF-kB and stat3 (the drug's targets) in human tumors, and is able to suppress levels of tum...e that inhibits NF-kB activation. The triterpenoids block the activation of stat3 and STAT5 in cancer cells by upregulating negative regulators of the STATs....

RTA 402 Shown to Protect Animals Against Toxicities of Standard Cancer Treatments

...atients with several different types of tumors, is well tolerated with only mild, transient side effects, and suppresses its target proteins NF-kB and stat3 in human tumors. A Phase 1/2 study of RTA 402 in combination with gemcitabine is underway in patients with pancreatic cancer. Analogues of RTA 402 are...

STAT3 in Biological News

New link in liver cancer

...liver by breaking down TGFbeta. But when TGFbeta is abundantas occurs in people with chronic liver damagegrowth hormone activates the cancer-promoting stat3 instead of the protective STAT5. These results might help explain how chronic liver damage can eventually lead to cancer. ...

Small molecules block cancer gene

...eardy and his colleagues identified an area on the stat3 molecule that was important to its activity. stat3 actually is critical in keeping malignant cells al... would fit in that pocket and block the ability of stat3 to maintain the cancer cell. That screen of nearly...

Researchers identify new function of protein in cellular respiration

...University researchers have found that the protein stat3 plays a key role in regulating mitochondria, the e...orm of cellular energy. The findings revealed that stat3 is necessary for the function of the mitochondrial...n cellular homeostasis. "We found evidence that stat3 is present in the mitochondria and that it serves ...

2 new compounds show promise for eliminating breast cancer tumors

...se they efficiently disrupt the abnormally active stat3 protein he said. "We all have the stat3 protein in our bodies, and under normal circumstan...oth compounds disrupt the bonding process that one stat3 molecule goes through to connect with another in t...

Two new compounds show promise for eliminating breast cancer tumors

...se they efficiently disrupt the abnormally active stat3 protein he said. "We all have the stat3 protein in our bodies, and under normal circumstan...oth compounds disrupt the bonding process that one stat3 molecule goes through to connect with another in t...

Wealth of genomic hotspots discovered in embryonic stem cells

...of binding that give rise to transcription factor co- localization hotspots. The Nanog/Oct4/Sox2 centric hotspots are commonly co-bound by Smad1 and stat3 and they represent points of integration for the intrinsic and external signaling pathways. The combinatorial wiring of transcription factors is imp...

Physical and functional interaction of key cell growth molecules linked to cancer

...erson Cancer Center found that EGFR interacts with stat3 in the cell nucleus. stat3 is a molecule that is known to bind to DNA and directly regulate gene expression. stat3 has also been shown to have a major role in oncoge...

Unraveling a stomach cancer puzzle

...mune system. "We showed that, in mice, hyperactive stat3 shuts down a vital controller of stomach cell grow...milar to those we would predict if the same thing, stat3 hyperactivity shutting down TGF, happens in humans...ther cancers. "We've demonstrated that by lowering stat3 hyperactivity we can suppress stomach cancer forma...

Used in a new way, RNA interference permanently silences key breast cancer gene

...ch (AACR), used a modified form of RNAi to silence stat3 in a permanent way. Typically, only a transient ef... providing some valuable insights into the role of stat3 and its downstream targets," adds Arlinghaus, who ... RNA (termed a short hairpin RNA, shRNA) for mouse stat3 into a mouse breast cancer cell line. They chose...

STAT3 in Biological Technology

JCI table of contents: April 22, 2008

...mice through activation of the signaling molecules stat3 and, to a lesser extent, Stat1. Further, the activation of stat3 and Stat1 was found to induce the expression of mo...t the University of Michigan, Ann Arbor. TITLE: stat3 and STAT1 mediate IL-11dependent and inflammation-...

JCI table of contents: Dec. 3, 2007

...tering Cancer Center, New York. A protein known as stat3 is persistently activated in 50% of lung cancers k...sted by the observed correlation between activated stat3 and IL-6 expression in primary lung adenocarcinoma...TITLE: Mutations in the EGFR kinase domain mediate stat3 activation via IL-6 production in human lung adeno...

Application of the Bio-Plex Cell Lysis Kit in Western Blot Analysis of Phosphoproteins, Rev A

...tion identified in parentheses: STAT6 (Tyr 641 ), p90RSK (Ser 380 ), Akt (Ser 473 ), ERK1/2 (Thr 202 /Tyr 204 ), PKC (Ser 916 ), stat3 (Tyr 705 ), NFκB p65 (Ser 536 ), JNK (Thr 183 /Tyr 185 ), p38 MAPK (Thr 180 /Tyr 182 ). Quantitation of Phosphoproteins ...