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STAT1 in Medical News

Lack of STAT1 -an Immune Protein, Pack Liver Infection Cure

Mice lacking a gene for normal immune functioning found to be safe when exposed against a pathogen that attacks //liver and spleen - a new study finds. Visceral leishmaniasis, an infectious disease caused by a pathogen called Leishmania donovani, affects certain internal organs. People in tropi...

Stanford researchers harness nanoparticles to track cancer-cell changes

... a protein's shape, in effect turning it on. Two intracellular proteins, stat1 and Stat6, play crucial roles in the development of cancer. The Stanford te...els of both proteins in lab-cultured myeloid leukemia cells. The changes in stat1 and Stat6 closely tracked those demonstrated with existing visualization me...

JCI online early table of contents: March 13, 2008

...and TLRs for the treatment of individuals with SLE, therapies that are currently in preclinical and/or early-stage clinical trials. TITLE: IRF9 and stat1 are required for IgG autoantibody production and B cell expression of TLR7 in mice AUTHOR CONTACT: Paul J. Utz Stanford University School of Medi...

Researchers led by Penn vet uncover the delicate protein balance behind the immune system response

...d concludes that cytokines like IL-27 can promote the ability of these cells to produce IL-10. The effect was dependent on the transcription factors stat1 and STAT3 for IL-27 and on STAT3 for IL-6. Researchers tested this hypothesis by removing the IL-27 receptor from genetically engineered mice. Once...
STAT1 in Biological News

New approach for attacking lupus identified

...s, called STATs, mediate the two functions of IFN. stat1 mediates the autoimmune and inflammatory functions... that calcium specifically increases activation of stat1 by interferons, and thus turned their attention to...um actually regulate the strength of activation of stat1 by the interferons, but they do not regulate the s...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

..." Holtzman says. The group engineered a mutant stat1 protein in which the identities of two amino acids...n cells growing in culture showed that the altered stat1 proteins reacted more efficiently to the presence ...rferons. Further tests revealed that the souped-up stat1 recruited more of a specific protein it needs to p...

Engineered molecule amplifies body's immune response

...o improve the body's defense against infection. stat1 is involved in immune responses that are initiated...Children who are born with genetic deficiencies of stat1 are also very susceptible to infection. In the mor...rferon treatment by engineering a hyper-responsive stat1 molecule. By increasing the efficiency of the...
STAT1 in Biological Technology

JCI table of contents: April 22, 2008

... Stat3 and, to a lesser extent, Stat1. Further, the activation of Stat3 and stat1 was found to induce the expression of more IL-11, generating an amplificati...ita Merchant, at the University of Michigan, Ann Arbor. TITLE: STAT3 and stat1 mediate IL-11dependent and inflammation-associated gastric tumorigenesis in...

JCI table of contents: Dec. 3, 2007

.... Similarly, megakaryocytes from mice deficient in stat1 lacked the chromosomal duplication inherent to thi...rom these results that inflammatory stimulation of stat1 can lead to thrombocytosis through enhanced differentiation of platelet precursor cells. TITLE: stat1 promotes megakaryopoiesis downstream of GATA-1 in ...

New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction Pathways

...AT1, STAT2, and another protein known as p48. This complex binds to the enhancer element, IFN-stimulated response element (ISRE). In contrast, the stat1 homodimer, which binds to the unique gamma-activated sequence (GAS), is formed in response to IFN- g . 3 The mechanism of the activation and nucl...
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