Lack of STAT1 -an Immune Protein, Pack Liver Infection Cure
Mice lacking a gene for normal immune functioning found to be safe when exposed against a pathogen that attacks //liver and spleen - a new study finds.
Visceral leishmaniasis, an infectious disease caused by a pathogen called Leishmania donovani, affects certain internal organs. People in tropi...
Stanford researchers harness nanoparticles to track cancer-cell changes
... a protein's shape, in effect turning it on.
Two intracellular proteins, stat1
and Stat6, play crucial roles in the development of cancer. The Stanford te...els of both proteins in lab-cultured myeloid leukemia cells. The changes in stat1
and Stat6 closely tracked those demonstrated with existing visualization me...
JCI online early table of contents: March 13, 2008
...and TLRs for the treatment of individuals with SLE, therapies that are currently in preclinical and/or early-stage clinical trials.
TITLE: IRF9 and stat1
are required for IgG autoantibody production and B cell expression of TLR7 in mice
Paul J. Utz
Stanford University School of Medi...
Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
...d concludes that cytokines like IL-27 can promote the ability of these cells to produce IL-10. The effect was dependent on the transcription factors stat1
and STAT3 for IL-27 and on STAT3 for IL-6.
Researchers tested this hypothesis by removing the IL-27 receptor from genetically engineered mice. Once...
STAT1 in Biological News
New approach for attacking lupus identified
...s, called STATs, mediate the two functions of IFN. stat1
mediates the autoimmune and inflammatory functions... that calcium specifically increases activation of stat1
by interferons, and thus turned their attention to...um actually regulate the strength of activation of stat1
by the interferons, but they do not regulate the s...
Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects
..." Holtzman says.
The group engineered a mutant stat1
protein in which the identities of two amino acids...n cells growing in culture showed that the altered stat1
proteins reacted more efficiently to the presence ...rferons. Further tests revealed that the souped-up stat1
recruited more of a specific protein it needs to p...
Engineered molecule amplifies body's immune response
...o improve the body's defense against infection.
is involved in immune responses that are initiated...Children who are born with genetic deficiencies of stat1
are also very susceptible to infection. In the mor...rferon treatment by engineering a hyper-responsive stat1
molecule. By increasing the efficiency of the...
STAT1 in Biological Technology
JCI table of contents: April 22, 2008
... Stat3 and, to a lesser extent, Stat1. Further, the activation of Stat3 and stat1
was found to induce the expression of more IL-11, generating an amplificati...ita Merchant, at the University of Michigan, Ann Arbor.
TITLE: STAT3 and stat1
mediate IL-11dependent and inflammation-associated gastric tumorigenesis in...
JCI table of contents: Dec. 3, 2007
.... Similarly, megakaryocytes from mice deficient in stat1
lacked the chromosomal duplication inherent to thi...rom these results that inflammatory stimulation of stat1
can lead to thrombocytosis through enhanced differentiation of platelet precursor cells.
promotes megakaryopoiesis downstream of GATA-1 in ...
New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction
...AT1, STAT2, and another
protein known as p48. This complex binds to the enhancer element, IFN-stimulated
response element (ISRE). In contrast, the stat1
homodimer, which binds to the
unique gamma-activated sequence (GAS), is formed in response to IFN- g . 3
The mechanism of the activation and nucl...