SLE

Several genes that regulate the disease SLE have been identified

Swedish researchers, in collaboration with foreign colleagues, have identified a number of new genes that can be tied to the disease SLE, including a gene that hopefully might be used to treat the disease in the future by regulating the production of antibodies. These unique findings are being pu...

Usage Of Oral Contraceptives Need Not Be Feared By SLE Patients

In a research co headed by Jill Buyon, M.D., of New York’s Hospital for Joint Diseases said that oral contraceptives can be given to women with inactive or stable Systemic// Lupus Erythematosus (SLE) and they would not show symptoms of increased risk of flares of the disease. This research was ...

Infertility is Seen in Men With SLE

The prognosis for systemic lupus erythematosus (SLE), an autoimmune disease that mainly affects women in their reproductive years , has improved recently, prompting a shift toward improving quality of life. For men with SLE, concerns have been raised about their future fertility. However, n...

Immune responses to flu vaccine are diminished in lupus patients

...sed patients, it is recommended that patients with sle get annual flu shots, which are safe and do not in...as the first to examine cell-mediated responses in sle patients prior to and following influenza vaccinat...e Netherlands, the study involved 54 patients with sle and 54 healthy controls who received subunit flu v...

Almost 1 quarter of Spanish women take antidepressants

...iazepine use increases with age. However, they did not find the same with antidepressant use. "We think that greater training is needed in identifying sle and family dysfunction, and recording these in patients' records in order to help psychologists, psychiatrists and primary healthcare specialists", Pr...

Human Genome Sciences Announces Second-Quarter 2009 Financial Results and Key Developments

...esented at the Congress of the European League against Rheumatism (EULAR). The data showed that BENLYSTA was associated with sustained improvement in sle disease activity and patient response rates, decreased frequency of disease flares and was generally well tolerated through four years on treatment in...

Anxiety and depression lower quality of life in majority of systemic lupus erythematosus patients

...(52 of 56) of the patients who were diagnosed with sle had an element of confirmed neuropsychiatric (NP) ... Several other conditions that may occur alongside sle were also shown to influence aspects of QoL (as me...Italy, who conducted the study, said: "People with sle experience a range of both psychological and physi...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

...eague Against Rheumatism in Copenhagen, Denmark. sle is a complex, chronic autoimmune disease that caus...idney failure, often a significant complication of sle associated with the more severe forms of the disea...ignaling molecules involved in the immune process. sle was induced in the mice and the levels of antibodi...

Decrease in sense of smell seen in lupus patients

...us system in a condition known as neuropsychiatric sle (NPSLE). Research in mice has shown that NPSLE-lik...plored. A new study assessed olfactory function in sle patients and found that there is a decrease in the...ter in Tel-Hashomer, Israel, the study involved 50 sle patients and 50 age and sex-matched controls. Rese...

Oral contraceptives associated with increased risk of lupus

...matched with up to 10 controls among women without sle at the time of the case's diagnosis. The result...and possibly a dose-response effect of estrogen on sle onset," according to the authors. They note that e...ce seen in SLE. Previous studies on the risk of sle following use of oral contraceptives have had conf...

More>>

SLE in Medical Technology

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

...at emerged in the serologically active subgroup of sle patients at Week 52 in our Phase 2 trial," said Da...significance. BENLYSTA also significantly reduced sle disease activity versus placebo based on a number ...n collaboration with GSK and leading international sle experts, and the program is being conducted under ...

Lupus Foundation of America Fosters the Next Generation of Lupus Researchers by Awarding Gina M. Finzi Memorial Student Summer Fellowships to Five Students

... Tarak Trivedi, The University of Chicago (Chicago, IL) "Analysis of sle Clinical Characteristics Using sle Susceptibility Genes" The Foundation's national research program, Bri...

Human Genome Sciences Reports Substantial Progress Toward Commercialization and Announces 2009 Goals at JPMorgan Healthcare Conference

... 2010, and we believe it could become the first new drug approved by the FDA for the treatment of lupus in 50 years," said Mr. Watkins. "Patients with sle need new treatment options; we hope to be able to help meet that need with LymphoStat-B." Key goals for LymphoStat-B in 2009: R...

Study Results Show Epratuzumab Provided Clinically Meaningful Reduced Disease Activity in Patients With Lupus

...lled trials evaluating the efficacy and safety of epratuzumab for the treatment of severe BILAG A and/or moderate BILAG B in two or more organ systems sle flare, respectively. Both trials terminated early due to interruptions in medication supply. Among both trials, 90 patients were randomized to receive...

Human Genome Sciences Completes Enrollment in Second Phase 3 LymphoStat-B(R) Trial

...ort of a potential Biologics License Application (BLA). HGS designed the belimumab Phase 3 program in collaboration with GSK and leading international sle experts. "The belimumab clinical investigators have done a tremendous job in completing the randomization and initial dosing of BLISS-52 and BLISS-7...

Medarex Announces Initiation of Phase 2 Clinical Development Program for the Treatment of Lupus

...uman monoclonal antibody targeting interferon-alpha. Published data indicate that levels of interferon-alpha are elevated in many patients with active sle and other autoimmune disorders, and may be associated with disease activity. Preclinical data from animal models suggest that MEDI-545 may suppress th...

Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus

...play an important role in the treatment of SLE." sle is a chronic, life-threatening autoimmune disease....cally active SLE, we saw significant reductions in sle disease activity versus placebo based on multiple ...epresent a significant advance in the treatment of sle if Phase 2 results are confirmed in the Phase 3 tr...

Human Genome Sciences Reports Progress With Late-Stage Products and New Initiatives

...tific meetings at earlier time points, including a significant reduction in sle disease activity as measured by the response rate chosen as the primary eff... a protocol design informed by prior randomized data. Today's therapy for sle patients involves a variety of immunosuppressive and cytotoxic agents, with...

Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus

...al of Rituxan (rituximab) for the treatment of lupus. The study did not meet its primary or secondary endpoints of clinically reducing the severity of sle (systemic lupus erythematosus) in people with moderate disease. The findings are initial results from a Phase II/III study conducted by Genentech,...

Human Genome Sciences Completes Enrollment in First of Two Phase 3 Lymphostat-B(R) Trials

...he results of previous studies suggest that belimumab significantly reduced sle disease activity in serologically active patients," said Professor Sandra V...oStat-B Phase 3 program in collaboration with GSK and leading international sle experts. "A total of nearly 1700 patients worldwide will be enrolled and ...

More>>

SLE in Medical Dictionary

Lupus nephritis

...ematosus (SLE), a disease of the immune system. Apart from the kidneys, sle can also damage the skin, joints, nervous system and virtually any organ ...rums, prevention, and prognosis. Lupus Nephritis Treatment. Cytoxan sle Treatment. Sjogren's Syndrome. Ask Questions ... The majority of patients w...

Lupus erythematosus

...ests, treatments, medications, and more. Lupus Erythematosus . What is lupus erythematosus . Systemic lupus erythematosus is also called sle ... Dogs get systemic lupus erythematosus , as well as humans. ... Lupus — Comprehensive overview covers symptoms and treatment of lupus...

Lupus

... as programs and ... Find out more on the many ways that lupus affects the body ... Lupus is a disease that affects the immune system. ... sle is the most serious form of lupus . ... This type of lupus is a skin disease that causes a rash on ... E-newsletter Sign up to receive th...

More>>

SLE in Biological News

DNA variations signal lupus risk

...udy, the largest of its kind to date, is the work of the International Consortium for Systemic Lupus Erythematosus (SLEGEN), of which UAB is a member. sle is the medical term for systemic lupus erythematosus, a common form of the disease. Looking at the genomes of 6,728 people, the researchers found t...

UT Southwestern secures $5 million NIH grant for lupus research

...onnected research groups focused on key aspects of sle development. Dr. Mohan, professor of internal ...ocusing on why B-cells start to attack the body in sle patients. Overseeing a group working to identi...c features that mark progression of the disease in sle patients are Dr. Olsen, professor of internal medi...

Lupus gene finding prompts call for more DNA samples

...requently causes skin rash, joint pains and malaise, but can also lead to inflammation of the kidneys and other internal organs. The risk of death in sle is increased fivefold over that of the general population. However, because the symptoms are often non-specific, diagnosing the condition can be diff...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

... of the American College of Rheumatology (ACR). sle is a chronic disease, and patients need new therap... observed for LymphoStat-B in serologically active sle patients at 52 weeks appears to be sustained throu...ymphoStat-B was well tolerated in combination with sle standard-of-care therapy during long-term exposure...

American Chemical Society's Weekly PressPac -- Sept. 26, 2007

..., kidneys and other body parts. Current treatments for lupus also known as sle include high doses of steroids and other medications with serious side eff...therapy warrants further evaluation as a possible approach for treatment of sle in humans, the report states. ARTICLE #1 FOR IMMEDIATE RELEASE Depletion...

New insights into autoimmunity and depression

...neral and in central nervous system dysfunction in sle in particular. Healthy female mice receiv...P antibodies extracted from the blood sample of an sle patient. For control purposes, equal numbers of mi...atients with clinical depression and patients with sle could help determine whether these pathways are si...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...s therefore possible to imagine the development of methods of treatment for sle based on blocking the function of the thyrosinkinase enzyme," explains Lars...javik provided the project with DNA samples and diagnostic information from sle patients. ...

More>>

SLE in Biological Technology

Human Genome Sciences Reports Positive Long-Term Data for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Patients With Active Systemic Lupus Erythematosus

...versity of Oklahoma Health Sciences Center . sle is a chronic, life-threatening autoimmune disease.... the sustained improvement in serologically active sle patients treated with belimumab through four years...epresent a significant advance in the treatment of sle if Phase 2 results are confirmed in the Phase 3 tr...

Trubion Pharmaceuticals, Inc. Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Systemic Lupus Erythematosus (SLE)

... and lymphoid tissues that was more profound and sustained in SBI-087-treated groups compared with rituximab. "Initiation of the SBI-087 Phase 1 sle clinical trial marks another important milestone in advancing our products developed in collaboration with Wyeth," said Peter Thompson, M.D., FACP, pr...

Results of First Interim Efficacy Analysis for Riquent Phase 3 ASPEN Trial: Continuation of the Trial is Futile

...a Jolla Pharmaceutical have decided to stop the study, unblind the data and evaluate all of the clinical results including secondary endpoints such as sle (Systemic Lupus Erythematosus) disease activity indices and proteinuria. "While the results of this first interim efficacy analysis are obvious...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

... diseases - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1346 -- Neutralizing IFN-alpha in sle affects GMCSF, TNF-alpha, IL-10, IL1-beta and BAFF signaling pathways - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m...

Human Genome Sciences Announces Second Quarter 2008 Financial Results and Key Developments

...ve SLE. The results confirm and extend the data presented at previous scientific meetings at earlier time points, including a significant reduction in sle disease activity as measured by the response rate chosen as the primary efficacy endpoint of the Phase 3 trials. Oncology Products: Initial Data fro...

Corgenix Announces FDA Clearance for IgG Anti-AtherOx(R) Test Kit

... antibodies," said Luis Lopez, M.D., Corgenix' Chief Medical Officer. "It provides vital clinical information for physicians treating individuals with sle and antiphospholipid syndrome, both of which are very important clinical problems." Douglass Simpson, Corgenix' President and Chief Executive Office...

Anthera Pharmaceuticals Forms Scientific Advisory Board

..., Ph.D. is the Executive Director in Inflammation Global Development at Amgen. About AMG 623 AMG 623, which has completed Phase 1b studies in sle patients, is a peptide fusion protein that binds to B-cell activating factor (BAFF). Anthera anticipates initiating Phase 2 studies in 2008. BAFF, a t...

ZymoGenetics and Merck Serono Receive FDA Special Protocol Assessment for Atacicept Pivotal Study in Lupus Nephritis

...age to the glomerulus and progressive loss of kidney function. In the U.S., sle affects 1 person in 2000, with higher rates among women and among individua...evels of BLyS and APRIL are elevated in patients with rheumatoid arthritis, sle and B-cell malignancies. Atacicept has been shown to affect several stages ...

Silicon Logic Enables High-Speed Communication

...ific integrated circuits (ASICs) for TI customers, sle now is quickly building a customer base for its fi...tworks and Cisco Systems . The key advantage for sle is that they license their product rather than pro...y, SPI-4 phase 2 is kind of red-hot at the moment. sle developed the product after getting out from under...

Silicon Logic Teams Up to Save Money

...ing done right from the start. With roots in the supercomputer industry, sle specializes in detecting possible functionality and performance errors early in the ASIC design cycle. sle has delivered more than 30 high-gate count, high-performance ASICs and syst...