Progression of SIV infection in monkeys raises
A sudden loss of T cells -- white blood cells crucial to the immune system -- is not the trigger for the onset of AIDS, according to a study published in the September 2007 issue of the Journal of Immunology by a team of researchers at Tulane National Primate Research Center.
The study, Acute ...
The Deadly Evolution of SIV to HIV
According to a study it was found that a mutation led to the deadly change from benign SIV
in apes and monkeys to a deadly infection called AIDS in humans. // Statistics show that the disease in man has killed more than 25 million people in 25 years. The researchers said that the virus appears to ...
Yerkes researchers propose ambitious new strategies for AIDS vaccine research
...ican monkey are critical for the AIDS vaccine effort and understanding why siv
infection does not progress to HIV/AIDS. SIV-infected sooty mangabeys devel...ad that does not increase their risk for developing AIDS. Additionally, the siv
virus is rarely transmitted from mothers to babies.
Silvestri also notes...
Vaccine Shields Monkeys From Simian Form of HIV
The researchers' efforts focused on preventing siv
infection in nine macaque monkeys who were "immunized" against siv
by inserting genes already known to express anti-S...began attacking the SIV.
After being exposed to siv
four weeks later, six of the nine monkeys appeared...
Nuvilex Advances Release of Citroxin(TM) Antiviral Surface Cleaner to Help Combat Swine Flu
...ted the use of Citroxin to treat viral subtypes of siv
(H1N1). In Dr. Goyal's first experiment, his team...s of 1:10 and 1:100) to inhibit the replication of siv
H1N1 in vitro. Compared to the controls, high conc...xin (1:10 dilution) were found to be virucidal for siv
growing in MDCK (Madin-Darby canine kidney) cells....
New HIV Drug May Help Those Resistant to Therapy
...ans. After six days of treatment, only three of the macaques had detectable siv
levels, and after 13 days, only very low siv
levels could be found in two of the macaques.
When the researchers gave ...
OHSU vaccine research targets HIV in the slower, early stage of infection
...duced an altered monkey form of cytomegalovirus (CMV) programmed to express siv
proteins and trigger specialized effector memory T-cells to look for and attack siv
in its early stages.
In total, 12 rhesus macaque monkeys at the Oregon N...
Possible AIDS Treatment Shows Promise in Monkeys
...s in monkeys.
Nine rhesus macaque monkeys infected with a virus known as siv
underwent treatment and remain alive eight months later. The treatment appe...ars in the Dec. 10 online edition of Nature
The monkeys, infected with siv
for as long as 21 months, were able to beat back the virus. Levels of virus...
Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce
...icine in New York City.
Like versions of the virus that occur in humans, siv
viral particles, or virions, are composed of a few fundamental parts. At t... its internal machineries in order to reproduce. HIV and its simian cousin siv
are members of a viral subspecies called retroviruses that invert the usual...
JCI table of contents: May 22, 2008
...ed to HIV. These viruses are known collectively as siv
and naturally infected monkeys do not develop AIDS... understanding why monkeys naturally infected with siv
do not develop AIDS might teach researchers import...beys naturally infected with SIVsmm, the strain of siv
that naturally infects sooty mangabeys, has now be...
Wild gorillas carriers of a SIV virus close to the AIDS virus
In 2005, 40.3 million people in the world, including 25.8 million in Sub-Saharan Africa, were living with HIV. The question of the origin of HIV-1, responsible for the AIDS pandemic, has been stimulating the scientific community for many years.
Some months ago, the team of Martine Peeters, direct...
Novel vaccine approach offers hope in fight against HIV
...sponse that was the target of all previous HIV and siv
vaccine candidates," said study leader Philip R. J...hesins) that were specifically designed to bind to siv
and block it from infecting cells. Once proven to work against siv
in the laboratory, DNA representing SIV-specific i...
Potential new HIV drug may help patients not responding to treatment
...ix days, only three of the macaques had detectable siv
levels and after 13 days the virus could only be f... able to block an enzyme called IDO, which HIV and siv
use to hold the immune system back. In healthy peo...the immune system from attacking the body. HIV and siv
hijack the machinery that makes IDO and use it to ...
Gene exchange common among sex-manipulating bacteria
"It's fascinating that bacteria, with only 1,000 genes, can control complicated developmental processes and behaviors in insects," says siv
By mapping how the genes in these bacteria change over time and figuring out the mechanisms behind sex manipulation, scientists will be ...
Computer superpower strengthens attempts to combat common diseases
...ous quantities of data from modern sequencing technology. The researchers, Kerstin Lindblad-Toh, Ulf Gyllensten, Ann-Christine Syvnen, Leif Andersson, siv
Andersson, Rolf Ohlsson, Claes Wadelius, Erik Bongcam-Rudloff, Helgi B. Schith, Hans Ronne, and Joakim Lundeberg, all work with different biological p...
Evolutionary biologist will study HIV with grant from AIDS research foundation
...led SIV, for millions of years. They rarely get sick from the virus. Evolutionary theory predicts that the primate genes and proteins most critical to siv
infection will have evolved more rapidly over time than other genes, as the primates evolved to sidestep the viral attack.
Sawyer will look for the...
Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
...e activated to a significantly lower extent during siv
infection than are the immune systems of rhesus macaques, and that this difference may explain why siv
and HIV infection leads to AIDS in some primate sp...hers.
"During both HIV infection in humans and siv
infection in macaques, the host immune system beco...
UC Davis researchers discover how HIV turns food-poisoning into lethal infection
...ion in rhesus macaques infected with simian immunodeficiency virus (SIV), an established model for HIV infection.
We found that animals that had no siv
infection were able to generate immediate responses to bacterial exposure, producing Th17 cells in large amounts, Dandekar said. The SIV-infected anim...
Jefferson scientists find rabies-based vaccine could be effective against HIV
...on, they gave a booster vaccine with the rabies-VSV vector, and saw SIV/HIV-specific immune responses.
The group then challenged the animals with siv
and measured various parameters of infection, such as immune system CD4 cell count, amount of virus in the bloodstream and immune system antibody resp...
HIV gets a makeover
...s and vaccines in animals. But therapies and vaccines that are effective on siv
don't necessarily translate into human success. Now, using a combination of...sceptible to the human virus's Vif. So Hatziioannou did another swap -- the siv
Vif gene for the HIV one -- and then another round of forced adaptation to ...