Internal Clock and Metabolism May Be Linked

...NAD), which regulates the activity of an enzyme called SIRT1, an important regulator of aging, metabolism and longevity. The discovery that NAD and sirt1 function together as a molecular "switch" to coordinate the circadian clock with metabolic systems should increase understanding of how aging, metabol...

New findings may improve treatment of inherited breast cancer

...ted in investigating the relationship among BRCA1, sirt1 and Survivin. sirt1 is a protein and histone deacetylase involved in n...rogrammed cell death, known as apoptosis. Although sirt1 has been implicated in tumorigenesis, no concrete ...

Cardiologist Praises Latest Resveratrol/Red Wine Research

...ses were shown to stimulate the SIRT1 gene, which plays a role in extending life span.) Low-dose resveratrol consumption does not seem to activate the sirt1 gene. "This supports human studies showing that red wine or red wine supplements containing resveratrol are especially beneficial for heart health,"...

Decoding Muscle Stem Cell Development

...egulation of life span and aging. Importantly, inhibition of AMPK, Nampt or sirt1 resulted in skeletal muscle cells that were oblivious to a nutrient-poor en...n of the AMPK-Nampt-SIRT1 axis," Sartorelli said. He added that AMPK and sirt1 may prove good targets for treatment of muscle-wasting. More informatio...

Cigarettes leave deadly path by purging protective genes

... red grape skins, to develop a treatment to target sirt1 and reverse lung damage, or at least enhance the w...hers are more fortunate, despite being smokers. sirt1 plays a pivotal role in the puzzle. It belongs to ...ulate chronic inflammation, cancer and aging. When sirt1 is highly active, or over-expressed in mice, worms...

Long-Life Gene Might Help Lower Cholesterol

...team explained. In their research with mice, the MIT team found that low sirt1 levels resulted in cholesterol buildup in cells such as macrophages (a type... cholesterol, macrophage cells can generate the plaques that clog arteries. sirt1 increases LXR activity and the movement of cholesterol out of macrophages a...

Low Doses of Red Wine Chemical May Fight Diabetes

...ich ordinarily works to decrease insulin activity. sirt1 levels were reduced in the animals' insulin-resistant cells. Increasing sirt1 activity with resveratrol improved insulin sensiti... is possible that regulating the hypothalamus with sirt1 can prevent diet-induced obesity." That is clea...

Researchers Pinpoint Link Between Caloric Restriction and Longevity

...is already has one sirtuin-activating compound in clinical trials. The company recently announced it was initiating early clinical trials of SRT501, a sirt1 activator based on resveratrol, a compound found in red wine. "This paper indicates that several other sirtuins, SIRT3 and SIRT4, also play an impo...

Intake of Polyphenol Speeds Up Fatty Acid Catabolism

... in their feed. The energy-sensing protein sirt1 is an important regulatory protein that can prolon...rganisms such as yeast and fruit flies. In humans, sirt1 is possibly involved in the regulation of energy use. Boer found that the sirt1 activity can be stimulated by various polyphenols,...

Caloric Restriction in Non-obese People Extends Life Span

...estion is whether caloric restriction can regulate sirt1 (the mammalian equivalent of Sir2) in humans. Civi...body metabolism in conjunction with an increase in sirt1 gene expression in skeletal muscle. These results raise the possibility that sirt1 may contribute to more efficient metabolism, less ...

SIRT1 in Medical Technology

Resveratrol Studies Suggest Broad Implications for SIRT1 Activation in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 26, 2007 - Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that activation of SIRT1, a member of the sirtuin family of enzymes, was...

Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged

... finding throws a scientific cloud over the use of Sirtuin1 gene activation tests as a measure of resveratrol activity. [Tissue-specific regulation of sirt1 by calorie restriction. Genes Dev. 2008 Jul 1; 22(13):1753-7; Regulation of SIRT1 protein levels by nutrient availability. FEBS Letters. 2008 Jul 9; 5...

SIRT1 in Biological News

Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging

Cambridge, MA, November 28, 2007 - Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that findings in the journal Nature demonstrate that Sirtris has developed novel drug ...

SIRT1 takes down tumors

...eding the destruction of the tumor promoter c-Myc, sirt1 curbs cell division. The study will be published o...iology . The yeast and nematode equivalents of sirt1 are fountains of youth that stretch lifespan. Whether sirt1 slows aging in mammals isn't certain, but it's ben...

A new weapon in the fight against obesity and diabetes

...lic disorders, interest has increased in using the sirt1 pathway as a target for possible pharmacological i...tabolism was specifically designed to activate the sirt1 pathway and assess its role in the beneficial meta... the hypothesis, demonstrating that activating the sirt1 pathway protects from diet-induced obesity and its...

Resveratrol prevents fat accumulation in livers of 'alcoholic' mice

...s they had expected, that resveratrol treatment increased the expression of sirt1 and stimulated the activity of AMPK in the livers of mice fed alcohol. They further found that the increased expression of sirt1 and AMPK led to: Reduction of sterol regulatory element binding protein ...

Food for thought -- regulating energy supply to the brain during fasting

...rient sensor that accumulates in the late fasting stage. Yi discovered that sirt1 has opposite effects on CRTC2 and FOXO1: it sends the former to the recycli...gar levels in diabetes patients. In, particular, chemical activators of the sirt1 switch may be key. "This way we could provide control for patients with ins...

Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery

...l of seven sirtuin enzymes that exist in mammals. sirt1 is the founding member of this class of enzymes an...ly the most studied of the group. When activated, sirt1 appears to mimic some of the positive health effec... "The body of clinical data supporting the role of sirt1 activation as a viable mechanism for treating a br...

Circadian rhythm-metabolism link discovered

...thms, works in balance with another protein called sirt1 that modulates how much energy a cell uses. "Th... he and his colleagues have shown that the protein sirt1 counterbalances the function of CLOCK. Even though...ng a bond that is finely regulated in the cell. sirt1 senses energy levels in the cell; its activity is ...

Long-term study of middle-aged mice shows

...al levels can delay the onset of age-related diseases. "A small molecule sirt1 activator that safely mimics the ability of dietary restriction to delay ag...ficacy signs in humans in Phase 1b testing, and we are also testing a novel sirt1 activator in a human clinical trial." ...

Relationship between environmental stress and cancer elucidated

...cuts a regulator called SUMO1 away from the enzyme sirt1 so its activity level drops, says Dr. Yonghua Yang...n block that process and make cells die. Increased sirt1 activity which is routinely present in cancer ev...y, says Dr. Yang. However he now has evidence that sirt1 also under study for its longevity role has diff...

MIT links gene to cholesterol

...(high density lipoprotein or good cholesterol). sirt1 is an important mediator of cholesterol efflux, an...lecular Cell. Drugs that enhance the effects of sirt1 could lower the risk of cholesterol-related diseas...er studies, Guarente has shown that high levels of sirt1 can be achieved with extreme calorie restriction, ...

SIRT1 in Biological Technology

Genstruct and Sirtris Pharmaceuticals Win Bio-IT World's Best Practices Award

...rated to further characterize the molecular MOA of sirt1 activating compounds. In blinded analysis, Genstru... caloric restriction (CR) -- showing that Sirtris' sirt1 activators are mimicking the effects of CR. These ...e able to help develop a deep understanding of the sirt1 pathway and allowed Sirtris to efficiently analyze...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

...s, and anti-cancer effects have been observed with sirt1 inhibitors in vitro and in vivo. As yet, no sirtui...e reexpression have been demonstrated by combining sirt1 inhibition with either standard cytotoxics or othe...ng with those found in cancer, and, in particular, sirt1 has emerged as a key contributor to the epigenetic...