Study Finds Discontinuation of Rosiglitazone Left Many Diabetes Patients Without Good Glycemic Control
JACKSONVILLE, Fla., April 14 /PRNewswire-USNewswire/ -- When concerns were raised about the safety of the diabetes medication, rosiglitazone, in May 2007, many patients and their doctors made the decision to discontinue use of the drug. A study published today in Endocrine Practice by Dr. Etta ...
Sideeffects of Rosiglitazone in Type2 Diabetes Patients
The trade-offs between potential benefits and potential harms when rosiglitazone
is used by people with type 2 diabetes has to be assessed .
This Cochrane Systematic Review analysed data from 18 trials that involved a total of 8432 people and found no evidence that rosiglitazone
led to bett...
Patients Advised for Using Rosiglitazone to See Their Doctor - ADA
The New England Journal of Medicine published results of an interim analysis of the cardiovascular safety trial of rosiglitazone
(brand name, Avandia). The article was accompanied by three editorials. Although the findings from RECORD (Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of...
Oral Drug Rosiglitazone Could Help Prevent Type 2 Diabetes
Rosiglitazone, an oral drug used to reduce the amount of sugar (glucose) in the blood, could help prevent Type 2 diabetes, says a study.//
Type 2 diabetes occurs when people cannot produce enough insulin, or do not respond to it properly. Insulin is the essential hormone that helps sugars to ...
Avandia Raises Risk of Heart Failure, Fractures
..., said during a Friday news conference. "There's no decreased risk, and that includes the heart failure element. If anything, deaths were reduced with rosiglitazone
[Avandia] compared to those in the control group. It doesn't reach statistical significance, but it's on the right side of benefit."
The trial was ...
Avandia Attorney Says Study Based on 'Useless Trick Science'
...six years, GlaxoSmithKline has been pouring money into this study to get the results they wanted, and that's exactly what's happening today."
Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes, or RECORD, study is based on information from diabetes patients who live in Eu...
Two Studies at AACE 2009 Annual Meeting Highlight Effects of Welchol(R) (colesevelam HCl) on Blood Glucose and LDL-C in Patients with Type 2 Diabetes
...ct #220 - Effect of Colesevelam HCl (Welchol(R)), rosiglitazone
(Avandia(R)), or Sitagliptin (Januvia (R) ) in...ere randomized to receive Welchol 3.75 g/d (n=57), rosiglitazone
4 mg/d (n=56) or sitagliptin 100 mg/d (n=56). Thi...t differences in A1C between the groups. Welchol, rosiglitazone
and sitagliptin each significantly reduced mean A1...
Halting Avandia Use Hikes Blood Sugar Levels
... Many patients who stopped using the diabetes drug rosiglitazone
(Avandia) due to concerns about the drug's safety ...of scientific evidence released in 2007 found that rosiglitazone
increased the risk of cardiovascular disease and h...udy reaffirms that patients who discontinue use of rosiglitazone
and another thiazolidinedione (TZD) called pioglit...
Certain Diabetes Drugs May Pose Eye Risk
...lling and fluid accumulation in the retina.
Glitazones are a newer class of diabetes drugs that includes medicines such as pioglitazone (Actos) and rosiglitazone
The U.S. study of 996 DME patients found that those who took glitazones were 2.6 times more likely to develop DME than those who didn't ...
Diabetes drug class linked to vision-threatening complication
...heart failure or other diseases can worsen DME. Most of the glitazone users in the study were taking pioglitazone (Actos). Other studies have linked rosiglitazone
(Avandia)the only other approved glitazone drugto a possible increase in the risk of myocardial infarction.
Although the study is not the first to ...
Rosiglitazone in Medical Technology
Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines
SOMERSET, N.J., July 21 /PRNewswire-FirstCall/ -- Alfacell Corporation
(Nasdaq: ACEL ) today announced that a paper published in Molecular Cancer
Therapeutics (2008; 7(7):1871-9) reports that a combination of ONCONASE
(ranpirnase) and the thiazolidinedione antidiabetic drug rosiglitazone
Research: Popular Diabetes Medications Associated with Increase in Bone Fractures
...of drugs used to control blood sugar -- are used by as many as 4 million Americans.
The study examined the effects of pioglitazone (Actos(R)) and rosiglitazone
(Avandia(R)), the two drugs that make up the TZD class, and found that both medications equally increase the risk of bone fracture. In addition, the ...
Large, Long-Term Study Shows Avandia Has No Increased Overall Cardiovascular Risk Compared to Other Commonly Used Diabetes Medicines
...e receiving metformin and sulfonylurea.
Results from the 4,447-patient rosiglitazone
Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (REC...safety and achieving the study's primary endpoint leads us to conclude that rosiglitazone
carries no increased risk of overall cardiovascular death or hospitalizatio...
InteKrin Therapeutics to Present at the 2009 American Diabetes Association Annual Meeting
...oven anti-diabetic efficacy of PPAR gamma activation, while mitigating or eliminating the well recognized side effects of TZD full PPAR gamma agonists rosiglitazone
and pioglitazone (Avandia(R) and Actos(R) respectively).
About InteKrin ( www.InteKrin.com )
InteKrin Therapeutics is a privately-held clinic...
Novo Nordisk New Data From a Phase 3 Study Confirms Clinical Benefits of Once-Daily Liraglutide in the Management of Type 2 Diabetes
...iraglutide, a human GLP-1 analog, to metformin and rosiglitazone
the treatment of type 2 diabetes, leads to impr... increase in weight of 0.6 kg in the
metformin and rosiglitazone
only group. Weight is a common problem among
indiv...tformin + metformin + rosiglitazone
Treating Depression Prolongs Life for Older People with Diabetes
...ts that the FDA "reevaluate criteria for approval
of drugs to treat type 2 diabetes," in light of the recent controversy
surrounding the diabetes drug rosiglitazone
Rosiglitazone, approved by the FDA in 1999, came under fire earlier
this year when a meta-analysis in the New England Journal of Medici...
ACTOS(R) (pioglitazone HCl) Demonstrates Reduced Risk of Ischemic Cardiovascular Disease in Patients with Type 2 Diabetes
... (excluding rosiglitazone, another member of the TZD class); or -- who were taking an antidiabetes drug regimen that did not include ACTOS or rosiglitazone
(55,273 patients). The study endpoint was timed to the first stroke or MI or end of the
study period, whichever occurred first. Additional data pres...
Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
...this year on the use of rosiglitazone
(Avandia(TM)), another commonly used diabetes drug. In his analysis of 42
clinical trials, Dr. Nissen found that rosiglitazone
raised patients' risk
of heart attack and cardiovascular death by 43% and 64%, respectively in
comparison to the use of a placebo or other anti-diabet...
Diabetes drug supported by Mexican Diabetes Federation
...risks of the
glitazone drugs. The first glitazone, troglitazone was approved in
1998 but was withdrawn shortly thereafter. Two additional
glitazones - rosiglitazone
and pioglitazone - have recently been
targeted with a "black box" warning by the U.S. FDA due to concerns
related to cardiac risk when taking these dr...
Reaction to Avandia Warnings Stronger Among Internists Than
Endocrinologists, According to Study by GfK Market Measures
Committee will meet to discuss the cardiovascular ischemic and
thrombotic (heart-related) risks of thiazolidinediones, focusing
particularly on rosiglitazone
About GfK Market Measures
GfK Market Measures provides healthcare clients with a unique
mix of custom and syndicated solutions to suppo...
Rosiglitazone in Biological News
Long-term use of diabetes drugs by women significantly increases risk of fractures
...f drugs used to treat type 2 diabetes. Included in this group are the drugs rosiglitazone
and pioglitazone. Latest figures show there are around 4 million users of t...gs in the US, while in the UK there were around 2 million prescriptions for rosiglitazone
and pioglitazone last year.
"Women with type 2 diabetes are already at ...
MIT: 'Micro' livers could aid drug screening
..., troglitazone, a drug withdrawn from the market by the FDA due to liver toxicity, showed toxicity levels much higher than its FDA-approved analogues, rosiglitazone
The model uses a fraction of the costly human liver cells used in other test platforms and can be assembled using frozen cells. M...
Rosiglitazone in Biological Technology
Rosiglitazone in Biological Products
PPARGamma-Competitor Assay Kit Green from Invitrogen
Description:... regulation of glucose and lipid metabolism. Agonists include the (TZD) class of anti-diabetic agents called thiazolidinediones (TZD) or "glitazones." rosiglitazone
(Avandia) and Pioglitazone (Actos) are two PPAR agonists currently marketed for treatment of type 2 diabetes. PPAR agonists may also be therapeuticall...