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Rodent in Medical News

Turmeric extract suppresses fat tissue growth in rodent models

BOSTON (May 18, 2009) Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed...

Improved rodent trials can speed cancer drug development

Better design of rodent trials could reduce the cost and time required for cancer drug development, according to a commentary in the October 28 online issue of the Journal of the National Cancer Institute . Cancer drug development is a multistep process that involves in vitro tests, animal stu...

New Report Finds U.S. Cities More Vulnerable Than Ever to Rodent Infestation

Experts Warn Homeowners to Take Matters into Their Own Hands This Fall PARSIPPANY, N.J., Oct. 4 /PRNewswire/ -- Wacky weather, aging cities, and urban sprawl have rats on the move across the country. For the first time, the nation's foremost rodent experts Dale Kaukeinen and Dr. Bruce Colvin,...

Developing gene therapy to fight blindness

...e in a viral vector a carrier commonly used to deliver genetic material to treat these cells in order to restore function of photoreceptors. Using a rodent model of RP with a similar MERTK mutation, the researchers have demonstrated in proof-of-concept studies that viral vector delivery of MERTK corrects ...

Financing Available for Healthcare Equipment from DRE Medical Equipment

...ensive selection of veterinary-specific equipment, including anesthesia machines for use with animals of every size—from the DRE Compact Mini, a rodent anesthesia machine, to the DRE Titan, a large animal anesthesia system. “The DRE Titan is extremely effective, easy to use and maintain, an...

Human cells secrete cancer-killing protein, UK study finds

... the tumor-suppressor protein Par-4, initially thought to be active only within cells expressing the Par-4 gene, is in fact secreted by most human and rodent cells and can target large numbers of cancer cells by binding to receptors on the cell surface. This discovery, published today in the leading jou...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

...g For Alzheimer Disease, Regulates Amyloid-Beta Metabolism In Cultured Cells, In Isolated Nerve Terminals, And In The Interstitial Fluid Of The Living rodent Brain (Funders: Cure Alzheimer's Fund, National Institute on Aging) Moran Boimel, et al -- Immunotherapy Targeting Pathologically Phosphorylated...

Elsevier launches official version of BrainNavigator

...cal Research Institute, Sydney. After unveiling the prototype version at the Society for Neuroscience's Neuroscience 2008 tradeshow last November, the rodent brain version is now available at www.brainnav.com . BrainNavigator is an online, interactive, 3D software tool that maps brain images and anatom...

InteKrin Therapeutics Announces INT131 Phase 2a Results at the 2009 American Diabetes Association Annual Meeting

...ded Dr Linda Higgins, Chief Scientific Officer of InteKrin Therapeutics. "INT131 retains or exceeds TZD potency and efficacy for glycemic lowering in rodent models of T2DM, while also showing remarkable safety in nonclinical studies of INT131 even at multiples of clinical exposures that far exceed those at...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

...od and the activity of its target, sEH, in both mice and humans. The data further demonstrate that AR9281 improves glucose metabolism in rodent models of type 2 diabetes. -- "A Novel Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves Glucose Homeostasis in Diet-Induced Obese ...
Rodent in Medical Technology

Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy

... ideal for restoring SERCA2a enzyme production by means of cardiac muscle gene transfer. The path of investigation for MYDICAR(R) (AAV1/SERCA2a), from rodent studies to the ongoing Phase II clinical trial, has yielded valuable insights for the entire gene therapy field, dispelling many myths and revealing s...

Astrocytes Help Separate Man From Mouse

... "There aren't many differences known between the rodent brain and the human brain, but we are finding stri...ction astrocyte, in the human brain but not in the rodent brain. The team also found that the most abundant ...tes, are approximately 2.6 times larger than their rodent counterparts, and that the human cells have about ...

Michael J. Fox Foundation Awards $2.4 Million for Validation of Nine Promising Therapeutic Targets for Parkinson's Disease

...ules to see if they can reduce PD-like symptoms in rodent models. Kalipada Pahan, Ph.D., of Rush University ...c inhibitors against NF-kB is neuroprotective in a rodent model of Parkinson's. He will now work to confirm ... California, Los Angeles, has developed a possible rodent model of PD-associated gastrointestinal (GI) dysfu...

Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference

...travenous infusion. Key findings from the study were as follows: -- In rodent intradermal models, injection of bisphosphonates without rHuPH20 creat... induration, and ulceration in a concentration dependent manner. -- In rodent intradermal models, the maximal concentration of bisphosphonates that ...

Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders

...ive neurons, primarily in the prefrontal cortex. In behavioral studies, ITI-002 displayed acute and chronic activity as a cognitive enhancing agent in rodent models. ITI-002 has been shown to be safe in all preliminary evaluations and is advancing to pre-clinical development. It is envisioned that activatio...

Pixantrone Shows Activity in a Preclinical Study of Experimental Autoimmune Myasthenia Gravis (EAMG)

...ell Therapeutics Inc.'s European branch, and one of the investigators in the preclinical study on EAMG. About the Preclinical Study In an in vitro rodent model, pixantrone demonstrated a dose-dependent inhibition of T cell responses up to complete suppression of the proliferation in EAMG. EAMG was induc...

Calando Pharmaceuticals Announces Preclinical Efficacy and Safety Data of Targeted, Systemic Delivery of siRNA at AACR Annual Meeting

...ndicate Significant Anti-Tumor Effects of Targeted, Systemic siRNA Therapeutic at Doses Significantly Lower Than the Limits of Safe Administrations in rodent and Non-Human Primates PASADENA, Calif., April 16, 2007 /PRNewswire/ -- Calando Pharmaceuticals, a leading siRNA therapeutics company and a majority-...

Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer

...more than 50 percent after a single injection of a VEGF-specific siRNA in a rodent model; -- Silencing of KSP mRNA in vivo by greater than 50 percent after a single injection of a KSP-specific siRNA in a rodent model; and -- Halting of human cancer cell proliferation in vitro when KS...

Novavax Reports Positive Pre-Clinical Study Results from Live Virus Challenge to Pandemic Flu Vaccine

...fluenza experience symptoms similar to humans, including runny noses, fevers, lethargy and weepy eyes. The ferret has proved to be the most predictive rodent model for success in human clinical trials for influenza. "Novavax's proprietary vaccine may be the very first VLP vaccine for influenza to enter hu...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

... The presentation described efficient differentiation of cardiomyocytes from hESCs and their effectiveness in preventing the onset of heart failure in rodent infarct models. In the differentiation procedure, cardiomyocytes were generated using non-conditioned, serum-free media and a directed differentiation...
Rodent in Medical Dictionary

Rickettsialpox

...Rickettsia akari. ... Rickettsialpox occurs in urban areas, usually where rodent ... Rickettsialpox is a mild, self-limiting disease caused by the ...cterial organism ... Rickettsialpox occurs in urban areas, usually where rodent infestation is common. ... Overview: Rickettsialpox is a mild, self-l...

Rabbit fever

...r ". The disease is caused by a gram ... Nevada Woman Contracts ' Rabbit Fever ' From Her Cat, A woman in Smith Valley, Nev. contracted a rare rodent illness from her pet cat. Rabbit Fever , a documentary directed by Amy Do about the bizarre love of rabbits. ... Rabbit Fever (www.rabbitfe...

Plague

...a pestis ( Plague ). The Centers for Disease Control and Preventon ... Plague , caused by a bacterium called Yersinia pestis, is transmitted from rodent ... The Centers for Disease Control and Preventon ... In North America, plague is found in certain animals and their fleas from the ... Ge...

Hantavirus

... the hantavirus - the disease carried by rodents (rats and mice), particularly their droppings! ... "Tips for Preventing Hantavirus : Cleaning Up rodent ... Hantavirus ... Hantavirus is a disease characterized by symptoms that resemble the flu, ... Since that discovery, hantavirus disease ...
Rodent in Biological News

Wild vs. lab rodent comparison supports hygiene hypothesis

In a study comparing wild rodents with their laboratory counterparts, researchers at Duke University Medical Center have found evidence that may help to explain why people in industrialized societies that greatly stress hygiene have higher rates of allergy and autoimmune diseases than do people in ...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... Ph.D., director of Neurology at Cincinnati Children's. "This is why the findings of this study may have important clinical implications because, in a rodent model of HIE, they that show inhibiting plasminogen activators in functional areas of the brain is powerful strategy for brain protection." Earlier...

Improved method developed to test carcinogen risk

...nts with trout in large numbers at very low cost, about 5 percent of what a rodent study would cost," Bailey said. "For most studies of carcinogens, exposing ... aflatoxins were determined using essentially the same methodology based on rodent studies," Bailey said. "But our research suggests that the findings for afl...

NAU discovery could help feed millions

...yer said. "We can easily increase rice production by 10 percent by reducing rodent fertility in half." She said this noninvasive approach is more humane t...e go to Vietnam," Mayer said. Scientists adapt the product to different rodent species at SenesTech, the Flagstaff-based company that grew out of Mayer's ...

Climate change driving Michigan mammals north

...and minimum daily temperatures from the National Climate Data Center for 16 weather stations in the Upper Peninsula, where changes in the small forest rodent community have been especially pronounced. They then calculated monthly averages for minimum and maximum daily temperatures for each year between 1970...

Study finds children's activity levels not influenced by more PE time in school

...not the range in environmental opportunities, but the range of individual activity set-points in the brains of children." Frmeaux pointed out that rodent experiments, as well as other observations in children and adults such as the same physical activity level in people from different geographical regio...

Flow of potassium into cells implicated in schizophrenia

... brain-specific form potentially opens the way to development of new treatments free of such cardiac side-effects. Dramatically changed activity in rodent brains toward a neuronal firing pattern that may be important for thinking and memory tasks unique to primates. Is expressed much more prior to bir...

Google Earth aids discovery of early African mammal fossils

...studying them and identified teeth and bones of fossil bats. Gunnell shared the materials with Ellen Miller of Wake Forest University, who found a few rodent jaws and some additional teeth. Recently, with funding from National Geographic Society, Gunnell, Miller, U-M assistant research scientist William San...

Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease

..., 8 females), coffee (5 males, 7 females), caffeine (5 males, 8 females), chlrogenic acid (5 males, 7 females). The control groups were fed a standard rodent diet and were not given any additional supplements. The intervention groups were provided with coffee, caffeine, and chlorogenic acid extracts, respec...

Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease

..., 8 females), coffee (5 males, 7 females), caffeine (5 males, 8 females), chlrogenic acid (5 males, 7 females). The control groups were fed a standard rodent diet and were not given any additional supplements. The intervention groups were provided with coffee, caffeine, and chlorogenic acid extracts, respec...

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Rodent in Biological Technology

Big Blue Rodent Cell Cultures for Mutagenesis Studies

Rat and mouse embryonic cell lines are useful for in vitro mutagenesis studies Denise L. Wyborski Stratagene Cloning Systems, Inc. The Big Blue rat cell line and the Big Blue transgenic mouse embryonic cell line are useful for in vitro mutagenesis studies. These cell lines are ...

World Renowned Scientists Gather to Share Latest Information on Answer to Wildlife Reproductive Fertility Control

...artnerships SenesTech has formed throughout the globe have helped this exciting technology reach countries that are in desperate need of a solution to rodent population management to provide sustainable food supplies to millions." The company is currently applying their revolutionary technology to ...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... phase I clinical trial in solid tumors with the LNA-based drug Survivin targeting cancer. SPC4955-ApoB inhibitor Santaris Pharma has in rodent and primate studies shown that ApoB inhibitors are able to lower LDL cholesterol and triglycerides effectively. In Q2 2009 the Company selected a lead...

Ausio Pharmaceuticals to Present at Bio(R) 2009

...a (ER beta) agonist. The safety profile of AUS-131 in FDA-required preclinical studies was excellent, and AUS-131 has demonstrated positive effects in rodent models of menopausal hot flashes and BPH, supporting its promise for the treatment of these conditions in humans. In Phase 1 trials, AUS-131 demonstra...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

...ed enhanced activity when combined with standard-of-care agents or other Idenix compounds in development (IDX184 and IDX375). Favorable PK profiles in rodent and non-human primate species suggest the potential for once- or twice-daily dosing in humans (half-life of 4.0-5.2 h; bioavailability of ~20%). ...

BioLife Solutions Completes Safety Studies on HypoThermosol(R) and CryoStor(TM)

...f these studies demonstrate that infusion of HypoThermosol and CryoStor present no safety risk within the parameters of this two-stage evaluation in a rodent model. No toxic deaths were noted in either Stage 1 or 2 at infusion or in the 7 day follow-up. Stage 1 involved infusion of carrier solutions alone ...

SenesTech, Inc. Commences Product Registration Process With Australian Government

...is unique rodent population management product to the agricultural ministries of Southeast Asia. ContraPest(R) will target the rice field rat, a major rodent pest species for rice agriculture in this region, known to eat or damage a significant portion of rice crops each year. ContraPest(R) works through ...

SenesTech, Inc. Initiates Research Field Trials for ContraPest(R) in Indonesia

...r ovulate, and the effect on rodent pest populations can be dramatic. These rodent pests can eat or damage up to 50% of a rice crop in Southeast Asia. Just a 10% increase in crop yield due to less rodent damage will result in feeding up to 380 million more people per year. "Fi...

Use it or lose it? Researchers investigate the dispensability of our DNA

...erved elements that are shared between primates and closely related mammals, were present in the ancestor of modern rodents, but have been lost in the rodent lineage more recently. The researchers found that the genomic evidence supports an important biological role for ultraconserved elements, as well as ...

Samaritan Partners 'Forgetful' Rat Model to Taconic to Commercialize

...nic was founded in 1952 as a family-owned business in New York's Hudson River Valley. Since then, the company has become one of the largest laboratory rodent providers in the world with a reputation for consistently producing high quality, well-defined rats and mice. Taconic has six breeding facilities and ...
Rodent in Biological Products

TaqMan Rodent GAPDH Control Reagents from Applied Biosystems

Description: ...
Company:Applied Biosystems

Anti-GLP-1 (7-36) (Glucagon-like peptide-1), C-terminus amide-reactive Polyclonal Antibody, Unconjugated from CHEMICON

Description:... SPECIES REACTIVITIES: Most mammalian species. GLP-1 is identical in all mammalian species studied except guinea pig and presumably its South American rodent relatives....
Company:CHEMICON

Plastic feeding tubes, 20ga x 38mm, sterile from Instech Solomon

Description:... These plastic feeding tubes for rodent oral gavage feature soft rubber tips to reduce the risk of perforation and trauma. Plus they are disposable, to eliminate the hassle of cleaning and t...
Company:Instech Solomon

IHC KIT FOR RAT ANTIBODIES ON MOUSE TISSUE, DAB KIT from BioGenex

Description:... BioGenex IHC Kits for rodent Tissues are designed for immunohistochemistry on rodent and rabbit tissues that are closely related to the source of the primary an...
Company:BioGenex
Rodent in Biological Dictionary

Terminator

...r) This article is about the character portrayed by Arnold Schwarzenegger. ... The Terminator " character first appeared in the 1984 movie ... rodent Pest. Owner Operated. Same Day Top Quality, Resonable Service. Call Us. Find us in New Jersey. The latest movie news, movie trailers, movie reviews...

Spermatids

... elongated spermatids from the testis (spermiation) is also ... Early round spermatids in stages I-VII are suppressed to 20% of normal, yet ... rodent spermatocytes, round and elongated spermatids (14–16), and Sertoli (13) ... ( 14) appeared to demonstrate that spermatids had more intense immunos...

Placental mammals

...rsupials. Marsupials: Opportunity to evolve. Survival today ... Information about Placental in the free online English dictionary and ... gnawer, rodent - relatively small placental mammals having a single pair of ... How are placental mammals , marsupials, and monotremes different? ... do ...
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(Date:4/18/2014)... have made a brain-related discovery that could revolutionize ... This discovery opens up the possibility that environmental ... specific brain activity that the researchers have identified ... Journal of Neuroscience has just published a ... associate professor of psychology and his doctoral student ...
(Date:4/18/2014)... to potential new treatments for breaking the cycle of ... or scarring, is a hallmark of the disease, and ... to serious organ damage and, in some cases, death. ... findings made by Swati Bhattacharyya, PhD, research assistant professor ... protein plays in promoting fibrosis. , "Our results ...
(Date:4/17/2014)... have identified the first genetic variant specifically associated ... accounting for around 10-15 per cent of all ... of the breast cancer sub-type, called invasive lobular ... causes of this particular kind of breast cancer, ... research, published today (Thursday) in the journal ...
(Date:4/17/2014)... According to a study published today in PLOS ... world where malaria is common can mount an immune ... them to avoid repeated bouts of high fever and ... in their bloodstream. The findings may help researchers develop ... by the malaria parasite. , Each year, approximately 200 ...
(Date:4/17/2014)... Two recent papers by a University of Colorado ... scientists develop treatments or vaccines for Dengue fever, ... other disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, ... the School of Medicine and an early career ... colleagues recently published articles in the scholarly journals ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:New clues on tissue scarring in scleroderma 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2
(Date:4/17/2014)... consumption advisories for expecting mothers are ineffective in ... organic pollutants (POPs). , The study, performed ... Toronto Scarborough PhD student Matt Binnington and Professor ... environmental contamination, a mother,s compliance with advisories, and ... exposure in her children. , Their model estimates ...
(Date:4/17/2014)... A Kansas State University engineer has developed ... remotely detects improvised explosive devices. The same technique ... Dunn, the Steven M. and Kay L. Theede ... and nuclear engineering, and his research team have ... underground or in car trunks. The distance detection ...
(Date:4/17/2014)... Europe, Asia and the United States are spreading across ... native honeybee populations at this time, according to an ... Nosema microsporidia and Varroa mites., ... these invasive pests, which suggests to us that the ... the United States currently are not necessary in East ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
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