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Ritonavir in Medical News

President Clinton and Mylan Chairman and CEO Robert J. Coury Announce New Agreement to Lower Price of Treatment for Patients with Drug-Resistant HIV in Developing Countries

...king available all four drugs -- Atazanavir (ATV), ritonavir (RTV), Tenofovir (TDF), and Lamivudine (3TC) -- ne...compliance. Our affordable, heat-stable version of ritonavir also represents another advance in the development...a second-line ARV therapy including Atazanavir and ritonavir as a top priority. However, until now, this regime...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

... INTELENCE should not be co-administered with the following ARVs: tipranavir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, full-dose ritonavir (600 mg bid), protease inhibitors administered without ritonavir, and other NNRTIs. INTELENCE should not be co-administered with carbamazepine, ...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

...apy -- PREZISTA(R) (darunavir) coadministered with ritonavir as part of combination therapy. GRACE findings we..., and tolerability of PREZISTA tablets with 100 mg ritonavir in treatment-experienced, HIV-1-infected women and...eived PREZISTA (600 mg) boosted with a low dose of ritonavir (100 mg) twice a day in combination with other ant...

Victory! Colombian Government Cuts Price of Abbott's Lifesaving AIDS Drug Kaletra 55%, Says AHF

...tually two drugs combined into a single capsule: lopinavir and low doses of ritonavir (Norvir), another protease inhibitor manufactured by Abbott Laboratories. This is because ritonavir increases the amount of lopinavir in the blood, thus making it more effecti...

New information points to safer methadone use for treatment of pain and addiction

...tine and liver and the protease inhibitors nelfinavir, indinavir and ritonavir. They gave study volunteers a combination of the protease inhibitors ritonavir and indinavir. Both drugs profoundly inhibited the actions of the enzyme. If that enzyme were responsible for methadone clearance, then inhibiting it ...

PREZISTA(R) Now Available for Pediatric Patients Six Years of Age and Older as part of HIV Combination Therapy

...the FDA approval of PREZISTA, co-administered with ritonavir (PREZISTA/r) and with other antiretroviral agents,... adult dose. PREZISTA tablets should be taken with ritonavir twice daily and with food. Specific pediatric... 44 lbs to less than 66 lbs: 375 mg PREZISTA/50 mg ritonavir twice daily At least 66 lbs to less than 8...

Tibotec Submits Application to U.S. Food and Drug Administration Seeking Traditional Approval for INTELENCE(TM) (etravirine)

... INTELENCE should not be co-administered with the following ARVs: tipranavir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, full-dose ritonavir (600 mg bid), protease inhibitors administered without ritonavir, and other NNRTIs. INTELENCE should not be co-administered with carbamazepine...

Johnson & Johnson Reports Full-Year and Fourth-Quarter 2008 Results

...dult patients. Outside the United States, the European Commission granted full approval of the Marketing Authorization of PREZISTA in combination with ritonavir and other antiretroviral medicinal products for the treatment of HIV-1 infection, and extended the indication to include all treatment-experienced adu...

Tibotec and Emcure Collaborate on Access to Darunavir for India

...arunavir. Tibotec has been working with regulatory authorities in India to register darunavir. When approved, darunavir, co-administered with ritonavir and with other antiretroviral agents (ARVs), is expected to be indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretr...

European Committee for Human Medicinal Products (CHMP) Issues Positive Opinion for Once-Daily PREZISTA(R) (Darunavir) as Part of Combination Therapy for Treatment-Naive Adults With HIV-1

...s received 800 mg darunavir once daily with 100 mg ritonavir as part of combination therapy. Darunavir,... with darunavir 600 mg co-administered with 100 mg ritonavir twice daily were mild to moderate in severity. Thi...patients allergic (hypersensitive) to darunavir or ritonavir or with severe liver problems. There were ...
Ritonavir in Medical Technology

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...ary efficacy endpoint is the proportion of patients with plasma HIV RNA less than 50 copies/mL at week 48 of treatment. Atazanavir boosted by ritonavir was selected for use in this study because it is recommended as an option for first-line therapy in both the International AIDS Society and Department...

Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily

...adjustments are required. Certain populations of PAH patients such as those with mild-to-moderate renal or hepatic impairment or those taking the drug ritonavir should use a dose of 20 mg daily when beginning therapy with ADCIRCA. Use of ADCIRCA with potent inducers of CYP3A, such as rifampin, should be avoide...

FDA Approves ADCIRCA(TM) (Tadalafil) Tablets for the Treatment of Pulmonary Arterial Hypertension

...djustments are required. Certain populations of PAH patients such as those with mild-to-moderate renal or hepatic impairment or those taking the drug ritonavir should use a dose of 20 mg daily when beginning therapy with ADCIRCA. Use of ADCIRCA with potent inducers of CYP3A, such as rifampin, should be avoid...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

...combination therapy with PEGINTRON with or without ritonavir in treatment-naive and treatment-experienced patie... with HCV genotype 1. In this study, low doses of ritonavir were used for metabolic inhibition to enhance the ...ng Phase IIa dose-finding study of SCH 900518 with ritonavir in combination with PEGINTRON and REBETOL. This s...

Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults

...REZISTA(R) 800 mg (two 400 mg tablets) with 100 mg ritonavir (r) once daily reached an undetectable viral load ...estigator. PREZISTA, co-administered with 100 mg ritonavir (PREZISTA/r), and with other antiretroviral agents...s is 800 mg (two 400 mg tablets) taken with 100 mg ritonavir once daily with food. The new 400 mg tablet will b...

Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients

...tients (60 per treatment arm) will be enrolled. The final analysis will be conducted at week 48 of treatment for all patients. Atazanavir boosted by ritonavir was selected for use in this study because it is recommended as an option for first-line therapy in both the International AIDS Society and Department...

New 48-Week Efficacy and Safety Data Presented for INTELENCE(TM) (etravirine) as Part of HIV Combination Therapy

...NTELENCE should not be co-administered with the following ARVs: tipranavir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, full-dose ritonavir (600 mg bid), protease inhibitors administered without ritonavir, and other NNRTIs -- INTELENCE should not be co-administered with carbamazepine...

CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ(R) (atazanavir sulfate)/ritonavir and Twice-Daily lopinavir/ritonavir at 48 Weeks in Previously Untreated HIV-Infected Adult Patients

...viral efficacy to twice-daily lopinavir 400 mg and ritonavir 100 mg (lopinavir/r) in previously untreated adult... use of a once-daily regimen including REYATAZ and ritonavir in antiretroviral-naive HIV-infected patients," sa...ts were randomized to receive lopinavir 400 mg and ritonavir 100 mg twice daily, each in combination with a onc...

Supplemental New Drug Application for PREZISTA(TM) Submitted to U.S. Food and Drug Administration

... PREZISTA. PREZISTA, co-administered with 100 mg ritonavir and with other antiretroviral agents, is currently...te. PREZISTA must be co-administered with 100 mg ritonavir and food to exert its therapeutic effect. Failure ...ieve the desired antiviral effect. Please refer to ritonavir prescribing information for additional information...

European Commission Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for Virologically Suppressed Adults With HIV-1 Infection

...tabine, may also occur. Liver enzymes should be monitored in patients with known or suspected hepatitis B or C and when ATRIPLA is administered with ritonavir or other medications associated with liver toxicity. Decreases in bone mineral density (BMD) have been seen with tenofovir DF. Cases of osteomalacia...
Ritonavir in Biological News

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...out a class of prescription drugs known as "HIV protease inhibitors." Drugs in this class go by the generic names of lopinavir, nelfinavir, indinavir, ritonavir and saquinavir. Brand names include Kaletra, Viracept, Crixivan, Norvir and Fortovase. The researchers emphasize that the drugs' therapeutic benefit...
Ritonavir in Biological Technology

FDA Approves Administration of LEXIVA(R) with Lower Dose of 'Boosting' Medication Ritonavir

Data Show Lower Dose Associated with Fewer Adverse Events in Healthy Volunteers RESEARCH TRIANGLE PARK, N.C., Oct. 12 /PRNewswire-FirstCall/ -- GlaxoSmithKline's (NYSE: GSK ) HIV protease inhibitor LEXIVA(R) (fosamprenavir calcium) may now be administered with ...

InterMune Reports Second Quarter 2009 Financial Results and Business Highlights

...MAD study of ITMN-191 in combination with low dose ritonavir in HCV patients in the third quarter; and finally,...-daily ITMN-191 co-administered with a low dose of ritonavir in combination with standard dose Pegasys(R) (pegi... Copegus(R) (ribavirin) in HCV-infected patients. ritonavir is an antiviral compound commonly used at low dose...

New Aptivus(R) (tipranavir) Oral Solution Approved for Treatment-Experienced Pediatric and Adolescent HIV Patients

...mg/kg ritonavir, or 375 mg/m2 co-administered with ritonavir 150 mg/m2, taken twice daily. A greater proportion... adult dose of APTIVUS 500 mg co-administered with ritonavir 200 mg twice daily. At 48 weeks, 40 percent of p...ibitors. -- APTIVUS must be co-administered with ritonavir to exert its therapeutic effect. Failure to correc...

FDA Approves INTELENCE(TM) (etravirine) for HIV Combination Therapy

...NTELENCE should not be co-administered with the following ARVs: tipranavir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, full-dose ritonavir (600 mg bid), protease inhibitors administered without ritonavir, and other NNRTIs. -- INTELENCE should not be co-administered with carbamazepine...
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