Genetic switch potential key to new class of antibiotics
...ed in 2002 that regulatory mechanisms arising from riboswitches
regulate gene expression at the level of the mRNA ...decoding process. Clarifying the principles of how riboswitches
change their spatial organization, which entails b...work has gained attention because interfering with riboswitches
in bacteria known to cause major human infections ...
Stanford researchers make first direct observation of 3-D molecule folding in real time
...shapes they do, and how they perform the functions they do," Block said. "No one has been able to explore in great detail tertiary structure yet." RNA riboswitches
must have this tertiary structure to work.
"Most RNAs just make secondary [two-dimensional] structure. But the ones that really do stuff," he added...
Salmonella bacteria use RNA to assess and adjust magnesium levels
...ubstantially expanding the types of molecules that riboswitches
can detect to help cells assess and react to their environment.
First identified in 2002, riboswitches
sense when a protein is needed and stop the creati... encoded in the message.
Previously identified riboswitches
respond to organic compounds such as nucleotides a...
Switching to new anti-bacterial targets: Riboswitches
... The recently emerged field of bacterial riboswitches
may be a good hunting ground for effective targets...esearchers in the journal Chemistry and Biology.
are RNA elements that control gene expression in e...s a path to the directed design of drugs targeting riboswitches
for use as antibiotics.
According to the resear...