Ribosomal in Medical Technology
Ribosomal in Medical Products
Description:...say for the diagnosis of gonorrhea. Thermo solved the challenge of developing a specific rapid assay for Neisseria gonorrhea by using the proprietary ribosomal
protein, L7/L12, to bring about a first in GC diagnostics....
MESACUP ANA Test Kit
Features:... Detects autoantibodies to specific nuclear
antigens, including RNP, Sm, SSA, SSB, Scl-70,
Jo-1, CENP-B, ribosomal
P, DNA and Histones
Excellent correlation with specific autoantibody
ELISA test kits
Improved specificity compared immunofluorescent
Ribosomal in Biological News
Study finds DNA barcoding requires caution without closer examination
...n proposed for plants, none of them serves as a universal barcode marker. Regions that have been proposed for plants include a section of the nuclear ribosomal
DNA: the internal non-transcribed spacer region (ITS); and various plastid regions to include the trnH-psbA intergenic spacer and the plastid genes rp...
American Chemical Society Weekly PressPac -- April 8, 2009
...ve to date for detecting ricin appear in ACS' Analytical Chemistry , a semi-monthly journal.
The scientists note in the new studies that ricin, a ribosomal
inactivating protein found in castor beans, is one of the agents most likely to be used in acts of aerosol or food-related bioterrorism. Ricin can be...
Penn biologists discover how 'silent' mutations influence protein production
...ein levels? Eventually, we looked at mRNA structure and discovered that this was the underlying mechanism."
The stability of mRNA folding near the ribosomal
binding site explained more than half the variation in protein levels. To understand this observation, the researchers simulated the spatial arrangem...
Einstein researchers devise a fast and sensitive way to detect ricin
...ake proteins─a basic cellular function. Ricin does this by disrupting ribosomal
RNA (the key component of ribosomes, the cell's protein manufacturing "machines"). The ricin attack causes ribosomal
RNA to release a molecule of adenine. Dr. Schramm's assay detects and quant...
Rhythmic genomics -- the yeast metronome and the walk of life
...oldest clock. In a paper published in Genome Research scientists show how ribosomal
RNA genes that are essential to all Earth's organisms provide insight into how genomes maintain their integrity on their evolutionary journey.
RNA sequence changes have been ticking away like clockwork for over 3 billi...
Cellular discovery may lead to targeted treatment for rare form of anemia
...wor even stopred blood cell death.
DBA has recently been attributed to a ribosomal
protein defect that the UC team hypothesizes leads to abnormal activation o...Previous research has attributed p53 activation to the passive diffusion of ribosomal
protein L11 from the nucleolus, the part of the nucleus where ribosomes are...
Ribosomal in Biological Technology
Celsis Introduces ReACT(TM) RNA-Based Microbial Detection Assays
...ed assay to obtain a fast, 2-hour result on samples that test positive for microbial contamination. Celsis ReACT assays use proprietary selections of ribosomal
RNA sequences to confirm or to rule out the presence of Gram-negative organisms, Staph. aureus, yeast and mold, and can be customized for facility-spe...
Cylene Pharmaceuticals Initiates Phase II Clinical Trial of Quarfloxin (CX-3543) in Patients With Carcinoid/Neuroendocrine Tumors
... fluoroquinolone class of drugs. Rationally designed
to selectively inhibit ribosomal
RNA (rRNA) biogenesis in cancer cells,
quarfloxin disrupts the interaction between the Nucleolin protein and a
G-quadruplex DNA structure in the ribosomal
DNA (rDNA) template, a critical
interaction for rRNA biogenesis and one tha...
AdvanDx's PNA FISH(TM) Test Shown to Reduce Mortality by 42% for Patients With Hospital-Acquired Enterococcus faecium Bloodstream Infections
...d highly sensitive and specific
fluorescence in situ hybridization (FISH) assay that uses PNA (peptide
nucleic acid) probes to target species specific ribosomal
RNA (rRNA) in
live bacteria and yeast. The unique properties of the non-charged, peptide
backbone of PNA probes enable the use of FISH assays in excee...
Molecular sleuths track evolution through the ribosome
...nary tree of life and suggests that differences in ribosomal
structure between the three main branches of that ... looked at the three-dimensional structures of the ribosomal
RNA and proteins and their proximity to each other... study, developed computer programs to analyze the ribosomal
sequences of different organisms. Whenever he foun...
Norgen Biotek Corp. Launches Four New Kits for the Purification of RNA and DNA from Plants and Fungi
...ctively from a wide range of plant and
filamentous fungal species. The Plant/Fungi RNA Purification Kit isolates all
sizes of RNA, from large mRNA and ribosomal
RNA down to microRNA. The purified
RNA is of the highest integrity, and can be used in a number of downstream
applications including Real-Time PCR, re...
Rib-X Pharmaceuticals to Present at Cambridge Healthtech Institute's 2nd Annual Challenge of Antibacterial Development Conference
...2008 in San
Dr. Johnson's presentation, entitled "Using Structure-Based Discovery
to Define Novel Macrolide Antibiotics Targeting the 50S ribosomal
will focus on Rib-X's ability to develop new antibiotic compounds using a
drug discovery engine that combines a sophisticated, structure-bas...
Ribosomal in Biological Products
GIBCO Streptomycin Sulfate from Invitrogen
Description:... Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal
subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula weight:...
Anisomycin from Sigma-Aldrich
Description:...inase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.• Inhibits formation of the 80S ribosomal
complex from 60S subunits• From Streptomyces griseolus Assay: ≥ 96.0 % (TLC)• Synonyms 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidined...
AmpliTaq DNA Polymerase, LD with Buffer I from Applied Biosystems
Description:...e effecitvely minimized when amplifying bacterial sequences. The enzyme is quality control tested to verify that less than 10 copies of bactieral 16S ribosomal
RNA gene sequences are present in a standard 2.5 Unit aliquot....
Ribosomal in Biological Definition
...re with bacterial protein synthesis
Antibiotics which bind to the 50S ribosomal
Lincosamides/lincosides including clindamycin and lincomycin; chloramphenicol, macrolides
Antibiotics which interfere the 30S ribosomal
Tetracyclines; aminoglycosides including gentamicin
...s from Sean Nee
"the contribution of visible life to biodiversity is very small indeed".
"On the tree of life, based on analyses of small-subunit ribosomal
RNA , visible life consists of barely noticeable twigs. This should not be surprising — invisible life had at least three billion years to dive...
...cleus, even if they are far apart on the chromosome. The short arm of a chromosome can be extended by a satellite chromosome that contains codes for ribosomal
Chromosomes in different species
Table 1: Examples of chromosome numbers (diploid).
# of chromosomes
...fungal taxa has undergone substantial changes in the last several decades, especially as techniques for comparing biochemical characteristics (such as ribosomal
RNA and DNA) have become increasingly more sophisticated. The phylogeny presented here is after Bruns et al. (1991, 1993) for the Eumycota (true fun...
...le" of the cell nucleus , which is an organelle .
It is a consequence of ribosomal
RNA ( rRNA ) synthesis: nucleolar organizers , special regions on some ...ns).
Following synthesis, rRNA molecules are attached to proteins, forming ribosomal
subunits, which leave for the cytosol through nuclear pores .
Transcription Start Site (TSS)
A binding site for RNA polymerase
RNA-polymerase I: transcribes genes encoding ribosomal
RNA-polymerase II: transcribes genes encoding mRNA and certain small nuclear RNAs
RNA-polymerase III: transcribes genes encoding tRNAs and o...
Ribosomal in Biological Dictionary
Wobble base pair
...... It has comparable thermodynamic stability of the Watson-Crick base pair . ... The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal
RNA is ... wobble base pairs by introducing both single and double mutations at each pair . ... ... for you below, a wobble interaction is t...
... Transfer RNA is a small RNA molecule that transfers a specific active amino acid to a growing polypeptide chain at the ribosomal
site of protein synthesis during translation. It has a 3' terminal site for amino acid... transfer RNA n. ( Abbr. tRNA ) One of a cl...
...tance ) ... Resistance to tetracyclines can arise through drug efflux, ribosomal
protection ... ... moderate resistance to macrolides (10), and tet genes coding for ribosomal
... resistance genes have been found in anaerobes (3, 18), only the tet ...
... of the ribosome is ... Class 1 RFs recognize stop codons within the ribosomal
A site and trigger the ... Stop codons : the Good, the Bad, and the...on the sequence surrounding ... In response to a stop codon in the ribosomal
A-site, ... This may result from an altered stop codon recognition abil...
...rts translating with the start of the first codon at base 0, base 1, or ... There is often more than one AUG codon in an mRNA, and the small ribosomal
... start codon prediction is the most difﬁcult remaining part of prokaryotic ... Among the possible start codon candidates, what extra evi...
Small nuclear RNA
...A ... focuses on transport of messenger RNA , small nuclear RNA , ribosomal
RNA , ... senger RNA (mRNA), small nuclear RNA (snRNA), ribosomal
RNA (rRNA) ... ... a new world of RNAs that subvert this formula, in w...