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Ribonuclease in Medical News

Enzyme with a sugar antenna

... Angewandte Chemie , scientists led by Carlo Unverzagt at the University of Bayreuth (Germany) have now successfully used a new strategy to synthesize ribonuclease C (RNase C), a glycosylated bovine pancreatic enzyme. Sugar components play an important role in the water solubility, stability, and folding of gly...

Alfacell Announces Management Update

...the end of January 2009. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whi...

Alfacell Reports Financial Results for First Quarter of Fiscal 2009

...the planned NDA submission. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whi...

Brain Tumor Drug in Frogs A New Report

...reatment of the future.Amphinase is a version of a ribonuclease enzyme that has been isolated from the oocytes (eg... in the future.Amphinase is the second anti-tumour ribonuclease to be isolated by Alfacell Corporation from Rana p...velopment and understanding of our family of novel ribonuclease based therapeutics with the potential to help pati...
Ribonuclease in Medical Technology

Alfacell Provides Shareholder Update

...dent, Chief Operating Officer About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Provides ONCONASE(R) NDA Submission Update

...e submission of its NDA. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whi...

Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines

...ortant role in treating the disease." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Announces ONCONASE(R) Distribution and Marketing Agreement with Megapharm for Israel

...essful collaboration with Megapharm." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial

...Alfacell's Web site at http://www.alfacell.com . About ONCONASE(R) ONCONASE is a first-in-class product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell's ONCONASE(R) Shows Potential as Radiation Sensitizer for Lung Cancer Treatment

...velops in, and confounds the treatment of NSCLC." About ONCONASE(R) ONCONASE is a first-in-class product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Pre-Clinical Data Show Intracellular Pathways Affected by ONCONASE(R)

...teins and to bring them forward into the clinic." About ONCONASE(R) ONCONASE is a first-in-class product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program

...tudy and receive at least one dose of study drug. About ONCONASE(R) ONCONASE is a first-in-class product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Reports Financial Results for First Quarter of Fiscal 2008

...eb site at http://www.alfacell.com . About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program

...r to discuss the company's fiscal 2007 performance. About ONCONASE(R) ONCONASE is a first-in-class product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...
Ribonuclease in Biological Technology

Alfacell Provides ONCONASE(R) NDA Submission Update

...fective as of January 1, 2009. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whi...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

...therapy in this disease. About ONCONASE (R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whi...

Alfacell Reports Fiscal Fourth Quarter and Full Year 2008 Financial Results

...CONASE clinical development program." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Paper in Cell Cycle Reports Alfacell's ONCONASE(R) Targets siRNA

...ioma that failed prior chemotherapy." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Hires Advisors to Advance Strategic Alternatives

... has approved a specific transaction. About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Reports Financial Results for Third Quarter of Fiscal 2008

...eb site at http://www.alfacell.com . About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Announces Retirement of Chief Executive Officer

...fic foundation she has built for us." About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Reports Financial Results for Second Quarter of Fiscal 2008

...eb site at http://www.alfacell.com . About ONCONASE(R) ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell Announces ONCONASE(R) Purchase and Supply Agreement with Scientific Protein Laboratories

...evelopment and straight through to commercial launch. About ONCONASE(R) ONCONASE is a first-in-class product candidate from Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells whil...

Alfacell to Host Webinar on RNA Interference-Like Mechanics of RNase Therapeutics on Nov. 29

...ters will Include World-Renowned RNase and RNA Researchers SOMERSET, N.J., Oct. 25 /PRNewswire-FirstCall/ -- The RNA interference- like mechanics of ribonuclease (RNase) therapeutics will be the focus of scientific presentations in a Nov. 29 Webinar hosted by Alfacell Corporation (Nasdaq: ACEL ). Moderated by...
Ribonuclease in Biological Products

Rnase-free Ribonuclease Inhibitor from Chimerx

Description: A very potent Rnase free Ribonuclease Inhibitor that is effective over a broad range of temperatures and pH's. This protein does not inhibit SP6, T7, or T3 RNA polymerase, AMV and M-MLV reverse transcriptase or Taq DNA polymerase. For bulk purchases contact lloconne@molbiores.com....
Company:Chimerx

RNase ONE™ Ribonuclease from Promega

Description: RNase ONE Ribonuclease is a 27kDa periplasmic enzyme from E. coli that catalyzes the degradation of RNA to cyclic nucleotide monophosphate (NMP) intermediates. Slower hydrolysis further catalyzes the degradation of these intermediates to 3-NMPs (1). RNase ONE Ribonuclease is one of the few known RN...
Company:Promega

RNaseOUT Recombinant Ribonuclease Inhibitor from Invitrogen

Description: RNaseOUT Recombinant Ribonuclease Inhibitor is a potent noncompetitive inhibitor of pancreatic-type ribonucleases such as RNase A. Like other RNase inhibitors RNaseOUT Recombinant Ribonuclease Inhibitor is an acidic protein with a molecular weight ~52 kDa. RNaseOUT inhibits RNase A RNase B and RNas...
Company:Invitrogen

GeneChoice RNA Safe Recombinant Ribonuclease Inhibitor from GeneChoice, Inc.

Description: Ribonuclease Inhibitor is a recombinant protein that has been shown to help maintain the integrity of RNA in the preparation of cDNA by reverse transcription, in vitro RNA transcription, and in vitro protein synthesis. RNA Safe Inhibitor tightly binds RNases in a 1:1 ratio. It inhibits a broad ran...
Company:GeneChoice, Inc.

Recombinant RNasin® Ribonuclease Inhibitor from Promega

Description: Natural and Recombinant RNasin Ribonuclease Inhibitors have broad spectrum RNase inhibitory properties, including the inhibition of eukaryotic RNases of the neutral type (1). The 50kDa protein exerts its inhibitory effect by noncovalently binding to RNases in a 1:1 ratio. The Ki value for the bindi...
Company:Promega

MAXIscript SP6/T7 Kit from Ambion

Description:...scription Kits synthesize RNA probes with specific activities reaching 1 x 10 9 cpm/g. High specific activity, single-stranded RNA probes are used in ribonuclease protection assays, in situ hybridization, and blot hybridizations. MAXIscript Kits can also be used for the synthesis of modest amounts of unlabeled R...
Company:Ambion

5X MEGAscript® T7 Kit from Ambion

Description:...ly incorporates many modified nucleotides Kits specific for templates with T7, T3 and SP6 RNA polymerase promoters All kits contain SUPERaseIn ribonuclease Inhibitor ...
Company:Ambion

HIV Volume 2 (Biochemistry, Molecular Biology and Drug Discovery) from Promega

Description:...nd information, detailed practical information and methods for the study of major HIV proteins including: the HIV growth cycle; reverse transcriptase, ribonuclease H, integrase and protease. Expression of HIV proteins using baculoviruses; RNA binding assays; Tat and Rev assays; HIV/CD4 interactions; transient ass...
Company:Promega

StabMRT Maxi Kit from RNAworks

Description:...l molecular biology applications including storage, transport, handling, analysis by gel electrophoresis, Agilent Bioanalyser 2100, mass spectrometry, ribonuclease protection assays and Northern blotting. Protocols on line on RNAworks website A free MRT-RNA sample is available on request from RNAworks. ...
Company:RNAworks

StabMRT Plus Mini Kit from RNAworks

Description:...ications including RT-PCR and microarrays, storage, transport, handling, analysis by gel electrophoresis, Agilent Bioanalyser 2100, mass spectrometry, ribonuclease protection assays and Northern blotting. Protocols on line on RNAworks website A free MRT-RNA sample is available on request from RNAworks. ...
Company:RNAworks
Ribonuclease in Biological Dictionary

Ribonuclease

Ribonuclease is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7... Ribonuclease A (RNase A) is an endonuclease that cleaves singl...

Tertiary Structure

...on of protein tertiary structure (Ab Initio) ... The tertiary structure of proteins is maintained by a host of weak, non-covalent ... ribonuclease has several disulphide bonds stabilising its tertiary structure . ... Tertiary structure is stabilized by noncovalent interactions and, in s...

RNase

... ribonuclease (commonly abbreviated RNase ) is a type of nuc...e turnover ribozymes in nature (the other ... ribonuclease P ( RNase P) is a type of ribonuclease which cleaves RNA. RNase P is unique from other ...
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