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Retroviral in Medical News

Importance of Retroviral Drugs Underestimated

The South Africa's health minister, Manto Tshabalala-Msimang, claims that including garlic, beetroot and lemon in one’s diet would delay the onset of AIDS//. She declares that she is telling the truth and has also warned about the ill effects of the anti-retroviral drugs. This has sparked ...

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

...s found. Raltegravir also had faster onset of action and fewer adverse side effects. In the clinical trial, both were combined with two other standard retroviral drugs, tenofovir and emtricitabine. The trial included 566 patients from 67 medical centers on five continents. The "primary endpoint" of the trial...

Nobel Laureate Celebrates With Thomson Reuters, Drs. Clotet and Gatell Ten Years of HIV Updates

...om/sida ), jointly sponsored by Abbott, Boehringer-Ingelheim, Gilead, Janssen-Cilag and Pfizer. Professor Barre-Sinoussi is a researcher at the retroviral Infections Regulation Unit of the Virology Department, Pasteur Institute, Paris, and was awarded the 2008 Nobel Prize in Medicine for the discovery of...

iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

...nounced that his lab succeeded in inducing iPS cells in mouse by using four transgenes - Oct3/4, Sox2, Klf4 and c-Myc - delivered into fibroblasts via retroviral vectors, which became the world's first report of its kind. He also reported the generation of human iPS cells the following year. iPS cell technology...

JCI table of contents: March 23, 2009

...any, discuss the clinical importance of these data and the numerous questions that they pose for future research. TITLE: The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy AUTHOR CONTACT: Eugenio Montini...

Keystone Symposia to Mark 25th Anniversary of its First HIV/AIDS Meeting

...co-discovered the virus that causes AIDS - Human Immunodeficiency Virus (HIV) - along with colleague Dr. Luc Montagnier. Barre-Sinoussi is Head of the retroviral Infection Control Unit at Institut Pasteur in Paris and won the 2008 Nobel Prize for this discovery. Keystone Symposia's first conference on AIDS...

Converting adult somatic cells to pluripotent stem cells using a single virus

...neration Using a Single Lentiviral Stem Cell Cassette" appears on line in the journal Stem Cells . Prior research studies have required multiple retroviral vectors for reprogramming -- steps that depended on four different viruses to transfer genes into the cells' DNA essentially a separate virus for ea...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

...es. Pikaard and his colleagues' work may have implications for applied medical research. For instance, gene therapy procedures sometimes use retroviral vectors as a way of introducing a foreign gene to replace a function impaired by disease. Often this foreign gene, called a transgene, restores the m...

Video: Magic Johnson Foundation and Abbott Call for Greater Prevention, Testing and Treatment on World AIDS Day

...epidemic. In 1985, the company developed the first licensed test to detect HIV antibodies in the blood and remains a leader in HIV diagnostics. Abbott retroviral and hepatitis tests are used to screen more than half of the world's donated blood supply. Abbott has developed two protease inhibitors for the treatm...

Open Biosystems' Open Access RNAi Program Continues to Gain Momentum Worldwide

... a collaboration that encourages and supports scientific advancements." Open Biosystems' portfolio of RNAi resources include shRNAmir lentiviral and retroviral libraries targeting the entire human and mouse genomes, the RNAi Consortium human and mouse lentiviral shRNA libraries as well as RNAi collections tar...

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Retroviral in Medical Technology

Abbott's Kaletra(R) Tablet Dosed Once-Daily or Twice-Daily Demonstrated Similar Clinical Results Across Race and Gender Lines

...epidemic. In 1985, the company developed the first licensed test to detect HIV antibodies in the blood and remains a leader in HIV diagnostics. Abbott retroviral and hepatitis tests are used to screen more than half of the world's donated blood supply. Abbott has developed two protease inhibitors for the treatm...

Dr. Harriet Robinson Joins GeoVax Team as V.P. of R & D to Accelerate AIDS Vaccine Trials Program

...mory University School of Medicine. Dr. Robinson is a pioneer in DNA vaccines and one of the world's leading AIDS vaccine researchers. Research with retroviral vectors led to her pioneering studies with DNA vaccines. Her developmental work with HIV/AIDS vaccines has been guided by the ability of candidate Geo...

Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine

...cientific interest. And we quote, "A third example is represented by the first and so far only targeted vector that has been tested in the clinic: the retroviral vector Rexin-G, which expresses a cytocidal dominant-negative form of cyclin G1." The article goes as far as to mention the fact that a number of clin...

Roche Diagnostics' HIV Viral Load Test Used in Clinical Trials for Isentress, a New Class of HIV Drug

...e, according to a 2007 peer reviewed study published in Antiviral Therapy. Roche's HIV-1 viral load test has been the predominant choice in HIV anti- retroviral clinical drug trials since 1996. Roche has provided research and expertise in comprehensive diagnostic tests for developing HIV anti-retroviral drugs....

AVEO Pharmaceuticals Novel Oncology Research Platform and Clinical Pipeline to Be Featured at AACR

...- Wednesday, April 18, 2007 at 10:40 a.m. to 10:55 a.m. "Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis" - Mini-symposium: Integrated Genomic Analysis of Human Cancer - Room 304 A-C -- Wednesday, April 18, 2007 at 10:25 a.m. to 10:40 a.m. "...
Retroviral in Medical Dictionary

Acute HIV infection

...other viral illnesses. ... HIV RNA viral load is positive in patients with acute HIV infection . ... Acute HIV Infection ( Acute retroviral Syndrome, HIV Seroconversion Syndrome, ... Acute HIV infection can resemble infectious mononucleosis or other viral flu ... Acute ...
Retroviral in Biological News

A clue from macaques yields evidence for impaired retroviral defense genes in humans

Researchers Harmit Malik and Michael Emerman and colleagues at the Fred Hutchinson Cancer Research Center have found that a surprisingly large fraction of humans may be impaired in the function of a recently discovered arm of the body's defense against invading retroviruses such as HIV. One of t...

Chimp genome reveals a retroviral invasion

It's been known for a long time that only 2% -- 3% of human DNA codes for proteins. Much of the rest of our genomes -- often referred to as junk DNA -- consists of retroelements: genomic elements that are transcribed into RNA, reverse-transcribed into DNA, and then reinserted into a new spot in the...

New tool isolates RNA within specific cells

...detect cell type-specific gene expression. The researchers say the method should work in other systems, including vertebrates, by using gene transfer, retroviral delivery, electrical pulses of molecules through cell membranes, or messenger RNA injection. ...

New method developed by UC San Diego bioengineers gives regenerative medicine a boost

... nuclear reprogramming of differentiated adult human cells into pluripotent stem cells. "We found that nuclear reprogramming based on the existing retroviral carriers appears to result in over-reprogramming, which will have profound implications on the use of induced pluripotent cells for personalized regen...

New gene-silencing pathway found in plants

... Pikaard and his colleagues' work may have important implications for applied medical research. For instance, gene therapy procedures sometimes use retroviral vectors as a way of introducing a foreign gene to replace a function impaired by disease. Often this foreign gene, called a transgene, restores the m...

ASU researchers receive NIH awards for studies of malaria and emergent disease

...udies. Two of the studies will examine the ecology and evolution of malaria and a third will delve into the genetic mysteries behind the host shift of retroviral disease from primates to humans. Escalante, lead investigator of the malarial studies, will undertake a global comparative study of the evolution ...

Landmark study unlocks stem cell, DNA secrets to speed therapies

...uripotent stem cells, out of many adult cell types, but there are two major hurdles remaining. First, the methods currently used rely on the unnatural retroviral insertion of genes into patients' cells, and these genes are capable of forming tumors. Second, this method is very inefficient as well because only o...

UT pathologists believe they have pinpointed Achilles heel of HIV

...r millions of years of evolution a lot of viral fragments called endogenous retroviral sequences. These endogenous retroviral sequences are overproduced in people with lupus, and an immune response to ...

2 French scientists win European award for communication

...us were confirmed for many other retroviruses, including HIV, and may represent a novel target for therapeutic intervention on the incoming phases of retroviral infections. On hearing the news of his selection, he said, "I'm really honored to receive this Award. Communicating life sciences to the public an...

Penn Veterinary Medicine report new strategy to create genetically-modified animals

...te transgenic animals. These inefficient and difficult methods also carry a risk of producing offspring with developmental abnormalities. The use of retroviral or lentiviral vectors has been reported in rodents, but it requires that animals be handled and maintained under higher biosafety precautions that ren...

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Retroviral in Biological Technology

pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins

Faster, easier screening for difficult transfections when using the complete control kit Peter Vaillancourt Katherine A. Felts Stratagene We describe the vector pFB-ERV, an MMLV-based replication-defective retroviral vector for delivery of the ecdysone receptor proteins...

Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries

Retroviral libraries with high-titer efficiency and larger insert potential Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries Katherine Felts Kim Zaharee Latha Sundar Jamie Limjoco Anna Waesche Peter Vaillancourt Stratagene ...

Gene Therapy Field Advances With Important Clinical Findings Reported in the New England Journal of Medicine

...ospects of continuing advancement of gene therapy to wider applications remain strong. Ongoing and upcoming clinical trials will use safer designs of retroviral vectors, newer types of vectors for viral gene therapy, and emerging methods for direct in situ gene repair. These approaches to the treatment of hemo...

Open Biosystems' Open Access RNAi Program Adopted by University of Copenhagen and University of Queensland

...disease," said Troy Moore, Chief Technology Officer at Open Biosystems. Open Biosystems' portfolio of RNAi resources include shRNAmir lentiviral and retroviral libraries targeting the entire human and mouse genomes, the RNAi Consortium human and mouse lentiviral shRNA libraries as well as RNAi collections tar...

Open Biosystems' Open Access RNAi Program Adopted by Harvard Medical School and University of North Carolina

...ce of Open Biosystems' unique portfolio of genome-wide RNAi resources." Open Biosystems' portfolio of RNAi resources include shRNAmir lentiviral and retroviral libraries targeting the entire human and mouse genomes, The RNAi Consortium human and mouse lentiviral shRNA libraries and RNAi libraries targeting Dr...

Biotech Hall of Fame Inductees Announced

... Varmus and J. Michael Bishop Co-recipients of the 1989 Nobel Prize in Physiology or Medicine for their discovery of the cellular origins of retroviral oncogenes. They directed the research that led to the discovery of proto-oncogenes -- normal genes that can be converted to cancer genes by ...

Americas Third Coast nurtures biotechnology

...that allows the rapid creation of stable, high-expressing mammalian cell lines for a variety of gene products. GPEx relies on a safe version of the retroviral gene insertion machinery discovered by the late Howard Temin at UW-Madison, who won the Nobel Prize in 1975 for his discovery. In biologics, theres a ...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

...on competent retrovirus in retroviral vector based gene therapy products and during follow-up of patients in clinical trials using retroviral vectors. 2000 Oct 18. Available at URL: http://www.fda.gov/cber/gdlns/ retrogt1000.pdf. ICH Steering Committee.Guideline...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

...llow for transient or stable transfection of the shRNA as well as production of lentiviral particles. Unlike adenovirus or murine-based MMLV or MSCV retroviral systems, lentiviral-based particles permit efficient infection and integration of the specific shRNA construct into differentiated and non-dividing ...

Gq-coupled Receptor Assays Using FLEXstation

... epithelial cell line MDCK-D1 (1, 9). The cP2Y 11 gene was cloned into the retroviral expression vector pLXSN, which was used to transfect PA317 retroviral packing cells. The resulting virus was used to infect the canine thymocyte ...
Retroviral in Biological Products

Rabbit Anti-Dideoxycytidine Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit polyclonal to Dideoxycytidine Dideoxycytidine is a cytidine analog that has been shown to be effective in inhibiting retroviral activity. Immunogen: Chemical / Small Molecule conjugated to BSA. Specificity: The specificity of the ddC antiserum was determined by calculatin...
Company:GeneTex
Retroviral in Biological Definition

Gene therapy

...is recognition by the immune system. When familiar viruses are detected in the bloodstream the body sends antibodies to bind to and consume them. In retroviral and other recombination-based approaches, a second problem arises in the unpredictablity of where the new DNA inserts into the chromsomes of transfect...

Retrovirus

... genome; the reverse transcription takes place in the host's cytosol . The retroviral DNA, when integrated into the host's genome, is termed a provirus . Whil...tase , protease and integrase ; and, env ( env elope) codes for the retroviral coat proteins. Four identified human retroviruses ( HTLV 1&2, ...
Retroviral in Biological Dictionary

Spermatogonia

...gonia , 3 spermatocyte 1st order, 4 spermatocyte 2nd Spermatogonia represent a new route to transgenesis in mice ... But the factors influencing retroviral transduction into spermatogonia are not well understood. ... The mitosis of differentiating spermatogonia , the meiosis of spermatocytes, ...

Palindromic Sequence

...lindromist ... Only one palindromic sequence was successfully cleaved by IN. ... The palindromic sequence in the 2-LTR circles generated in retroviral ... We find evidence that the palindromic motif has a clear consensus sequence , whereas Liao et al. ... optimal target site is a palindrom...

Mismatch repair

...tic Cancer Outcomes ... Eukaryotic cells possess several distinct mismatch repair pathways. ... In order to evaluate mismatch repair of retroviral double-stranded DNA, Moloney ... The European ... Mismatch repair contributes to the overall fidelity of DNA ... The post-replicative Mismatch...

Inverted Repeats

...2. Inverted Repeats ... The DNA of many transposons is flanked by inverted repeats such as this one: ... Inverted repeats at either end of retroviral gene ... to differ in the number of inverted repeats . ... of inverted repeats . Fourth, when measuring the recombining potential of inver...

Direct Repeats

...fect direct repeats argues that the majority of deletion ... nascent strand at the direct repeats ... Deletion of direct repeats in retroviral genomes provides an in vivo system for ... did not increase the rate of template switching for shorter direct repeats . ... U, considering ...

Cloning vector

... such as a bacterial plasmid ( cloning vector ) ... MicroRNA-adapted retroviral Vectors - for flexible shRNAmir cloning and expression ... Easy cloning of shRNAmir from pSM2 into Pol II retroviral vectors ... A searchable gene bank of over 33,000 human full-lengt...
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