International team cracks mammalian gene control code
... and leave copies of themselves behind.
"The dogma in the field is that retrotransposons
are only active in cancer cells and cells that turn into eggs and sperm," Dr Faulkner said. "Our results showed that retrotransposons
that can no longer move around the genome may still be expressed in a broad...
BWF awards $11.2 million to support physician-scientists
...ovel regulators of the osteoclast differentiation program
Kathleen H. Burns, M.D., Ph.D.
Johns Hopkins University
Investigating the role of retrotransposons
in hematopoietic neoplasias
Daniel Cahill, M.D., Ph.D.
Harvard Medical School
Translational molecular genetic analyses of chemotherapeutic ...
Darwin's legacy in 21st century biology
Lunch: 12:15 to 1:30
Dr. Haig Kazazian, Seymour Gray Professor of Molecular and Medical Genetics, University of Pennsylvania School of Medicine. retrotransposons
Dr. Nancy Cox, Professor, Department of Human Genetics, Chief of the Section of Genetic Medicine University of Chicago. Genetic variation...
New research shows how gene function drives natural selection in important class of genetic elements
...ian leukosis and feline leukemia.
"Because LTR retrotransposons
are abundant and impact host genomes, we wanted to...
The researchers examined selection pressure on retrotransposons
using Oryza sativariceas a model plant genome. The...re inserted.
"Overwhelmingly, we found that LTR retrotransposons
are under significant evolutionary constraint, by ...
Researchers solve piece of large-scale gene silencing mystery
...RNA's nucleotide sequence.
In nature, cells use RNAi to silence "junk DNA," noncoding regions of the DNA, and "selfish DNA" such as virus-derived retrotransposons
(jumping genes) that can be detrimental if activated.
In the lab, Pikaard and his collaborators use RNAi to "knockdown" expression of target gene...
New gene-silencing pathway found in plants
...siRNAs generated by Pol IV. By acting as a scaffold for these siRNAs, the Pol V transcripts enable silencing of adjacent, virus-derived genes such as retrotransposons
(jumping genes) that can be detrimental if activated. Pikaard and colleagues were able to confirm that both Pol IV and Pol V are necessary for silenc...
Mapping a clan of mobile selfish genes
...ments, some become unable to make copies of themselves. To identify the Alu retrotransposons
that are still capable of moving around, Devine and graduate student E. And...eatest transposon-mediated threat to our genomes," Devine says.
The term retrotransposons
comes from how they replicate: first, the DNA is transcribed (copied) into ...
Kansas state flower receives scientific attention
"We are trying to understand the circumstances that caused retrotransposons
to become active and proliferate in these sunflowers and the evolutionary a...nsequences of these proliferation events," Ungerer said. He also noted that retrotransposons
are not just found in sunflowers but in virtually all plants and animals, e...
Insight into DNA's 'weakest links' may yield clues to cancer biology
... containing "retrotransposons" called Ty elements. retrotransposons
are mobile gene segments that duplicate themselves...A is in a single-stranded form, multiple copies of retrotransposons
are more likely to interact, forming a kink in the... improperly excised and repaired by rejoining with retrotransposons
on other chromosomes.
"The current findings off...
New RNA polymerase discovered in plants
...small RNAs called siRNAs corresponding to highly repeated 5S rRNA genes and retrotransposons
(jumping genes) are completely eliminated and DNA methylation at 5S genes and retrotransposons
Methylation is a vital process involving a chemical modificatio...