Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
For patients with high-risk breast cancer treated with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy leads to better survival outcomes with few long-term toxic effects, according to a 20-year follow-up of a randomized trial, which appears in the January 19 issue of the Journal of the National Cancer Institute. The British Columbia randomized radiation the...Gene variations explain drug dose required to control seizures
Determining which variants of particular genes patients with epilepsy carry might enable doctors to better predict the dose of drugs necessary to control their seizures, suggest basic findings by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and the University College London. Patients often undergo a lengthy process of trial and error to find the dose of ant...B cells are required for development of epithelial cancer associated with chronic inflammation
Chronic inflammation is linked to the development of certain types of cancer, but mechanisms mediating inflammation during premalignancy are not well understood. A new research study published in the May issue of Cancer Cell identifies B lymphocytes as important regulators of premalignancy associated with chronic inflammation. The results suggest that drugs targeted against B lymphocytes or recru...Molecular Partners Required For Appropriate Neuronal Gene Repression
Oregon Health & Science University researchers have identified some of the key factors that prevent the repair of brain damage caused by multiple sclerosis (MS), complications of premature birth, and other diseases and conditions. The findings offer important clues about why the nervous system fails to repair itself and suggest ways that at least some forms of brain damage could be reversed....Malignant melanoma cells secrete protein required for embryo formation
A Northwestern University research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to proper embryo formation. An article describing this research was published today in the advanced online issue of the journal Nature Medicine. The researchers identified the potent and highly unstable embryonic growth factor by injecting aggressive melanoma c...Care for footwear not required diabetic patients
According to a new study, shows that ulcer rates among diabetes wearing special shoes are no lower than among those wearing ordinary good quality footwear. People with diabetes should be well aware that good foot care is an essential// part of managing their condition. For the poor circulation that is typical in diabetes leaves the foot vulnerable to ulceration and other problems which ca...Advanced STD programs required
There is always a question of how effective are programs intended to reduce the number of people with sexually transmitted infections, including HIV. That is the question researchers from Scotland set out to answer in a study reported //in this month's Archives of Internal Medicine. The answer they come up with is, essentially, that it'sdiifficult to say. More than 1,500 studies were g...Easier Methods Required to Screen Insulin Resistance
Insulin resistance is a major medical problem often leading to diabetes and cardiovascular disease. Being overweight greatly increases the odds someone will be insulin //resistant, but not all overweight or obese people are afflicted. The insulin suppression test used to identify insulin resistance, however, it is too difficult to administer to large numbers of people. Researchers have...Easier Methods Required to Screen Insulin Resistance
Insulin resistance is a major medical problem often leading to diabetes and cardiovascular disease. Being overweight greatly increases the odds someone will be insulin // resistant, but not all overweight or obese people are afflicted. The insulin suppression test used to identify insulin resistance, however, it is too difficult to administer to large numbers of people. Researchers hav...Better Care Required for Breast Cancer Survivors
A recent study by Germany researchers shows young breast cancer survivors may suffer from more long-term effects than older patients. // As patients may not be getting the appropriate therapy needed for coping with the aftermath of the disease. Researchers sampled nearly 200 breast cancer patients who had been diagnosed 10 years ago and asked about their physical symptoms and current the...